{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T23:59:53Z","timestamp":1781049593594,"version":"3.54.1"},"reference-count":289,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,2]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Neurodegenerative disorders comprise a diverse group of progressive neurological diseases characterized by the gradual loss of neuronal structure and function. Conditions such as Alzheimer\u2019s disease, Parkinson\u2019s disease, Huntington\u2019s disease, and amyotrophic lateral sclerosis arise from multifactorial mechanisms involving genetic susceptibility, environmental factors, and age-related cellular decline.<\/jats:p>\n <\/jats:sec>\n \n Pathophysiology<\/jats:title>\n Key pathogenic processes include oxidative stress, mitochondrial dysfunction, protein misfolding and aggregation, impaired axonal transport, Golgi fragmentation, and chronic neuroinflammation, all of which disrupt neuronal homeostasis and synaptic communication, ultimately leading to neuronal death. Hormonal imbalances further exacerbate these effects by promoting oxidative damage, inflammation, and metabolic dysfunction.<\/jats:p>\n <\/jats:sec>\n \n Challenges in Therapy<\/jats:title>\n Despite advances in understanding disease mechanisms, effective drug delivery remains challenging due to the restrictive nature of the blood\u2013brain barrier.<\/jats:p>\n <\/jats:sec>\n \n Nanotechnology-Based Therapeutic Strategies<\/jats:title>\n Recent developments highlight the potential of nanoparticle-based drug delivery systems to overcome these limitations. Functionalized nanoparticles enhance blood\u2013brain barrier penetration, improve targeting specificity, and enable controlled drug release. These systems can deliver neuroprotective agents, antioxidants, peptides, and gene therapies directly to affected brain regions. Thus, integrating disease pathophysiology with nanotechnology-based strategies offers a promising approach for improving therapeutic outcomes and advancing precision treatment in neurodegenerative disorders.<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/jpp\/rgag060","type":"journal-article","created":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T11:46:34Z","timestamp":1778931994000},"source":"Crossref","is-referenced-by-count":0,"title":["Nanotechnology-enabled targeting strategies for neurodegenerative disorders: role of functionalized nanoparticles"],"prefix":"10.1093","volume":"78","author":[{"given":"Himanshu","family":"Vishwakarma","sequence":"first","affiliation":[{"name":"Chitkara College of Pharmacy, Chitkara University , Rajpura 140401, Punjab ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek","family":"Chauhan","sequence":"additional","affiliation":[{"name":"Chitkara College of Pharmacy, Chitkara University , Rajpura 140401, Punjab ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loveleen","family":"Kaur","sequence":"additional","affiliation":[{"name":"Chitkara College of Pharmacy, Chitkara University , Rajpura 140401, Punjab ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3266-7649","authenticated-orcid":false,"given":"Ankit","family":"Awasthi","sequence":"additional","affiliation":[{"name":"Chitkara College of Pharmacy, Chitkara University , Rajpura 140401, Punjab ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,6,9]]},"reference":[{"key":"2026060919231041900_ref1","doi-asserted-by":"publisher","first-page":"93","DOI":"10.5114\/fn.2020.96707","article-title":"What causes neurodegenerative disease?","volume":"58","author":"Armstrong","year":"2020","journal-title":"Folia Neuropathol"},{"key":"2026060919231041900_ref2","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1242\/dmm.030205","article-title":"Neurodegenerative disease: models, mechanisms, and a new hope","volume":"10","author":"Gitler","year":"2017","journal-title":"Dis Model Mech"},{"key":"2026060919231041900_ref3","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1172\/JCI200317522","article-title":"Neurodegeneration: what is it and where are we","volume":"111","author":"Serge","year":"2003","journal-title":"J Clin Invest"},{"key":"2026060919231041900_ref4","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1111\/j.1365-2567.2009.03225.x","article-title":"Inflammation in neurodegenerative diseases","volume":"129","author":"Amor","year":"2010","journal-title":"Immunology"},{"key":"2026060919231041900_ref5","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1038\/nrd1330","article-title":"Neurodegenerative diseases and oxidative stress","volume":"3","author":"Barnham","year":"2004","journal-title":"Nat Rev Drug Discov"},{"key":"2026060919231041900_ref6","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1016\/S1474-4422(19)30029-8","article-title":"The global burden of neurological disorders","volume":"18","author":"Carroll","year":"2019","journal-title":"Lancet Neurol"},{"key":"2026060919231041900_ref7","doi-asserted-by":"publisher","first-page":"2556","DOI":"10.1038\/s41591-025-03834-0","article-title":"The global neurodegeneration proteomics consortium: biomarker and drug target discovery for common neurodegenerative diseases and aging","volume":"31","author":"Imam","year":"2025","journal-title":"Nat Med"},{"key":"2026060919231041900_ref8","doi-asserted-by":"crossref","DOI":"10.1385\/159259106X","volume-title":"Pathogenesis of Neurodegenerative Disorders","author":"Mattson","year":"2001"},{"key":"2026060919231041900_ref9","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1186\/s13041-024-01118-1","article-title":"The duality of amyloid-\u03b2: its role in normal and Alzheimer\u2019s disease states","volume":"17","author":"Azargoonjahromi","year":"2024","journal-title":"Mol Brain"},{"key":"2026060919231041900_ref10","doi-asserted-by":"publisher","first-page":"105990","DOI":"10.1016\/j.ebiom.2025.105990","article-title":"Pathological role of immunoproteasome PSMB8 in Parkinson's disease: A link between \u03b1-synuclein aggregation and immune activation","volume":"121","author":"Nguyen","year":"2025","journal-title":"EBioMedicine"},{"key":"2026060919231041900_ref11","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s10048-025-00801-2","article-title":"Neuroinflammation and neurodegeneration in Huntington\u2019s disease: genetic hallmarks, role of metals and organophosphates","volume":"26","author":"Kunwar","year":"2025","journal-title":"Neurogenetics"},{"key":"2026060919231041900_ref12","doi-asserted-by":"publisher","first-page":"fcag098","DOI":"10.1093\/braincomms\/fcag098","article-title":"Excitotoxicity in amyotrophic lateral sclerosis: A key pathogenic mechanism","volume":"8","author":"Silva-Hucha","year":"2026","journal-title":"Brain Commun"},{"key":"2026060919231041900_ref13","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1080\/27697061.2023.2203235","article-title":"Pathogenesis of neurodegenerative diseases and the protective role of natural bioactive components","volume":"43","author":"Samanta","year":"2024","journal-title":"J Am Nutr Assoc"},{"key":"2026060919231041900_ref14","doi-asserted-by":"publisher","first-page":"376","DOI":"10.3969\/j.issn.1673-5374.2012.05.009","article-title":"Oxidative stress in neurodegenerative diseases\u2606","volume":"7","author":"Chen","year":"2012","journal-title":"Neural Regen Res"},{"key":"2026060919231041900_ref15","doi-asserted-by":"publisher","first-page":"9328","DOI":"10.3390\/ijms23169328","article-title":"Antioxidant therapeutic strategies in neurodegenerative diseases","volume":"23","author":"Mor\u00e9n","year":"2022","journal-title":"Int J Mol Sci"},{"key":"2026060919231041900_ref16","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.dnarep.2005.03.002","article-title":"Role of mitochondrial DNA in toxic responses to oxidative stress","volume":"5","author":"Van Houten","year":"2006","journal-title":"DNA Repair (Amst)"},{"key":"2026060919231041900_ref17","doi-asserted-by":"publisher","first-page":"1728","DOI":"10.1074\/jbc.M208752200","article-title":"Cell sorting experiments link persistent mitochondrial DNA damage with loss of mitochondrial membrane potential and apoptotic cell death","volume":"278","author":"Santos","year":"2003","journal-title":"J Biol Chem"},{"key":"2026060919231041900_ref18","doi-asserted-by":"publisher","first-page":"65","DOI":"10.2174\/157015909787602823","article-title":"Oxidative stress and neurodegenerative diseases: A review of upstream and downstream antioxidant therapeutic options","volume":"7","author":"Uttara","year":"2009","journal-title":"Curr Neuropharmacol"},{"key":"2026060919231041900_ref19","doi-asserted-by":"publisher","first-page":"e11440","DOI":"10.1016\/j.heliyon.2022.e11440","article-title":"Potential therapeutic use of plant flavonoids in AD and PD","volume":"8","author":"Meng-Zhen","year":"2022","journal-title":"Heliyon"},{"key":"2026060919231041900_ref20","doi-asserted-by":"publisher","first-page":"106751","DOI":"10.1016\/j.intimp.2020.106751","article-title":"Cytotoxicity of Saikosaponin A targets HEKa cell through apoptosis induction by ROS accumulation and inflammation suppression via NF-\u03baB pathway","volume":"86","author":"Liu","year":"2020","journal-title":"Int Immunopharmacol"},{"key":"2026060919231041900_ref21","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1007\/s13258-020-00987-9","article-title":"Trans-cinnamaldehyde protects C2C12 myoblasts from DNA damage, mitochondrial dysfunction and apoptosis caused by oxidative stress through inhibiting ROS production","volume":"43","author":"Choi","year":"2021","journal-title":"Genes Genomics"},{"key":"2026060919231041900_ref22","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1152\/physrev.00030.2022","article-title":"Oxidative damage in neurodegeneration: roles in the pathogenesis and progression of Alzheimer disease","volume":"104","author":"Perluigi","year":"2024","journal-title":"Physiol Rev"},{"key":"2026060919231041900_ref23","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/S0166-2236(00)01584-8","article-title":"Energetics in the pathogenesis of neurodegenerative diseases","volume":"23","author":"Beal","year":"2000","journal-title":"Trends Neurosci"},{"key":"2026060919231041900_ref24","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s13578-023-01189-y","article-title":"Abnormal protein post-translational modifications induces aggregation and abnormal deposition of protein, mediating neurodegenerative diseases","volume":"14","author":"Li","year":"2024","journal-title":"Cell Biosci"},{"key":"2026060919231041900_ref25","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1007\/978-981-96-0259-9_12","article-title":"Targeted drug delivery: amyloid beta targeting drugs, immunotherapy, anti-tau and aggregation inhibitor, microtubule-stabilizing, and neuroinflammation modulation","author":"Chintamaneni","year":"2025","journal-title":"Multi-Factorial Approach as a Therapeutic Strategy for the Management of Alzheimer\u2019s Disease"},{"key":"2026060919231041900_ref26","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s13024-025-00797-1","article-title":"Emerging targets of \u03b1-synuclein spreading in \u03b1-synucleinopathies: A review of mechanistic pathways and interventions","volume":"20","author":"Kuo","year":"2025","journal-title":"Mol Neurodegener"},{"key":"2026060919231041900_ref27","doi-asserted-by":"publisher","first-page":"3845","DOI":"10.3390\/ijms25073845","article-title":"Huntington\u2019s disease: complex pathogenesis and therapeutic strategies","volume":"25","author":"Tong","year":"2024","journal-title":"Int J Mol