{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:19:57Z","timestamp":1790011197196,"version":"4.0.1"},"reference-count":63,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Organizational Key R&D Program of SHUTCM","award":["2023YZZ01"],"award-info":[{"award-number":["2023YZZ01"]}]},{"name":"CAS \u2018Light of West China\u2019 Program, CAS Interdisciplinary Innovation Team","award":["xbzg-zdsys-202303"],"award-info":[{"award-number":["xbzg-zdsys-202303"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82274171"],"award-info":[{"award-number":["82274171"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The present study explored whether allyl isothiocyanate from the traditional Chinese medicine mustard seed, ameliorated the arthritis by modulating immune cell responses, particularly by inhibiting mast cell activation and the Pim1 pathway.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Micro-CT, hematoxylin and eosin staining, and flow cytometry were performed to evaluate pathological changes in collagen-induced arthritis mice. To investigate the mechanism underlying allyl isothiocyanate-mediated mast cells activation, degranulation, intracelluar calcium measurement, RNA sequencing, real-time polymerase chain reaction and western blotting were carried out.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key findings<\/jats:title>\n                    <jats:p>Allyl isothiocyanate reduced the number of mast cells in the ankle joints of collagen-induced arthritis mice, and it inhibited the degranulation of mouse bone marrow-derived mast cells and RBL-2H3. RNA sequencing revealed that allyl isothiocyanate significantly inhibited Pim1 expression. Additionally, it inhibited the expression of Pim1, p-STAT5, p-AKT and c-myc in RBL-2H3 and RAW264.7 cells and the ankle joints of collagen-induced arthritis mice. Adoptive transfer of mouse bone marrow-derived mast cells early in collagen-induced arthritis exacerbated joint inflammation, which was similarly inhibited by allyl isothiocyanate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings support mast cell as a major cellular target of AITC in CIA and suggest that Pim1-related signaling contributes to AITC-mediated suppression of mast cell activation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jpp\/rgag027","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T07:47:16Z","timestamp":1774511236000},"source":"Crossref","is-referenced-by-count":1,"title":["Allyl isothiocyanate ameliorates collagen-induced arthritis via mast cells and the pim1 pathway"],"prefix":"10.1093","volume":"78","author":[{"given":"Heng","family":"Wang","sequence":"first","affiliation":[{"name":"Experimental Center for Science and Technology, Shanghai University of Traditional Chinese Medicine , No. 1200 Cai Lun Road, Pudong New Area, Shanghai 201203 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiying","family":"Wang","sequence":"additional","affiliation":[{"name":"Experimental Center for Science and Technology, Shanghai University of Traditional Chinese Medicine , No. 1200 Cai Lun Road, Pudong New Area, Shanghai 201203 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronghao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Experimental Center for Science and Technology, Shanghai University of Traditional Chinese Medicine , No. 1200 Cai Lun Road, Pudong New Area, Shanghai 201203 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Experimental Center for Science and Technology, Shanghai University of Traditional Chinese Medicine , No. 1200 Cai Lun Road, Pudong New Area, Shanghai 201203 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengjie","family":"Wang","sequence":"additional","affiliation":[{"name":"Experimental Center for Science and Technology, Shanghai University of Traditional Chinese Medicine , No. 1200 Cai Lun Road, Pudong New Area, Shanghai 201203 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijun","family":"He","sequence":"additional","affiliation":[{"name":"Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine , No. 1200 Cai Lun Road, Pudong New Area, Shanghai 201203 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1206-9692","authenticated-orcid":false,"given":"Xiaoyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Experimental Center for Science