{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T18:23:57Z","timestamp":1787682237159,"version":"build-2784847793"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Northern Border University, Saudi Arabia","award":["NBU-FFR-2026-2510-13"],"award-info":[{"award-number":["NBU-FFR-2026-2510-13"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>With advancing age, individuals experience a decline in liver function, an increase in oxidative stress, and diminished mitochondrial efficiency. This research examined the protective effects of curcumin (CUR), in both free and nanoliposomal (CUR-LNP) forms, against D-galactose (D-gal)\u2013induced liver aging in male Wistar rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Rats were assigned to six groups: control, CUR, CUR-LNPs, D-gal, D-gal+CUR, and D-gal+CUR-LNPs. CUR and CUR-LNPs (40\u00a0mg\/kg) and D-gal (150\u00a0mg\/kg) were administered orally for 10\u00a0weeks. Liver function, lipid profile, oxidative stress (GSH, CAT, SOD, and NRF2\/HO-1), mitochondrial function (ATP and respiratory complexes), inflammation (NF-\u03baB, TNF-\u03b1, IL-1\u03b2, IL-6, and iNOS), and apoptosis (caspases, Bax\/Bcl-2) were assessed. Histological and ultrastructural analyses were also performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key findings<\/jats:title>\n                    <jats:p>D-gal induced hepatic injury, oxidative stress, mitochondrial dysfunction, inflammation, and apoptosis. CUR partially attenuated these alterations, whereas CUR-LNPs produced greater protection by restoring liver enzymes and lipid homeostasis, enhancing antioxidant and mitochondrial functions, suppressing NF-\u03baB signaling and inflammatory mediators, and reducing apoptotic markers. Histological and ultrastructural analyses confirmed preserved hepatocyte and mitochondrial architecture.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CUR, especially in its nanoliposomal form, exerts potent hepatoprotective, antioxidant, anti-inflammatory, and anti-apoptotic effects against D-gal\u2013induced liver aging, supporting its potential as a therapeutic strategy for age-related hepatic dysfunction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jpp\/rgag087","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T11:51:58Z","timestamp":1785498718000},"source":"Crossref","is-referenced-by-count":0,"title":["Nanoliposomal curcumin protects against D-galactose\u2013induced hepatic aging by targeting oxidative stress, mitochondrial dysfunction, and inflammatory signaling"],"prefix":"10.1093","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7444-2499","authenticated-orcid":false,"given":"Ekramy M","family":"Elmorsy","sequence":"first","affiliation":[{"name":"Center for Health Research, Northern Border University , P.O. Box 1321, Arar 91431 ,","place":["Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayat B","family":"Al-Ghafari","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Science, King Abdulaziz University , Jeddah 21589 ,","place":["Saudi Arabia"]},{"name":"Experimental Biochemistry Unit, King Fahd Medical Research Center, King Abdulaziz University , Jeddah 21589 ,","place":["Saudi Arabia"]},{"name":"Editome: Precision Gene Editing Unit, King Fahd Medical Research Center, King Abdulaziz University , Jeddah 21589 ,","place":["Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huda A","family":"Al Doghaither","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Science, King Abdulaziz University , Jeddah 21589 ,","place":["Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Sajid Hussain","family":"Shah","sequence":"additional","affiliation":[{"name":"Pathology Department, Faculty of Medicine, Northern Border University , P.O. Box 1321, Arar 91431 ,","place":["Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asmara","family":"Syed","sequence":"additional","affiliation":[{"name":"Pathology Department, Faculty of Medicine, Northern Border University , P.O. Box 1321, Arar 91431 ,","place":["Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Jan","sequence":"additional","affiliation":[{"name":"Pharmacology Department, Faculty of Medicine, Northern Border University , P.O. 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