Sci"},{"key":"2026060919231041900_ref28","doi-asserted-by":"publisher","first-page":"1314","DOI":"10.1002\/prot.26561","article-title":"Protein aggregation and neurodegenerative disease: structural outlook for the novel therapeutics","volume":"93","author":"Arar","year":"2025","journal-title":"Proteins Struct Funct Bioinf"},{"key":"2026060919231041900_ref29","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.bbapap.2008.10.016","article-title":"Protein aggregation kinetics, mechanism, and curve-fitting: A review of the literature","volume":"1794","author":"Morris","year":"2009","journal-title":"Biochim Biophys Acta Proteins Proteomics"},{"key":"2026060919231041900_ref30","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1146\/annurev.pathol.1.110304.100113","article-title":"Neurodegenerative diseases: new concepts of pathogenesis and their therapeutic implications","volume":"1","author":"Skovronsky","year":"2006","journal-title":"Annu Rev Pathol Mech Dis"},{"key":"2026060919231041900_ref31","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/nature20413","article-title":"Decoding ALS: from genes to mechanism","volume":"539","author":"Taylor","year":"2016","journal-title":"Nature"},{"key":"2026060919231041900_ref32","doi-asserted-by":"publisher","first-page":"a028035","DOI":"10.1101\/cshperspect.a028035","article-title":"Pathology of neurodegenerative diseases","volume":"9","author":"Dugger","year":"2017","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"2026060919231041900_ref33","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1111\/j.1749-6632.2000.tb06900.x","article-title":"The \u03b1-synucleinopathies: Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy","volume":"920","author":"Spillantini","year":"2000","journal-title":"Ann N Y Acad Sci"},{"key":"2026060919231041900_ref34","first-page":"97","article-title":"Pathophysiology and classification of neurodegenerative diseases","volume":"15","author":"Relja","year":"2004","journal-title":"Ejifcc"},{"key":"2026060919231041900_ref35","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/S1474-4422(03)00662-8","article-title":"Multiple system atrophy","volume":"3","author":"Wenning","year":"2004","journal-title":"Lancet Neurol"},{"key":"2026060919231041900_ref36","doi-asserted-by":"publisher","first-page":"169","DOI":"10.4103\/0972-2327.179979","article-title":"Prions, prion-like prionoids, and neurodegenerative disorders","volume":"19","author":"Verma","year":"2016","journal-title":"Ann Indian Acad Neurol"},{"key":"2026060919231041900_ref37","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.3390\/ijms25021018","article-title":"Aging, neurodegenerative disorders, and cerebellum","volume":"25","author":"Iskusnykh","year":"2024","journal-title":"Int J Mol Sci"},{"key":"2026060919231041900_ref38","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1016\/j.dnarep.2008.03.012","article-title":"Mitochondrial DNA damage and repair in neurodegenerative disorders","volume":"7","author":"Yang","year":"2008","journal-title":"DNA Repair (Amst)"},{"key":"2026060919231041900_ref39","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1111\/j.1582-4934.2009.00697.x","article-title":"The mitochondrial death pathway: A promising therapeutic target in diseases","volume":"13","author":"Gupta","year":"2009","journal-title":"J Cell Mol Med"},{"key":"2026060919231041900_ref40","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.expneurol.2009.05.020","article-title":"Heterogeneity of nervous system mitochondria: location, location, location!","volume":"218","author":"Dubinsky","year":"2009","journal-title":"Exp Neurol"},{"key":"2026060919231041900_ref41","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1038\/jcbfm.2009.197","article-title":"Altered brain mitochondrial metabolism in healthy aging as assessed by in vivo magnetic resonance spectroscopy","volume":"30","author":"Boumezbeur","year":"2010","journal-title":"J Cereb Blood Flow Metab"},{"key":"2026060919231041900_ref42","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1007\/s12017-008-8044-z","article-title":"Mitochondrial medicine for aging and neurodegenerative diseases","volume":"10","author":"Reddy","year":"2008","journal-title":"NeuroMolecular Med"},{"key":"2026060919231041900_ref43","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.bbadis.2009.08.010","article-title":"Cause and consequence: mitochondrial dysfunction initiates and propagates neuronal dysfunction, neuronal death and behavioral abnormalities in age-associated neurodegenerative diseases","volume":"1802","author":"Gibson","year":"2010","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"2026060919231041900_ref44","doi-asserted-by":"publisher","first-page":"e14217","DOI":"10.1111\/eci.14217","article-title":"Primary mitochondrial diseases: the intertwined pathophysiology of bioenergetic dysregulation, oxidative stress and neuroinflammation","volume":"54","author":"Aguilar","year":"2024","journal-title":"Eur J Clin Investig"},{"key":"2026060919231041900_ref45","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1016\/j.ijdevneu.2008.05.006","article-title":"Golgi apparatus and neurodegenerative diseases","volume":"26","author":"Fan","year":"2008","journal-title":"Int J Dev Neurosci"},{"key":"2026060919231041900_ref46","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.jns.2006.01.019","article-title":"Fragmentation of the Golgi apparatus in neurodegenerative diseases and cell death","volume":"246","author":"Gonatas","year":"2006","journal-title":"J Neurol Sci"},{"key":"2026060919231041900_ref47","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1111\/j.1582-4934.2010.01010.x","article-title":"Basic mechanisms of neurodegeneration: A critical update","volume":"14","author":"Jellinger","year":"2010","journal-title":"J Cell Mol Med"},{"key":"2026060919231041900_ref48","first-page":"224","article-title":"Biomarkers in neurodegenerative diseases","volume":"7","author":"Am","year":"2019","journal-title":"EC Pharmacol Toxicol"},{"key":"2026060919231041900_ref49","volume-title":"Approved Treatment Strategies for Neurodegenerative Diseases","author":"Sandhanam","year":"2026"},{"key":"2026060919231041900_ref50","doi-asserted-by":"publisher","first-page":"3391","DOI":"10.3892\/mmr.2016.4948","article-title":"Role of neuroinflammation in neurodegenerative diseases","volume":"13","author":"Chen","year":"2016","journal-title":"Mol Med Rep"},{"key":"2026060919231041900_ref51","doi-asserted-by":"publisher","first-page":"20221051","DOI":"10.1515\/biol-2022-1051","article-title":"Neurodegenerative diseases and neuroinflammation-induced apoptosis","volume":"20","author":"Huang","year":"2025","journal-title":"Open Life Sci"},{"key":"2026060919231041900_ref52","doi-asserted-by":"publisher","first-page":"e202400162","DOI":"10.1002\/tcr.202400162","article-title":"Nanomotors as therapeutic agents: advancing treatment strategies for inflammation-related diseases","volume":"24","author":"Luo","year":"2024","journal-title":"Chem Rec"},{"key":"2026060919231041900_ref53","doi-asserted-by":"publisher","first-page":"2011","DOI":"10.3390\/ijms27042011","article-title":"Microglia\u2013neuron crosstalk: An intimate molecular conversation in neurodegeneration","volume":"27","author":"Wang","year":"2026","journal-title":"Int J Mol Sci"},{"key":"2026060919231041900_ref54","doi-asserted-by":"publisher","first-page":"5938","DOI":"10.3390\/ijms23115938","article-title":"An overview of oxidative stress, Neuroinflammation, and neurodegenerative diseases","volume":"23","author":"Teleanu","year":"2022","journal-title":"Int J Mol Sci"},{"key":"2026060919231041900_ref55","doi-asserted-by":"crossref","first-page":"1561636","DOI":"10.3389\/978-2-8325-6051-8","volume-title":"Neuroinflammation and Neurodegenerative Diseases","author":"Kumar","year":"2025"},{"key":"2026060919231041900_ref56","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1007\/s13311-014-0295-9","article-title":"Genetics of Alzheimer's disease","volume":"11","author":"Guerreiro","year":"2014","journal-title":"Neurotherapeutics"},{"key":"2026060919231041900_ref57","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1002\/mds.25249","article-title":"The genetics of Parkinson's disease: progress and therapeutic implications","volume":"28","author":"Singleton","year":"2013","journal-title":"Mov Disord"},{"key":"2026060919231041900_ref58","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/B978-0-12-802395-2.00022-5","article-title":"Genetics of neurodegenerative diseases: an overview","volume":"145","author":"Pihlstr\u00f8m","year":"2018","journal-title":"Handb Clin Neurol"},{"key":"2026060919231041900_ref59","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.1172\/JCI24761","article-title":"The genetic epidemiology of neurodegenerative disease","volume":"115","author":"Bertram","year":"2005","journal-title":"J Clin Invest"},{"key":"2026060919231041900_ref60","doi-asserted-by":"publisher","first-page":"995045","DOI":"10.3389\/fnins.2022.995045","article-title":"Genetic predisposition to neurodegenerative diseases and risk of stroke: A Mendelian randomization study","volume":"16","author":"Li","year":"2022","journal-title":"Front Neurosci"},{"key":"2026060919231041900_ref61","volume-title":"Translational Research in Biomedical Sciences: Recent Progress and Future Prospects","author":"Ravi","year":"2024"},{"key":"2026060919231041900_ref62","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1038\/nrn3380","article-title":"Axonal transport deficits and neurodegenerative diseases","volume":"14","author":"Millecamps","year":"2013","journal-title":"Nat Rev Neurosci"},{"key":"2026060919231041900_ref63","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1146\/annurev.neuro.31.061307.090711","article-title":"Role of axonal transport in neurodegenerative diseases","volume":"31","author":"De Vos","year":"2008","journal-title":"Annu Rev Neurosci"},{"key":"2026060919231041900_ref64","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1038\/s41582-019-0257-2","article-title":"Axonal transport and neurological disease","volume":"15","author":"Sleigh","year":"2019","journal-title":"Nat Rev Neurol"},{"key":"2026060919231041900_ref65","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.neuron.2014.10.019","article-title":"Axonal transport: cargo-specific mechanisms of motility and regulation","volume":"84","author":"Maday","year":"2014","journal-title":"Neuron"},{"key":"2026060919231041900_ref66","doi-asserted-by":"publisher","first-page":"12495","DOI":"10.3390\/ijerph191912495","article-title":"Neurodegenerative diseases: implications of environmental and climatic influences on neurotransmitters and neuronal hormones activities","volume":"19","author":"Ayeni","year":"2022","journal-title":"Int J Environ Res Public Health"},{"key":"2026060919231041900_ref67","first-page":"123","article-title":"Neurodegenerative diseases and infertility","volume":"1","author":"\u00d6nger","year":"2025","journal-title":"North J Health Sci"},{"key":"2026060919231041900_ref68","doi-asserted-by":"publisher","first-page":"406","DOI":"10.3389\/fnagi.2017.00406","article-title":"Role of sex hormones on brain mitochondrial function, with special reference to aging and neurodegenerative diseases","volume":"9","author":"Gaignard","year":"2017","journal-title":"Front Aging Neurosci"},{"key":"2026060919231041900_ref69","doi-asserted-by":"publisher","first-page":"1578439","DOI":"10.3389\/fnagi.2025.1578439","article-title":"From hormones to neurodegeneration: how FSH drives Alzheimer\u2019s disease","volume":"17","author":"Xue","year":"2025","journal-title":"Front Aging Neurosci"},{"key":"2026060919231041900_ref70","doi-asserted-by":"publisher","first-page":"1430","DOI":"10.4239\/wjd.v15.i7.1430","article-title":"Insulin resistance as the molecular link between diabetes and Alzheimer's disease","volume":"15","author":"Abdalla","year":"2024","journal-title":"World J Diabetes"},{"key":"2026060919231041900_ref71","article-title":"Hypothalamic-pituitary-adrenal (HPA) axis: unveiling the potential mechanisms involved in stress-induced Alzheimer\u2019s disease and depression","volume":"16","author":"Sharan","year":"2024","journal-title":"Cureus"},{"key":"2026060919231041900_ref72","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1007\/s13205-026-04697-z","article-title":"Bridging pathway dysfunction and therapy: novel compounds for neuroprotection. 