{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T14:07:53Z","timestamp":1770905273419,"version":"3.50.1"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:00:00Z","timestamp":1761782400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Presidency of the Turkish Institutes of Health","award":["2022-AC\u0130L 01\/6.Term"],"award-info":[{"award-number":["2022-AC\u0130L 01\/6.Term"]}]},{"name":"Presidency of the Turkish Institutes of Health","award":["19037"],"award-info":[{"award-number":["19037"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study investigated the effects of pigment epithelium-derived factor (PEDF) on bone homeostasis in a glucocorticoid-induced osteoporosis (GIOP) rat model, focusing on prostaglandin E2 receptors EP2 and EP4.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Male Sprague\u2013Dawley rats were divided into six groups. Dexamethasone (DEX, 1\u00a0mg\/kg) was administered intramuscularly twice weekly for 90\u00a0days to induce osteoporosis. PEDF (50, 100, 200\u00a0mg\/kg) was then given subcutaneously for 30\u00a0days. Bone mineral density (BMD) and bone morphology were assessed by computed tomography. Bone turnover markers\u2014C-terminal telopeptide of type I collagen (CTX-1), tartrate-resistant acid phosphatase 5b (TRAP-5b), and bone-specific alkaline phosphatase\u2014as well as EP2\/EP4 mRNA expressions were evaluated using qRT-PCR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key findings<\/jats:title>\n                    <jats:p>Immunohistochemical analysis was performed for ALP, osteopontin, osteocalcin, and VEGFR1. PEDF partially mitigated DEX-induced weight loss and dose-dependently restored BMD. Histopathological analyses showed improved bone architecture in all PEDF-treated groups. PEDF increased bone formation markers, reduced bone resorption markers, and upregulated EP2\/EP4 expression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings indicate that PEDF exerts protective effects against GIOP and may modulate bone metabolism through EP2\/EP4 signalling pathways. PEDF shows promise as a potential therapeutic agent for preventing bone loss in GIOP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jpp\/rgaf102","type":"journal-article","created":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T11:57:33Z","timestamp":1759406253000},"source":"Crossref","is-referenced-by-count":0,"title":["Effect of pigment epithelium-derived factor on prostaglandin E2 receptors (EP2\/EP4) in glucocorticoid-induced osteoporosis in rats"],"prefix":"10.1093","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6279-9810","authenticated-orcid":false,"given":"Zerrin","family":"Kutlu","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmacy, Ataturk University , Erzurum 25240 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