{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T13:04:15Z","timestamp":1785330255981,"version":"3.55.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The cardioprotective potential of Hymenaea rubriflora Ducke\u2019s stem bark hydroalcoholic extract (HR-HAc) has not yet been investigated. This study aimed to quantify HR-HAc\u2019s antioxidant capacity and evaluate its effects on blood pressure (BP) and vascular reactivity in spontaneously hypertensive rats (SHR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>SHR and normotensive Wistar Kyoto (WKY) rats received intravenous HR-HAc (2.5\u201360\u00a0mg\/kg). Mean arterial pressure (MAP) and heart rate (HR) were measured with or without atropine and propranolol. Isolated aortas from SHR and WKY rats were exposed to HR-HAc (0.1\u2013729\u00a0\u03bcg\/ml), with or without endothelium and K+ channel blockers. Phenolic content and antioxidant activity were quantified using standard colorimetric and chromatographic methods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key findings<\/jats:title>\n                    <jats:p>In SHR rats, HR-HAc produced dose-dependent hypotension and bradycardia. MAP reduction in WKY rats was similar, while HR was unaffected. Atropine significantly attenuated HR-HAc-induced reductions in MAP and HR in SHR rats. HR-HAc induced potent endothelium-independent relaxation in SHR rat aortas, which was significantly reduced by tetraethylammonium or 4-aminopyridine. In WKY rats, vasorelaxant effects were endothelium-dependent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HR-HAc lowers MAP and induces bradycardia in SHR via muscarinic receptors, while also promoting vasodilation through activation of voltage- and calcium-activated K+ channels. These distinct mechanisms highlight HR-HAc as a promising preclinical antihypertensive candidate.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jpp\/rgag082","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T11:45:43Z","timestamp":1783424743000},"source":"Crossref","is-referenced-by-count":0,"title":["Acute intravenous antihypertensive and\n                    <i>in vitro<\/i>\n                    vasorelaxant effect of the hydroalcoholic stem bark extract of\n                    <i>Hymenaea rubriflora<\/i>\n                    Ducke in spontaneously hypertensive rats"],"prefix":"10.1093","volume":"78","author":[{"given":"Luciana Tavares","family":"Toscano","sequence":"first","affiliation":[{"name":"Graduate Program in Science Nutrition, Federal University of Paraiba , Jo\u00e3o Pessoa, Para\u00edba ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milton 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