3","volume":"16","author":"Patel","year":"2026","journal-title":"Biotech"},{"key":"2026060919231041900_ref73","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.pmr.2024.11.006","article-title":"Rehabilitation of women with neurodegenerative diseases","volume":"36","author":"Markos","year":"2025","journal-title":"Phys Med Rehabil Clin"},{"key":"2026060919231041900_ref74","first-page":"062","article-title":"Peptide hormones and neurodegenerative diseases","volume":"2","author":"Yayla","year":"2021","journal-title":"J Exp Basic Med Sci"},{"key":"2026060919231041900_ref75","first-page":"1","article-title":"Innovative interventions: Postbiotics and Psychobiotics in neurodegenerative disease treatment","volume":"18","author":"Gupta","year":"2025","journal-title":"Probiotics Antimicrob Proteins"},{"key":"2026060919231041900_ref76","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1210\/endrev\/bnz005","article-title":"The role of sex and sex hormones in neurodegenerative diseases","volume":"41","author":"Vegeto","year":"2020","journal-title":"Endocr Rev"},{"key":"2026060919231041900_ref77","doi-asserted-by":"publisher","first-page":"2726","DOI":"10.3390\/cells12232726","article-title":"The role of cortisol in chronic stress, neurodegenerative diseases, and psychological disorders","volume":"12","author":"Knezevic","year":"2023","journal-title":"Cells"},{"key":"2026060919231041900_ref78","article-title":"Role of cortisol in the synthesis of glutamate during oxidative stress","volume":"2","author":"Godonu","year":"2025","journal-title":"Int J Sci Res Technol"},{"key":"2026060919231041900_ref79","doi-asserted-by":"crossref","DOI":"10.1007\/s12035-026-05760-9","article-title":"Targeting autophagy, Ferroptosis, and Neuroinflammation: polyphenol-mediated modulation of emerging Signaling pathways in neurodegeneration","volume":"63","author":"Jindal","year":"2026","journal-title":"Mol Neurobiol"},{"key":"2026060919231041900_ref80","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/s40520-015-0353-0","article-title":"Recent advances in the role of cortisol and metabolic syndrome in age-related degenerative diseases","volume":"28","author":"Martocchia","year":"2016","journal-title":"Aging Clin Exp Res"},{"key":"2026060919231041900_ref81","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.3390\/brainsci14111121","article-title":"Neurobiology research on neurodegenerative disorders","volume":"14","author":"Lietzau","year":"2024","journal-title":"MDPI"},{"key":"2026060919231041900_ref82","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1007\/s00109-003-0499-7","article-title":"Role of insulin-like growth factor I signaling in neurodegenerative diseases","volume":"82","author":"Trejo","year":"2004","journal-title":"J Mol Med"},{"key":"2026060919231041900_ref83","doi-asserted-by":"publisher","first-page":"3195","DOI":"10.1007\/s12035-024-04457-1","article-title":"Insulin-like growth factor signaling in Alzheimer\u2019s disease: pathophysiology and therapeutic strategies","volume":"62","author":"Miao","year":"2025","journal-title":"Mol Neurobiol"},{"key":"2026060919231041900_ref84","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1007\/BF03346653","article-title":"Growth hormone\/insulin-like growth factor I axis in neurodegenerative diseases","volume":"33","author":"Gasperi","year":"2010","journal-title":"J Endocrinol Investig"},{"key":"2026060919231041900_ref85","doi-asserted-by":"publisher","first-page":"73","DOI":"10.3389\/fnins.2018.00073","article-title":"The role of insulin\/IGF-1\/PI3K\/Akt\/GSK3\u03b2 signaling in Parkinson's disease dementia","volume":"12","author":"Yang","year":"2018","journal-title":"Front Neurosci"},{"key":"2026060919231041900_ref86","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1186\/s12967-020-02223-0","article-title":"Is insulin-like growth factor-1 involved in Parkinson\u2019s disease development?","volume":"18","author":"Castilla-Cort\u00e1zar","year":"2020","journal-title":"J Transl Med"},{"key":"2026060919231041900_ref87","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1007\/s12035-025-05290-w","article-title":"The role of thyroid hormones in neurodegenerative disorders: opportunities and challenges","volume":"63","author":"Zhang","year":"2026","journal-title":"Mol Neurobiol"},{"key":"2026060919231041900_ref88","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1007\/s43440-022-00377-w","article-title":"Relationship between thyroid hormones and central nervous system metabolism in physiological and pathological conditions","volume":"74","author":"Sawicka-Gutaj","year":"2022","journal-title":"Pharmacol Rep"},{"key":"2026060919231041900_ref89","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1159\/000545369","article-title":"Thyroid disorders as a risk factor for neurodegenerative Proteinopathies: A large-scale propensity score-matched analysis","volume":"60","author":"Toraih","year":"2025","journal-title":"Neuroepidemiology"},{"key":"2026060919231041900_ref90","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1007\/s13205-025-04673-z","article-title":"Neuropharmacology of synaptic plasticity: pathways to cognitive resilience in healthy aging","volume":"16","author":"Goel","year":"2026","journal-title":"3 Biotech"},{"key":"2026060919231041900_ref91","doi-asserted-by":"publisher","first-page":"140","DOI":"10.3390\/cells14020140","article-title":"Role of thyroid hormone in neurodegenerative disorders of older people","volume":"14","author":"Mooradian","year":"2025","journal-title":"Cells"},{"key":"2026060919231041900_ref92","doi-asserted-by":"publisher","first-page":"104844","DOI":"10.1016\/j.psyneuen.2020.104844","article-title":"Altered thyroid hormone profile in patients with Alzheimer\u2019s disease","volume":"121","author":"Quinlan","year":"2020","journal-title":"Psychoneuroendocrinology"},{"key":"2026060919231041900_ref93","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1007\/BF03033887","article-title":"Role of melatonin in neurodegenerative diseases","volume":"7","author":"Srinivasan","year":"2005","journal-title":"Neurotox Res"},{"key":"2026060919231041900_ref94","doi-asserted-by":"publisher","first-page":"7174","DOI":"10.3390\/ijms21197174","article-title":"Melatonin and autophagy in aging-related neurodegenerative diseases","volume":"21","author":"Luo","year":"2020","journal-title":"Int J Mol Sci"},{"key":"2026060919231041900_ref95","doi-asserted-by":"publisher","first-page":"819","DOI":"10.3390\/antiox14070819","article-title":"Melatonin\u2014A powerful oxidant in neurodegenerative diseases","volume":"14","author":"Ko\u0142odziejska","year":"2025","journal-title":"Antioxidants"},{"key":"2026060919231041900_ref96","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.3390\/biom10081158","article-title":"Cellular mechanisms of melatonin: insight from neurodegenerative diseases","volume":"10","author":"Chen","year":"2020","journal-title":"Biomolecules"},{"key":"2026060919231041900_ref97","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.3390\/antiox14101190","article-title":"Melatonin-mediated Nrf2 activation as a potential therapeutic strategy in mutation-driven neurodegenerative diseases","volume":"14","author":"\u00cd\u00f1igo-Catalina","year":"2025","journal-title":"Antioxidants"},{"key":"2026060919231041900_ref98","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/S0161-813X(03)00090-1","article-title":"Neurotoxicity of MAO metabolites of catecholamine neurotransmitters: role in neurodegenerative diseases","volume":"25","author":"Burke","year":"2004","journal-title":"Neurotoxicology"},{"key":"2026060919231041900_ref99","doi-asserted-by":"publisher","first-page":"6003","DOI":"10.1039\/C8DT04216K","article-title":"The interaction of aluminum with catecholamine-based neurotransmitters: can the formation of these species be considered a potential risk factor for neurodegenerative diseases?","volume":"48","author":"Dalla Torre","year":"2019","journal-title":"Dalton Trans"},{"key":"2026060919231041900_ref100","doi-asserted-by":"publisher","first-page":"R1032","DOI":"10.1152\/ajpregu.00169.2025","article-title":"Peripheral catecholamine systems: an evolutionary perspective","volume":"329","author":"Goldstein","year":"2025","journal-title":"Am J Phys Regul Integr Comp Phys"},{"key":"2026060919231041900_ref101","doi-asserted-by":"publisher","first-page":"fcaf310","DOI":"10.1093\/braincomms\/fcaf310","article-title":"Noradrenergic therapies in neurodegenerative disease: from symptomatic to disease modifying therapy? Brain","volume":"7","author":"Durcan","year":"2025","journal-title":"Communications"},{"key":"2026060919231041900_ref102","doi-asserted-by":"publisher","first-page":"e70097","DOI":"10.1111\/psyg.70097","article-title":"Dopamine system dysfunction in Alzheimer's disease","volume":"25","author":"Moreira","year":"2025","journal-title":"Psychogeriatrics"},{"key":"2026060919231041900_ref103","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/S0741-8329(01)00150-1","article-title":"Nicotinic acetylcholine receptors and neurodegenerative disease","volume":"24","author":"Nakamura","year":"2001","journal-title":"Alcohol"},{"key":"2026060919231041900_ref104","article-title":"Neuroprotective and antioxidant properties of Oxotremorine-M, a non selective muscarinic acetylcholine receptors agonist, in cellular and animal models of Alzheimer disease","author":"Scordino","year":"2025"},{"key":"2026060919231041900_ref105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11030-025-11170-1","article-title":"Innovative approaches in acetylcholinesterase inhibition: A pathway to effective Alzheimer\u2019s disease treatment","volume":"29","author":"Arora","year":"2025","journal-title":"Mol Divers"},{"key":"2026060919231041900_ref106","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1007\/s11064-007-9497-4","article-title":"The place of choline acetyltransferase activity measurement in the \u201ccholinergic hypothesis\u201d of neurodegenerative diseases","volume":"33","author":"Contestabile","year":"2008","journal-title":"Neurochem Res"},{"key":"2026060919231041900_ref107","doi-asserted-by":"publisher","first-page":"G949","DOI":"10.1152\/ajpgi.00493.2012","article-title":"Emerging neuropeptide targets in inflammation: NPY and VIP","volume":"304","author":"Chandrasekharan","year":"2013","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"2026060919231041900_ref108","doi-asserted-by":"publisher","first-page":"35","DOI":"10.3390\/neuroglia6030035","article-title":"Pro-and anti-inflammatory neuropeptides and glia: the balance between neuroprotection and