{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T18:16:18Z","timestamp":1775499378857,"version":"3.50.1"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T00:00:00Z","timestamp":1748476800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100004479","name":"Jiangxi Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["20242BAB26167"],"award-info":[{"award-number":["20242BAB26167"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82060757"],"award-info":[{"award-number":["82060757"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Jiangxi University of Chinese Medicine Science and Technology Innovation Team Development Program","award":["CXTD22002"],"award-info":[{"award-number":["CXTD22002"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Fragaria orientalis Losinsk is widely used in Tibetan medicine to remove and eliminate yellow water, a symptom of visceral abscesses including hepatitis, suggesting that Fragaria orientalis may exert potential therapeutic benefits for liver conditions. This study aimed to elucidate the hepatoprotective mechanisms of Fragaria orientalis extract against hepatic fibrosis in rats, focusing on the FXR\/CYP7A1, ERK\/p38 MAPK, and TLR4\/MyD88\/NF-\u03baB signaling pathways.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Chemical profiling was measured by UPLC-Q-TOF\/MS, followed by HPLC fingerprint. Hepatic fibrosis was induced in rats treated with 40% CCl4. Subsequently, the anti-fibrotic effects of Fragaria orientalis involved in different signaling pathways were examined.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Administration of Fragaria orientalis extract reduced serum levels of ALT, AST, ALP, TNF-\u03b1, IL-1\u03b2, and IL-6, as well as hepatic MDA, while increasing GSH-Px and SOD in liver homogenates. UPLC analysis identified key constituents, including quercetin-3-O-glucuronide and ellagic acid, contributing to its hepatoprotective profile. The extract modulated the FXR\/CYP7A1, ERK\/p38 MAPK, and TLR4\/MyD88\/NF-\u03baB pathways, supporting its role in attenuating liver fibrosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In conclusion, these findings suggest that Fragaria orientalis possesses hepatoprotective effects against hepatic fibrosis, likely through modulating oxidative stress, inflammation, and bile acid regulation pathways.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jpp\/rgaf022","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T06:51:47Z","timestamp":1748587907000},"page":"922-932","source":"Crossref","is-referenced-by-count":1,"title":["<i>Fragaria orientalis<\/i> attenuates hepatic fibrosis through modulation of FXR\/CYP7A1, ERK\/p38 MAPK, and TLR4\/MyD88\/NF-\u03baB signaling in 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Xiamen, 361021, Fujian province ,","place":["PR China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng-Ke","family":"Song","sequence":"additional","affiliation":[{"name":"Research Center of Traditional Chinese Medicine Resources and Ethnic Medicine, Jiangxi University of Chinese Medicine , Nanchang 330004 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhao-Da","family":"Yu","sequence":"additional","affiliation":[{"name":"Research Center of Traditional Chinese Medicine Resources and Ethnic Medicine, Jiangxi University of Chinese Medicine , Nanchang 330004 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia-Yu","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Chemical and Pharmaceutical Engineering, College of Chemical Engineering, Huaqiao University , Xiamen, 361021, Fujian province ,","place":["PR 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