{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T18:30:13Z","timestamp":1771525813954,"version":"3.50.1"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Daqing People\u2019s Hospital","award":["WYJJ-2025-05"],"award-info":[{"award-number":["WYJJ-2025-05"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Cardiac microvascular dysfunction contributes to the pathogenesis of cardiac hypertrophy (CH) and potentially progresses to cardiac failure. Dendrophenol (Den), a naturally derived compound isolated from Dendrobium moschatum, exhibits diverse biological properties, including anti-inflammatory, antioxidant, anti-angiogenic, anti-proliferative, and anti-metastatic effects. This investigation aimed to examine ferroptosis involvement in microvascular dysfunction and assess Den\u2019s capacity to suppress ferroptosis while ameliorating pressure overload-induced endothelial damage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A rat CH model was established, and comprehensive experimental approaches were implemented, including network pharmacology (NP), molecular docking, Western blot analysis, hematoxylin and eosin staining, wheat germ agglutinin staining, Masson staining, Gel-ink staining, immunohistochemistry, Laser speckle contrast analysis, immunofluorescence, quantitative reverse transcription polymerase chain reaction, and luciferase reporter gene.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key findings<\/jats:title>\n                    <jats:p>NP methodologies were applied to predict Den\u2019s potential molecular targets. Echocardiographic assessments demonstrated that Den markedly enhanced cardiac function, while morphological staining analyses revealed that Den substantially suppressed CH development in rats. Additionally, Den ameliorated cardiac microvascular dysfunction in the abdominal aortic constriction-induced CH rat model. Mechanistic investigations revealed that Den suppresses C-Jun phosphorylation and decreases NCOA4 expression, consequently inhibiting ferroptosis in cardiac microvascular endothelial cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Den attenuated CH by suppressing ferroptosis in cardiac microvascular endothelial cells through the C-Jun\/NCOA4 pathway.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jpp\/rgag011","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T12:31:07Z","timestamp":1769430667000},"source":"Crossref","is-referenced-by-count":0,"title":["Dendrophenol attenuates cardiac hypertrophy through inhibition of ferroptosis via the C-Jun\/NCOA4 signaling pathway"],"prefix":"10.1093","volume":"78","author":[{"given":"Yongcheng","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery, The Affiliated Dongguan Songshan Lake Central Hospital, Guangdong Medical University Dongguan , No. 1 Xianglong Road, Huangzhou District, Shilong Town, Guangdong 523326 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueyi","family":"Liu","sequence":"additional","affiliation":[{"name":"The Electrocardiogram Department, Daqing People's Hospital , 213 Jianshe Road, Daqing, Heilongjiang 163319 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiming","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, The Affiliated Dongguan Songshan Lake Central Hospital, Guangdong Medical University Dongguan , No. 1 Xianglong Road, Huangzhou District, Shilong Town, Guangdong 523326 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenbin","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, The Affiliated Dongguan Songshan Lake Central Hospital, Guangdong Medical University Dongguan , No. 1 Xianglong Road, Huangzhou District, Shilong Town, Guangdong 523326 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaohui","family":"He","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, The Affiliated Dongguan Songshan Lake Central Hospital, Guangdong Medical University Dongguan , No. 1 Xianglong Road, Huangzhou District, Shilong Town, Guangdong 523326 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yufeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, The Affiliated Dongguan Songshan Lake Central Hospital, Guangdong Medical University Dongguan , No. 1 Xianglong Road, Huangzhou District, Shilong Town, Guangdong 523326 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haijian","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, The Affiliated Dongguan Songshan Lake Central Hospital, Guangdong Medical University Dongguan , No. 1 Xianglong Road, Huangzhou District, Shilong Town, Guangdong 523326 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liwei","family":"Pang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, The