Neuroinflammation","volume":"6","author":"Futran-Sheinberg","year":"2025","journal-title":"Neuroglia"},{"key":"2026060919231041900_ref109","doi-asserted-by":"publisher","first-page":"1717","DOI":"10.2174\/1570159X19666210906120302","article-title":"Neuroprotective effects of neuropeptide Y against neurodegenerative disease","volume":"20","author":"Pain","year":"2022","journal-title":"Curr Neuropharmacol"},{"key":"2026060919231041900_ref110","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.3390\/neurolint16060100","article-title":"The role of neuropeptide Y in the pathogenesis of Alzheimer\u2019s disease: diagnostic significance and neuroprotective functions","volume":"16","author":"Shapovalova","year":"2024","journal-title":"Neurol Int"},{"key":"2026060919231041900_ref111","doi-asserted-by":"publisher","first-page":"670","DOI":"10.3390\/pharmaceutics16050670","article-title":"A review of recent developments in biopolymer nano-based drug delivery systems with antioxidative properties: insights into the last five years","volume":"16","author":"Stevanovi\u0107","year":"2024","journal-title":"Pharmaceutics"},{"key":"2026060919231041900_ref112","doi-asserted-by":"publisher","first-page":"1644633","DOI":"10.3389\/fddev.2025.1644633","article-title":"Strategies for delivering drugs across the blood-brain barrier for the treatment of neurodegenerative diseases","volume":"5","author":"Zhang","year":"2025","journal-title":"Front Drug Deliv"},{"key":"2026060919231041900_ref113","doi-asserted-by":"publisher","first-page":"5843","DOI":"10.3390\/ijms26125843","article-title":"Brain endothelial cells in blood\u2013brain barrier regulation and neurological therapy","volume":"26","author":"Xiang","year":"2025","journal-title":"Int J Mol Sci"},{"key":"2026060919231041900_ref114","doi-asserted-by":"publisher","first-page":"2363","DOI":"10.1016\/j.bpj.2024.06.010","article-title":"Biophysics of claudin proteins in tight junction architecture: three decades of progress","volume":"123","author":"Marsch","year":"2024","journal-title":"Biophys J"},{"key":"2026060919231041900_ref115","doi-asserted-by":"publisher","first-page":"706","DOI":"10.3390\/pharmaceutics17060706","article-title":"Crossing the blood\u2013brain barrier: innovations in receptor-and transporter-mediated transcytosis strategies","volume":"17","author":"Ding","year":"2025","journal-title":"Pharmaceutics"},{"key":"2026060919231041900_ref116","doi-asserted-by":"publisher","first-page":"e30207","DOI":"10.1016\/j.heliyon.2024.e30207","article-title":"Hypoxia modulates P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) drug transporters in brain endothelial cells of the developing human blood-brain barrier","volume":"10","author":"Mughis","year":"2024","journal-title":"Heliyon"},{"key":"2026060919231041900_ref117","doi-asserted-by":"publisher","first-page":"127938","DOI":"10.1016\/j.molliq.2025.127938","article-title":"Surface-functionalized nanoparticles for targeted drug delivery across the blood-brain barrier: advances and challenges in neurodegenerative disease therapy","volume":"433","author":"Pramoda","year":"2025","journal-title":"J Mol Liq"},{"key":"2026060919231041900_ref118","doi-asserted-by":"publisher","first-page":"2653","DOI":"10.1007\/s10072-021-05234-x","article-title":"Nanoparticles approaches in neurodegenerative diseases diagnosis and treatment","volume":"42","author":"Asefy","year":"2021","journal-title":"Neurol Sci"},{"key":"2026060919231041900_ref119","doi-asserted-by":"publisher","first-page":"4302","DOI":"10.3390\/ma18184302","article-title":"Functionalized magnetic nanoparticles: can they revolutionize the treatment of neurodegenerative disorders?","volume":"18","author":"Zahariev","year":"2025","journal-title":"Materials"},{"key":"2026060919231041900_ref120","doi-asserted-by":"publisher","first-page":"11015","DOI":"10.2147\/IJN.S549893","article-title":"Nanotechnology for neurodegenerative diseases: recent progress in brain-targeted delivery, stimuli-responsive platforms, and organelle-specific therapeutics","volume":"Volume 20","author":"Gao","year":"2025","journal-title":"Int J Nanomedicine"},{"key":"2026060919231041900_ref121","doi-asserted-by":"publisher","first-page":"105314","DOI":"10.1016\/j.ejps.2020.105314","article-title":"Quercetin lipid nanoparticles functionalized with transferrin for Alzheimer's disease","volume":"148","author":"Pinheiro","year":"2020","journal-title":"Eur J Pharm Sci"},{"key":"2026060919231041900_ref122","doi-asserted-by":"publisher","first-page":"1522223","DOI":"10.3389\/fmed.2025.1522223","article-title":"Targeted drug delivery in neurodegenerative diseases: the role of nanotechnology","volume":"12","author":"Dhariwal","year":"2025","journal-title":"Front Med"},{"key":"2026060919231041900_ref123","volume-title":"Liposomes in Drug Delivery","author":"Musumeci","year":"2024"},{"key":"2026060919231041900_ref124","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1007\/978-3-031-81991-9_19","volume-title":"Neuroreceptor Endocytosis and Signaling in Health and Disease","author":"Talwar","year":"2025"},{"key":"2026060919231041900_ref125","doi-asserted-by":"publisher","first-page":"56","DOI":"10.3390\/chemengineering9030056","article-title":"Liposome-based drug delivery systems: from laboratory research to industrial production\u2014instruments and challenges","volume":"9","author":"Basak","year":"2025","journal-title":"ChemEngineering"},{"key":"2026060919231041900_ref126","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1080\/00222348.2025.2468118","article-title":"Advancing structure-property insights of poly (lactic-co-glycolic acids): A mini review on the biodegradable polymers applications in drug delivery","volume":"65","author":"Thakkar","year":"2026","journal-title":"J Macromol Sci B"},{"key":"2026060919231041900_ref127","doi-asserted-by":"publisher","first-page":"2536","DOI":"10.3390\/polym16172536","article-title":"Biodegradable polymeric nanoparticle-based drug delivery systems: comprehensive overview, perspectives and challenges","volume":"16","author":"Geszke-Moritz","year":"2024","journal-title":"Polymers"},{"key":"2026060919231041900_ref128","doi-asserted-by":"publisher","first-page":"1530","DOI":"10.3390\/pharmaceutics16121530","article-title":"Dendrimers, dendrons, and the dendritic state: reflection on the last decade with expected new roles in pharma, medicine, and the life sciences","volume":"16","author":"Tomalia","year":"2024","journal-title":"Pharmaceutics"},{"key":"2026060919231041900_ref129","doi-asserted-by":"publisher","first-page":"23202","DOI":"10.1039\/D5NR02548F","article-title":"Crossing the blood\u2013brain barrier: advances in dendrimer-based nanocarriers for central nervous system delivery","volume":"17","author":"Bharadwaj","year":"2025","journal-title":"Nanoscale"},{"key":"2026060919231041900_ref130","doi-asserted-by":"publisher","first-page":"1","DOI":"10.14715\/cmb\/2025.70.1.1","article-title":"Dendrimers as drug delivery vehicles: A comprehensive review","volume":"71","author":"Zorab","year":"2025","journal-title":"Cell Mol Biol"},{"key":"2026060919231041900_ref131","doi-asserted-by":"publisher","first-page":"188","DOI":"10.3390\/jnt5040012","article-title":"Characteristics and preparation of solid lipid nanoparticles and nanostructured lipid carriers","volume":"5","author":"Queiroz","year":"2024","journal-title":"J Nanotheranostics"},{"key":"2026060919231041900_ref132","doi-asserted-by":"publisher","first-page":"6509","DOI":"10.3390\/ijms26136509","article-title":"A review of formulation strategies for cyclodextrin-enhanced solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs)","volume":"26","author":"Alloush","year":"2025","journal-title":"Int J Mol Sci"},{"key":"2026060919231041900_ref133","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/01932691.2025.2496388","article-title":"Unlocking the multifaceted potential of lipid-based dispersion as a drug carrier: targeted applications and stability improvement strategies","author":"Puri","year":"2025","journal-title":"J Dispers Sci Technol"},{"key":"2026060919231041900_ref134","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1208\/s12249-025-03316-z","article-title":"Challenges and opportunities of drug delivery for treatment of Alzheimer\u2019s disease","volume":"27","author":"Abd El-Fattah","year":"2026","journal-title":"AAPS PharmSciTech"},{"key":"2026060919231041900_ref135","volume-title":"Synthetic Polymeric Materials-Based Drug Delivery Systems for Inflammatory Diseases","author":"Kabra","year":"2025"},{"key":"2026060919231041900_ref136","doi-asserted-by":"publisher","first-page":"3260","DOI":"10.3390\/ijms27073260","article-title":"Targeting non-coding RNAs as a potential therapeutic and delivery strategy against neurodegenerative diseases","volume":"27","author":"Bougea","year":"2026","journal-title":"Int J Mol Sci"},{"key":"2026060919231041900_ref137","doi-asserted-by":"publisher","first-page":"2830","DOI":"10.1021\/acs.molpharmaceut.5c00501","article-title":"A critical view on the biocompatibility of silica nanoparticles and liposomes as drug delivery systems","volume":"22","author":"Solarska-Sciuk","year":"2025","journal-title":"Mol Pharm"},{"key":"2026060919231041900_ref138","first-page":"30573","article-title":"Advances in nanomaterials for precision drug delivery: insights into pharmacokinetics and toxicity","volume":"15","author":"Tripathi","year":"2024","journal-title":"Bioimpacts"},{"key":"2026060919231041900_ref139","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1038\/nrneurol.2017.188","article-title":"Blood\u2013brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders","volume":"14","author":"Sweeney","year":"2018","journal-title":"Nat Rev Neurol"},{"key":"2026060919231041900_ref140","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1186\/s12951-025-03415-w","article-title":"Advances in brain-targeted delivery strategies and natural product-mediated enhancement of blood\u2013brain barrier permeability","volume":"23","author":"Liu","year":"2025","journal-title":"J Nanobiotechnol"},{"key":"2026060919231041900_ref141","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1016\/S0028-3908(01)00019-3","article-title":"Oxidative stress induced-neurodegenerative diseases: the need for antioxidants that penetrate the blood brain barrier","volume":"40","author":"Gilgun-Sherki","year":"2001","journal-title":"Neuropharmacology"},{"key":"2026060919231041900_ref142","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1007\/s10571-024-01473-6","article-title":"The progress in molecular transport and therapeutic development in human blood\u2013brain barrier models in neurological disorders","volume":"44","author":"Korszun-Karbowniczak","year":"2024","journal-title":"Cell Mol Neurobiol"},{"key":"2026060919231041900_ref143","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.3390\/pharmaceutics17081041","article-title":"Overcoming the blood\u2013brain barrier: advanced strategies in targeted drug delivery for neurodegenerative diseases","volume":"17","author":"Yang","year":"2025","journal-title":"Pharmaceutics"},{"key":"2026060919231041900_ref144","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1016\/j.biomaterials.2013.09.063","article-title":"Dual-functional nanoparticles targeting amyloid plaques in the brains of Alzheimer's disease mice","volume":"35","author":"Zhang","year":"2014","journal-title":"Biomaterials"},{"key":"2026060919231041900_ref145","doi-asserted-by":"publisher","first-page":"138190","DOI":"10.1016\/j.colsurfa.2025.138190","article-title":"Nose-to-brain targeting of pregabalin via