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Rats were assigned to model, valsartan, and high-\/low-dose QYYYG groups and treated for 8\u00a0weeks. Blood pressure (BP), blood urea nitrogen (BUN), renal histopathology, and related biochemical indicators were evaluated. In vitro, HK-2 cells pretreated with QYYYG or valsartan were subjected to hypoxic conditions. The expression levels of HIF-1\u03b1, NOX4, HO-1, Nrf2, and SESN2 were quantified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key findings<\/jats:title>\n                    <jats:p>QYYYG markedly reduced BP and BUN levels and ameliorated renal histopathological damage. It upregulated SESN2, activated AMPK\u03b1, inhibited mTOR phosphorylation, and suppressed NOX4 expression, thereby reducing HIF-1\u03b1 accumulation. QYYYG also enhanced the expression of SESN2, Nrf2, and HO-1. Consistently, in vitro, QYYYG significantly increased SESN2, Nrf2, and HO-1 expression while reducing NOX4 and HIF-1\u03b1 levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>QYYYG alleviates hypertensive renal injury by regulating the Sestrin2 signaling pathway and improving local oxidative stress responses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jpp\/rgag008","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T12:25:30Z","timestamp":1768911930000},"source":"Crossref","is-referenced-by-count":1,"title":["Qian Yang Yu Yin Granule ameliorates hypertension-induced renal injury through the modulation of oxidative stress via Sestrin2 signaling pathway"],"prefix":"10.1093","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-3071-3011","authenticated-orcid":false,"given":"Lichao","family":"Qian","sequence":"first","affiliation":[{"name":"Department of Geratology, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine , No. 157 Daming Road, Qinhuai District, Nanjing, Jiangsu 210022 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Shen","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine, Nanjing University of Chinese Medicine , No. 138, Xianlin Avenue, Qixia District, Nanjing, Jiangsu 210046 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Affiliated Hospital of Nanjing University of Chinese Medicine , No. 155 Hanzhong Road, Qinhuai District, Nanjing, Jiangsu 210029 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Radiology, Affiliated Hospital of Nanjing University of Chinese Medicine , No. 155 Hanzhong Road, Qinhuai District, Nanjing, Jiangsu 210029 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4902-6298","authenticated-orcid":false,"given":"Shuai","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Radiology, Affiliated Hospital of Nanjing University of Chinese Medicine , No. 155 Hanzhong Road, Qinhuai District, Nanjing, Jiangsu 210029 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Affiliated Hospital of Nanjing University of Chinese Medicine , No. 155 Hanzhong Road, Qinhuai District, Nanjing, 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