{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T09:06:28Z","timestamp":1774515988984,"version":"3.50.1"},"reference-count":141,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071239"],"award-info":[{"award-number":["82071239"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ningbo Top Medical and Health Research Program","award":["2024010317"],"award-info":[{"award-number":["2024010317"]}]},{"DOI":"10.13039\/100007834","name":"Ningbo Natural Science Foundation","doi-asserted-by":"publisher","award":["2025\u00a0J070"],"award-info":[{"award-number":["2025\u00a0J070"]}],"id":[{"id":"10.13039\/100007834","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Chemotherapy-induced peripheral neuropathy (CIPN) is a common and serious side effect of cancer treatment. Studies have shown that there is significant sexual dimorphism in animal models, molecular mechanisms and drug treatment responses of CIPN-related pain. This review systematically explores these sex differences in CIPN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key findings<\/jats:title>\n                    <jats:p>Mechanistically, the pain sensitivity of female mice is mainly dependent on the IL-23\/IL-17A\/TRPV1 signaling axis, bidirectionally regulated by estrogen and its receptor \u03b1 (ER-\u03b1). In contrast, male mice are more driven by TLR9-mediated macrophage activation and subsequent TNF\/CXCL1 release. Pharmaco-therapeutically, both pre-clinical and clinical studies of duloxetine have shown that females may have better efficacy. The efficacy of \u03ba-opioid receptor (KOR) agonist, resolvin D5 (RvD5), Mitragynine, sphingosine-1-phosphate receptor 1 (S1PR1) antagonist and adenosine A3 receptor (A3AR) agonist also varies by sex and type of chemotherapy drugs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Sex is a crucial biological variable in CIPN, influencing drug efficacy through sex-specific neuroimmune mechanisms and hormonal regulation. These findings underscore the necessity of incorporating sex as a key variable in analgesic development and clinical practice to achieve personalized pain management in CIPN patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jpp\/rgag025","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T07:46:56Z","timestamp":1774511216000},"source":"Crossref","is-referenced-by-count":0,"title":["Sex differences in chemotherapy-induced neuropathic pain: mechanisms and pharmacotherapy"],"prefix":"10.1093","volume":"78","author":[{"given":"Xuewei","family":"Wu","sequence":"first","affiliation":[{"name":"Health Science Center, Ningbo University , 818 Fenghua Road, Ningbo, Zhejiang 315211 ,","place":["P. R. China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Litao","family":"Chen","sequence":"additional","affiliation":[{"name":"Health Science Center, Ningbo University , 818 Fenghua Road, Ningbo, Zhejiang 315211 ,","place":["P. R. China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yushan","family":"Chen","sequence":"additional","affiliation":[{"name":"Health Science Center, Ningbo University , 818 Fenghua Road, Ningbo, Zhejiang 315211 ,","place":["P. R. China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yixin","family":"Liu","sequence":"additional","affiliation":[{"name":"Health Science Center, Ningbo University , 818 Fenghua Road, Ningbo, Zhejiang 315211 ,","place":["P. R. China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1049-3016","authenticated-orcid":false,"given":"Xiaowei","family":"Chen","sequence":"additional","affiliation":[{"name":"Health Science Center, Ningbo University , 818 Fenghua Road, Ningbo, Zhejiang 315211 ,","place":["P. R. China"]},{"name":"Zhejiang Key Laboratory of Drug Addiction & Brain Health, The Affiliated Kangning Hospital of Ningbo University , 1 Zhuangyu South Road, Ningbo, Zhejiang 315211 ,","place":["P. R. 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