{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T16:09:00Z","timestamp":1779379740955,"version":"3.53.1"},"reference-count":71,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100012547","name":"Natural Science Foundation of Guangxi Zhuang Autonomous Region","doi-asserted-by":"publisher","award":["2021GXNSFAA196039"],"award-info":[{"award-number":["2021GXNSFAA196039"]}],"id":[{"id":"10.13039\/100012547","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012547","name":"Natural Science Foundation of Guangxi Zhuang Autonomous Region","doi-asserted-by":"publisher","award":["2025GXNSFAA069916"],"award-info":[{"award-number":["2025GXNSFAA069916"]}],"id":[{"id":"10.13039\/100012547","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Isobavachin (Ibv), a monomeric compound derived from a traditional Chinese herb, demonstrates a range of biological activities. However, the precise effects of Ibv on inflammatory osteolysis remain inadequately understood. The present study seeks to elucidate the mechanisms underlying Ibv's inhibitory effects on osteoclasts (OCs) differentiation and inflammatory osteolysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The CCK-8 assay assessed cell viability with Ibv treatment, while tartrate acid phosphatase staining, podosome belt staining, and bone resorption assays evaluated Ibv\u2019s impact on OCs differentiation and OCs function. PCR and Western blot analyses were conducted to assess the expression of key genes and proteins. The model of inflammatory osteolysis induced by lipopolysaccharide was utilized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key findings<\/jats:title>\n                    <jats:p>Ibv significantly inhibits OCs differentiation besides suppressing lipopolysaccharide-induced inflammatory osteolysis. micro-computed tomography analysis demonstrated that Ibv treatment markedly improved bone microarchitecture. Ibv hinders OCs formation and activation by downregulating TRAF6 and enhancing NRF2 expression, lowering ROS levels in OCs. This modulation further impeded the downstream NF-\u03baB and MAPK pathways, ultimately suppressing bone resorption.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The present study highlights Ibv\u2019s capacity to restrain OCs differentiation and inflammatory osteolysis, imposing its probability as a therapeutic agent for conditions. The proposed mechanism of action encompasses the regulation of the ROS\/NF-\u03baB and MAPK pathways, establishing a conceptual basis for the advancement of Ibv in therapeutic applications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jpp\/rgag049","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T11:24:58Z","timestamp":1777289098000},"source":"Crossref","is-referenced-by-count":0,"title":["Isobavachin inhibits osteoclastogenesis in inflammatory osteolysis loss by modulating the ROS-mediated Nrf2\/HO-1 signaling pathway"],"prefix":"10.1093","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8241-9419","authenticated-orcid":false,"given":"Liang","family":"Liao","sequence":"first","affiliation":[{"name":"Department of Traumatic Orthopedics and Hand Surgery, The First Affiliated Hospital of Guangxi Medical University , Nanning, Guangxi 530021 ,","place":["China"]},{"name":"Guangxi Key Laboratory of Regenerative Medicine, Guangxi Medical University , Nanning, Guangxi 530021 ,","place":["China"]},{"name":"Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-constructed by the Province and Ministry, Guangxi Medical University , Nanning, Guangxi 530021 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunde","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Traumatic Orthopedics and Hand Surgery, The First Affiliated Hospital of Guangxi Medical University , Nanning, Guangxi 530021 ,","place":["China"]},{"name":"Guangxi Key Laboratory of Regenerative Medicine, Guangxi Medical University , Nanning, Guangxi 530021 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jindeng","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Traumatic Orthopedics and Hand Surgery, The First Affiliated Hospital of Guangxi Medical University , Nanning, Guangxi 530021 ,","place":["China"]},{"name":"Guangxi Key Laboratory of Regenerative Medicine, Guangxi Medical University , Nanning, Guangxi 530021 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Traumatic Orthopedics and Hand Surgery, The First Affiliated Hospital of Guangxi Medical University , Nanning, Guangxi 530021 ,","place":["China"]},{"name":"Guangxi Key Laboratory of Regenerative Medicine, Guangxi Medical University , Nanning, Guangxi 530021 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianwen","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Traumatic Orthopedics and Hand Surgery, The First Affiliated Hospital of Guangxi Medical University , Nanning, Guangxi 530021 ,","place":["China"]},{"name":"Guangxi Key Laboratory of Regenerative Medicine, Guangxi Medical University , Nanning, Guangxi 530021 ,","place":["China"]},{"name":"Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-constructed by the Province and Ministry, Guangxi Medical University , Nanning, Guangxi 530021 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinmin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Traumatic Orthopedics and Hand Surgery, The First Affiliated Hospital of Guangxi Medical University , Nanning, Guangxi 530021 ,","place":["China"]},{"name":"Guangxi Key Laboratory of Regenerative Medicine, Guangxi Medical University , Nanning, Guangxi 530021 ,","place":["China"]},{"name":"Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-constructed by the Province and Ministry, Guangxi Medical University , Nanning, Guangxi 530021 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,5,21]]},"reference":[{"key":"2026052111511317600_ref1","doi-asserted-by":"publisher","first-page":"e940","DOI":"10.5435\/jaaos-d-23-00164","article-title":"Bone homeostasis and physiology in normal and orthopaedic disease conditions","volume":"31","author":"Anderson","year":"2023","journal-title":"J Am Acad Orthop Surg"},{"key":"2026052111511317600_ref2","doi-asserted-by":"publisher","first-page":"106778","DOI":"10.1016\/j.phrs.2023.106778","article-title":"Therapeutic effects of curcumin liposomes and nanocrystals on inflammatory osteolysis: in vitro and in vivo comparative study","volume":"192","author":"Huang","year":"2023","journal-title":"Pharmacol Res"},{"key":"2026052111511317600_ref3","doi-asserted-by":"publisher","first-page":"283","DOI":"10.2174\/1389200224666230419090052","article-title":"Folate targeting peptide conjugates for inflammatory response suppression","volume":"24","author":"Ruff","year":"2023","journal-title":"Curr Drug Metab"},{"key":"2026052111511317600_ref4","doi-asserted-by":"publisher","first-page":"8380","DOI":"10.3892\/mmr.2017.7625","article-title":"High-dose PMA with RANKL and MCSF induces THP-1 cell differentiation into human functional osteoclasts in vitro","volume":"16","author":"Li","year":"2017","journal-title":"Mol Med Rep"},{"key":"2026052111511317600_ref5","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1038\/s41413-018-0019-6","article-title":"Paracrine and endocrine actions of bone\u2014the functions of secretory proteins from osteoblasts, osteocytes, and osteoclasts","volume":"6","author":"Han","year":"2018","journal-title":"Bone Res"},{"key":"2026052111511317600_ref6","doi-asserted-by":"publisher","first-page":"11","DOI":"10.4248\/br201301003","article-title":"Osteoclasts: new insights","volume":"1","author":"Xu","year":"2013","journal-title":"Bone Res"},{"key":"2026052111511317600_ref7","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1111\/j.1600-065X.2009.00821.x","article-title":"Ca2+-NFATc1 signaling is an essential axis of osteoclast differentiation","volume":"231","author":"Negishi-Koga","year":"2009","journal-title":"Immunol Rev"},{"key":"2026052111511317600_ref8","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1172\/jci36809","article-title":"Selective inhibition of RANK blocks osteoclast maturation and function and prevents bone loss in mice","volume":"119","author":"Kim","year":"2009","journal-title":"J Clin Invest"},{"key":"2026052111511317600_ref9","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.1038\/s41418-023-01161-w","article-title":"IKK-mediated