{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:49:01Z","timestamp":1783039741179,"version":"3.54.6"},"reference-count":76,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T00:00:00Z","timestamp":1721001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Migraine, typically occurs on one side of the head, lasts for hours to days. Trigemino-vascular system (TVS) plays a vital role in pain generation, with neurogenic inflammation and oxidative stress playing key roles in its pathophysiology.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This study aimed to investigate genistein\u2019s potential as anti-inflammatory and anti-oxidant agent in mitigating migraine pain. Genistein (20 and 50 mg\/kg) was administered intraperitoneally (IP) to nitroglycerin (NTG; 10 mg\/kg)-induced migraine model in rats. Behavioral analysis, antioxidant assay, immunohistochemistry (IHC), histopathological examination, ELISA, and RT-PCR were conducted to evaluate the antimigraine potential of genistein.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>key findings<\/jats:title>\n                  <jats:p>In-silico analysis showed genestien\u2019s ACE values of \u22124.8 to \u22129.2 Kcal\/mol against selected protein targets. Genistein significantly reversed mechanical and thermal nociception, light phobicity, and head scratching; increased the intensities of GST, GSH, catalase; and down regulated lipid peroxidase (LPO) in cortex and trigeminal nucleus caudalis (TNC). It also reduced Nrf2, NF-kB, and IL6 expression, analyzed through IHC, improved histopathological features, and increased COX-2 and decreased PPAR-\u03b3 expressions, while RT-PCR analysis revealed increased PPAR-\u03b3 expressions in genistein-treated rats.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Genistein exhibited potent antioxidant and anti-inflammatory properties in migraine treatment, acting through multifactorial mechanisms by modulating the expression of numerous proteins in the region cortex and TNC.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jpp\/rgae084","type":"journal-article","created":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T06:15:54Z","timestamp":1721110554000},"page":"76-94","source":"Crossref","is-referenced-by-count":3,"title":["Pharmacological investigation of genistein for its therapeutic potential against nitroglycerin-induced migraine headache"],"prefix":"10.1093","volume":"77","author":[{"given":"Qirrat","family":"Sajjad","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Institute of Pharmaceutical Sciences, Riphah International University , Islamabad ,","place":["Pakistan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arif-ullah","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Institute of Pharmaceutical Sciences, Riphah International University , Islamabad ,","place":["Pakistan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3490-799X","authenticated-orcid":false,"given":"Aslam","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Institute of Pharmaceutical Sciences, Riphah International University , Islamabad 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