{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T09:56:29Z","timestamp":1782294989596,"version":"3.54.5"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of this study was to evaluate the antiallodynic and antihyperalgesic effects of rutin alone and in combination with pregabalin in a chronic constriction injury-induced neuropathic pain model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The potential antiallodynic and antihyperalgesic effects of combining rutin at doses of 25, 50, and 100\u00a0mg\/kg with 3\u00a0mg\/kg of pregabalin were evaluated in a rat neuropathic pain model induced by chronic constriction injury. Assessments were conducted over a 180-minute period using an electronic von Frey device and the plantar test. Spontaneous locomotor activity was evaluated using a Plexiglas activity cage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key findings<\/jats:title>\n                    <jats:p>All combination groups exhibited statistically significant antiallodynic and antihyperalgesic effects at specific time intervals compared to the groups where rutin or 3\u00a0mg\/kg pregabalin were administered alone. Furthermore, the efficacy of the combinations was found to be comparable to that of the group treated with 30\u00a0mg\/kg pregabalin. The 25\u00a0mg\/kg rutin combination was most effective and independent of locomotor activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Given rutin\u2019s low side-effect profile and the dose-dependent risks of pregabalin, their combination at low-dose pregabalin may represent a safe and effective alternative for neuropathic pain treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jpp\/rgag054","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T11:45:05Z","timestamp":1778067905000},"source":"Crossref","is-referenced-by-count":1,"title":["Rutin enhances the analgesic efficacy of low-dose pregabalin without sedative side effects in a rat model of chronic constriction injury"],"prefix":"10.1093","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-4029-473X","authenticated-orcid":false,"given":"G\u00fcls\u00fcm","family":"Helvac\u0131","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Faculty of Pharmacy, Karadeniz Technical University , 61080, Trabzon ,","place":["T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8041-6844","authenticated-orcid":false,"given":"Rana","family":"Arslan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Pharmacy, Anadolu University , 26470, Eski\u015fehir ,","place":["T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurcan","family":"Bekta\u015f","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Pharmacy, Anadolu University , 26470, Eski\u015fehir 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