TRAF6 and RIPK1 interaction stifles cell death complex assembly leading to the suppression of TNF-\u03b1-induced cell death","volume":"30","author":"Lee","year":"2023","journal-title":"Cell Death Differ"},{"key":"2026052111511317600_ref10","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.1038\/s41418-017-0048-5","article-title":"STAC2 negatively regulates osteoclast formation by targeting the RANK signaling complex","volume":"25","author":"Jeong","year":"2018","journal-title":"Cell Death Differ"},{"key":"2026052111511317600_ref11","first-page":"484","article-title":"Osteoclast differentiation and activation","volume":"17","author":"Takayanagi","year":"2007","journal-title":"Clin Calcium"},{"key":"2026052111511317600_ref12","doi-asserted-by":"publisher","first-page":"E13","DOI":"10.1111\/j.1749-6632.2011.06373.x","article-title":"New regulation mechanisms of osteoclast differentiation","volume":"1240","author":"Nakashima","year":"2011","journal-title":"Ann N Y Acad Sci"},{"key":"2026052111511317600_ref13","doi-asserted-by":"publisher","first-page":"1756","DOI":"10.1016\/j.biomaterials.2008.12.018","article-title":"Inhibition of titanium particle-induced osteoclastogenesis through inactivation of NFATc1 by VIVIT peptide","volume":"30","author":"Liu","year":"2009","journal-title":"Biomaterials"},{"key":"2026052111511317600_ref14","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.pharmthera.2016.01.015","article-title":"Preclinical studies and clinical evaluation of compounds from the genus Epimedium for osteoporosis and bone health","volume":"162","author":"Indran","year":"2016","journal-title":"Pharmacol Ther"},{"key":"2026052111511317600_ref15","doi-asserted-by":"publisher","first-page":"3773","DOI":"10.1038\/ncomms4773","article-title":"FoxO proteins restrain osteoclastogenesis and bone resorption by attenuating H2O2 accumulation","volume":"5","author":"Bartell","year":"2014","journal-title":"Nat Commun"},{"key":"2026052111511317600_ref16","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1172\/jci18859","article-title":"A crucial role for thiol antioxidants in estrogen-deficiency bone loss","volume":"112","author":"Lean","year":"2003","journal-title":"J Clin Invest"},{"key":"2026052111511317600_ref17","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1210\/er.2009-0024","article-title":"From estrogen-centric to aging and oxidative stress: a revised perspective of the pathogenesis of osteoporosis","volume":"31","author":"Manolagas","year":"2010","journal-title":"Endocr Rev"},{"key":"2026052111511317600_ref18","doi-asserted-by":"publisher","first-page":"373","DOI":"10.3390\/antiox12020373","article-title":"Oxidative stress and natural antioxidants in osteoporosis: novel preventive and therapeutic approaches","volume":"12","author":"Marcucci","year":"2023","journal-title":"Antioxidants (Basel)"},{"key":"2026052111511317600_ref19","doi-asserted-by":"publisher","first-page":"3955","DOI":"10.3390\/nu14193955","article-title":"Trimethylamine-N-oxide promotes osteoclast differentiation and bone loss via activating ROS-dependent NF-\u03baB signaling pathway","volume":"14","author":"Wang","year":"2022","journal-title":"Nutrients"},{"key":"2026052111511317600_ref20","doi-asserted-by":"publisher","first-page":"309","DOI":"10.3390\/ph14040309","article-title":"The immunomodulatory and anti-inflammatory effect of curcumin on immune cell populations, cytokines, and in vivo models of rheumatoid arthritis","volume":"14","author":"Makuch","year":"2021","journal-title":"Pharmaceuticals (Basel)"},{"key":"2026052111511317600_ref21","doi-asserted-by":"publisher","first-page":"106400","DOI":"10.1016\/j.phrs.2022.106400","article-title":"Alpinetin ameliorates bone loss in LPS-induced inflammation osteolysis via ROS mediated P38\/PI3K signaling pathway","volume":"184","author":"Wei","year":"2022","journal-title":"Pharmacol Res"},{"key":"2026052111511317600_ref22","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.bioactmat.2021.11.012","article-title":"Bone targeting antioxidative nano-iron oxide for treating postmenopausal