{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T01:01:06Z","timestamp":1789174866864,"version":"build-2803163510"},"reference-count":71,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2024,8,3]],"date-time":"2024-08-03T00:00:00Z","timestamp":1722643200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100004484","name":"Tehran University of Medical Sciences","doi-asserted-by":"publisher","award":["1402-1-233-65870"],"award-info":[{"award-number":["1402-1-233-65870"]}],"id":[{"id":"10.13039\/501100004484","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Osteoarthritis, a degenerative condition that results in significant morbidity, is typically managed with treatments aimed at symptom relief rather than addressing the underlying degeneration. Dapsone, recognized for its anti-inflammatory, antioxidant, antiexcitotoxic, and antiapoptotic properties, has demonstrated promising effects in various neurodegenerative diseases. This study explores the potential of dapsone to mitigate articular destruction, inflammation, and pain in rat models of osteoarthritis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Osteoarthritis was induced in rats by injecting MIA into the right knee joint. Dapsone was then administered intraperitoneally at 5, 10, or 20 mg\/kg every 2 days for 2 weeks. Behavioural tests were done on days 0, 7, and 14. On day 14, the articular cartilage was histologically analysed using H&amp;E staining. Serum levels of NF-kB, IL-1\u03b2, and TNF-\u03b1 were evaluated by ELISA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Dapsone effectively reduces pain, inflammation, and articular cartilage damage in osteoarthritis. Specifically, it improves mechanical allodynia and thermal hyperalgesia, reduces inflammatory markers (TNF-\u03b1, IL-1\u03b2, and NF-\u03baB), and protects against cartilage destruction and chondrocyte loss, with the most significant effects at 20 mg\/kg.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Dapsone effectively prevents pain, inflammation, and cartilage damage in osteoarthritis rats, suggesting its potential as a therapeutic option for managing osteoarthritis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jpp\/rgae087","type":"journal-article","created":{"date-parts":[[2024,8,3]],"date-time":"2024-08-03T19:25:37Z","timestamp":1722713137000},"page":"1497-1507","source":"Crossref","is-referenced-by-count":4,"title":["Evaluating the protective effect of dapsone on experimental osteoarthritis models induced by MIA in male rats"],"prefix":"10.1093","volume":"76","author":[{"given":"Kimia","family":"Nazari","sequence":"first","affiliation":[{"name":"Department of Toxicology and Pharmacology, School of Pharmacy, Tehran Medical Sciences, Islamic Azad University , Tehran ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saereh","family":"Hosseindoost","sequence":"additional","affiliation":[{"name":"Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences , Tehran ,","place":["Iran"]},{"name":"Pain Research Center, Neuroscience Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences , Tehran ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad Reza","family":"Dehpour","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences , Tehran ,","place":["Iran"]},{"name":"Experimental Medicine Research Center, School of Medicine, Tehran University of Medical Sciences , Tehran ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasaman","family":"Kheirandish","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Radiology, School of Dentistry, Tehran University of Medical Sciences , Tehran ,","place":["Iran"]},{"name":"Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences , Tehran ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5471-674X","authenticated-orcid":false,"given":"Hamed","family":"Shafaroodi","sequence":"additional","affiliation":[{"name":"Pain Research Center, Neuroscience Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences , Tehran ,","place":["Iran"]},{"name":"Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences , Tehran ,","place":["Iran"]},{"name":"Experimental Medicine Research Center, School of Medicine, Tehran University of Medical Sciences , Tehran ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,8,3]]},"reference":[{"key":"2024110408190269300_CIT0001","doi-asserted-by":"crossref","first-page":"16044","DOI":"10.1038\/boneres.2016.44","article-title":"Osteoarthritis: toward a comprehensive understanding of pathological mechanism","volume":"5","author":"Chen","year":"2017","journal-title":"Bone Res"},{"key":"2024110408190269300_CIT0002","doi-asserted-by":"crossref","first-page":"16072","DOI":"10.1038\/nrdp.2016.72","article-title":"Osteoarthritis","volume":"2","author":"Martel-Pelletier","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"2024110408190269300_CIT0003","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1136\/annrheumdis-2013-203355","article-title":"Incidence and risk factors for clinically diagnosed knee, hip and hand osteoarthritis: influences of age, gender and osteoarthritis affecting other joints","volume":"73","author":"Prieto-Alhambra","year":"2014","journal-title":"Ann Rheum Dis"},{"key":"2024110408190269300_CIT0004","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1002\/jcp.26011","article-title":"Histomorphology and innate immunity during the progression of osteoarthritis: does synovitis affect cartilage degradation","volume":"233","author":"Wang","year":"2018","journal-title":"J Cell Physiol"},{"key":"2024110408190269300_CIT0005","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/j.joca.2009.04.005","article-title":"Prevalence of radiographic knee osteoarthritis and its association with knee pain in the elderly of Japanese population-based cohorts: the ROAD study","volume":"17","author":"Muraki","year":"2009","journal-title":"Osteoarthr Cartil"},{"key":"2024110408190269300_CIT0006","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1097\/01.bor.0000209426.84775.f8","article-title":"Epidemiology of osteoarthritis: an update","volume":"18","author":"Sharma","year":"2006","journal-title":"Curr Opin Rheumatol"},{"key":"2024110408190269300_CIT0007","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1136\/annrheumdis-2019-215325","article-title":"Discovery of an autoantibody signature for the early diagnosis of knee osteoarthritis: data from the osteoarthritis initiative","volume":"78","author":"Camacho-Encina","year":"2019","journal-title":"Ann Rheum Dis"},{"key":"2024110408190269300_CIT0008","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/s12891-020-3120-0","article-title":"Profiling of inflammatory mediators in the synovial fluid related to pain in knee osteoarthritis","volume":"21","author":"Li","year":"2020","journal-title":"BMC Musculoskelet Disord"},{"key":"2024110408190269300_CIT0009","doi-asserted-by":"crossref","first-page":"9208","DOI":"10.3390\/ijms22179208","article-title":"Cytokines and chemokines involved in osteoarthritis pathogenesis","volume":"22","author":"Molnar","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2024110408190269300_CIT0010","doi-asserted-by":"crossref","first-page":"8293921","DOI":"10.1155\/2020\/8293921","article-title":"The role of inflammation in the pathogenesis of osteoarthritis","volume":"2020","author":"Chow","year":"2020","journal-title":"Mediators Inflamm"},{"key":"2024110408190269300_CIT0011","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.2147\/JPR.S143024","article-title":"Antiallodynic and antihyperalgesic activities of zerumbone via the suppression of IL-1beta, IL-6, and TNF-alpha in a mouse model of neuropathic pain","volume":"10","author":"Gopalsamy","year":"2017","journal-title":"J Pain Res"},{"key":"2024110408190269300_CIT0012","doi-asserted-by":"crossref","first-page":"153166","DOI":"10.1016\/j.phymed.2019.153166","article-title":"Loganin prevents chronic constriction injury-provoked neuropathic pain by reducing TNF-alpha\/IL-1beta-mediated NF-kappaB activation and Schwann cell demyelination","volume":"67","author":"Chu","year":"2020","journal-title":"Phytomedicine"},{"key":"2024110408190269300_CIT0013","doi-asserted-by":"crossref","first-page":"n104","DOI":"10.1136\/bmj.n104","article-title":"Non-steroidal anti-inflammatory drugs (NSAIDs) for musculoskeletal pain","volume":"372","author":"Machado","year":"2021","journal-title":"BMJ"},{"key":"2024110408190269300_CIT0014","doi-asserted-by":"crossref","first-page":"442","DOI":"10.22270\/jddt.v9i1-s.2287","article-title":"Non-steroidal anti-inflammatory drugs: an overview","volume":"9","author":"Narender","year":"2019","journal-title":"J Drug Deliv Ther"},{"key":"2024110408190269300_CIT0015","doi-asserted-by":"crossref","first-page":"3410","DOI":"10.1002\/jnr.21775","article-title":"Antioxidant, antiinflammatory and antiapoptotic effects of dapsone in a model of