{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T19:39:48Z","timestamp":1788982788412,"version":"build-2803163510"},"reference-count":72,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T00:00:00Z","timestamp":1743724800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100023670","name":"key fund","doi-asserted-by":"crossref","award":["CYFY2019ZD02"],"award-info":[{"award-number":["CYFY2019ZD02"]}],"id":[{"id":"10.13039\/501100023670","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Clinical Key Specialized Training Project","award":["CYFY2019GLPHX02"],"award-info":[{"award-number":["CYFY2019GLPHX02"]}]},{"name":"First Affiliated Hospital of Chengdu Medical College and Sichuan Province Science and Technology Program","award":["2022NSFSC0725"],"award-info":[{"award-number":["2022NSFSC0725"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Despite significant advancements in innovative therapy, lung cancer continues to have an unexpectedly low 5-year survival rate. This necessitates the urgent development of novel and effective therapies. One such potential therapy is Honokiol (HNK, C18H18O2), a biphenolic natural compound isolated from the leaves and bark of Magnolia plant species. The objective of this review is to examine the various studies supporting the anti-lung cancer effects of HNK and its potential use in the treatment of lung cancer.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>Emerging research has shown that HNK possesses a range of pharmacological characteristics that make it a promising agent in the fight against lung cancer. Specifically, HNK has been found to regulate various molecular targets, including the activation of pro-apoptotic factors and the suppression of anti-apoptotic proteins and different transcription factors. It also downregulates various enzymes, chemokines, cell surface adhesion molecules, and cell cycle proteins. Additionally, HNK inhibits the activity of protein tyrosine kinases and serine\/threonine kinases. These effects contribute to its ability to efficiently prevent the progression of lung cancer, either solely or in combination with other therapeutic strategies. Furthermore, several nanotechnologies have been employed to modify HNK for the treatment of lung cancer, enhancing its potential efficacy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Summary<\/jats:title>\n                  <jats:p>In summary, Honokiol (HNK) is a biphenolic natural compound with significant anti-lung cancer properties. Its pharmacological characteristics, including the regulation of various molecular targets and the inhibition of key enzymes and kinases, make it a promising agent for the treatment of lung cancer. Emerging research supports its ability to prevent the progression of lung cancer, either alone or in combination with other therapies. Additionally, nanotechnologies have been used to modify HNK, potentially enhancing its efficacy in the treatment of lung cancer. This review highlights the various studies documenting the anti-lung cancer effects of HNK, underscoring its potential as a novel and effective therapy for this deadly disease.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jpp\/rgaf007","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T15:59:11Z","timestamp":1743782351000},"page":"1293-1302","source":"Crossref","is-referenced-by-count":4,"title":["Updated progression of honokiol in lung cancer treatment"],"prefix":"10.1093","volume":"77","author":[{"given":"Ziwei","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chengdu Medical College , Chengdu, Sichuan 610500 ,","place":["China"]},{"name":"Key Laboratory of Geriatic Respiratory Diseases of Sichuan Higher Education Institutes , Chengdu, Sichuan 610500 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,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2421-7311","authenticated-orcid":false,"given":"Wei","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine, The First Affiliated Hospital, Chengdu Medical College , Chengdu, Sichuan 610500 ,","place":["China"]},{"name":"School of Laboratory Medicine, Chengdu Medical College , Chengdu, Sichuan 610500 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,4,4]]},"reference":[{"key":"2025100323021234100_CIT0001","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J 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