phospholipid complex nanoparticles for facilitated epilepsy therapy: design, optimization and in vitro-in vivo evaluations","volume":"727","author":"Trivedi","year":"2025","journal-title":"Colloids Surf A Physicochem Eng Asp"},{"key":"2026060919231041900_ref146","doi-asserted-by":"publisher","first-page":"132210","DOI":"10.1016\/j.cej.2021.132210","article-title":"Brain-targeted gene delivery of ZnO quantum dots nanoplatform for the treatment of Parkinson disease","volume":"429","author":"Lin","year":"2022","journal-title":"Chem Eng J"},{"key":"2026060919231041900_ref147","doi-asserted-by":"publisher","first-page":"111028","DOI":"10.1016\/j.msec.2020.111028","article-title":"Actively targeted gold nanoparticle composites improve behavior and cognitive impairment in Parkinson's disease mice","volume":"114","author":"Liu","year":"2020","journal-title":"Mater Sci Eng C"},{"key":"2026060919231041900_ref148","doi-asserted-by":"publisher","first-page":"841","DOI":"10.3390\/molecules28020841","article-title":"Management of brain cancer and neurodegenerative disorders with polymer-based nanoparticles as a biocompatible platform","volume":"28","author":"Bazi Alahri","year":"2023","journal-title":"Molecules"},{"key":"2026060919231041900_ref149","doi-asserted-by":"publisher","first-page":"135323","DOI":"10.1016\/j.ijbiomac.2024.135323","article-title":"Chitosan nanoparticles encapsulated Piper betle essential oil alleviates Alzheimer's disease associated pathology in Caenorhabditis elegans","volume":"279","author":"Muthusamy","year":"2024","journal-title":"Int J Biol Macromol"},{"key":"2026060919231041900_ref150","doi-asserted-by":"crossref","DOI":"10.1007\/978-981-95-2790-8","volume-title":"Rejuvenating the Brain: Nutraceuticals, Autophagy, and Longevity","author":"Singh","year":"2025"},{"key":"2026060919231041900_ref151","doi-asserted-by":"publisher","first-page":"138336","DOI":"10.1016\/j.ijbiomac.2024.138336","article-title":"Chitosan nanoparticle-mediated nose-to-brain delivery of naringenin: attenuating memory decline in experimental animals via behavioural assessment and modulation of biochemical parameters","volume":"286","author":"Chakraborty","year":"2025","journal-title":"Int J Biol Macromol"},{"key":"2026060919231041900_ref152","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1021\/acs.chemrestox.9b00368","article-title":"Surface functionalization of pegylated gold nanoparticles with antioxidants suppresses nanoparticle-induced oxidative stress and neurotoxicity","volume":"33","author":"Zhang","year":"2020","journal-title":"Chem Res Toxicol"},{"key":"2026060919231041900_ref153","doi-asserted-by":"publisher","first-page":"10453","DOI":"10.2147\/IJN.S272831","article-title":"Polymeric nanoparticles-based brain delivery with improved therapeutic efficacy of Ginkgolide B in Parkinson\u2019s disease","volume":"Volume 15","author":"Zhao","year":"2020","journal-title":"Int J Nanomedicine"},{"key":"2026060919231041900_ref154","doi-asserted-by":"publisher","first-page":"1452","DOI":"10.1089\/neu.2016.4644","article-title":"Cerium oxide nanoparticles improve outcome after in vitro and in vivo mild traumatic brain injury","volume":"37","author":"Bailey","year":"2020","journal-title":"J Neurotrauma"},{"key":"2026060919231041900_ref155","doi-asserted-by":"publisher","first-page":"51","DOI":"10.62347\/QHVI3317","article-title":"Advances in nanotechnology for targeted drug delivery in neurodegenerative diseases","volume":"14","author":"Rafieezadeh","year":"2025","journal-title":"Am J Neurodegener Dis"},{"key":"2026060919231041900_ref156","volume-title":"Neurobiology of Aging","author":"Prajapati","year":"2026"},{"key":"2026060919231041900_ref157","doi-asserted-by":"publisher","first-page":"125875","DOI":"10.1016\/j.ijpharm.2025.125875","article-title":"Cell membrane-coated nanoparticles for neurodegenerative disorders management","volume":"681","author":"Thakur","year":"2025","journal-title":"Int J Pharm"},{"key":"2026060919231041900_ref158","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.ijpharm.2005.09.040","article-title":"Therapeutic potential of controlled drug delivery systems in neurodegenerative diseases","volume":"314","author":"Popovic","year":"2006","journal-title":"Int J Pharm"},{"key":"2026060919231041900_ref159","doi-asserted-by":"publisher","first-page":"e13804","DOI":"10.1111\/cpr.13804","article-title":"The application of polymeric nanoparticles as drug delivery carriers to cells in neurodegenerative diseases","volume":"58","author":"Jin","year":"2025","journal-title":"Cell Prolif"},{"key":"2026060919231041900_ref160","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.3390\/ph17081059","article-title":"Nanoparticle-based drug delivery systems in inhaled therapy: improving respiratory medicine","volume":"17","author":"Cojocaru","year":"2024","journal-title":"Pharmaceuticals"},{"key":"2026060919231041900_ref161","doi-asserted-by":"publisher","first-page":"2410030","DOI":"10.1002\/smll.202410030","article-title":"Stimuli-responsive Nano drug delivery Systems for the Treatment of neurological diseases","volume":"21","author":"Dai","year":"2025","journal-title":"Small"},{"key":"2026060919231041900_ref162","doi-asserted-by":"publisher","first-page":"6960","DOI":"10.1039\/D4NR03706E","article-title":"Understanding the interplay between pH and charges for theranostic nanomaterials","volume":"17","author":"Ow","year":"2025","journal-title":"Nanoscale"},{"key":"2026060919231041900_ref163","doi-asserted-by":"publisher","first-page":"e70185","DOI":"10.1002\/ddr.70185","article-title":"Enzyme responsive magnetic nanoparticles for targeted drug delivery and precision medicine","volume":"86","author":"Du","year":"2025","journal-title":"Drug Dev Res"},{"key":"2026060919231041900_ref164","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.3390\/pharmaceutics17091123","article-title":"Peptide-based inorganic nanoparticles as efficient intracellular delivery systems","volume":"17","author":"Shirazi","year":"2025","journal-title":"Pharmaceutics"},{"key":"2026060919231041900_ref165","doi-asserted-by":"publisher","first-page":"e09337","DOI":"10.1002\/adma.202509337","article-title":"Developments and opportunities in temperature-responsive thermal smart materials","author":"Shen","year":"2025","journal-title":"Adv Mater"},{"key":"2026060919231041900_ref166","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1021\/acsapm.4c03406","article-title":"Recent progress on regulating the LCST of PNIPAM-based thermochromic materials","volume":"7","author":"Li","year":"2024","journal-title":"ACS Appl Polym Mater"},{"key":"2026060919231041900_ref167","doi-asserted-by":"publisher","first-page":"106142","DOI":"10.1016\/j.jddst.2024.106142","article-title":"Preparation and in vitro characterization of memantine HCl loaded PLGA nanoparticles for Alzheimer's disease","volume":"100","author":"Tezel","year":"2024","journal-title":"J Drug Delivery Sci Technol"},{"key":"2026060919231041900_ref168","doi-asserted-by":"publisher","first-page":"106857","DOI":"10.1016\/j.jddst.2025.106857","article-title":"Nose to brain delivery of insulin loaded in PLGA and chitosan-coated PLGA nanoparticles: A promising approach for Alzheimer's disease therapy","volume":"108","author":"Kouhjani","year":"2025","journal-title":"J Drug Delivery Sci Technol"},{"key":"2026060919231041900_ref169","doi-asserted-by":"publisher","first-page":"19961","DOI":"10.1021\/acsnano.3c05011","article-title":"Engineered selenium\/human serum albumin nanoparticles for efficient targeted treatment of Parkinson\u2019s disease via oral gavage","volume":"17","author":"Xu","year":"2023","journal-title":"ACS Nano"},{"key":"2026060919231041900_ref170","doi-asserted-by":"publisher","first-page":"4305","DOI":"10.3390\/app11094305","article-title":"Surface functionalization of PLGA nanoparticles to increase transport across the BBB for Alzheimer\u2019s disease","volume":"11","author":"Del Amo","year":"2021","journal-title":"Appl Sci"},{"key":"2026060919231041900_ref171","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/01932691.2026.2649021","article-title":"Mesalamine and fucoxanthin co-loaded SNEDDS for neuroprotection in Parkinson\u2019s disease","author":"Chauhan","year":"2026","journal-title":"J Dispers Sci Technol"},{"key":"2026060919231041900_ref172","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1007\/s11095-020-02865-1","article-title":"RVG29-functionalized lipid nanoparticles for quercetin brain delivery and Alzheimer\u2019s disease","volume":"37","author":"Pinheiro","year":"2020","journal-title":"Pharm Res"},{"key":"2026060919231041900_ref173","doi-asserted-by":"publisher","first-page":"120714","DOI":"10.1016\/j.carbpol.2023.120714","article-title":"Brain targeted peptide-functionalized chitosan nanoparticles for resveratrol delivery: impact on insulin resistance and gut microbiota in obesity-related Alzheimer's disease","volume":"310","author":"Yang","year":"2023","journal-title":"Carbohydr Polym"},{"key":"2026060919231041900_ref174","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/j.jconrel.2020.12.051","article-title":"Insights into kinetics, release, and behavioral effects of brain-targeted hybrid nanoparticles for cholesterol delivery in Huntington's disease","volume":"330","author":"Birolini","year":"2021","journal-title":"J Control Release"},{"key":"2026060919231041900_ref175","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1021\/acsnano.5c14751","article-title":"Small gold nanoparticles alleviate Huntington\u2019s disease via modulating p38\u03b1 mitogen-activated protein kinase and pyruvate dehydrogenase kinase 1","volume":"20","author":"Lee","year":"2026","journal-title":"ACS Nano"},{"key":"2026060919231041900_ref176","doi-asserted-by":"publisher","first-page":"4003","DOI":"10.3390\/cells11244003","article-title":"Development of a nanoparticle-based approach for the blood\u2013brain barrier passage in a murine model of amyotrophic lateral sclerosis","volume":"11","author":"Violatto","year":"2022","journal-title":"Cells"},{"key":"2026060919231041900_ref177","doi-asserted-by":"publisher","first-page":"1","DOI":"10.29245\/2572.942X\/2025\/1.1311","article-title":"Nanomedicine: transforming neurological therapies and precision medicine","volume":"9","author":"Ikram","year":"2025","journal-title":"J Neurol Neuromedicine"},{"key":"2026060919231041900_ref178","doi-asserted-by":"crossref","DOI":"10.61797\/ijanca.v3i2.398","volume":"3","author":"Sengar","year":"2024","journal-title":"Int J Adv Nano Comput Anal"},{"key":"2026060919231041900_ref179","doi-asserted-by":"publisher","first-page":"967","DOI":"10.3390\/books978-3-7258-0187-9","article-title":"Neurodegenerative disease: from molecular basis to therapy","volume":"25","author":"Ricci","year":"2024","journal-title":"MDPI"},{"key":"2026060919231041900_ref180","doi-asserted-by":"publisher","first-page":"4039","DOI":"10.1021\/acsnano.4c11858","article-title":"Emerging delivery systems for enabling precision nucleic acid therapeutics","volume":"19","author":"Bian","year":"2025","journal-title":"ACS Nano"},{"key":"2026060919231041900_ref181","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1515\/revneuro-2024-0040","article-title":"Revealing the mechanisms of blood\u2013brain barrier in chronic neurodegenerative disease: an opportunity for therapeutic intervention","volume":"35","author":"Yu","year":"2024","journal-title":"Rev Neurosci"},{"key":"2026060919231041900_ref182","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1080\/17425247.2025.2578384","article-title":"Receptor-mediated