brain ischemia\/reperfusion in rats","volume":"86","author":"Diaz-Ruiz","year":"2008","journal-title":"J Neurosci Res"},{"key":"2024110408190269300_CIT0016","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.brainres.2016.06.023","article-title":"Dapsone improves functional deficit and diminishes brain damage evaluated by 3-Tesla magnetic resonance image after transient cerebral ischemia and reperfusion in rats","volume":"1646","author":"Diaz-Ruiz","year":"2016","journal-title":"Brain Res"},{"key":"2024110408190269300_CIT0017","doi-asserted-by":"crossref","first-page":"194","DOI":"10.2174\/1570159X19666210617143108","article-title":"Dapsone, more than an effective neuro and cytoprotective drug","volume":"20","author":"Diaz-Ruiz","year":"2022","journal-title":"Curr Neuropharmacol"},{"key":"2024110408190269300_CIT0018","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s00403-013-1409-7","article-title":"Dapsone in dermatology and beyond","volume":"306","author":"Wozel","year":"2014","journal-title":"Arch Dermatol Res"},{"key":"2024110408190269300_CIT0019","doi-asserted-by":"crossref","first-page":"744","DOI":"10.4142\/jvs.2018.19.6.744","article-title":"Dapsone modulates lipopolysaccharide-activated bone marrow cells by inducing cell death and down-regulating tumor necrosis factor-alpha production","volume":"19","author":"Kwon","year":"2018","journal-title":"J Vet Sci"},{"key":"2024110408190269300_CIT0020","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.brainres.2018.12.017","article-title":"Efficacy of dapsone administered alone or in combination with diazepam to inhibit status epilepticus in rats","volume":"1708","author":"Rios","year":"2019","journal-title":"Brain Res"},{"key":"2024110408190269300_CIT0021","doi-asserted-by":"crossref","first-page":"104737","DOI":"10.1016\/j.yexmp.2021.104737","article-title":"Protective effect of dapsone against bleomycin-induced lung fibrosis in rat","volume":"124","author":"Yousefi-Manesh","year":"2022","journal-title":"Exp Mol Pathol"},{"key":"2024110408190269300_CIT0022","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1007\/s00210-022-02297-1","article-title":"A comprehensive insight into the anti-inflammatory properties of dapsone","volume":"395","author":"Khalilzadeh","year":"2022","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"2024110408190269300_CIT0023","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1111\/ijd.14761","article-title":"Update on the use of dapsone in dermatology","volume":"59","author":"Ghaoui","year":"2020","journal-title":"Int J Dermatol"},{"key":"2024110408190269300_CIT0024","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0165-0270(94)90144-9","article-title":"Quantitative assessment of tactile allodynia in the rat paw","volume":"53","author":"Chaplan","year":"1994","journal-title":"J Neurosci Methods"},{"key":"2024110408190269300_CIT0025","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.1016\/j.joca.2010.05.030","article-title":"The OARSI histopathology initiative","volume":"18","author":"Gerwin","year":"2010","journal-title":"Osteoarthr Cartil"},{"key":"2024110408190269300_CIT0026","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1136\/annrheumdis-2018-214940","article-title":"PPARgamma preservation via promoter demethylation alleviates osteoarthritis in mice","volume":"78","author":"Zhu","year":"2019","journal-title":"Ann Rheum Dis"},{"key":"2024110408190269300_CIT0027","first-page":"450","article-title":"Anti-NGF therapy improves osteoarthritis pain","volume":"15","author":"Collison","year":"2019","journal-title":"Nat Rev Rheumatol"},{"key":"2024110408190269300_CIT0028","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/j.joca.2019.06.008","article-title":"Trends in gabapentinoid prescribing in patients with osteoarthritis: a United Kingdom national cohort study in primary care","volume":"27","author":"Appleyard","year":"2019","journal-title":"Osteoarthritis Cartilage"},{"key":"2024110408190269300_CIT0029","doi-asserted-by":"crossref","first-page":"393","DOI":"10.3389\/fphar.2019.00393","article-title":"The protective effect of magnolol in osteoarthritis: in vitro and in vivo studies","volume":"10","author":"Hu","year":"2019","journal-title":"Front Pharmacol"},{"key":"2024110408190269300_CIT0030","article-title":"Dapsone","volume-title":"Seminars in Arthritis and