{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T21:19:11Z","timestamp":1783113551914,"version":"3.54.6"},"reference-count":133,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Muntingia calabura L. has long been utilized in traditional therapies, with various plant parts (fruits, leaves, and stem bark) used to treat a range of conditions, including diabetes, inflammatory disorders, and respiratory diseases. This review aims to provide a comprehensive synthesis of current knowledge on M. calabura, including its chemical constituents, biological activities, and emerging applications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comprehensive literature search was conducted using several electronic databases, including PubMed, Web of Science, SciFinder, and ScienceDirect. The search strategy employed keywords such as \u201cM. calabura\u201d, \u201cM. calabura\u201d, \u201cJamaican cherry\u201d, \u201cbotanical characteristics\u201d, \u201cdistribution\u201d, \u201cphytoconstituents\u201d, \u201cbiological activities\u201d, \u201ctoxicological profiles\u201d, and \u201cgreen-synthesized nanoparticles\u201d.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key findings<\/jats:title>\n                    <jats:p>Based on the synthesis of available literature, a total of 98 flavonoids have been characterized, alongside 22 phenolic compounds, 25 terpenoids, 7 tocopherol derivatives, and other secondary metabolites, demonstrating the diversity of phytochemical constituents from M. calabura. Pharmacological investigations have revealed a wide range of bioactivities, including antidiabetic, anti-inflammatory, antioxidant, antimicrobial, gastroprotective, hepatoprotective, cardioprotective, anticancer, wound-healing, respiratory-supportive, anti-obesity, immunomodulatory, renoprotective, metabolic, and antidepressant effects. Additionally, recent studies highlight its potential as a green bioconstituent for eco-friendly nanoparticle synthesis, extending its relevance to environmental technologies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jpp\/rgag059","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T16:13:59Z","timestamp":1782922439000},"source":"Crossref","is-referenced-by-count":0,"title":["Phytochemical constituents, biological activities, toxicological profiles, and current applications of\n                    <i>Muntingia calabura<\/i>\n                    L.: an updated review"],"prefix":"10.1093","volume":"78","author":[{"given":"Thi Ly","family":"Pham","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy, College of Medicine and Pharmacy, Duy Tan University , Da Nang 550000 ,","place":["Viet Nam"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Dat","family":"Lam","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Keimyung University , Daegu 42601 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1715-4455","authenticated-orcid":false,"given":"Viet Phong","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Biology Education, Teachers College and Institute for Phylogenomics and Evolution, Kyungpook National University , Daegu 41566 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,3]]},"reference":[{"key":"2026070316433727100_ref1","first-page":"12","article-title":"An extended distribution of non-native tree species Muntingia calabura L. in Rajshahi, Bangladesh","volume":"5","author":"Hasan","journal-title":"J Prog Res Biol"},{"key":"2026070316433727100_ref2","doi-asserted-by":"publisher","first-page":"1598","DOI":"10.3109\/13880209.2014.908397","article-title":"Muntingia calabura: a review of its traditional uses, chemical properties, and pharmacological observations","volume":"52","author":"Mahmood","year":"2014","journal-title":"Pharm Biol"},{"key":"2026070316433727100_ref3","unstructured":"Fathima BR . 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