{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T17:50:17Z","timestamp":1785779417564,"version":"3.56.0"},"reference-count":63,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"National Institute of Pharmaceutical Educations and Research","award":["2025-26-NPLC-NP-IPS"],"award-info":[{"award-number":["2025-26-NPLC-NP-IPS"]}]},{"name":"S.A.S. 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Neuroprotective targets were identified through the GeneCards database, followed by Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses. Network pharmacology integrated molecular docking were employed to identify key bioactive constituents and their targets. The neuroprotective activity of isolated euglobals and the enriched fraction was evaluated in vitro using the N2a neuronal cell line.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key findings<\/jats:title>\n                    <jats:p>High-Resolution Mass Spectrometry (HRMS) and 1H NMR confirmed the presence of euglobals in the enriched fraction of E. tereticornis leaves, with qNMR identifying euglobal-Ia2, euglobal BI-1, and robustadial A and B as major constituents. Network pharmacology and docking revealed the multitarget interactions involving PI3K-Akt, MAPK, mTOR, and NF-\u03baB signalling pathway. In lipopolysaccharide-stimulated N2a cells, tested compounds restored neurite outgrowth, reduced intracellular and mitochondrial reactive oxygen species, suppressed IL-1\u03b2, enhanced IL-10, and modulated NF-\u03bab\/Nrf2-HO-1-SOD signalling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Network pharmacology identified euglobals as potential neuroprotective compounds. Tested compounds exhibited significant neuroprotective effects in the N2a cell line. The integrated approach combining qNMR, network pharmacology, and in vitro validation highlights euglobals as promising neuroprotective agents.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jpp\/rgag081","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T11:29:59Z","timestamp":1783337399000},"source":"Crossref","is-referenced-by-count":0,"title":["Neuroprotective euglobals from\n                    <i>Eucalyptus tereticornis<\/i>\n                    Smith. leaves: quantification, network pharmacology-guided\n                    <i>in silico<\/i>\n                    analysis, and experimental validation"],"prefix":"10.1093","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5972-3047","authenticated-orcid":false,"given":"Indu","family":"Pathania","sequence":"first","affiliation":[{"name":"Department of Natural Products, National Institute of Pharmaceutical Education and Research , S.A.S. Nagar, Punjab 160062 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akash Kumar","family":"Mourya","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research , S.A.S. Nagar, Punjab 160062 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditya","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research , S.A.S. Nagar, Punjab 160062 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6659-4751","authenticated-orcid":false,"given":"Ashutosh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research , S.A.S. 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