osteoporosis","volume":"14","author":"Zheng","year":"2022","journal-title":"Bioact Mater"},{"key":"2026052111511317600_ref23","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1111\/jop.12516","article-title":"Use of new targeted cancer therapies in children: effects on dental development and risk of jaw osteonecrosis: a review","volume":"46","author":"Hernandez","year":"2016","journal-title":"J Oral Pathol Med"},{"key":"2026052111511317600_ref24","doi-asserted-by":"publisher","first-page":"86","DOI":"10.3390\/bioengineering10010086","article-title":"Bone morphogenetic protein 2 promotes bone formation in bone defects in which bone remodeling is suppressed by long-term and high-dose zoledronic acid","volume":"10","author":"Moon","year":"2023","journal-title":"Bioengineering (Basel)"},{"key":"2026052111511317600_ref25","doi-asserted-by":"publisher","first-page":"e113033","DOI":"10.15252\/embj.2022113033","article-title":"A mitochondrial SCF-FBXL4 ubiquitin E3 ligase complex degrades BNIP3 and NIX to restrain mitophagy and prevent mitochondrial disease","volume":"42","author":"Cao","year":"2023","journal-title":"EMBO J"},{"key":"2026052111511317600_ref26","doi-asserted-by":"publisher","first-page":"2224","DOI":"10.1093\/bbb\/zbab149","article-title":"Inhibitory effects of luteolin and its derivatives on osteoclast differentiation and differences in luteolin production by Capsicum annuum varieties","volume":"85","author":"Onishi","year":"2021","journal-title":"Biosci Biotechnol Biochem"},{"key":"2026052111511317600_ref27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2022\/2011625","article-title":"Exploration of the effect of icariin on nude mice with lung cancer bone metastasis via the OPG\/RANKL\/RANK system","volume":"2022","author":"Ruilian","year":"2022","journal-title":"Comput Math Methods Med"},{"key":"2026052111511317600_ref28","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1038\/s41413-024-00362-4","article-title":"Mapping RANKL- and OPG-expressing cells in bone tissue: the bone surface cells as activators of osteoclastogenesis and promoters of the denosumab rebound effect","volume":"12","author":"El-Masri","year":"2024","journal-title":"Bone Res"},{"key":"2026052111511317600_ref29","doi-asserted-by":"publisher","first-page":"1873","DOI":"10.1210\/clinem\/dgae012","article-title":"Efficacy and safety of denosumab vs zoledronic acid in OI adults: a prospective, open-label, randomized study","volume":"109","author":"Lin","year":"2024","journal-title":"J Clin Endocrinol Metab"},{"key":"2026052111511317600_ref30","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1080\/14740338.2024.2386365","article-title":"The use of denosumab in osteoporosis\u2014an update on efficacy and drug safety","volume":"23","author":"Diab","year":"2024","journal-title":"Expert Opin Drug Saf"},{"key":"2026052111511317600_ref31","doi-asserted-by":"publisher","DOI":"10.1177\/1759720x20966135","article-title":"Re-appraising the potential of naringin for natural, novel orthopedic biotherapies","volume":"12","author":"Yu","year":"2020","journal-title":"Ther Adv Musculoskelet Dis"},{"key":"2026052111511317600_ref32","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1002\/ptr.972","article-title":"Antioxidative components of Psoralea corylifolia (Leguminosae)","volume":"16","author":"Haraguchi","year":"2002","journal-title":"Phytother Res"},{"key":"2026052111511317600_ref33","doi-asserted-by":"publisher","first-page":"109278","DOI":"10.1016\/j.intimp.2022.109278","article-title":"Astragalin mitigates inflammatory osteolysis by negatively modulating osteoclastogenesis via ROS and MAPK signaling pathway","volume":"112","author":"Xing","year":"2022","journal-title":"Int Immunopharmacol"},{"key":"2026052111511317600_ref34","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1016\/j.phymed.2013.09.015","article-title":"Osteoblasts proliferation and differentiation stimulating activities of the main components of Fructus Psoraleae corylifoliae","volume":"21","author":"Li","year":"2014","journal-title":"Phytomedicine"},{"key":"2026052111511317600_ref35","doi-asserted-by":"publisher","first-page":"112230","DOI":"10.1016\/j.jep.2019.112230","article-title":"Best