{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T17:25:47Z","timestamp":1778174747888,"version":"3.51.4"},"reference-count":90,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T00:00:00Z","timestamp":1727222400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>This study investigates the dual role of ALKBH5, an eraser enzyme, in colorectal cancer (CRC), focusing on how N6-methyladenosine (m6A) mutations influence CRC development and progression.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We reviewed various studies that highlighted the role of ALKBH5 in colorectal cancer (CRC). This includes the impact of ALKBH5 on tumor cell behavior including immune system interactions, invasion, and proliferation in CRC. We also looked into how ALKBH5 acts as a tumor suppressor under different conditions analyzed clinical data to assess the impact of ALKBH5 expression on outcomes in colorectal cancer patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>In CRC, ALKBH5 plays a dual role. In certain situations, it inhibits the progression of the tumor, but in other circumstances, it promotes tumor growth and immunosuppression. The interaction with RABA5 plays a role in the development of CRC. Having elevated levels of ALKBH5 has been associated with unfavorable patient outcomes, such as reduced survival rates and more advanced cancer stages. Various factors, including tumor differentiation, TNM stages, and carcinoembryonic antigen (CEA) levels, be linked to ALKBH5 expression.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>ALKBH5 plays a complicated and situation-specific role in colorectal cancer (CRC). Targeting ALKBH5 could result in novel therapy options that balance its tumor-promoting and tumor-fighting properties in CRC. Further research into m6A alterations and ALKBH5 could enhance CRC treatment approaches and patient outcomes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jpp\/rgae108","type":"journal-article","created":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T19:24:37Z","timestamp":1727292277000},"page":"1393-1403","source":"Crossref","is-referenced-by-count":2,"title":["Unraveling molecular and clinical aspects of ALKBH5 as dual role in colorectal cancer"],"prefix":"10.1093","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6001-6763","authenticated-orcid":false,"given":"Furqan","family":"Memon","sequence":"first","affiliation":[{"name":"Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University , Nanjing 210009 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Momina","family":"Nadeem","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, University of Sindh , Jamshoro-76080, Sindh ,","place":["Pakistan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Sulaiman","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University , Nanjing 210009 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mudassar Iqbal","family":"Arain","sequence":"additional","affiliation":[{"name":"San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California , San Diego, CA 92035 ,","place":["United States"]},{"name":"School of Pharmacy, University of Kansas , 2010 Becker Dr., Lawrenece, KS 66047 ,","place":["United States"]},{"name":"Pharmacy Practice, University of Sindh , Jamshoro, 76080 Sindh ,","place":["Pakistan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umm-E-","family":"Hani","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Engineering, School of Engineering, China 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