and Technology, Shanghai University of Traditional Chinese Medicine , No. 1200 Cai Lun Road, Pudong New Area, Shanghai 201203 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Kadowaki","sequence":"additional","affiliation":[{"name":"Division of Gastrointestinal Pathophysiology, Institute of Natural Medicine, University of Toyama , 2630 Sugitani, Toyama 930-0194 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,3,25]]},"reference":[{"key":"2026032603471178300_ref1","doi-asserted-by":"publisher","first-page":"2019","DOI":"10.1016\/S0140-6736(23)01525-8","article-title":"Rheumatoid arthritis","volume":"402","author":"Di Matteo","year":"2023","journal-title":"Lancet"},{"key":"2026032603471178300_ref2","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1056\/NEJMra2103726","article-title":"Rheumatoid arthritis - common origins, divergent mechanisms","volume":"388","author":"Gravallese","year":"2023","journal-title":"N Engl J Med"},{"key":"2026032603471178300_ref3","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.3390\/jcm12041291","article-title":"The burden of rheumatoid arthritis: findings from the 2019 global burden of diseases study and forecasts for 2030 by Bayesian age-period-cohort analysis","volume":"12","author":"Cai","year":"2023","journal-title":"J Clin Med"},{"key":"2026032603471178300_ref4","doi-asserted-by":"publisher","first-page":"4046","DOI":"10.1038\/s41467-022-31519-6","article-title":"Single cell sequencing identifies clonally expanded synovial CD4(+) T(PH) cells expressing GPR56 in rheumatoid arthritis","volume":"13","author":"Argyriou","year":"2022","journal-title":"Nat Commun"},{"key":"2026032603471178300_ref5","doi-asserted-by":"publisher","first-page":"eadg5678","DOI":"10.1126\/scisignal.adg5678","article-title":"TNF-\u03b1 signals through ITK-Akt-mTOR to drive CD4(+) T cell metabolic reprogramming, which is dysregulated in rheumatoid arthritis","volume":"17","author":"Bishop","year":"2024","journal-title":"Sci Signal"},{"key":"2026032603471178300_ref6","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1186\/s10020-024-01005-4","article-title":"MIF promotes Th17 cell differentiation in rheumatoid arthritis through ATF6 signal pathway","volume":"30","author":"Yan","year":"2024","journal-title":"Mol Med"},{"key":"2026032603471178300_ref7","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1136\/ard-2023-224225","article-title":"T follicular helper cells and T peripheral helper cells in rheumatic and musculoskeletal diseases","volume":"82","author":"Akiyama","year":"2023","journal-title":"Ann Rheum Dis"},{"key":"2026032603471178300_ref8","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1038\/s41577-024-00994-x","article-title":"The regulation and differentiation of regulatory T cells and their dysfunction in autoimmune diseases","volume":"24","author":"Sumida","year":"2024","journal-title":"Nat Rev Immunol"},{"key":"2026032603471178300_ref9","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1136\/ard-2023-225343","article-title":"NAT10 promotes synovial aggression by increasing the stability and translation of N4-acetylated PTX3 mRNA in rheumatoid arthritis","volume":"83","author":"Liu","year":"2024","journal-title":"Ann Rheum Dis"},{"key":"2026032603471178300_ref10","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1016\/j.joca.2023.01.005","article-title":"The multifaceted role of mast cells in joint inflammation and arthritis","volume":"31","author":"Loucks","year":"2023","journal-title":"Osteoarthr Cartil"},{"key":"2026032603471178300_ref11","doi-asserted-by":"publisher","first-page":"e41003","DOI":"10.1016\/j.heliyon.2024.e41003","article-title":"Synovial mast cells and osteoarthritis: current understandings and future perspectives","volume":"10","author":"Hao","year":"2024","journal-title":"Heliyon"},{"key":"2026032603471178300_ref12","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1186\/s12951-024-02711-1","article-title":"Adipose-derived stem cell exosomes loaded with icariin alleviates rheumatoid arthritis by modulating macrophage polarization in rats","volume":"22","author":"Yan","year":"2024","journal-title":"J Nanobiotechnology"},{"key":"2026032603471178300_ref13","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1038\/s41392-023-01499-0","article-title":"Metabolic