Rheumatism","author":"Chang","year":"1996"},{"key":"2024110408190269300_CIT0031","doi-asserted-by":"crossref","first-page":"e0194288","DOI":"10.1371\/journal.pone.0194288","article-title":"Development and characterization of various osteoarthritis models for tissue engineering","volume":"13","author":"Kim","year":"2018","journal-title":"PLoS One"},{"key":"2024110408190269300_CIT0032","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.neulet.2004.08.023","article-title":"The monosodium iodoacetate model of osteoarthritis: a model of chronic nociceptive pain in rats","volume":"370","author":"Combe","year":"2004","journal-title":"Neurosci Lett"},{"key":"2024110408190269300_CIT0033","first-page":"e5","article-title":"The monoiodoacetate model of osteoarthritis pain in the mouse","volume":"2016","author":"Pitcher","year":"3746","journal-title":"J Vis Exp"},{"key":"2024110408190269300_CIT0034","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1002\/art.1780400917","article-title":"Mono-iodoacetate-induced experimental osteoarthritis: a dose-response study of loss of mobility, morphology, and biochemistry","volume":"40","author":"Guingamp","year":"1997","journal-title":"Arthritis Rheum"},{"key":"2024110408190269300_CIT0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2023.12.015","article-title":"Oxidation of the active site cysteine residue of glyceraldehyde-3-phosphate dehydrogenase to the hyper-oxidized sulfonic acid form is favored under crowded conditions","volume":"212","author":"Glover","year":"2024","journal-title":"Free Radic Biol Med"},{"key":"2024110408190269300_CIT0036","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s12079-017-0420-8","article-title":"Metabolic regulation of the CCN family genes by glycolysis in chondrocytes","volume":"12","author":"Akashi","year":"2018","journal-title":"J Cell Commun Signal"},{"key":"2024110408190269300_CIT0037","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1002\/jor.22250","article-title":"Monosodium iodoacetate induces apoptosis via the mitochondrial pathway involving ROS production and caspase activation in rat chondrocytes in vitro","volume":"31","author":"Jiang","year":"2013","journal-title":"J Orthop Res"},{"key":"2024110408190269300_CIT0038","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.2147\/JPR.S310368","article-title":"Moderate to severe osteoarthritis pain and its impact on patients in the United States: a national survey","volume":"14","author":"Schepman","year":"2021","journal-title":"J Pain Res"},{"key":"2024110408190269300_CIT0039","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1097\/BRS.0000000000004015","article-title":"Dapsone prevents allodynia and hyperalgesia and decreased oxidative stress after spinal cord injury in rats","volume":"46","author":"Mata-Bermudez","year":"2021","journal-title":"Spine (Phila Pa 1976)"},{"key":"2024110408190269300_CIT0040","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s40199-022-00448-6","article-title":"Dapsone improves the vincristine-induced neuropathic nociception by modulating neuroinflammation and oxidative stress","volume":"30","author":"Shayesteh","year":"2022","journal-title":"Daru"},{"key":"2024110408190269300_CIT0041","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/j.1346-8138.2005.tb00729.x","article-title":"Adult Henoch","volume":"32","author":"Shimomura","year":"2005","journal-title":"J Dermatol"},{"key":"2024110408190269300_CIT0042","doi-asserted-by":"crossref","first-page":"685","DOI":"10.3390\/medicina56120685","article-title":"Anti-osteoarthritic mechanisms of Chrysanthemum zawadskii var. latilobum in MIA-induced osteoarthritic rats and interleukin-1beta-induced SW1353 human chondrocytes","volume":"56","author":"Byun","year":"2020","journal-title":"Medicina (Kaunas)"},{"key":"2024110408190269300_CIT0043","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1039\/C8FO01786G","article-title":"Inhibiting the PI3K\/AKT\/NF-kappaB signal pathway with nobiletin for attenuating the development of osteoarthritis: in vitro and in vivo studies","volume":"10","author":"Xie","year":"2019","journal-title":"Food Funct"},{"key":"2024110408190269300_CIT0044","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/1471-2474-12-134","article-title":"Pain-related sensory innervation in monoiodoacetate-induced osteoarthritis in rat knees that gradually develops neuronal injury in addition to inflammatory pain","volume":"12","author":"Orita","year":"2011","journal-title":"BMC Musculoskelet