Affiliated Dongguan Songshan Lake Central Hospital, Guangdong Medical University Dongguan , No. 1 Xianglong Road, Huangzhou District, Shilong Town, Guangdong 523326 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fanxin","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The Affiliated Dongguan Songshan Lake Central Hospital, Guangdong Medical University Dongguan , No. 1 Xianglong Road, Huangzhou District, Shilong Town, Guangdong 523326 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9186-8779","authenticated-orcid":false,"given":"Dezhe","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, The Affiliated Dongguan Songshan Lake Central Hospital, Guangdong Medical University Dongguan , No. 1 Xianglong Road, Huangzhou District, Shilong Town, Guangdong 523326 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,2,19]]},"reference":[{"key":"2026021912534038000_ref1","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1038\/s41569-018-0007-y","article-title":"Mechanisms of physiological and pathological cardiac hypertrophy","volume":"15","author":"Nakamura","year":"2018","journal-title":"Nat Rev Cardiol"},{"key":"2026021912534038000_ref2","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.yjmcc.2016.06.001","article-title":"Physiological and pathological cardiac hypertrophy","volume":"97","author":"Shimizu","year":"2016","journal-title":"J Mol Cell Cardiol"},{"key":"2026021912534038000_ref3","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1139\/cjpp-2019-0566","article-title":"Mechanisms for the transition from physiological to pathological cardiac hypertrophy","volume":"98","author":"Oldfield","year":"2020","journal-title":"Can J Physiol Pharmacol"},{"key":"2026021912534038000_ref4","doi-asserted-by":"publisher","first-page":"e70","DOI":"10.1111\/j.1440-1681.2009.05315.x","article-title":"Regulation of cardiac angiotensin-converting enzyme and angiotensin AT1 receptor gene expression in Npr1 gene-disrupted mice","volume":"37","author":"Pandey","year":"2010","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"2026021912534038000_ref5","doi-asserted-by":"publisher","first-page":"A13","DOI":"10.1253\/circj.CJ-08-0481","article-title":"Molecular mechanisms underlying the transition of cardiac hypertrophy to heart failure","volume":"72","author":"Oka","year":"2008","journal-title":"Circ J"},{"key":"2026021912534038000_ref6","doi-asserted-by":"crossref","first-page":"19196","DOI":"10.1038\/srep19196","article-title":"Endothelial cell dysfunction and cardiac hypertrophy in the STOX1 model of preeclampsia","volume":"6","author":"Ducat","year":"2016","journal-title":"Sci Rep"},{"key":"2026021912534038000_ref7","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/nature05602","article-title":"p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload","volume":"446","author":"Sano","year":"2007","journal-title":"Nature."},{"key":"2026021912534038000_ref8","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/s41419-020-2298-2","article-title":"Ferroptosis: past, present and future","volume":"11","author":"Li","year":"2020","journal-title":"Cell Death Dis"},{"key":"2026021912534038000_ref9","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","article-title":"Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease","volume":"171","author":"Stockwell","year":"2017","journal-title":"Cell."},{"key":"2026021912534038000_ref10","doi-asserted-by":"publisher","first-page":"2672","DOI":"10.1073\/pnas.1821022116","article-title":"Ferroptosis as a target for protection against cardiomyopathy","volume":"116","author":"Fang","year":"2019","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026021912534038000_ref11","doi-asserted-by":"publisher","first-page":"e169756","DOI":"10.1172\/jci.insight.169756","article-title":"Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity","volume":"8","author":"Tadokoro","year":"2023","journal-title":"JCI Insight"},{"key":"2026021912534038000_ref12","doi-asserted-by":"crossref","first-page":"154132","DOI":"10.1016\/j.phymed.2022.154132","article-title":"Alkaloids from dendrobium and their biosynthetic pathway, biological activity and total synthesis","volume":"102","author":"Duan","year":"2022","journal-title":"Phytomedicine."