reprogramming of proinflammatory macrophages by target delivered roburic acid effectively ameliorates rheumatoid arthritis symptoms","volume":"8","author":"Jia","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"2026032603471178300_ref14","doi-asserted-by":"publisher","first-page":"1671","DOI":"10.1007\/s00011-024-01924-2","article-title":"The role of Pim-1 kinases in inflammatory signaling pathways","volume":"73","author":"Baek","year":"2024","journal-title":"Inflamm Res"},{"key":"2026032603471178300_ref15","doi-asserted-by":"publisher","first-page":"11582","DOI":"10.3390\/ijms241411582","article-title":"Pim kinases: important regulators of cardiovascular disease","volume":"24","author":"Nock","year":"2023","journal-title":"Int J Mol Sci"},{"key":"2026032603471178300_ref16","doi-asserted-by":"publisher","first-page":"109","DOI":"10.15430\/JCP.2018.23.3.109","article-title":"PIM kinase as an executional target in cancer","volume":"23","author":"Zhang","year":"2018","journal-title":"J Cancer Prev"},{"key":"2026032603471178300_ref17","doi-asserted-by":"publisher","first-page":"3123","DOI":"10.3390\/ijms25063123","article-title":"PIM kinases as potential biomarkers and therapeutic targets in inflammatory arthritides","volume":"25","author":"Assirelli","year":"2024","journal-title":"Int J Mol Sci"},{"key":"2026032603471178300_ref18","doi-asserted-by":"publisher","first-page":"107107","DOI":"10.1016\/j.phrs.2024.107107","article-title":"Isothiocyanates in medicine: a comprehensive review on phenylethyl-, allyl-, and benzyl-isothiocyanates","volume":"201","author":"Hoch","year":"2024","journal-title":"Pharmacol Res"},{"key":"2026032603471178300_ref19","doi-asserted-by":"publisher","first-page":"995","DOI":"10.3390\/plants13070995","article-title":"The antimicrobial effects of myrosinase hydrolysis products derived from glucosinolates isolated from lepidium draba","volume":"13","author":"Polozs\u00e1nyi","year":"2024","journal-title":"Plants (Basel)"},{"key":"2026032603471178300_ref20","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.freeradbiomed.2021.02.044","article-title":"Nanodelivery of natural isothiocyanates as a cancer therapeutic","volume":"167","author":"Wang","year":"2021","journal-title":"Free Radic Biol Med"},{"key":"2026032603471178300_ref21","doi-asserted-by":"publisher","first-page":"579","DOI":"10.3390\/foods14040579","article-title":"Health benefits, applications, and analytical methods of freshly produced allyl isothiocyanate","volume":"14","author":"Alibrahem","year":"2025","journal-title":"Foods"},{"key":"2026032603471178300_ref22","doi-asserted-by":"publisher","first-page":"115334","DOI":"10.1016\/j.biopha.2023.115334","article-title":"Allyl isothiocyanate mitigates airway inflammation and constriction in a house dust mite-induced allergic asthma model via upregulation of tight junction proteins and the TRPA1 modulation","volume":"166","author":"Lai","year":"2023","journal-title":"Biomed Pharmacother"},{"key":"2026032603471178300_ref23","doi-asserted-by":"publisher","first-page":"1112653","DOI":"10.3389\/fmolb.2023.1112653","article-title":"The effect of allyl isothiocyanate on chondrocyte phenotype is matrix stiffness-dependent: possible involvement of TRPA1 activation","volume":"10","author":"Che","year":"2023","journal-title":"Front Mol Biosci"},{"key":"2026032603471178300_ref24","doi-asserted-by":"publisher","first-page":"1952","DOI":"10.1002\/ptr.7425","article-title":"Protective effects of functional foods against Parkinson's disease: a narrative review on pharmacology, phytochemistry, and molecular mechanisms","volume":"36","author":"Iranshahy","year":"2022","journal-title":"Phytother Res"},{"key":"2026032603471178300_ref25","doi-asserted-by":"publisher","first-page":"e167671","DOI":"10.1172\/JCI167671","article-title":"Microbiota-dependent indole production stimulates the development of collagen-induced arthritis in mice","volume":"134","author":"Seymour","year":"2023","journal-title":"J Clin Invest"},{"key":"2026032603471178300_ref26","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1038\/s41392-025-02381-x","article-title":"Inhibition of salt-inducible kinases resolves autoimmune arthritis by promoting macrophage efferocytosis","volume":"10","author":"Lee","year":"2025","journal-title":"Signal