{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T20:17:06Z","timestamp":1783628226518,"version":"3.55.0"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873055"],"award-info":[{"award-number":["81873055"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To develop a gelatin methacrylate hydrogel dressing loaded with traditional Chinese medicine active components\u2014resveratrol (RES), 18-\u03b2-glycyrrhetinic acid (GA), and berberine (BBR)\u2014for the treatment of infected wounds, aiming to enhance wound healing through their anti-inflammatory, antibacterial, and antioxidant properties.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Methacrylamidated gelatin was synthesized from gelatin and methacrylic anhydride and used to load RES, GA, and BBR. The wound-healing and anti-infective effects were evaluated in a mouse model with full-thickness dorsal skin defects. Histological evaluation was performed via hematoxylin and eosin staining to assess re-epithelialization and hair follicle regeneration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key findings<\/jats:title>\n                    <jats:p>Gelatin methacrylate hydrogel dressings loaded with RES, 18-GA, or BBR alone showed therapeutic effects in clearing infection and promoting healing. Gelatin methacrylate hydrogel dressings co-loaded with RES, GA, and BBR achieved a wound closure rate of 77.92% by Day 12. The triple-loaded dressing demonstrated higher infection clearance, more continuous epidermis, and increased hair follicle regeneration compared with single-component dressings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Gelatin methacrylate hydrogel dressings co-loaded with RES, GA, and BBR exhibit superior potential in promoting the healing of infected wounds, as evidenced by enhanced wound closure, infection clearance, and skin structure regeneration in vivo.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jpp\/rgag075","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T19:23:38Z","timestamp":1783625018000},"source":"Crossref","is-referenced-by-count":0,"title":["A GelMA hydrogel co-loaded with resveratrol, 18-\u03b2-glycyrrhetinic acid, and berberine for the combination therapy of infected wounds"],"prefix":"10.1093","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4239-7125","authenticated-orcid":false,"given":"Wenbo","family":"Ji","sequence":"first","affiliation":[{"name":"Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine , 210023 Nanjing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaxu","family":"Yang","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine , 210023 Nanjing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University , 211198 Nanjing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Song","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine , 210023 Nanjing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine , 210023 Nanjing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huixia","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University , 211198 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