practice in research\u2014overcoming common challenges in phytopharmacological research","volume":"246","author":"Heinrich","year":"2020","journal-title":"J Ethnopharmacol"},{"key":"2026052111511317600_ref36","doi-asserted-by":"publisher","first-page":"3547","DOI":"10.1111\/bph.17300","article-title":"Natural product pharmacology: the British Journal of Pharmacology perspective","volume":"181","author":"Wang","year":"2024","journal-title":"Br J Pharmacol"},{"key":"2026052111511317600_ref37","doi-asserted-by":"publisher","first-page":"116698","DOI":"10.1016\/j.bcp.2024.116698","article-title":"Isobavachin attenuates Fc\u03b5RI-mediated inflammatory allergic responses by regulating SHP-1-dependent Fyn\/Lyn\/Syk\/Lck signaling","volume":"232","author":"Sim","year":"2025","journal-title":"Biochem Pharmacol"},{"key":"2026052111511317600_ref38","doi-asserted-by":"publisher","first-page":"e995","DOI":"10.1002\/cpz1.995","article-title":"Mouse and rat anesthesia and analgesia","volume":"4","author":"Oh","year":"2024","journal-title":"Curr Protoc"},{"key":"2026052111511317600_ref39","doi-asserted-by":"publisher","first-page":"346","DOI":"10.30802\/aalas-jaalas-19-000081","article-title":"Review of intraperitoneal injection of sodium pentobarbital as a method of euthanasia in laboratory rodents","volume":"59","author":"Pang","year":"2020","journal-title":"J Am Assoc Lab Anim Sci"},{"key":"2026052111511317600_ref40","doi-asserted-by":"publisher","first-page":"5445","DOI":"10.3390\/ijms22115445","article-title":"Regulation and role of transcription factors in osteogenesis","volume":"22","author":"Chan","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2026052111511317600_ref41","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1038\/s41574-024-00969-x","article-title":"Metabolic regulation of skeletal cell fate and function","volume":"20","author":"Stegen","year":"2024","journal-title":"Nat Rev Endocrinol"},{"key":"2026052111511317600_ref42","doi-asserted-by":"publisher","first-page":"114396","DOI":"10.1016\/j.jep.2021.114396","article-title":"A new strategy for discovering effective substances and mechanisms of traditional Chinese medicine based on standardized drug containing plasma and the absorbed ingredients composition, a case study of Xian-Ling-Gu-Bao capsules","volume":"279","author":"Qiu","year":"2021","journal-title":"J Ethnopharmacol"},{"key":"2026052111511317600_ref43","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1038\/aps.2011.5","article-title":"Promoting effects of isobavachin on neurogenesis of mouse embryonic stem cells were associated with protein prenylation","volume":"32","author":"Wang","year":"2011","journal-title":"Acta Pharmacol Sin"},{"key":"2026052111511317600_ref44","doi-asserted-by":"publisher","first-page":"1955","DOI":"10.1038\/s41598-017-02023-5","article-title":"Structure based docking studies towards exploring potential anti-androgen activity of selected phytochemicals against prostate cancer","volume":"7","author":"Singh","year":"2017","journal-title":"Sci Rep"},{"key":"2026052111511317600_ref45","doi-asserted-by":"publisher","first-page":"2030","DOI":"10.1172\/jci93356","article-title":"Inflammatory osteolysis: a conspiracy against bone","volume":"127","author":"Mbalaviele","year":"2017","journal-title":"J Clin Invest"},{"key":"2026052111511317600_ref46","doi-asserted-by":"publisher","first-page":"3418","DOI":"10.1172\/jci26132","article-title":"M-CSF mediates TNF-induced inflammatory osteolysis","volume":"115","author":"Kitaura","year":"2005","journal-title":"J Clin Invest"},{"key":"2026052111511317600_ref47","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1152\/physrev.00043.2020","article-title":"The osteocyte as a signaling cell","volume":"102","author":"Delgado-Calle","year":"2022","journal-title":"Physiol Rev"},{"key":"2026052111511317600_ref48","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1152\/physrev.00012.2019","article-title":"Bone metastasis: mechanisms, therapies, and biomarkers","volume":"101","author":"Cl\u00e9zardin","year":"2021","journal-title":"Physiol