Transduct Target Ther"},{"key":"2026032603471178300_ref27","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1007\/s11302-024-10065-4","article-title":"CD39 activities in the treated acupoints contributed to the analgesic mechanism of acupuncture on arthritis rats","volume":"21","author":"Li","year":"2025","journal-title":"Purinergic Signal"},{"key":"2026032603471178300_ref28","doi-asserted-by":"publisher","first-page":"2217","DOI":"10.32604\/biocell.2025.068450","article-title":"Allyl isothiocyanate ameliorates allergic contact dermatitis and food allergy via inhibition of mast cells","volume":"49","author":"Sun","year":"2025","journal-title":"Biocell"},{"key":"2026032603471178300_ref29","doi-asserted-by":"publisher","first-page":"e141008","DOI":"10.1172\/JCI141008","article-title":"IL-1\u03b2-driven osteoclastogenic Tregs accelerate bone erosion in arthritis","volume":"131","author":"Levescot","year":"2021","journal-title":"J Clin Invest"},{"key":"2026032603471178300_ref30","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1002\/art.41150","article-title":"Increased T cell plasticity with dysregulation of follicular helper T, peripheral helper T, and Treg cell responses in children with juvenile idiopathic arthritis and down syndrome-associated arthritis","volume":"72","author":"Foley","year":"2020","journal-title":"Arthritis Rheumatol"},{"key":"2026032603471178300_ref31","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1007\/s12016-019-08769-2","article-title":"Mast cell biology at molecular level: a comprehensive review","volume":"58","author":"Elieh Ali Komi","year":"2020","journal-title":"Clin Rev Allergy Immunol"},{"key":"2026032603471178300_ref32","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1016\/j.jaci.2022.12.805","article-title":"Novel small molecule MRGPRX2 antagonists inhibit a murine model of allergic reaction","volume":"151","author":"Kumar","year":"2023","journal-title":"J Allergy Clin Immunol"},{"key":"2026032603471178300_ref33","doi-asserted-by":"publisher","first-page":"622","DOI":"10.3390\/cells11040622","article-title":"Fc\u03b5RI: a master regulator of mast cell functions","volume":"11","author":"Nagata","year":"2022","journal-title":"Cells"},{"key":"2026032603471178300_ref34","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1165\/rcmb.2022-0159OC","article-title":"An inhibitory function of TRPA1 channels in TGF-\u03b21-driven fibroblast-to-myofibroblast differentiation","volume":"68","author":"Geiger","year":"2023","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026032603471178300_ref35","doi-asserted-by":"publisher","first-page":"116074","DOI":"10.1016\/j.bcp.2024.116074","article-title":"Allyl isothiocyanate, a TRPA1 agonist, protects against olanzapine-induced hypothalamic and hepatic metabolic aberrations in female mice","volume":"222","author":"Kaur Sodhi","year":"2024","journal-title":"Biochem Pharmacol"},{"key":"2026032603471178300_ref36","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1007\/s12016-022-08955-9","article-title":"New mechanistic advances in Fc\u03b5RI-mast cell-mediated allergic signaling","volume":"63","author":"Li","year":"2022","journal-title":"Clin Rev Allergy Immunol"},{"key":"2026032603471178300_ref37","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s12943-023-01721-1","article-title":"Targeting Pim kinases in hematological cancers: molecular and clinical review","volume":"22","author":"Bellon","year":"2023","journal-title":"Mol Cancer"},{"key":"2026032603471178300_ref38","doi-asserted-by":"publisher","first-page":"132030","DOI":"10.1016\/j.ijbiomac.2024.132030","article-title":"A review on structure-function mechanism and signaling pathway of serine\/threonine protein PIM kinases as a therapeutic target","volume":"270","author":"Rout","year":"2024","journal-title":"Int J Biol Macromol"},{"key":"2026032603471178300_ref39","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1186\/s12964-020-00618-6","article-title":"PIM1 accelerates prostate cancer cell motility by phosphorylating actin capping proteins","volume":"18","author":"Santio","year":"2020","journal-title":"Cell Commun Signal"},{"key":"2026032603471178300_ref40","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.coi.2021.03.002","article-title":"The actin cytoskeleton and mast cell