{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T15:50:44Z","timestamp":1782489044034,"version":"3.54.5"},"reference-count":67,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Artemisia scoparia is a perennial herb belonging to the Asteraceae family. Although research has shown that A. scoparia possesses antioxidant and anti-inflammatory properties, the anti-inflammatory activity and mechanisms of A. scoparia essential oil (ASEO) remain poorly understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Anti-inflammatory activities and mechanisms of ASEO were investigated using cellular experiments, gas chromatography\u2013mass spectrometry (GC\u2013MS), network pharmacology, and molecular docking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key findings<\/jats:title>\n                    <jats:p>Cellular assays showed that ASEO ameliorated lipopolysaccharide (LPS)-induced inflammation in RAW264.7 cells by inhibiting nitric oxide (NO), myeloperoxidase (MPO), and tumor necrosis factor alpha (TNF-\u03b1) production and thereby suppressing inflammation in a dose-dependent manner. Notably, the effect of ASEO (6.25\u00a0\u03bcg\/mL) was stronger than that of the positive control dexamethasone (7.85\u00a0\u03bcg\/mL). The network pharmacology and molecular docking results indicated that the key components (methyleugenol, L-\u03b1-terpineol, \u03b1-bisabolol, and \u03b1-cadinol) exerted significant anti-inflammatory effects by acting on the key targets [peroxisome proliferative activated receptor gamma (PPARG), prostaglandin-endoperoxide synthase 2 (PTGS2), estrogen receptor 1 (ESR1), E1A Binding Protein P300 (EP300), peroxisome proliferator activated receptor alpha (PPARA), and 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR)], and the main pathways involved were mainly the PPAR signaling pathway, neuroactive ligand-receptor interaction, cyclic adenosine monophosphate (cAMP) signaling pathway, and serotonergic synapse.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings suggest that ASEO has great potential as a natural anti-inflammatory agent, its key compositions and multiple anti-inflammatory mechanisms make it a promising candidate for further research and development for clinical applications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jpp\/rgag004","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T12:39:18Z","timestamp":1767789558000},"source":"Crossref","is-referenced-by-count":1,"title":["Anti-inflammatory activity and potential anti-inflammatory mechanisms of\n                    <i>Artemisia scoparia<\/i>\n                    essential oil"],"prefix":"10.1093","volume":"78","author":[{"given":"Panpan","family":"Zhang","sequence":"first","affiliation":[{"name":"Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University , No. 26 Hexing Road, Xiangfang District, Harbin 150040, Heilongjiang Province ,","place":["China"]},{"name":"Heilongjiang Provincial Key Laboratory of Ecological Utilization of Forestry-Based Active Substances , Northeast Forestry University, No. 26 Hexing Road, Xiangfang District, Harbin 150040, Heilongjiang Provice ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Xu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University , No. 26 Hexing Road, Xiangfang District, Harbin 150040, Heilongjiang Province ,","place":["China"]},{"name":"Heilongjiang Provincial Key Laboratory of Ecological Utilization of Forestry-Based Active Substances , Northeast Forestry University, No. 26 Hexing Road, Xiangfang District, Harbin 150040, Heilongjiang Provice ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University , No. 26 Hexing Road, Xiangfang District, Harbin 150040, Heilongjiang Province 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