Disord"},{"key":"2024110408190269300_CIT0045","doi-asserted-by":"crossref","first-page":"R7","DOI":"10.1186\/ar3555","article-title":"Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4","volume":"14","author":"Sohn","year":"2012","journal-title":"Arthritis Res Ther"},{"key":"2024110408190269300_CIT0046","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.arcmed.2021.03.005","article-title":"Dapsone ameliorates colitis through TLR4\/NF-kB pathway in TNBS induced colitis model in rat","volume":"52","author":"Mohammad Jafari","year":"2021","journal-title":"Arch Med Res"},{"key":"2024110408190269300_CIT0047","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s00280-019-04019-6","article-title":"Cardioprotective effects of dapsone against doxorubicin-induced cardiotoxicity in rats","volume":"85","author":"Sheibani","year":"2020","journal-title":"Cancer Chemother Pharmacol"},{"key":"2024110408190269300_CIT0048","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1080\/08923973.2020.1755308","article-title":"Protective effect of dapsone against renal ischemia","volume":"42","author":"Nezamoleslami","year":"2020","journal-title":"Immunopharmacol Immunotoxicol"},{"key":"2024110408190269300_CIT0049","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/exd.13869","article-title":"Mechanistic insight into the activity of a sulfone compound dapsone on Propionibacterium (newly reclassified as Cutibacterium) acnes-mediated cytokine production","volume":"28","author":"Geyfman","year":"2019","journal-title":"Exp Dermatol"},{"key":"2024110408190269300_CIT0050","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1080\/08923973.2019.1678635","article-title":"Dapsone reduced acetic acid-induced inflammatory response in rat colon tissue through inhibition of NF-kB signaling pathway","volume":"41","author":"Rashidian","year":"2019","journal-title":"Immunopharmacol Immunotoxicol"},{"key":"2024110408190269300_CIT0051","doi-asserted-by":"crossref","first-page":"669679","DOI":"10.3389\/fphar.2021.669679","article-title":"Dapsone ameliorates isoproterenol-induced myocardial infarction via Nrf2\/HO-1; TLR4\/TNF-\u03b1 signaling pathways and the suppression of oxidative stress, inflammation, and apoptosis in rats","volume":"12","author":"Abdelzaher","year":"2021","journal-title":"Front Pharmacol"},{"key":"2024110408190269300_CIT0052","first-page":"985","article-title":"The implication of reactive oxygen species and antioxidants in knee osteoarthritis","volume":"10","author":"Tudorachi","year":"2021","journal-title":"Antioxidants (Basel, Switzerland)"},{"key":"2024110408190269300_CIT0053","doi-asserted-by":"crossref","first-page":"110452","DOI":"10.1016\/j.biopha.2020.110452","article-title":"Oxidative stress and inflammation in osteoarthritis pathogenesis: Role of polyphenols","volume":"129","author":"Ansari","year":"2020","journal-title":"Biomed Pharmacother"},{"key":"2024110408190269300_CIT0054","first-page":"1","article-title":"The role of Nrf2-mediated pathway in cardiac remodeling and heart failure","volume":"2014","author":"Zhou","year":"2014","journal-title":"Oxid Med Cell Longevity"},{"key":"2024110408190269300_CIT0055","doi-asserted-by":"crossref","first-page":"2758","DOI":"10.1128\/MCB.01704-07","article-title":"Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity","volume":"28","author":"Yamamoto","year":"2008","journal-title":"Mol Cell Biol"},{"key":"2024110408190269300_CIT0056","volume-title":"Nrf2 and Cardiovascular Defense","author":"Howden","year":"2013"},{"key":"2024110408190269300_CIT0057","first-page":"353","article-title":"Protective effect of heme oxygenase-1 on Wistar rats with heart failure through the inhibition of inflammation and amelioration of intestinal microcirculation","volume":"12","author":"Zhang","year":"2015","journal-title":"J Geriatr Cardiol"},{"key":"2024110408190269300_CIT0058","doi-asserted-by":"crossref","first-page":"5474","DOI":"10.3390\/molecules25225474","article-title":"An overview of Nrf2 signaling pathway and its role in inflammation","volume":"25","author":"Saha","year":"2020","journal-title":"Molecules"},{"key":"2024110408190269300_CIT0059","doi-asserted-by":"crossref","first-page":"418","DOI":"10.3390\/nu8070418","article-title":"Total flavonoids from Rosa laevigata Michx fruit ameliorates hepatic ischemia\/reperfusion injury through inhibition of oxidative stress and inflammation in