{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:30:22Z","timestamp":1792031422536,"version":"4.4.0"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100004761","name":"Natural Sciences Foundation of Hunan Province","doi-asserted-by":"crossref","award":["2025JJ50664"],"award-info":[{"award-number":["2025JJ50664"]}],"id":[{"id":"10.13039\/501100004761","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Scientific Research Project of Hunan Provincial Department of Education","award":["23A0338"],"award-info":[{"award-number":["23A0338"]}]},{"name":"Project of Hunan Provincial Health Committee","award":["D202302048902"],"award-info":[{"award-number":["D202302048902"]}]},{"name":"University of South China, China"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Atherosclerosis (AS) is a chronic inflammatory disease driven by lipids that poses a serious threat to human health. Therefore, the development of drugs with both anti-inflammatory and lipid-lowering properties can provide new hope for the treatment of AS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Previous studies have shown that the N-salicyloyl tryptamine derivative B2, formed by combining salicylic acid derivatives and the melatonin skeleton, exhibits strong anti-inflammatory activity and high biosafety. In this study, we used lipopolysaccharide (LPS)\/ adenosine triphosphate (ATP) or LPS-stimulated macrophage-conditioned medium to establish an endothelial cell inflammation model. Apolipoprotein E\u2212\/\u2212 (ApoE\u2212\/\u2212) mice fed a high-fat diet (HFD) were used to establish the atherosclerosis animal model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key findings<\/jats:title>\n                    <jats:p>We found that B2 inhibited LPS\/ATP-induced inflammation and apoptosis of endothelial cells, reduced monocyte\u2013endothelial cell adhesion, decreased vascular cell adhesion molecule-1, intercellular adhesion molecule-1, monocyte chemoattractant protein-1, interleukin-6 (IL-6), and interleukin-1\u03b2, and inhibited the mitogen-activated protein kinase kinase 4\/c-Jun N-terminal kinase pathway. In ApoE\u2212\/\u2212 mice fed a HFD, ELISA and lipid assay revealed that B2 reduced plasma IL-6 and triglyceride levels. Meanwhile, Oil Red O staining and Masson staining showed that B2 decreased the aortic plaque area and the degree of fibrosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings suggested that B2 exerts both anti-inflammatory and lipid-lowering effects, providing a new intervention approach and direction for the prevention and treatment of AS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jpp\/rgaf116","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T11:17:49Z","timestamp":1763983069000},"source":"Crossref","is-referenced-by-count":1,"title":["<i>N<\/i>\n                    -salicyloyl tryptamine derivative exerts antiatherosclerotic effects by ameliorating endothelial inflammation and apoptosis"],"prefix":"10.1093","volume":"78","author":[{"given":"Liuli","family":"Cao","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Science, Hengyang Medical School, University of South China , No. 28, Changsheng West Road, Zhengxiang District, Hengyang, Hunan 421001 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Ding","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Science, Hengyang Medical School, University of South China , No. 28, Changsheng West Road, Zhengxiang District, Hengyang, Hunan 421001 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixia","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Science, Hengyang Medical School, University of South China , No. 28, Changsheng West Road, Zhengxiang District, Hengyang, Hunan 421001 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Science, Hengyang Medical School, University of South China , No. 28, Changsheng West Road, Zhengxiang District, Hengyang, Hunan 421001 ,","place":["China"]},{"name":"The First Affiliated Hospital, Hengyang Medical School, University of South China , No. 69, Chuanshan Road, Shigu District, Hengyang, Hunan 421001 ,","place":["China"]},{"name":"National Health Commission Key Laboratory of Birth Defect Research and Prevention, Hunan Provincial Maternal and Child Health Care Hospital , No. 53, Xiangchun Road, Kaifu District, Changsha, Hunan 410008 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3573-6638","authenticated-orcid":false,"given":"Shu-zhi","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Science, Hengyang Medical School, University of South China , No. 28, Changsheng West Road, Zhengxiang District, Hengyang, Hunan 421001 ,","place":["China"]},{"name":"The First Affiliated Hospital, Hengyang Medical School, University of South China , No. 69, Chuanshan Road, Shigu District, Hengyang, Hunan 421001 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,11,24]]},"reference":[{"key":"2026031309520769700_ref1","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1038\/s41586-021-03392-8","article-title":"The changing landscape of atherosclerosis","volume":"592","author":"Libby","year":"2021","journal-title":"Nature"},{"key":"2026031309520769700_ref2","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1161\/CIRCRESAHA.115.306471","article-title":"From lipids to inflammation: new approaches to reducing atherosclerotic risk","volume":"118","author":"Shapiro","year":"2016","journal-title":"Circ 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