nose-to-brain delivery of drug combination-loaded polymeric nanocarriers for the treatment of glioblastoma-current progress and future perspectives part I: receptor-mediated nose-to-brain delivery approaches for glioblastoma","volume":"23","author":"Qamar","year":"2026","journal-title":"Expert Opin Drug Deliv"},{"key":"2026060919231041900_ref183","volume-title":"Harnessing Endogenous Mechanisms for Targeted Drug Delivery","author":"Mahmoudi","year":"2026"},{"key":"2026060919231041900_ref184","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12195-026-00888-z","article-title":"Nanoparticle\u2013host interactions: the impact of physiological and pathological factors on biodistribution, immune processes, and translational challenges","volume":"19","author":"Abo Qoura","year":"2026","journal-title":"Cell Mol Bioeng"},{"key":"2026060919231041900_ref185","doi-asserted-by":"publisher","first-page":"5232","DOI":"10.1039\/D5BM00660K","article-title":"Advances in cell membrane-coated nanoparticles: multifunctional platforms for targeted drug delivery, precision phototherapy, and enhanced immunotherapy","volume":"13","author":"Sultana","year":"2025","journal-title":"Biomater Sci"},{"key":"2026060919231041900_ref186","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/s10522-025-10209-y","article-title":"Aging, vascular dysfunction, and the blood\u2013brain barrier: unveiling the pathophysiology of stroke in older adults","volume":"26","author":"Alaqel","year":"2025","journal-title":"Biogerontology"},{"key":"2026060919231041900_ref187","doi-asserted-by":"publisher","first-page":"20250161","DOI":"10.1515\/ntrev-2025-0161","article-title":"An updated overview of nanoparticle-induced cardiovascular toxicity","volume":"14","author":"Zhu","year":"2025","journal-title":"Nanotechnol Rev"},{"key":"2026060919231041900_ref188","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/s12035-025-05417-z","article-title":"Targeted nanoparticles for drug delivery across the blood\u2013brain barrier in early and late stages of Alzheimer's disease: A review","volume":"63","author":"Kochman","year":"2026","journal-title":"Mol Neurobiol"},{"key":"2026060919231041900_ref189","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1146\/annurev-bioeng-110824-031709","article-title":"Opportunities and challenges in precision Neurotherapeutics","volume":"28","author":"Mujica-Parodi","year":"2026","journal-title":"Annu Rev Biomed Eng"},{"key":"2026060919231041900_ref190","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1080\/17425247.2024.2440618","article-title":"Artificial intelligence for personalized nanomedicine; from material selection to patient outcomes","volume":"22","author":"Mazumdar","year":"2025","journal-title":"Expert Opin Drug Deliv"},{"key":"2026060919231041900_ref191","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1208\/s12249-025-03319-w","article-title":"Recent trends in the development and clinical translation of polymer-based targeted therapeutic nanoparticle","volume":"27","author":"Singh","year":"2026","journal-title":"AAPS PharmSciTech"},{"key":"2026060919231041900_ref192","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.68419","article-title":"Utilizing multifaceted approaches to target drug delivery in the brain: from nanoparticles to biological therapies","volume":"16","author":"Anwarkhan","year":"2024","journal-title":"Cureus"},{"key":"2026060919231041900_ref193","doi-asserted-by":"publisher","first-page":"733","DOI":"10.21608\/ejvs.2023.234784.1609","article-title":"Therapeutic and toxicological aspects of some metal nanoparticles on the central nervous system: A review","volume":"55","author":"Youssef","year":"2024","journal-title":"Egypt J Vet Sci"},{"key":"2026060919231041900_ref194","doi-asserted-by":"crossref","first-page":"1677612","DOI":"10.3389\/fimmu.2025.1677612","article-title":"Engineering neuroimmune regulation: biomaterial and nanotechnology platforms for neuropathology diagnosis and targeted immunomodulation","volume":"16","author":"Jackson","year":"2025","journal-title":"Front Immunol"},{"key":"2026060919231041900_ref195","doi-asserted-by":"publisher","first-page":"1347987","DOI":"10.3389\/fnagi.2024.1347987","article-title":"The role of neuroinflammation in neurodegenerative diseases: current understanding and future therapeutic targets","volume":"16","author":"Adamu","year":"2024","journal-title":"Front Aging Neurosci"},{"key":"2026060919231041900_ref196","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1038\/s44222-025-00321-6","article-title":"Polyethylene glycol immunogenicity in nanomedicine","volume":"3","author":"Chen","year":"2025","journal-title":"Nat Rev Bioeng"},{"key":"2026060919231041900_ref197","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s41936-025-00449-2","article-title":"A mini-review of nanoparticle therapeutics targeting oxidative stress and inflammation in diabetes","volume":"86","author":"Taha","year":"2025","journal-title":"J Basic Appl Zool"},{"key":"2026060919231041900_ref198","doi-asserted-by":"publisher","first-page":"1334","DOI":"10.1007\/s10646-025-02907-7","article-title":"Metal and metal-oxide nanoparticles inducing changes in reactive oxygen species levels and enzymes of oxidative stress: A review focused on daphnids","volume":"34","author":"Queiroz","year":"2025","journal-title":"Ecotoxicology"},{"key":"2026060919231041900_ref199","doi-asserted-by":"publisher","first-page":"1704814","DOI":"10.3389\/fphar.2025.1704814","article-title":"How do nanoparticle properties shape pharmacokinetics and pharmacodynamics? A mechanistic review","volume":"16","author":"Peralta-Cuevas","year":"2026","journal-title":"Front Pharmacol"},{"key":"2026060919231041900_ref200","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.2147\/DDDT.S447496","article-title":"Advances in nanotechnology for enhancing the solubility and bioavailability of poorly soluble drugs","volume":"Volume 18","author":"Liu","year":"2024","journal-title":"Drug Des Devel Ther"},{"key":"2026060919231041900_ref201","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s44475-025-00003-2","article-title":"Nanomaterial toxicity: A comprehensive review of mechanisms and mitigation strategies","volume":"1","author":"Abegunde","year":"2025","journal-title":"Discov Hazards"},{"key":"2026060919231041900_ref202","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.2174\/0118715273283338240104112106","article-title":"Application of nanocomposites and nanoparticles in treating neurodegenerative disorders","volume":"23","author":"Fatima","year":"2024","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"2026060919231041900_ref203","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.3390\/pharmaceutics17081074","article-title":"Anti-PEG antibodies and their biological impact on PEGylated drugs: challenges and strategies for optimization","volume":"17","author":"Fu","year":"2025","journal-title":"Pharmaceutics"},{"key":"2026060919231041900_ref204","doi-asserted-by":"publisher","first-page":"661","DOI":"10.3390\/pharmaceutics17050661","article-title":"Advancing brain targeting: cost-effective surface-modified nanoparticles for faster market entry","volume":"17","author":"Gomes","year":"2025","journal-title":"Pharmaceutics"},{"key":"2026060919231041900_ref205","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1021\/jm7009364","article-title":"Multi-target-directed ligands to combat neurodegenerative diseases","volume":"51","author":"Cavalli","year":"2008","journal-title":"J Med Chem"},{"key":"2026060919231041900_ref206","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.maturitas.2011.12.015","article-title":"Nanotechnology for neurodegenerative disorders","volume":"73","author":"Re","year":"2012","journal-title":"Maturitas"},{"key":"2026060919231041900_ref207","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1186\/s12951-024-02511-7","article-title":"Brain-targeted drug delivery-nanovesicles directed to specific brain cells by brain-targeting ligands","volume":"22","author":"Moreira","year":"2024","journal-title":"J Nanobiotechnol"},{"key":"2026060919231041900_ref208","doi-asserted-by":"publisher","first-page":"2041731419897460","DOI":"10.1177\/2041731419897460","article-title":"Targeting with nanoparticles for the therapeutic treatment of brain diseases","volume":"11","author":"Jin","year":"2020","journal-title":"J Tissue Eng"},{"key":"2026060919231041900_ref209","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.jconrel.2020.01.039","article-title":"A dual-ligand fusion peptide improves the brain-neuron targeting of nanocarriers in Alzheimer's disease mice","volume":"320","author":"Guo","year":"2020","journal-title":"J Control Release"},{"key":"2026060919231041900_ref210","doi-asserted-by":"publisher","first-page":"4","DOI":"10.3390\/jfb10010004","article-title":"Biocompatible polymer nanoparticles for drug delivery applications in cancer and neurodegenerative disorder therapies","volume":"10","author":"Calzoni","year":"2019","journal-title":"J Funct Biomater"},{"key":"2026060919231041900_ref211","doi-asserted-by":"publisher","first-page":"119981","DOI":"10.1016\/j.ijpharm.2020.119981","article-title":"Poly (ethylene glycol)-block-poly (D, L-lactide)(PEG-PLA) micelles for brain delivery of baicalein through nasal route for potential treatment of neurodegenerative diseases due to oxidative stress and inflammation: an in vitro and in vivo study","volume":"591","author":"Zhang","year":"2020","journal-title":"Int J Pharm"},{"key":"2026060919231041900_ref212","doi-asserted-by":"publisher","first-page":"e05824","DOI":"10.1016\/j.heliyon.2020.e05824","article-title":"Electrophysiological effects of polyethylene glycol modified gold nanoparticles on mouse hippocampal neurons","volume":"6","author":"Tuna","year":"2020","journal-title":"Heliyon"},{"key":"2026060919231041900_ref213","doi-asserted-by":"publisher","first-page":"2838","DOI":"10.3390\/polym17212838","article-title":"Chitosan (Nano) formulations as therapeutic tools for neurodegenerative diseases: A comprehensive review","volume":"17","author":"Gomes","year":"2025","journal-title":"Polymers"},{"key":"2026060919231041900_ref214","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/B978-0-443-13997-0.00014-X","volume-title":"Chitosan-Based Nanoparticles for Biomedical Applications","author":"Enejiyon","year":"2025"},{"key":"2026060919231041900_ref215","doi-asserted-by":"publisher","first-page":"538","DOI":"10.2174\/1389201022666210622111028","article-title":"A review on chitosan in drug delivery for treatment of neurological and psychiatric disorders","volume":"23","author":"Shayganfard","year":"2022","journal-title":"Curr Pharm Biotechnol"},{"key":"2026060919231041900_ref216","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s13346-025-01963-0","article-title":"Synthesis and characterization of chitosan-grafted-dopamine based micelles as multifunctional nanomedicines for Parkinson\u2019s disease treatment by intranasal administration","author":"Trapani","year":"2025","journal-title":"Drug Deliv Transl Res"},{"key":"2026060919231041900_ref217","doi-asserted-by":"publisher","first-page":"657","DOI":"10.3390\/pharmaceutics11120657","article-title":"Trimethyl chitosan hydrogel nanoparticles for progesterone delivery in neurodegenerative disorders","volume":"11","author":"Cardia","year":"2019","journal-title":"Pharmaceutics"},{"key":"2026060919231041900_ref218","doi-asserted-by":"publisher","first-page":"100750","DOI":"10.1016\/j.chphi.2024.100750","article-title":"Cetuximab