rats","volume":"8","author":"Tao","year":"2016","journal-title":"Nutrients"},{"key":"2024110408190269300_CIT0060","doi-asserted-by":"crossref","first-page":"111063","DOI":"10.1016\/j.biopha.2020.111063","article-title":"Diacerein protects rats with liver ischemia\/reperfusion damage: down-regulation of TLR4\/NF\u03ba-B signaling pathway","volume":"134","author":"Ibrahim","year":"2021","journal-title":"Biomed Pharmacother"},{"key":"2024110408190269300_CIT0061","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bmcl.2018.11.031","article-title":"The development of myeloperoxidase inhibitors","volume":"29","author":"Galijasevic","year":"2019","journal-title":"Bioorg Med Chem Lett"},{"key":"2024110408190269300_CIT0062","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1016\/0006-2952(93)90010-T","article-title":"Superoxide is an antagonist of anti-inflammatory drugs that inhibit hypochlorous acid production by myeloperoxidase","volume":"45","author":"Kettle","year":"1993","journal-title":"Biochem Pharmacol"},{"key":"2024110408190269300_CIT0063","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/0006-2952(92)90449-S","article-title":"Inhibition of the human leukocyte enzymes myeloperoxidase and eosinophil peroxidase by dapsone","volume":"44","author":"Bozeman","year":"1992","journal-title":"Biochem Pharmacol"},{"key":"2024110408190269300_CIT0064","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.det.2010.03.014","article-title":"Innovative use of dapsone","volume":"28","author":"Wozel","year":"2010","journal-title":"Dermatol Clin"},{"key":"2024110408190269300_CIT0065","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1111\/j.1365-2133.2005.06559.x","article-title":"Dapsone suppresses human neutrophil superoxide production and elastase release in a calcium-dependent manner","volume":"152","author":"Suda","year":"2005","journal-title":"Br J Dermatol"},{"key":"2024110408190269300_CIT0066","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1001\/archderm.144.7.845","article-title":"Dapsone treatment for eosinophilic fasciitis","volume":"144","author":"Smith","year":"2008","journal-title":"Arch Dermatol"},{"key":"2024110408190269300_CIT0067","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1002\/cbf.3589","article-title":"Molecular insights of NADPH oxidases and its pathological consequences","volume":"39","author":"Waghela","year":"2021","journal-title":"Cell Biochem Funct"},{"key":"2024110408190269300_CIT0068","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.mrrev.2012.04.002","article-title":"The emerging role of ROS-generating NADPH oxidase NOX4 in DNA-damage responses","volume":"751","author":"Weyemi","year":"2012","journal-title":"Mutat Res"},{"key":"2024110408190269300_CIT0069","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.neulet.2014.11.045","article-title":"Surgical stress induced depressive and anxiety like behavior are improved by dapsone via modulating NADPH oxidase level","volume":"585","author":"Zhang","year":"2015","journal-title":"Neurosci Lett"},{"key":"2024110408190269300_CIT0070","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1159\/000211346","article-title":"Dapsone inhibits the generation of 5-lipoxygenase products in human polymorphonuclear leukocytes","volume":"8","author":"Wozel","year":"1995","journal-title":"Skin Pharmacol"},{"key":"2024110408190269300_CIT0071","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/0091-6749(83)90501-8","article-title":"Inhibition of rat mast cell arachidonic acid cyclooxygenase by dapsone","volume":"72","author":"Ruzicka","year":"1983","journal-title":"J Allergy Clin Immunol"}],"container-title":["Journal of Pharmacy and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/76\/11\/1497\/60213073\/rgae087.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/76\/11\/1497\/60213073\/rgae087.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T08:19:48Z","timestamp":1730708388000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jpp\/article\/76\/11\/1497\/7726897"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,3]]},"references-count":71,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2024,8,3]]},"published-print":{"date-parts":[[2024,11,4]]}},"URL":"https:\/\/doi.org\/10.1093\/jpp\/rgae087","relation":{},"ISSN":["0022-3573","2042-7158"],"issn-type":[{"value":"0022-3573","type":"print"},{"value":"2042-7158","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,11]]},"published":{"date-parts":[[2024,8,3]]}}}