{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:37:28Z","timestamp":1792143448426,"version":"4.4.0"},"reference-count":68,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T00:00:00Z","timestamp":1739491200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Ministry of University and Research"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>This research studied two extracts from Treculia africana leaves for their potential against hyperglycaemia-related disorders.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The influence of the extracts on \u03b1-glucosidase activity and albumin glycation was investigated, and cell viability was estimated in HT-29 human colorectal cells. Phenolic and flavonoid contents and antiradical activity were also detected. The extracts were examined using HPLC-DAD analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>The methanol and dichloromethane leaf extracts showed a significant concentration-dependent inhibition of \u03b1-glucosidase activity (IC50= 3.73 and 21.28 \u00b5g\/ml, respectively). Both extracts also inhibited ribose-induced glycation of bovine serum albumin from 250 \u00b5g\/ml. Phytochemical analysis revealed the presence of chlorogenic acid and \u03b1-mangostin in the extracts. The extracts did not change HT-29 cell viability up to 250 \u00b5g\/ml, thus showing very low cytotoxicity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The methanol leaf extract of T. africana inhibited \u03b1-glucosidase activity in a concentration-dependent manner, supporting the use of the leaves in traditional medicine to control hyperglycaemia. Chlorogenic acid and \u03b1-mangostin, the latter identified for the first time in this species, were found in the T. africana leaves. Further, in vivo studies and pilot clinical trials should be conducted using standardized T. africana leaf extracts to evaluate their potential effectiveness in diabetes mellitus.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jpp\/rgaf003","type":"journal-article","created":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T20:18:22Z","timestamp":1736281102000},"page":"501-510","source":"Crossref","is-referenced-by-count":1,"title":["<i>In vitro<\/i> antidiabetic activity of <i>Treculia africana<\/i> leaf extracts: identification of chlorogenic acid and \u03b1-mangostin"],"prefix":"10.1093","volume":"77","author":[{"given":"Victorine Lorette","family":"Yimgang","sequence":"first","affiliation":[{"name":"Antimicrobial & Biocontrol Agents Unit (AmBcAU), Laboratory for Phytobiochemistry and Medicinal Plants Studies, Department of Biochemistry, University of Yaound\u00e9 I , Yaound\u00e9 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Taghu","sequence":"additional","affiliation":[{"name":"Antimicrobial & Biocontrol Agents Unit (AmBcAU), Laboratory for Phytobiochemistry and Medicinal Plants Studies, Department of Biochemistry, University of Yaound\u00e9 I , Yaound\u00e9 ,","place":["Cameroon"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rufin Marie Toghueo","family":"Kouipou","sequence":"additional","affiliation":[{"name":"Antimicrobial & Biocontrol Agents Unit (AmBcAU), Laboratory for Phytobiochemistry and Medicinal Plants Studies, Department of Biochemistry, University of Yaound\u00e9 I , Yaound\u00e9 ,","place":["Cameroon"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice Fekam","family":"Boyom","sequence":"additional","affiliation":[{"name":"Antimicrobial & Biocontrol Agents Unit (AmBcAU), Laboratory for Phytobiochemistry and Medicinal Plants Studies, Department of Biochemistry, University of Yaound\u00e9 I , Yaound\u00e9 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