{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:31:15Z","timestamp":1792794675191,"version":"4.5.0"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"9","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82074276"],"award-info":[{"award-number":["82074276"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine","award":["ZYYCXTD-D-202002"],"award-info":[{"award-number":["ZYYCXTD-D-202002"]}]},{"DOI":"10.13039\/501100019065","name":"Science and Technology Program of Tianjin","doi-asserted-by":"crossref","award":["22ZYJDSS00100"],"award-info":[{"award-number":["22ZYJDSS00100"]}],"id":[{"id":"10.13039\/501100019065","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Science and Technology Project of Haihe Laboratory of Modern Chinese Medicine","award":["22HHZYSS00003"],"award-info":[{"award-number":["22HHZYSS00003"]}]},{"name":"Innovation Research Project of Chinese People\u2019s Armed Police Force","award":["ZZKY20222419"],"award-info":[{"award-number":["ZZKY20222419"]}],"id":[{"id":"https:\/\/ror.org\/011gh0524","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Program for Science and Technology of Logistics University of Chinese People\u2019s Armed Police Force","award":["WHJ202301"],"award-info":[{"award-number":["WHJ202301"]}],"id":[{"id":"https:\/\/ror.org\/011gh0524","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Shuxuetong injection (SXT) treats cerebral ischemic injury by inhibiting apoptosis. However, the specific active ingredient responsible for this effect and its mechanism of action remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In previous research, we identified the small peptide YLKTT in SXT, which has shown protective effects on astrocytes subjected to oxygen-glucose deprivation\/reoxygenation (OGD\/R). In this study, we utilized transcriptomics technology to predict the specific target genes and pathways of YLKTT in the context of stroke treatment. We further validated these predictions through RT-PCR, lipid peroxidation assays, Western blotting, and other related methods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key findings<\/jats:title>\n                    <jats:p>The transcriptomics results indicated that YLKTT could further alleviate ischemia-reperfusion injury by inhibiting ferroptosis, with the specific pathway likely involving the regulation of glutathione peroxidase 4 (GPX4) by ACSL4 and SLC7A11. Experimental results demonstrated that YLKTT interfered with the SLC7A11\/GPX4 and ACSL4\/GPX4 pathways, thereby enhancing antioxidant capacity, inhibiting the accumulation of lipid peroxidation, and ultimately reversing OGD-induced ferroptosis. Additionally, erastin significantly reduced SLC7A11 mRNA and protein levels and decreased GPX4 levels, while YLKTT was able to reverse these changes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>YLKTT can exert anti-ferroptosis effects through the ACSL4\/GPX4 and SLC7A11\/GPX4 pathways, thereby improving the treatment of cerebral ischemic injury.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jpp\/rgaf037","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T08:04:40Z","timestamp":1747123480000},"page":"1244-1254","source":"Crossref","is-referenced-by-count":5,"title":["YLKTT, a potent biopeptide that ameliorates oxygen-glucose deprivation-induced neuronal cell ferroptosis by ACSL4\/GPX4 and SLC7A11\/GPX4 axis"],"prefix":"10.1093","volume":"77","author":[{"given":"Yujie","family":"Wu","sequence":"first","affiliation":[{"name":"College of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine , Tianjin 301617 ,","place":["China"]},{"name":"Tianjin Key Laboratory of Intelligent and Green Pharmaceuticals for Traditional Chinese Medicine, State Key Laboratory of Chinese Medicine Modernization, Haihe Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine , 10 Poyang Lake Road, West Zone of Tuanbo New City, Jinghai District, Tianjin 301617 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yansu","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics,Characteristic Medical Center of Chinese People\u2019s Armed Police Force , Tianjin300162 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Jin","sequence":"additional","affiliation":[{"name":"Military Medicine Section, Department of Health Services, Logistics University of Chinese People\u2019s Armed Police Force , 1 Huizhihuan Road, Dongli District , Tianjin 300309,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangjing","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine , Tianjin 301617 ,","place":["China"]},{"name":"Tianjin Key Laboratory of Intelligent and Green Pharmaceuticals for Traditional Chinese Medicine, State Key Laboratory of Chinese Medicine Modernization, Haihe Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine , 10 Poyang Lake Road, West Zone of Tuanbo New City, Jinghai District, Tianjin 301617 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine , Tianjin 301617 ,","place":["China"]},{"name":"Tianjin Key Laboratory of Intelligent and Green Pharmaceuticals for Traditional Chinese Medicine, State Key Laboratory of Chinese Medicine Modernization, Haihe Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine , 10 Poyang Lake Road, West Zone of Tuanbo New City, Jinghai District, Tianjin 301617 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saisai","family":"Song","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine , Tianjin 301617 ,","place":["China"]},{"name":"Tianjin Key Laboratory of Intelligent and Green Pharmaceuticals for Traditional Chinese Medicine, State Key Laboratory of Chinese Medicine Modernization, Haihe Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine , 10 Poyang Lake Road, West Zone of Tuanbo New City, Jinghai District, Tianjin 301617 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Li","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine , Tianjin 301617 ,","place":["China"]},{"name":"Tianjin Key Laboratory of Intelligent and Green Pharmaceuticals for Traditional Chinese Medicine, State Key Laboratory of Chinese Medicine Modernization, Haihe Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine , 10 Poyang Lake Road, West Zone of Tuanbo New City, Jinghai District, Tianjin 301617 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhan","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Chemistry, Tianjin Normal University , Tianjin 300387,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7439-7966","authenticated-orcid":false,"given":"Rui","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine , Tianjin 301617 ,","place":["China"]},{"name":"Tianjin Key Laboratory of Intelligent and Green Pharmaceuticals for Traditional Chinese Medicine, State Key Laboratory of Chinese Medicine Modernization, Haihe Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine , 10 Poyang Lake Road, West Zone of Tuanbo New City, Jinghai District, Tianjin 301617 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