{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T03:40:07Z","timestamp":1791862807459,"version":"4.3.4"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T00:00:00Z","timestamp":1721779200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"S\u00e3o Paulo Scientific Foundations-FAPESP","award":["2017\/04138-8"],"award-info":[{"award-number":["2017\/04138-8"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To investigate the effects of Araucaria sp. brown propolis (ABP) against trinitrobenzenesulfonic acid (TNBS)-induced colitis in rats.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Animals received vehicle (1% DMSO, 1 ml\/kg) or hydroalcoholic extract of ABP (hydroalcoholic extract of Araucaria sp. brown propolis (HEABP), 30, 100, and 300 mg\/kg) orally, or dexamethasone (25 mg\/kg, s.c.) for 5 days. On day 4, the animals received intracolonic TNBS (150 mg\/kg), on day 6 they were euthanized. The weight of the animals, the macroscopic and microscopic colonic damage, reduced glutathione (GSH) and malondialdehyde (MDA) levels, and the activity of glutathione S-transferase (GST), catalase (CAT), superoxide dismutase (SOD), and myeloperoxidase (MPO) were measured in colon homogenate. The action of HEABP and two isolated compounds in neutrophil migration was recorded.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>HEABP (100 and 300 mg\/kg), but not dexamethasone, decreased colonic lesion, and increased colonic mucin staining. In parallel, HEABP decreased MDA and restored GSH levels and the activity of SOD, CAT, and GST in the colon. A dose-dependent inhibition of MPO activity was observed (LogIC50 = 1.9). Moreover, HEBPA and the junicedric and abietic acids inhibited the neutrophil chemotaxis in vitro and HEBPA reduced neutrophil migration in vivo.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>HEABP may be promising in the therapies for inflammatory bowel diseases, reducing oxidative and inflammatory damage, especially mediated by neutrophils.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jpp\/rgae083","type":"journal-article","created":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T11:01:25Z","timestamp":1721905285000},"page":"1379-1392","source":"Crossref","is-referenced-by-count":9,"title":["Hydroalcoholic extract of <i>Araucaria<\/i> sp. brown propolis alleviates ulcerative colitis induced by TNBS in rats by reducing inflammatory cell infiltration and oxidative damage"],"prefix":"10.1093","volume":"76","author":[{"given":"Benhur Judah","family":"Cury","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Science, University of Vale do Itaja\u00ed , Itaja\u00ed , Santa Catarina,","place":["Brazil"]},{"name":"Department of Pharmacology, Laboratory of Pharmacology Applied to the Gastrointestinal Tract and its Interactions, Federal University of Santa Catarina , Florian\u00f3pols ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele Teixeira","family":"Jer\u00f4nimo","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Science, University of Vale do Itaja\u00ed , Itaja\u00ed , Santa Catarina,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Levy Mota","family":"da Silva","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Science, University of Vale do Itaja\u00ed , Itaja\u00ed , Santa 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Lucena","family":"Andriolo","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Science, University of Vale do Itaja\u00ed , Itaja\u00ed , Santa Catarina,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Roberto","family":"Santin","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Science, University of Vale do Itaja\u00ed , Itaja\u00ed , Santa Catarina,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa","family":"Benvenutti","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Science, University of Vale do Itaja\u00ed , Itaja\u00ed , Santa Catarina,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Rafael","family":"Vaz","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Science, University of Vale do Itaja\u00ed , Itaja\u00ed , Santa 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