{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T14:07:44Z","timestamp":1770905264073,"version":"3.50.1"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:00:00Z","timestamp":1761868800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Drug resistance critically impedes renal cell carcinoma therapy. A dual-targeted liposomal system that codelivered resveratrol (RES) and paclitaxel (PTX) with \u03b1v\u03b23 integrin-targeting was developed to overcome multidrug resistance (MDR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>RGDfC peptide-functionalized liposomes (PTX\/RES-RGDfC-Lip) were synthesized via film hydration-ultrasound methods. The particle size, zeta potential, drug encapsulation efficiency, and release kinetics were evaluated. P-glycoprotein (P-gp) modulation, cellular uptake, and chemosensitization in PTX-resistant A498 cells (PTX-res-A498) and in vivo antitumor efficacy were studied in xenograft models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The RGDfC ligand enables selective tumor delivery by binding to \u03b1v\u03b23 integrins that are overexpressed in the renal carcinoma vasculature, whereas RES enhances PTX efficacy by modulating P-gp-mediated drug efflux. Liposomes were synthesized via film hydration\u2013ultrasound methods and systematically characterized for size (109.8\u2009\u00b1\u20094.2\u00a0nm), zeta potential (\u22128.91\u2009\u00b1\u20090.75\u00a0mV), dual-drug encapsulation efficiency (RES: 90.56\u2009\u00b1\u20094.30%; PTX: 90.23\u2009\u00b1\u20094.66%), and sustained release kinetics. In vitro studies demonstrated 3.19-fold greater cellular uptake in resistant renal carcinoma cells (PTX-res-A498 cells) than in nontargeted formulations. In vivo, PTX\/RES-RGDfC-Lip resulted in 70.2% tumor reduction in xenograft models. Mechanistic studies confirmed the RES-mediated downregulation of P-gp expression and the restoration of chemosensitivity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This dual-targeted codelivery system represents a promising strategy for overcoming MDR in advanced renal carcinoma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jpp\/rgaf104","type":"journal-article","created":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T11:39:22Z","timestamp":1759837162000},"source":"Crossref","is-referenced-by-count":0,"title":["Co-encapsulated resveratrol and paclitaxel in liposomes coating with RGDfC peptide for drug resistance reversal in renal cell carcinoma"],"prefix":"10.1093","volume":"78","author":[{"given":"Jianqiang","family":"Bian","sequence":"first","affiliation":[{"name":"Department of Urology, Tianjin Hospital , No. 406 Jiefang South Road, Tianjin 300210 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