functionalized chitosan\/hyaluronic acid-based nanoparticles loaded with cabazitaxel enhances anti-tumor efficacy in DMBA-induced breast cancer model in rats through spatial targeting","volume":"9","author":"Jha","year":"2024","journal-title":"Chem Phys Impact"},{"key":"2026060919231041900_ref219","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1021\/acsbiomaterials.4c02390","article-title":"Chitosan-functionalized fluorescent calcium carbonate nanoparticle loaded with methotrexate: future theranostics for triple negative breast cancer","volume":"11","author":"Verma","year":"2025","journal-title":"ACS Biomater Sci Eng"},{"key":"2026060919231041900_ref220","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.brainres.2008.01.039","article-title":"Poly (n-butylcyanoacrylate) nanoparticles coated with polysorbate 80 for the targeted delivery of rivastigmine into the brain to treat Alzheimer's disease","volume":"1200","author":"Wilson","year":"2008","journal-title":"Brain Res"},{"key":"2026060919231041900_ref221","first-page":"52","article-title":"Polysorbate emulsifier in drug delivery systems for cancer and neurodegenerative diseases: current status and emerging applications","volume":"4","author":"Mirzaei","year":"2025","journal-title":"Nano Micro Biosystems"},{"key":"2026060919231041900_ref222","doi-asserted-by":"publisher","first-page":"7035","DOI":"10.1007\/s00289-023-05030-x","article-title":"Development and evaluation of polysorbate-80 coated Mangiferin PLGA nanoparticles used in the treatment of cerebral ischemia","volume":"81","author":"Ahmad","year":"2024","journal-title":"Polym Bull"},{"key":"2026060919231041900_ref223","doi-asserted-by":"publisher","first-page":"1456939","DOI":"10.3389\/fnano.2024.1456939","article-title":"Recent advances in surface decoration of nanoparticles in drug delivery","volume":"6","author":"Ly","year":"2024","journal-title":"Front Nanotechnol"},{"key":"2026060919231041900_ref224","doi-asserted-by":"publisher","first-page":"671","DOI":"10.3390\/pharmaceutics11120671","article-title":"Poloxamer hydrogels for biomedical applications","volume":"11","author":"Russo","year":"2019","journal-title":"Pharmaceutics"},{"key":"2026060919231041900_ref225","doi-asserted-by":"publisher","first-page":"1572","DOI":"10.3390\/pharmaceutics17121572","article-title":"Drug-dependent enhancement of blood\u2013brain barrier permeation by Polysorbate 80 minor components","volume":"17","author":"Wang","year":"2025","journal-title":"Pharmaceutics"},{"key":"2026060919231041900_ref226","first-page":"1","article-title":"Crossing the blood\u2013brain barrier: nanoparticle-based strategies for neurodegenerative disease therapy","volume":"16","author":"Haro-Mart\u00ednez","year":"2025","journal-title":"Drug Deliv Transl Res"},{"key":"2026060919231041900_ref227","doi-asserted-by":"publisher","first-page":"19516","DOI":"10.1038\/s41598-024-69888-1","article-title":"Combination chemotherapy via poloxamer 188 surface-modified PLGA nanoparticles that traverse the blood\u2013brain\u2013barrier in a glioblastoma model","volume":"14","author":"Madani","year":"2024","journal-title":"Sci Rep"},{"key":"2026060919231041900_ref228","doi-asserted-by":"publisher","first-page":"101060","DOI":"10.1016\/j.ajps.2025.101060","article-title":"Recent advances in cell membrane-based biomimetic delivery systems for Parkinson\u2019s disease: perspectives and challenges","volume":"20","author":"Kaur","year":"2025","journal-title":"Asian J Pharm Sci"},{"key":"2026060919231041900_ref229","doi-asserted-by":"publisher","first-page":"2336","DOI":"10.3390\/molecules28052336","article-title":"Cell membrane biomimetic nanoparticles with potential in treatment of Alzheimer\u2019s disease","volume":"28","author":"Zhong","year":"2023","journal-title":"Molecules"},{"key":"2026060919231041900_ref230","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1186\/s12951-024-02548-8","article-title":"Application and advances of biomimetic membrane materials in central nervous system disorders","volume":"22","author":"Liao","year":"2024","journal-title":"J Nanobiotechnol"},{"key":"2026060919231041900_ref231","doi-asserted-by":"publisher","first-page":"2201","DOI":"10.1039\/D5BM00179J","article-title":"Biofunctionalized nanomaterials for Parkinson's disease theranostics: potential for efficient PD biomarker detection and effective therapy","volume":"13","author":"Sabnam","year":"2025","journal-title":"Biomater Sci"},{"key":"2026060919231041900_ref232","doi-asserted-by":"publisher","first-page":"e1907308","DOI":"10.1002\/smll.201907308","article-title":"Redox-responsive nanobiomaterials-based therapeutics for neurodegenerative diseases","volume":"16","author":"Eleftheriadou","year":"2020","journal-title":"Small"},{"key":"2026060919231041900_ref233","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.3390\/biomedicines13061464","article-title":"Next-generation drug delivery for Neurotherapeutics: the promise of stimuli-triggered Nanocarriers","volume":"13","author":"Boyuklieva","year":"2025","journal-title":"Biomedicines"},{"key":"2026060919231041900_ref234","doi-asserted-by":"publisher","first-page":"20502","DOI":"10.1039\/C7RA03326E","article-title":"Tyrosinase mediated oxidative functionalization in the synthesis of DOPA-derived peptidomimetics with anti-Parkinson activity","volume":"7","author":"Bizzarri","year":"2017","journal-title":"RSC Adv"},{"key":"2026060919231041900_ref235","doi-asserted-by":"publisher","first-page":"2304103","DOI":"10.1002\/adfm.202304103","article-title":"Acceptor functionalization via green chemistry enables high-performance n-type organic electrochemical transistors for biosensing, memory applications","volume":"34","author":"Wang","year":"2024","journal-title":"Adv Funct Mater"},{"key":"2026060919231041900_ref236","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.bbadis.2005.06.006","article-title":"Nanoparticle and other metal chelation therapeutics in Alzheimer disease","volume":"1741","author":"Liu","year":"2005","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"2026060919231041900_ref237","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/j.aej.2024.10.069","article-title":"A new immunofluorescence determination of Parkinson's disease biomarkers using silver nanoparticles","volume":"111","author":"Qin","year":"2025","journal-title":"Alex Eng J"},{"key":"2026060919231041900_ref238","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1007\/s12035-024-04260-y","article-title":"Novel gene therapy approaches for targeting neurodegenerative disorders: focusing on delivering neurotrophic genes","volume":"62","author":"Kumari","year":"2025","journal-title":"Mol Neurobiol"},{"key":"2026060919231041900_ref239","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/bs.pmbts.2023.12.022","article-title":"Types of RNA therapeutics","volume":"203","author":"Goleij","year":"2024","journal-title":"Prog Mol Biol Transl Sci"},{"key":"2026060919231041900_ref240","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1016\/j.jconrel.2024.12.045","article-title":"In vivo self-assembled siRNAs within small extracellular vesicles attenuate LRRK2-induced neurodegeneration in Parkinson's disease models","volume":"378","author":"Zhang","year":"2025","journal-title":"J Control Release"},{"key":"2026060919231041900_ref241","doi-asserted-by":"publisher","DOI":"10.2174\/0115672050421604251108045622","article-title":"Targeting non-coding RNAs in neurodegeneration: advances in therapeutic RNA modalities and next-gen delivery technologies","volume":"23","author":"Thakur","year":"2026","journal-title":"Curr Alzheimer Res"},{"key":"2026060919231041900_ref242","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1007\/s12033-025-01374-z","article-title":"Appraisal of CRISPR technology as an innovative screening to therapeutic toolkit for genetic disorders","volume":"68","author":"Shahid","year":"2026","journal-title":"Mol Biotechnol"},{"key":"2026060919231041900_ref243","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1097\/MS9.0000000000001500","article-title":"Application of CRISPR\/Cas9 in the management of Alzheimer\u2019s disease and Parkinson\u2019s disease: A review","volume":"86","author":"Thapar","year":"2024","journal-title":"Ann Med Surg"},{"key":"2026060919231041900_ref244","doi-asserted-by":"publisher","first-page":"7333","DOI":"10.3390\/ijms25137333","article-title":"Viral and non-viral systems to deliver gene therapeutics to clinical targets","volume":"25","author":"Taghdiri","year":"2024","journal-title":"Int J Mol Sci"},{"key":"2026060919231041900_ref245","doi-asserted-by":"publisher","first-page":"102671","DOI":"10.1016\/j.omtn.2025.102671","article-title":"Nose-to-brain siRNA delivery by PEI\/PPI-based nanoparticles reduces \u03b1-synuclein expression in a Parkinson\u2019s disease mouse model","volume":"36","author":"Feja","year":"2025","journal-title":"Mol Ther Nucleic Acids"},{"key":"2026060919231041900_ref246","doi-asserted-by":"publisher","first-page":"287","DOI":"10.3233\/JAD-2011-0007","article-title":"DTI analyses and clinical applications in Alzheimer's disease","volume":"26","author":"Oishi","year":"2011","journal-title":"J Alzheimer's Dis"},{"key":"2026060919231041900_ref247","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1124\/pr.54.3.469","article-title":"Amyloid precursor protein, presenilins, and \u03b1-synuclein: molecular pathogenesis and pharmacological applications in Alzheimer\u2019s disease","volume":"54","author":"Suh","year":"2002","journal-title":"Pharmacol Rev"},{"key":"2026060919231041900_ref248","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1039\/D4MH01256A","article-title":"Application of carbon-based nanomaterials in Alzheimer's disease","volume":"12","author":"Bai","year":"2025","journal-title":"Mater Horiz"},{"key":"2026060919231041900_ref249","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1517\/phgs.4.5.597.23795","article-title":"The application of functional genomics to Alzheimer\u2019s disease","volume":"4","author":"Cacabelos","year":"2003","journal-title":"Pharmacogenomics"},{"key":"2026060919231041900_ref250","doi-asserted-by":"publisher","first-page":"124962","DOI":"10.1016\/j.ijpharm.2024.124962","article-title":"Rabies virus-mimicking liposomes for targeted gene therapy in Alzheimer\u2019s disease","volume":"668","author":"Erel-Akbaba","year":"2025","journal-title":"Int J Pharm"},{"key":"2026060919231041900_ref251","doi-asserted-by":"publisher","first-page":"127771","DOI":"10.1016\/j.talanta.2025.127771","article-title":"Chromium-functionalized metal-organic frameworks as highly sensitive, dual-mode sensors for real time and rapid detection of dopamine","volume":"289","author":"Kumar","year":"2025","journal-title":"Talanta"},{"key":"2026060919231041900_ref252","doi-asserted-by":"publisher","first-page":"102869","DOI":"10.1016\/j.tice.2025.102869","article-title":"In vitro and in silico anti-Alzheimer study of rutin embedded with zinc chloride loaded bovine serum albumin nanoparticles","volume":"95","author":"Satpathy","year":"2025","journal-title":"Tissue Cell"},{"key":"2026060919231041900_ref253","doi-asserted-by":"publisher","first-page":"5106","DOI":"10.1021\/acsanm.2c03936","article-title":"Iron oxide nanoparticle-mediated siRNA delivery system for Huntington\u2019s disease treatment","volume":"6","author":"Rohiwal","year":"2023","journal-title":"ACS Appl Nano Mater"},{"key":"2026060919231041900_ref254","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s40035-025-00466-9","article-title":"Application