Rev"},{"key":"2026052111511317600_ref49","doi-asserted-by":"publisher","first-page":"1330","DOI":"10.1016\/j.cell.2021.02.002","article-title":"Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption","volume":"184","author":"McDonald","year":"2021","journal-title":"Cell"},{"key":"2026052111511317600_ref50","doi-asserted-by":"publisher","first-page":"1631","DOI":"10.1038\/s41590-019-0526-7","article-title":"Identification of a novel arthritis-associated osteoclast precursor macrophage regulated by FoxM1","volume":"20","author":"Hasegawa","year":"2019","journal-title":"Nat Immunol"},{"key":"2026052111511317600_ref51","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1038\/s41586-019-1105-7","article-title":"Developmental origin, functional maintenance and genetic rescue of osteoclasts","volume":"568","author":"Jacome-Galarza","year":"2019","journal-title":"Nature"},{"key":"2026052111511317600_ref52","doi-asserted-by":"publisher","first-page":"117501","DOI":"10.1016\/j.jep.2023.117501","article-title":"Isobavachin, a main bioavailable compound in Psoralea corylifolia, alleviates lipopolysaccharide-induced inflammatory responses in macrophages and zebrafish by suppressing the MAPK and NF-\u03baB signaling pathways","volume":"321","author":"Chung","year":"2024","journal-title":"J Ethnopharmacol"},{"key":"2026052111511317600_ref53","doi-asserted-by":"publisher","first-page":"110651","DOI":"10.1016\/j.cellsig.2023.110651","article-title":"Inhibitory effects of Formononetin on CoCrMo particle-induced osteoclast activation and bone loss through downregulating NF-\u03baB and MAPK signaling","volume":"106","author":"Yu","year":"2023","journal-title":"Cell Signal"},{"key":"2026052111511317600_ref54","doi-asserted-by":"publisher","first-page":"2209","DOI":"10.1016\/j.immuni.2022.10.007","article-title":"Hypoxia-sensitive COMMD1 integrates signaling and cellular metabolism in human macrophages and suppresses osteoclastogenesis","volume":"55","author":"Murata","year":"2022","journal-title":"Immunity"},{"key":"2026052111511317600_ref55","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1016\/j.ccr.2013.09.008","article-title":"Tumor-induced osteoclast miRNA changes as regulators and biomarkers of osteolytic bone metastasis","volume":"24","author":"Ell","year":"2013","journal-title":"Cancer Cell"},{"key":"2026052111511317600_ref56","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1038\/ni.2378","article-title":"The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-\u03baB","volume":"13","author":"Schneider","year":"2012","journal-title":"Nat Immunol"},{"key":"2026052111511317600_ref57","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1038\/cr.2013.21","article-title":"UBE2O negatively regulates TRAF6-mediated NF-\u03baB activation by inhibiting TRAF6 polyubiquitination","volume":"23","author":"Zhang","year":"2013","journal-title":"Cell Res"},{"key":"2026052111511317600_ref58","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.1038\/s41467-017-01527-y","article-title":"DJ-1 controls bone homeostasis through the regulation of osteoclast differentiation","volume":"8","author":"Kim","year":"2017","journal-title":"Nat Commun"},{"key":"2026052111511317600_ref59","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1111\/jcmm.17692","article-title":"CRISPR\/Cas9 knockout of MTA1 enhanced RANKL-induced osteoclastogenesis in RAW264.7 cells partly via increasing ROS activities","volume":"27","author":"Feng","year":"2023","journal-title":"J Cell Mol Med"},{"key":"2026052111511317600_ref60","doi-asserted-by":"publisher","DOI":"10.3390\/biom12091220","article-title":"Polyphenolic compounds inhibit osteoclast differentiation while reducing autophagy through limiting ROS and the mitochondrial membrane potential","volume":"12","author":"Laha","year":"2022","journal-title":"Biomolecules"},{"key":"2026052111511317600_ref61","doi-asserted-by":"publisher","first-page":"4428","DOI":"10.1111\/jcmm.17467","article-title":"Urolithin B suppresses osteoclastogenesis via inhibiting RANKL-induced signalling pathways and attenuating ROS activities","volume":"26","author":"Qu","year":"2022","journal-title":"J