function","volume":"72","author":"Lazki-Hagenbach","year":"2021","journal-title":"Curr Opin Immunol"},{"key":"2026032603471178300_ref41","doi-asserted-by":"publisher","first-page":"1678","DOI":"10.1038\/s41375-025-02594-7","article-title":"Ruxolitinib mediated paradoxical JAK2 hyperphosphorylation is due to the protection of activation loop tyrosines from phosphatases","volume":"39","author":"Gorantla","year":"2025","journal-title":"Leukemia"},{"key":"2026032603471178300_ref42","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1158\/2767-9764.CRC-23-0379","article-title":"Pim kinase inhibitors increase Gilteritinib cytotoxicity in FLT3-ITD acute myeloid leukemia through GSK-3\u03b2 activation and c-Myc and Mcl-1 proteasomal degradation","volume":"4","author":"Lee","year":"2024","journal-title":"Cancer Res Commun"},{"key":"2026032603471178300_ref43","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1158\/1535-7163.MCT-20-0663","article-title":"PP2A-activating drugs enhance FLT3 inhibitor efficacy through AKT inhibition-dependent GSK-3\u03b2-mediated c-Myc and Pim-1 proteasomal degradation","volume":"20","author":"Scarpa","year":"2021","journal-title":"Mol Cancer Ther"},{"key":"2026032603471178300_ref44","doi-asserted-by":"publisher","first-page":"e002066","DOI":"10.1136\/bmjresp-2023-002066","article-title":"Pim1 inactivating induces RUNX3 upregulation that improves\/alleviates airway inflammation and mucus hypersecretion in vitro and in vivo","volume":"11","author":"Fang","year":"2024","journal-title":"BMJ Open Respir Res"},{"key":"2026032603471178300_ref45","doi-asserted-by":"publisher","first-page":"e2412688","DOI":"10.1002\/smll.202412688","article-title":"Multifunctional co-delivery systems with downregulation of the novel target PIM1 in macrophages to ameliorate TF-mediated coagulopathy in sepsis","volume":"21","author":"Zhou","year":"2025","journal-title":"Small"},{"key":"2026032603471178300_ref46","doi-asserted-by":"publisher","first-page":"5237","DOI":"10.1038\/s41467-022-32976-9","article-title":"PIM1 promotes hepatic conversion by suppressing reprogramming-induced ferroptosis and cell cycle arrest","volume":"13","author":"Yuan","year":"2022","journal-title":"Nat Commun"},{"key":"2026032603471178300_ref47","doi-asserted-by":"publisher","first-page":"2166936","DOI":"10.1080\/14756366.2023.2166936","article-title":"Design, synthesis and cytotoxic evaluation of novel bis-thiazole derivatives as preferential Pim1 kinase inhibitors with in vivo and in silico study","volume":"38","author":"Al-Sanea","year":"2023","journal-title":"J Enzyme Inhib Med Chem"},{"key":"2026032603471178300_ref48","doi-asserted-by":"publisher","first-page":"1164157","DOI":"10.3389\/fimmu.2023.1164157","article-title":"Pathological pathway analysis in an experimental rheumatoid arthritis model and the tissue repair effect of acupuncture at ST36","volume":"14","author":"Zhang","year":"2023","journal-title":"Front Immunol"},{"key":"2026032603471178300_ref49","doi-asserted-by":"publisher","first-page":"460","DOI":"10.3390\/biology14050460","article-title":"Animal models in rheumatoid arthritis: is there a correlation between autoantibodies in human pathology and animal models?","volume":"14","author":"Marco-Bonilla","year":"2025","journal-title":"Biology (Basel)"},{"key":"2026032603471178300_ref50","doi-asserted-by":"publisher","first-page":"938849","DOI":"10.3389\/fphar.2022.938849","article-title":"Tripterygium wilfordii glycosides ameliorates collagen-induced arthritis and aberrant lipid metabolism in rats","volume":"13","author":"Zhu","year":"2022","journal-title":"Front Pharmacol"},{"key":"2026032603471178300_ref51","doi-asserted-by":"publisher","first-page":"1502","DOI":"10.1038\/s41565-023-01523-y","article-title":"Ceria-vesicle nanohybrid therapeutic for modulation of innate and adaptive immunity in a collagen-induced arthritis model","volume":"18","author":"Koo","year":"2023","journal-title":"Nat Nanotechnol"},{"key":"2026032603471178300_ref52","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1038\/s41392-024-01952-8","article-title":"Evolving understanding of autoimmune mechanisms and new therapeutic strategies of autoimmune disorders","volume":"9","author":"Song","year":"2024","journal-title":"Signal Transduct Target