{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T19:48:57Z","timestamp":1782762537184,"version":"3.54.5"},"reference-count":76,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Funda\u00e7\u00e3o Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We aim to evaluate the influence of A. conyzoides essential oil on uterine contractility, considering hormonal status and potential mechanisms of action.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Uterine strips from mice at different estrous stages or after ovariectomy were mounted in an organ bath, and contractile responses were evoked by potassium chloride (KCl, 80\u00a0mM) following pre-incubation with increasing concentrations of the essential oil, in the presence or absence of nifedipine, a calcium channel blocker.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key findings<\/jats:title>\n                    <jats:p>The oil significantly reduced both phasic and tonic components of KCl-induced contractions (P\u2009&amp;lt;\u2009.01), demonstrating marked relaxant activity. These effects were consistent across estrous cycle stages but were more pronounced in ovariectomized mice. Nifedipine failed to block the oil\u2019s inhibitory action, although a potentiation was observed in the tonic phase during estrus (pIC50; \u22124671 vs \u22125734; P &amp;lt; .01).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A. conyzoides essential oil modulates uterine contractility partly through calcium-independent pathways. This mechanism potentially involves broader smooth muscle signaling mechanisms. The study showcases the therapeutic potential of A. conyzoides in managing uterine hyperactivity and related reproductive disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jpp\/rgag063","type":"journal-article","created":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T11:42:53Z","timestamp":1780141373000},"source":"Crossref","is-referenced-by-count":0,"title":["Uterine relaxant effects of\n                    <i>Ageratum conyzoides<\/i>\n                    essential oil: influence of hormonal status and calcium modulation"],"prefix":"10.1093","volume":"78","author":[{"given":"Matheus","family":"Viana","sequence":"first","affiliation":[{"name":"Departamento de Ci\u00eancias Naturais, Universidade Federal de S\u00e3o Jo\u00e3o del Rei , Pra\u00e7a Dom Helv\u00e9cio, 74, S\u00e3o Jo\u00e3o del Rei, Minas Gerais CEP 36301-160 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00falia Assun\u00e7\u00e3o","family":"de Castro Oliveira","sequence":"additional","affiliation":[{"name":"Departamento de Entomologia, Escola de Ci\u00eancias Agr\u00e1rias, Universidade Federal de Lavras , Caixa Postal 3037, Lavras, Minas Gerais CEP 37200-900 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzan Kelly Vilela","family":"Bertolucci","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Fitoqu\u00edmica, Departamento de Agricultura, Universidade Federal de Lavras , Caixa Postal 3037, Lavras, Minas Gerais CEP 37200-900 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscila Totarelli","family":"Monteforte","sequence":"additional","affiliation":[{"name":"Departamento de Ci\u00eancias Naturais, Universidade Federal de S\u00e3o Jo\u00e3o del Rei , Pra\u00e7a Dom Helv\u00e9cio, 74, S\u00e3o Jo\u00e3o del Rei, Minas Gerais CEP 36301-160 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