of antisense oligonucleotide drugs in amyotrophic lateral sclerosis and Huntington\u2019s disease","volume":"14","author":"Ou","year":"2025","journal-title":"Transl Neurodegener"},{"key":"2026060919231041900_ref255","doi-asserted-by":"publisher","first-page":"103513","DOI":"10.1016\/j.jksus.2024.103513","article-title":"Novel drug delivery to the brain for neurodegenerative disorder treatment using carbon nanotubes","volume":"36","author":"Al-zharani","year":"2024","journal-title":"J King Saud Univ Sci"},{"key":"2026060919231041900_ref256","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1186\/1752-0509-6-63","article-title":"Network methods for describing sample relationships in genomic datasets: application to Huntington\u2019s disease","volume":"6","author":"Oldham","year":"2012","journal-title":"BMC Syst Biol"},{"key":"2026060919231041900_ref257","first-page":"1","article-title":"Huntington\u2019s disease: neurophysiological insights into molecular mechanisms, disease models, and therapeutic strategies","volume":"56","author":"Anjum","year":"2026","journal-title":"Neurophysiology"},{"key":"2026060919231041900_ref258","doi-asserted-by":"publisher","first-page":"33","DOI":"10.3390\/nano15010033","article-title":"Iron oxide nanoparticle-based T1 contrast agents for magnetic resonance imaging: A review","volume":"15","author":"Zhang","year":"2024","journal-title":"Nanomaterials"},{"key":"2026060919231041900_ref259","doi-asserted-by":"publisher","first-page":"12665","DOI":"10.1038\/s41598-024-62901-7","article-title":"Biomass-derived carbon dots as fluorescent quantum probes to visualize and modulate inflammation","volume":"14","author":"Kumar","year":"2024","journal-title":"Sci Rep"},{"key":"2026060919231041900_ref260","doi-asserted-by":"publisher","first-page":"548892","DOI":"10.2147\/IJN.S548892","article-title":"Surface-engineered precision Nano-Systems for targeted treatment of Huntington\u2019s disease: A review of recent advancements","volume":"21","author":"Zhang","year":"2026","journal-title":"Int J Nanomedicine"},{"key":"2026060919231041900_ref261","doi-asserted-by":"publisher","first-page":"106823","DOI":"10.1016\/j.phrs.2023.106823","article-title":"Chronic cholesterol administration to the brain supports complete and long-lasting cognitive and motor amelioration in Huntington\u2019s disease","volume":"194","author":"Birolini","year":"2023","journal-title":"Pharmacol Res"},{"key":"2026060919231041900_ref262","article-title":"Synthesis and characterization of fluorinated amphiphilic dendrons as vectors for gene delivery in amyotrophic lateral sclerosis","author":"BONA","year":"2018"},{"key":"2026060919231041900_ref263","doi-asserted-by":"publisher","first-page":"197","DOI":"10.12775\/JEHS.2020.10.07.021","article-title":"Nanotechnology in amyloid lateral sclerosis (ALS)-review","volume":"10","author":"Rocka","year":"2020","journal-title":"J Educ Health Sport"},{"key":"2026060919231041900_ref264","doi-asserted-by":"publisher","first-page":"1985","DOI":"10.4103\/1673-5374.308072","article-title":"Current application of neurofilaments in amyotrophic lateral sclerosis and future perspectives","volume":"16","author":"Falzone","year":"2021","journal-title":"Neural Regen Res"},{"key":"2026060919231041900_ref265","article-title":"Microglia-targeted nanovectors for tracking and shaping neuroinflammation in amyotrophic lateral sclerosis","author":"Renato","year":"2020"},{"key":"2026060919231041900_ref266","doi-asserted-by":"publisher","first-page":"1383453","DOI":"10.3389\/fmolb.2024.1383453","article-title":"Protein aggregation and therapeutic strategies in SOD1-and TDP-43-linked ALS","volume":"11","author":"Tsekrekou","year":"2024","journal-title":"Front Mol Biosci"},{"key":"2026060919231041900_ref267","doi-asserted-by":"publisher","first-page":"12252","DOI":"10.1039\/D2NJ00452F","article-title":"In vivo and in silico investigations of the pegylated gold nanoparticle treatment of amyotrophic lateral sclerosis in mice","volume":"46","author":"Vimal","year":"2022","journal-title":"New J Chem"},{"key":"2026060919231041900_ref268","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.1038\/s41565-024-01683-5","article-title":"Polystyrene nanoparticles trigger aberrant condensation of TDP-43 and amyotrophic lateral sclerosis-like symptoms","volume":"19","author":"Sun","year":"2024","journal-title":"Nat Nanotechnol"},{"key":"2026060919231041900_ref269","doi-asserted-by":"publisher","first-page":"9095","DOI":"10.3390\/ijms23169095","article-title":"NH2-functionalized magnetic nanoparticles for the N-Glycomic analysis of patients with multiple sclerosis","volume":"23","author":"Dojcs\u00e1k","year":"2022","journal-title":"Int J Mol Sci"},{"key":"2026060919231041900_ref270","doi-asserted-by":"publisher","first-page":"59","DOI":"10.17975\/sfj-2024-005","article-title":"The use of nanoparticles in the diagnosis and treatment of multiple sclerosis: A scoping review","volume":"10","author":"Takei","year":"2024","journal-title":"STEM Fellow J"},{"key":"2026060919231041900_ref271","doi-asserted-by":"publisher","first-page":"603","DOI":"10.3109\/1547691X.2016.1159264","article-title":"Application of nanomedicine for crossing the blood\u2013brain barrier: Theranostic opportunities in multiple sclerosis","volume":"13","author":"Ghalamfarsa","year":"2016","journal-title":"J Immunotoxicol"},{"key":"2026060919231041900_ref272","doi-asserted-by":"publisher","first-page":"104220","DOI":"10.1016\/j.jddst.2023.104220","article-title":"Review on theranostic and neuroprotective applications of nanotechnology in multiple sclerosis","volume":"81","author":"Sharma","year":"2023","journal-title":"J Drug Delivery Sci Technol"},{"key":"2026060919231041900_ref273","doi-asserted-by":"publisher","first-page":"eady4135","DOI":"10.1126\/sciadv.ady4135","article-title":"Nanoparticle-boosted myeloid-derived suppressor cell therapy for immune reprogramming in multiple sclerosis. Science","volume":"11","author":"Zhang","year":"2025","journal-title":"Advances"},{"key":"2026060919231041900_ref274","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1111\/j.1528-1167.2008.01615.x","article-title":"Functionalized magnetonanoparticles for MRI diagnosis and localization in epilepsy","volume":"49","author":"Akhtari","year":"2008","journal-title":"Epilepsia"},{"key":"2026060919231041900_ref275","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s42494-024-00171-6","article-title":"Advancements in the application of nanotechnology for the management of epileptic seizures","volume":"6","author":"Ping","year":"2024","journal-title":"Acta Epileptol"},{"key":"2026060919231041900_ref276","doi-asserted-by":"publisher","first-page":"143174","DOI":"10.1016\/j.ijbiomac.2025.143174","article-title":"Apolipoprotein E3 functionalized mesoporous silica nanoparticles for targeted and enhanced therapeutic efficacy of Levetiracetam in brain tumor-associated epilepsy: insights into brain uptake, biodistribution and pharmacokinetic behavior","volume":"310","author":"Athalye","year":"2025","journal-title":"Int J Biol Macromol"},{"key":"2026060919231041900_ref277","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2016\/2412958","article-title":"Value of functionalized superparamagnetic iron oxide nanoparticles in the diagnosis and treatment of acute temporal lobe epilepsy on MRI","volume":"2016","author":"Fu","year":"2016","journal-title":"Neural Plast"},{"key":"2026060919231041900_ref278","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1097\/WCO.0000000000000433","article-title":"Advances in epilepsy gene discovery and implications for epilepsy diagnosis and treatment","volume":"30","author":"Symonds","year":"2017","journal-title":"Curr Opin Neurol"},{"key":"2026060919231041900_ref279","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1007\/s12035-021-02638-w","article-title":"CRISPR-Cas9-mediated gene therapy in neurological disorders","volume":"59","author":"Guan","year":"2022","journal-title":"Mol Neurobiol"},{"key":"2026060919231041900_ref280","doi-asserted-by":"publisher","first-page":"8505","DOI":"10.1039\/D1RA00550B","article-title":"Application progress of RVG peptides to facilitate the delivery of therapeutic agents into the central nervous system","volume":"11","author":"Wang","year":"2021","journal-title":"RSC Adv"},{"key":"2026060919231041900_ref281","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1007\/978-981-97-0308-1_11","volume-title":"Nanomaterials for Drug Delivery and Neurological Diseases Management","author":"Swati","year":"2024"},{"key":"2026060919231041900_ref282","doi-asserted-by":"publisher","first-page":"6652","DOI":"10.7150\/thno.99260","article-title":"Macrophage membrane\u2013biomimetic nanoparticles target inflammatory microenvironment for epilepsy treatment","volume":"14","author":"Geng","year":"2024","journal-title":"Theranostics"},{"key":"2026060919231041900_ref283","doi-asserted-by":"publisher","first-page":"1654003","DOI":"10.3389\/fmedt.2025.1654003","article-title":"Nanoparticles: A new frontier in neurodegenerative disease therapy","volume":"7","author":"Kumar","year":"2025","journal-title":"Front Med Technol"},{"key":"2026060919231041900_ref284","doi-asserted-by":"publisher","first-page":"e2502315","DOI":"10.1002\/smll.202502315","article-title":"Nanoparticle therapeutics in clinical perspective: classification, marketed products, and regulatory landscape","volume":"21","author":"Desai","year":"2025","journal-title":"Small"},{"key":"2026060919231041900_ref285","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1186\/s12951-024-02954-y","article-title":"The role of patient-specific variables in protein corona formation and therapeutic efficacy in nanomedicine","volume":"22","author":"Cisneros","year":"2024","journal-title":"J Nanobiotechnol"},{"key":"2026060919231041900_ref286","volume-title":"Nanomedicine: Innovations, Applications, and Breakthroughs in the Quest for Health and Medicine's Future","author":"Kumar","year":"2024"},{"key":"2026060919231041900_ref287","doi-asserted-by":"publisher","first-page":"206","DOI":"10.3390\/polym16020206","article-title":"Degradable polymeric bio (nano) materials and their biomedical applications: A comprehensive overview and recent updates","volume":"16","author":"Kuperkar","year":"2024","journal-title":"Polymers"},{"key":"2026060919231041900_ref288","doi-asserted-by":"publisher","first-page":"e20982","DOI":"10.7717\/peerj.20982","article-title":"Biomaterials in personalized drug delivery: innovations, challenges, and future directions","volume":"14","author":"Hrapovi\u0107","year":"2026","journal-title":"PeerJ"},{"key":"2026060919231041900_ref289","volume-title":"Commercial Scale Production of Nanomedicines","author":"Khopade","year":"2025"}],"container-title":["Journal of Pharmacy and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/78\/6\/rgag060\/68496381\/rgag060.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/78\/6\/rgag060\/68496381\/rgag060.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T23:23:25Z","timestamp":1781047405000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jpp\/article\/doi\/10.1093\/jpp\/rgag060\/8704580"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":289,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6,2]]}},"URL":"https:\/\/doi.org\/10.1093\/jpp\/rgag060","relation":{},"ISSN":["2042-7158"],"issn-type":[{"value":"2042-7158","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,6]]},"published":{"date-parts":[[2026,6]]},"article-number":"rgag060"}}