{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T23:12:36Z","timestamp":1793833956707,"version":"4.6.1"},"reference-count":119,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000199","name":"United States Department of Agriculture","doi-asserted-by":"publisher","award":["2020\u201367013-40658"],"award-info":[{"award-number":["2020\u201367013-40658"]}],"id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["2340995"],"award-info":[{"award-number":["2340995"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to elucidate potential mechanisms associated with the cardioprotective efficacy of methanolic Delonix regia extract against the pathophysiological diabetic cardiac remodeling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Phytochemical analysis of the D. regia extract was conducted utilizing liquid chromatography\u2013tandem mass spectrometry. Diabetes was induced using a high fructose\/salt\/fat diet, with a concurrent low dose streptozotocin. The extract was administered orally during the final six weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key findings<\/jats:title>\n                    <jats:p>The analysis identified fifty-nine phytoconstituents within the floral extract. Functionally, the extract was associated with improvements in diabetes-induced alterations in cardiac performance and normalization of electrocardiographic indicators of ventricular activity. Structurally, the extract was associated with attenuation of cardiac remodeling, including reduced cardiomyocyte hypertrophy, improvement of diabetes-induced structural distortions, and decreased fibrotic deposition. Additionally, the extract was associated with modulation of apoptotic markers and increased levels of endothelial nitric oxide synthase (eNOS), tetrahydrobiopterin, cyclic guanosine monophosphate, and glutathione. Molecular docking suggested that these effects may be attributable to the combined actions of phenolic and flavonoid constituents.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Methanolic extract of D. regia may have therapeutic potential in the attenuating left ventricular remodeling associated with diabetic cardiomyopathy. These effects appear to be associated with modulation of eNOS\/NO\/cGMP and NF-\u03baB\/iNOS\/TNF-\u03b1 trajectories, along with anti-apoptotic and antifibrotic actions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jpp\/rgag024","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T07:47:06Z","timestamp":1774511226000},"source":"Crossref","is-referenced-by-count":1,"title":["<i>Delonix regia<\/i>\n                    flower extract protects against diabetic cardiac remodeling via modulating eNOS\/NO\/cGMP and NF-\u03baB\/iNOS\/TNF-\u03b1 trajectories"],"prefix":"10.1093","volume":"78","author":[{"given":"Nadia","family":"Hassan","sequence":"first","affiliation":[{"name":"Fellow Pharmacology Pharmacist in Al-Ahrar Teaching Hospital, General Organization of Teaching Hospitals and Institutes , Zagazig 44511 ,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maged","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University , Al-Ahsa 31982 ,","place":["Saudi Arabia"]},{"name":"Department of Pharmacognosy , Faculty of Pharmacy, Zagazig University, Zagazig 44519 ,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8941-3781","authenticated-orcid":false,"given":"Noura A","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology , Faculty of Pharmacy, Zagazig University, Zagazig 44519 ,","place":["Egypt"]},{"name":"Clinical Pharmacy Program , Medical sector, Zagazig National University, Tenth of Ramadan City ,","place":["Egypt"]},{"name":"Pharmaceutical Services Center, Faculty of Pharmacy, Zagazig University , Zagazig 44519 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,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed S","family":"Abdelkhalek","sequence":"additional","affiliation":[{"name":"Medicinal Chemistry Department , Faculty of Pharmacy, Zagazig University, Zagazig 44519 ,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig","family":"Dufresne","sequence":"additional","affiliation":[{"name":"Thermo Fisher Scientific Inc. , 1400 Northpoint Pkwy, Suite 10, West Palm Beach, Fl 33407 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed E","family":"El-Sadek","sequence":"additional","affiliation":[{"name":"Medicinal Chemistry Department , Faculty of Pharmacy, Zagazig University, Zagazig 44519 ,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sixue","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biology , University of Mississippi, 218 Shoemaker Hall, Oxford, MS 38677-1848 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Islam","family":"Mostafa","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy , Faculty of Pharmacy, Zagazig University, Zagazig 44519 ,","place":["Egypt"]},{"name":"Clinical Pharmacy Program , Medical sector, Zagazig National University, Tenth of Ramadan City ,","place":["Egypt"]},{"name":"Pharmaceutical Services Center, Faculty of Pharmacy, Zagazig University , Zagazig 44519 ,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2900-7279","authenticated-orcid":false,"given":"Asmaa M","family":"Arafa","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy , Faculty of Pharmacy, Zagazig University, Zagazig 44519 ,","place":["Egypt"]},{"name":"Clinical Pharmacy Program , Medical sector, Zagazig National University, Tenth of Ramadan City 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