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Although anti-obesity effects have been suggested, the bioactive constituents and underlying mechanisms remain poorly understood. Thus, we aimed to identify the key bioactive components responsible for the anti-obesity effects of MIX8 and elucidate the underlying mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Modified MIX8 formulations lacking processed aconite root (PAR) (MIX7) or PAR and cinnamon (MIX6) were administered to diet-induced obese C57BL\/6J mice. Body weight, fat mass, insulin sensitivity, hepatic lipid accumulation, and circulating leptin levels were evaluated. To assess the underlying mechanisms, a leptin challenge test was conducted following cinnamon extract administration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key findings<\/jats:title>\n                    <jats:p>MIX7 suppressed weight gain, adipocyte hypertrophy, systemic insulin resistance, hepatic steatosis, and hyperleptinemia. MIX6 failed to suppress weight gain, implicating cinnamon as having anti-obesity activity. Cinnamon extract enhanced the acute anorexigenic response to leptin and restored hypothalamic leptin signalling, indicating the reversal of central leptin resistance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Cinnamon is an essential component of MIX8 that mediates its anti-obesity effects by restoring central leptin sensitivity. The present study provides mechanistic insights into the pharmacological basis of MIX8, supporting the preventive potential of cinnamon in managing diet-induced obesity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jpp\/rgag090","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T11:12:34Z","timestamp":1785323554000},"source":"Crossref","is-referenced-by-count":0,"title":["Cinnamon plays a key role in the anti-obesity action of Hachimijiogan by ameliorating leptin resistance in the hypothalamus"],"prefix":"10.1093","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4500-3531","authenticated-orcid":false,"given":"Syota","family":"Kagawa","sequence":"first","affiliation":[{"name":"Department of Natural Products Chemistry, Daiichi University of Pharmacy , 22-1 Tamagawa-machi, Minami-ku, Fukuoka 815-8511 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