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This study investigated the inhibitory effects of rosavin and salidroside on neuroinflammation induced by \u03b2-amyloid oligomers using primary microglia derived from the cerebral tissue of C57BL\/6\u00a0J mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key findings<\/jats:title>\n                    <jats:p>Following \u03b2-amyloid oligomers\u2019 production, a series of continuous neurological deterioration takes place. Rosavin and salidroside exhibited distinct inhibitory effects on different neurodegenerative damage. Subsequent studies indicated that the protective mechanism of rosavin was associated with nuclear factor \u043a-B phosphorylation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Lay summary<\/jats:title>\n                    <jats:p>Rhodiola rosea L., with its natural small molecule compounds like rosavin may be potential candidates for the treatment of AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jpp\/rgaf094","type":"journal-article","created":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T11:43:42Z","timestamp":1758023022000},"source":"Crossref","is-referenced-by-count":2,"title":["Rosavin and salidroside attenuate microglia injury via nuclear factor\n                    <b>\u03ba<\/b>\n                    -B signaling pathway"],"prefix":"10.1093","volume":"78","author":[{"given":"Hang","family":"Liu","sequence":"first","affiliation":[{"name":"Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region, School of Medicine, Xizang Minzu University , No. 6, Wenhui East Road, Xianyang City, Shaanxi Province 712082 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yandong","family":"Ma","sequence":"additional","affiliation":[{"name":"Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region, School of Medicine, Xizang Minzu University , No. 6, Wenhui East Road, Xianyang City, Shaanxi Province 712082 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region, School of Medicine, Xizang Minzu University , No. 6, Wenhui East Road, Xianyang City, Shaanxi Province 712082 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