Ther"},{"key":"2026032603471178300_ref53","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.bbrc.2011.11.014","article-title":"Suppression of phospholipase C\u03b31 phosphorylation by cinnamaldehyde inhibits antigen-induced extracellular calcium influx and degranulation in mucosal mast cells","volume":"416","author":"Kageyama-Yahara","year":"2011","journal-title":"Biochem Biophys Res Commun"},{"key":"2026032603471178300_ref54","doi-asserted-by":"publisher","first-page":"e202208136","DOI":"10.1083\/jcb.202208136","article-title":"PIM1 phosphorylates ABI2 to enhance actin dynamics and promote tumor invasion","volume":"222","author":"Jensen","year":"2023","journal-title":"J Cell Biol"},{"key":"2026032603471178300_ref55","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1038\/s12276-025-01421-4","article-title":"Pim1 promotes the maintenance of bone homeostasis by regulating osteoclast function","volume":"57","author":"Seo","year":"2025","journal-title":"Exp Mol Med"},{"key":"2026032603471178300_ref56","doi-asserted-by":"publisher","first-page":"652077","DOI":"10.3389\/fcell.2021.652077","article-title":"Cytoskeletal transport, reorganization, and fusion regulation in mast cell-stimulus secretion coupling","volume":"9","author":"M\u00e9nasch\u00e9","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"2026032603471178300_ref57","doi-asserted-by":"publisher","first-page":"106166","DOI":"10.1016\/j.leukres.2019.106166","article-title":"The upregulation of Pim kinases is essential in coordinating the survival, proliferation, and migration of KIT D816V-mutated neoplastic mast cells","volume":"83","author":"Park","year":"2019","journal-title":"Leuk Res"},{"key":"2026032603471178300_ref58","doi-asserted-by":"publisher","first-page":"109008","DOI":"10.1016\/j.clim.2022.109008","article-title":"Dok-1 regulates mast cell degranulation negatively through inhibiting calcium-dependent F-actin disassembly","volume":"238","author":"Du","year":"2022","journal-title":"Clin Immunol"},{"key":"2026032603471178300_ref59","doi-asserted-by":"publisher","first-page":"5866","DOI":"10.1038\/s41467-022-33502-7","article-title":"Multicellular immune dynamics implicate PIM1 as a potential therapeutic target for uveitis","volume":"13","author":"Li","year":"2022","journal-title":"Nat Commun"},{"key":"2026032603471178300_ref60","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1038\/s41698-024-00638-2","article-title":"PIM1 is a potential therapeutic target for the leukemogenic effects mediated by JAK\/STAT pathway mutations in T-ALL\/LBL","volume":"8","author":"Lahera","year":"2024","journal-title":"NPJ Precis Oncol"},{"key":"2026032603471178300_ref61","doi-asserted-by":"publisher","first-page":"1443784","DOI":"10.3389\/fimmu.2024.1443784","article-title":"PIM1 signaling in immunoinflammatory diseases: an emerging therapeutic target","volume":"15","author":"Yang","year":"2024","journal-title":"Front Immunol"},{"key":"2026032603471178300_ref62","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1038\/s41467-023-44304-w","article-title":"Synovial microenvironment-influenced mast cells promote the progression of rheumatoid arthritis","volume":"15","author":"Lei","year":"2024","journal-title":"Nat Commun"},{"key":"2026032603471178300_ref63","doi-asserted-by":"publisher","first-page":"1820","DOI":"10.1002\/art.41744","article-title":"Pim kinases as therapeutic targets in early rheumatoid arthritis","volume":"73","author":"Maney","year":"2021","journal-title":"Arthritis Rheumatol"}],"container-title":["Journal of Pharmacy and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/78\/3\/rgag027\/67510956\/rgag027.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/78\/3\/rgag027\/67510956\/rgag027.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T07:47:18Z","timestamp":1774511238000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jpp\/article\/doi\/10.1093\/jpp\/rgag027\/8540491"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":63,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3,5]]}},"URL":"https:\/\/doi.org\/10.1093\/jpp\/rgag027","relation":{},"ISSN":["0022-3573","2042-7158"],"issn-type":[{"value":"0022-3573","type":"print"},{"value":"2042-7158","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,3]]},"published":{"date-parts":[[2026,3]]},"article-number":"rgag027"}}