{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:01:46Z","timestamp":1787162506241,"version":"build-2736575974"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"State Administration of Traditional Chinese Medicine 2022 Young Qi Huang Scholars Support Project"},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260876"],"award-info":[{"award-number":["82260876"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Chinese Traditional Medicine Teaching Letter"},{"name":"TCM Geriatrics Construction Project"},{"name":"Key Discipline of National Administration of TCM"},{"name":"Key Clinical Specialty of the National Administration of Traditional Chinese Medicine\u2013Department of Preventive Treatment"},{"name":"Letter of the State Medical Administration of Traditional Chinese Medicine"},{"name":"Hainan Provincial Master-Physician Heritage Studio Project"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Conventional pharmacotherapies afford only modest renoprotection in diabetic nephropathy (DN). Oleanolic acid (OA), a pentacyclic triterpenoid abundant in Traditional Chinese Medicine (TCM), mitigates DN, but its mechanism remains unclear. This study aimed to verify the hypothesis that OA protects podocytes by modulating autophagy, thereby exploring the potential therapeutic mechanism of OA in attenuating DN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>High glucose-injured MPC5 podocytes were treated with OA to evaluate its impact on autophagy. Podocytes were further treated with graded concentrations of OA, rapamycin (an autophagy inducer), or 3-methyladenine (an autophagy inhibitor). Cell viability was quantified using the Cell Counting Kit-8 assay. Nuclear morphology was visualized by DAPI staining, autophagosomes were enumerated by transmission electron microscopy, and the expression of autophagy-related genes was determined by quantitative reverse transcription polymerase chain reaction. These complementary approaches were used to assess high-glucose-induced podocyte injury and the capacity of OA to enhance autophagy and attenuate cellular damage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key findings<\/jats:title>\n                    <jats:p>The effective concentration window for OA was established at 5\u201310\u00a0\u03bcM. Within this concentration range, podocyte viability was significantly increased, accompanied by a higher autophagosome count and elevated expression of autophagosomal markers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Oleanolic acid alleviates high glucose-induced podocyte injury by robustly activating autophagy, underscoring its potential as a sustainable therapeutic strategy for DN, along with other active compounds derived from TCM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jpp\/rgag014","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T12:42:14Z","timestamp":1770295334000},"source":"Crossref","is-referenced-by-count":1,"title":["Oleanolic acid ameliorates podocyte injury by increasing autophagy to attenuate diabetic nephropathy"],"prefix":"10.1093","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0595-7214","authenticated-orcid":false,"given":"Yawei","family":"Cheng","sequence":"first","affiliation":[{"name":"The Second Clinical Medical College, Shandong University of Traditional Chinese Medicine , No. 4655 Daxue Road, Changqing District, Jinan, 250355, Shandong ,","place":["China"]},{"name":"Preventive Treatment Center, Guangdong Provincial Hospital of Chinese Medicine Hainan Hospital (Hainan Provincial Hospital of Traditional Chinese Medicine) , No. 47 Heping North Road, Meilan District, Haikou, 570203, Hainan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gengliang","family":"Li","sequence":"additional","affiliation":[{"name":"Guangzhou University of Chinese Medicine , No. 232 Waihuan East Road, University Town, Panyu District, Guangzhou, 510006, Guangdong 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