},{"key":"2026021912534038000_ref13","doi-asserted-by":"crossref","first-page":"605994","DOI":"10.3389\/fphar.2021.605994","article-title":"Identification, biological activities and biosynthetic pathway of dendrobium alkaloids","volume":"12","author":"Mou","year":"2021","journal-title":"Front Pharmacol"},{"key":"2026021912534038000_ref14","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1007\/s12032-024-02467-6","article-title":"Moscatilin, a potential therapeutic agent for cancer treatment: insights into molecular mechanisms and clinical prospects","volume":"41","author":"Silva-Reis","year":"2024","journal-title":"Med Oncol"},{"key":"2026021912534038000_ref15","doi-asserted-by":"publisher","first-page":"827","DOI":"10.14336\/AD.2017.0214","article-title":"Dendrobium: sources of active ingredients to treat age-related pathologies","volume":"8","author":"Cakova","year":"2017","journal-title":"Aging Dis"},{"key":"2026021912534038000_ref16","doi-asserted-by":"crossref","first-page":"765894","DOI":"10.1155\/2013\/765894","article-title":"Moscatilin inhibits lung cancer cell motility and invasion via suppression of endogenous reactive oxygen species","volume":"2013","author":"Kowitdamrong","year":"2013","journal-title":"Biomed Res Int"},{"key":"2026021912534038000_ref17","doi-asserted-by":"crossref","first-page":"113323","DOI":"10.1016\/j.ecoenv.2022.113323","article-title":"Evaluation of the binding performance of flavonoids to estrogen receptor alpha by Autodock, Autodock Vina and Surflex-dock","volume":"233","author":"Xue","year":"2022","journal-title":"Ecotoxicol Environ Saf"},{"key":"2026021912534038000_ref18","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1093\/bib\/bbaa379","article-title":"A comprehensive drug repurposing study for COVID19 treatment: novel putative dihydroorotate dehydrogenase inhibitors show association to serotonin-dopamine receptors","volume":"22","author":"Berber","year":"2021","journal-title":"Brief Bioinform"},{"key":"2026021912534038000_ref19","doi-asserted-by":"crossref","first-page":"108972","DOI":"10.1016\/j.jnutbio.2022.108972","article-title":"Up-regulation of IRF3 is required for docosahexaenoic acid suppressing ferroptosis of cardiac microvascular endothelial cells in cardiac hypertrophy rat","volume":"104","author":"Shi","year":"2022","journal-title":"J Nutr Biochem"},{"key":"2026021912534038000_ref20","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.omtn.2021.10.024","article-title":"Neutrophil-like cell membrane-coated siRNA of lncRNA AABR07017145.1 therapy for cardiac hypertrophy via inhibiting ferroptosis of CMECs","volume":"27","author":"Shi","year":"2021","journal-title":"Mol Ther Nucleic Acids"},{"key":"2026021912534038000_ref21","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1007\/s10456-016-9537-2","article-title":"Angiopoietins as serum biomarkers for lymphatic anomalies","volume":"20","author":"Le Cras","year":"2017","journal-title":"Angiogenesis."},{"key":"2026021912534038000_ref22","doi-asserted-by":"publisher","first-page":"e12503","DOI":"10.1111\/jpi.12503","article-title":"Inhibitory effect of melatonin on necroptosis via repressing the Ripk3-PGAM5-CypD-mPTP pathway attenuates cardiac microvascular ischemia-reperfusion injury","volume":"65","author":"Zhou","year":"2018","journal-title":"J Pineal Res"},{"key":"2026021912534038000_ref23","doi-asserted-by":"publisher","first-page":"e22569","DOI":"10.1096\/fj.202200935R","article-title":"Galangin inhibited ferroptosis through activation of the PI3K\/AKT pathway in vitro and in vivo","volume":"36","author":"Chen","year":"2022","journal-title":"FASEB J"},{"key":"2026021912534038000_ref24","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.freeradbiomed.2023.03.008","article-title":"JNK-JUN-NCOA4 axis contributes to chondrocyte ferroptosis and aggravates osteoarthritis via ferritinophagy","volume":"200","author":"Sun","year":"2023","journal-title":"Free Radic Biol Med"},{"key":"2026021912534038000_ref25","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","article-title":"Regulation of ferroptotic cancer cell death by GPX4","volume":"156","author":"Yang","year":"2014","journal-title":"Cell."},{"key":"2026021912534038000_ref26","doi-asserted-by":"crossref","first-page":"212","DOI":"10.3390\/jcm10020212","article-title":"Inhibition of MLKL attenuates Necroptotic cell death in a murine cell model of ischaemia injury","volume":"10","author":"Baidya","year":"2021","journal-title":"J Clin Med"},{"key":"2026021912534038000_ref27","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1161\/CIRCRESAHA.114.300507","article-title":"Angiogenesis and cardiac hypertrophy: maintenance of cardiac function and causative roles in heart failure","volume":"114","author":"Oka","year":"2014","journal-title":"Circ Res"},{"key":"2026021912534038000_ref28","doi-asserted-by":"publisher","first-page":"2657","DOI":"10.1016\/j.bmc.2019.04.027","article-title":"Design, synthesis and antitumour and anti-angiogenesis evaluation of 22 moscatilin derivatives","volume":"27","author":"Guan","year":"2019","journal-title":"Bioorg