{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:28:20Z","timestamp":1790872100389,"version":"4.1.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Industrial Technology Foundation Public Service Platform Project of 2022","award":["2022-230-221"],"award-info":[{"award-number":["2022-230-221"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Curcuma longa L. (CL) is renowned for its various health benefits and has shown potential in alleviating Alzheimer\u2019s disease (AD). The post-aqueous extraction residues (CLR) may retain valuable nutritional components. The research aimed to explore their chemical composition and neuroprotective mechanism against A\u03b21-42-induced AD mice.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We employed UPLC-Q-Exactive\/MS to characterize the chemical constituents of CL and CLR. An HPLC method was developed to quantify three predominant curcuminoids. To investigate their neuroprotective effects against A\u03b21-42-induced AD mice, we assessed cognitive function using the Morris water maze and evaluated neuronal damage through histopathological examination. Molecular mechanisms were explored using immunofluorescence, ELISA, and qRT-PCR assays.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The study unveiled 47 and 36 compounds in CL and CLR, respectively, and eight significant differential components. HPLC analysis revealed that CLR contained substantial curcuminoids. In A\u03b21-42-induced AD mice, CL and CLR improved spatial learning and memory ability, ameliorated pathological alterations in the hippocampal region, and regulated overactivated microglia. Moreover, CL and CLR inhibited the TLR4\/NF-\u03baB in\ufb02ammatory pathway.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>CL and CLR exhibit the anti-AD effect by regulating microglia and suppressing the TLR4\/NF-\u03baB signaling pathway, which provides a scientific basis for future nutraceutical and pharmaceutical development.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jpp\/rgaf034","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T08:14:52Z","timestamp":1746173692000},"page":"1192-1202","source":"Crossref","is-referenced-by-count":6,"title":["<i>Curcuma longa<\/i> L. extract and residue prevent Alzheimer\u2019s disease in mice by regulating microglia and TLR4\/NF-<i>\u03ba<\/i>B signaling pathway"],"prefix":"10.1093","volume":"77","author":[{"given":"Zhihui","family":"Xu","sequence":"first","affiliation":[{"name":"School of Traditional Materia Medica, Guangdong Pharmaceutical University , Guangzhou, Guangdong 510006 ,","place":["P.R. 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