Cell Mol Med"},{"key":"2026052111511317600_ref62","doi-asserted-by":"publisher","first-page":"383","DOI":"10.21037\/atm-20-4255","article-title":"Rosavin suppresses osteoclastogenesis in vivo and in vitro by blocking the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-\u03baB) and mitogen-activated protein kinase (MAPK) signaling pathways","volume":"9","author":"Zhang","year":"2021","journal-title":"Ann Transl Med"},{"key":"2026052111511317600_ref63","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/j.cmet.2011.08.013","article-title":"Inositol polyphosphate 4-phosphatase B as a regulator of bone mass in mice and humans","volume":"14","author":"Ferron","year":"2011","journal-title":"Cell Metab"},{"key":"2026052111511317600_ref64","doi-asserted-by":"publisher","first-page":"121742","DOI":"10.1016\/j.biomaterials.2022.121742","article-title":"NRF2 is a critical regulator and therapeutic target of metal implant particle-incurred bone damage","volume":"288","author":"Dong","year":"2022","journal-title":"Biomaterials"},{"key":"2026052111511317600_ref65","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1038\/s41413-020-00128-8","article-title":"Nrf2 epigenetic derepression induced by running exercise protects against osteoporosis","volume":"9","author":"Chen","year":"2021","journal-title":"Bone Res"},{"key":"2026052111511317600_ref66","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.939929","article-title":"BNTA alleviates inflammatory osteolysis by the SOD mediated anti-oxidation and anti-inflammation effect on inhibiting osteoclastogenesis","volume":"13","author":"Wang","year":"2022","journal-title":"Front Pharmacol"},{"key":"2026052111511317600_ref67","doi-asserted-by":"publisher","first-page":"25026","DOI":"10.1038\/s41598-024-75758-7","article-title":"Differential effects of alendronate on chondrocytes, cartilage matrix and subchondral bone structure in surgically induced osteoarthritis in mice","volume":"14","author":"Ehrnsperger","year":"2024","journal-title":"Sci Rep"},{"key":"2026052111511317600_ref68","doi-asserted-by":"publisher","first-page":"113321","DOI":"10.1016\/j.intimp.2024.113321","article-title":"Isosakuranetin inhibits subchondral osteoclastogenesis for attenuating osteoarthritis via suppressing NF-\u03baB\/CXCL2 axis","volume":"143","author":"Lu","year":"2024","journal-title":"Int Immunopharmacol"},{"key":"2026052111511317600_ref69","doi-asserted-by":"publisher","first-page":"33574","DOI":"10.1021\/acsomega.4c01308","article-title":"Regorafenib attenuates osteoclasts differentiation by inhibiting the NF-\u03baB, NFAT, ERK, and p38 Signaling pathways","volume":"9","author":"Zhou","year":"2024","journal-title":"ACS Omega"},{"key":"2026052111511317600_ref70","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.901647","article-title":"Expression and clinical significance of Cathepsin K and MMPs in invasive non-functioning pituitary adenomas","volume":"12","author":"Liu","year":"2022","journal-title":"Front Oncol"},{"key":"2026052111511317600_ref71","doi-asserted-by":"publisher","first-page":"850","DOI":"10.3390\/antiox13070850","article-title":"Novel inhibitor of Keap1-Nrf2 protein-protein interaction attenuates osteoclastogenesis in vitro and prevents OVX-induced bone loss in vivo","volume":"13","author":"Chen","year":"2024","journal-title":"Antioxidants (Basel)"}],"container-title":["Journal of Pharmacy and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/78\/5\/rgag049\/68359817\/rgag049.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/78\/5\/rgag049\/68359817\/rgag049.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T15:51:17Z","timestamp":1779378677000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jpp\/article\/doi\/10.1093\/jpp\/rgag049\/8690013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":71,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5,2]]}},"URL":"https:\/\/doi.org\/10.1093\/jpp\/rgag049","relation":{},"ISSN":["2042-7158"],"issn-type":[{"value":"2042-7158","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,5]]},"published":{"date-parts":[[2026,5]]},"article-number":"rgag049"}}