Med Chem"},{"key":"2026021912534038000_ref29","doi-asserted-by":"publisher","first-page":"15593258211001251","DOI":"10.1177\/15593258211001251","article-title":"Moscatilin suppresses the breast cancer both In vitro and In vivo by inhibiting HDAC3","volume":"19","author":"Su","year":"2021","journal-title":"Dose Response"},{"key":"2026021912534038000_ref30","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1038\/s41571-020-00462-0","article-title":"Broadening horizons: the role of ferroptosis in cancer","volume":"18","author":"Chen","year":"2021","journal-title":"Nat Rev Clin Oncol"},{"key":"2026021912534038000_ref31","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.3892\/mmr.2017.6144","article-title":"Moscatilin induces apoptosis of pancreatic cancer cells via reactive oxygen species and the JNK\/SAPK pathway","volume":"15","author":"Zhang","year":"2017","journal-title":"Mol Med Rep"},{"key":"2026021912534038000_ref32","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1097\/SHK.0b013e3181a7ff4a","article-title":"Moscatilin repressed lipopolysaccharide-induced HIF-1alpha accumulation and NF-kappaB activation in murine RAW264.7 cells","volume":"33","author":"Liu","year":"2010","journal-title":"Shock."},{"key":"2026021912534038000_ref33","doi-asserted-by":"publisher","first-page":"1979","DOI":"10.1021\/acs.jnatprod.9b00375","article-title":"Moscatilin ameliorates tau phosphorylation and cognitive deficits in Alzheimer's disease models","volume":"82","author":"Huang","year":"2019","journal-title":"J Nat Prod"},{"key":"2026021912534038000_ref34","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1248\/bpb.b19-01073","article-title":"Dendrobium officinale attenuates myocardial fibrosis via inhibiting EMT Signaling pathway in HFD\/STZ-induced diabetic mice","volume":"43","author":"Zeng","year":"2020","journal-title":"Biol Pharm Bull"},{"key":"2026021912534038000_ref35","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1007\/s10741-017-9628-1","article-title":"Role of PET to evaluate coronary microvascular dysfunction in non-ischemic cardiomyopathies","volume":"22","author":"Bravo","year":"2017","journal-title":"Heart Fail Rev"},{"key":"2026021912534038000_ref36","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.phymed.2018.10.021","article-title":"Allicin improves the function of cardiac microvascular endothelial cells by increasing PECAM-1 in rats with cardiac hypertrophy","volume":"51","author":"Shi","year":"2018","journal-title":"Phytomedicine."},{"key":"2026021912534038000_ref37","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1038\/s41568-022-00459-0","article-title":"Targeting ferroptosis as a vulnerability in cancer","volume":"22","author":"Lei","year":"2022","journal-title":"Nat Rev Cancer"},{"key":"2026021912534038000_ref38","doi-asserted-by":"publisher","first-page":"2082","DOI":"10.1002\/med.21574","article-title":"JNK signaling in cancer cell survival","volume":"39","author":"Wu","year":"2019","journal-title":"Med Res Rev"},{"key":"2026021912534038000_ref39","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.jare.2024.09.029","article-title":"The role of JNK signaling pathway in organ fibrosis","volume":"74","author":"Hao","year":"2025","journal-title":"J Adv Res"},{"key":"2026021912534038000_ref40","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.freeradbiomed.2024.12.007","article-title":"Inhibition of JNK signaling attenuates photoreceptor ferroptosis caused by all-trans-retinal","volume":"227","author":"Yang","year":"2025","journal-title":"Free Radic Biol Med"},{"key":"2026021912534038000_ref41","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3892\/ijmm.2023.5264","article-title":"Involvement of the JNK\/HO-1\/FTH1 signaling pathway in nanoplastic-induced inflammation and ferroptosis of BV2 microglia cells","volume":"52","author":"Sun","year":"2023","journal-title":"Int J Mol Med"}],"container-title":["Journal of Pharmacy and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/78\/2\/rgag011\/66992536\/rgag011.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/78\/2\/rgag011\/66992536\/rgag011.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T17:53:49Z","timestamp":1771523629000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jpp\/article\/doi\/10.1093\/jpp\/rgag011\/8490628"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2,6]]}},"URL":"https:\/\/doi.org\/10.1093\/jpp\/rgag011","relation":{},"ISSN":["0022-3573","2042-7158"],"issn-type":[{"value":"0022-3573","type":"print"},{"value":"2042-7158","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,2]]},"published":{"date-parts":[[2026,2]]},"article-number":"rgag011"}}