{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T18:24:38Z","timestamp":1787682278203,"version":"build-2784847793"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To develop a marker-standardized Melastoma malabathricum leaf extract\u2013poly(lactic-co-glycolic acid) (PLGA) nanocurcumin hydrogel and test whether Chou-Talalay-guided ratio selection improves diabetic wound repair.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The extract was standardized using phenolic and flavonoid indices, high-performance liquid chromatography with diode-array detection fingerprinting, and quantification of gallic acid and quercetin. PLGA nanocurcumin was qualified for particle size, surface charge, encapsulation, and release. Cytocompatibility, migration, inflammatory responses, reactive oxygen species-related redox responses, and fixed\u2013ratio interactions were assessed in keratinocytes, macrophages, and fibroblasts. The Chou-Talalay-selected ratio was incorporated into a Carbopol hydrogel and tested in splinted diabetic excisional wounds in mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key findings<\/jats:title>\n                    <jats:p>Both components met predefined quality criteria. The 1:1 equipotent ratio showed consistent synergy and was formulated at 2.0\u00a0mg extract plus 0.2\u00a0mg curcumin-equivalent PLGA nanocurcumin per 0.1\u00a0g gel. The hydrogel showed acceptable quality, release, retention, and 30-day stability. It improved Day 14 wound closure compared with vehicle, from 56\u2009\u00b1\u20098% to 90\u2009\u00b1\u20092%, with greater histological repair, collagen maturation, and hydroxyproline content. Supportive tissue markers indicated lower inflammation, improved redox balance, repair-associated macrophage marker shifts, angiogenesis, and matrix remodelling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This ratio-defined, marker-standardized extract\u2013PLGA nanocurcumin hydrogel improved diabetic wound repair and provides a quality-controlled, quantitatively optimized topical platform for further preclinical development.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jpp\/rgag092","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T11:45:17Z","timestamp":1785843917000},"source":"Crossref","is-referenced-by-count":0,"title":["A marker-standardized\n                    <i>Melastoma malabathricum<\/i>\n                    leaf extract\u2013poly(lactic-\n                    <i>co<\/i>\n                    -glycolic acid) nanocurcumin hydrogel improves repair in splinted diabetic wounds in mice"],"prefix":"10.1093","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5733-8545","authenticated-orcid":false,"given":"Thi Phuong Nhung","family":"Tran","sequence":"first","affiliation":[{"name":"Institute of Biotechnology and Food Technology, Industrial University of Ho Chi Minh City , 12 Nguyen Van Bao, Hanh Thong Ward, Ho Chi Minh City 700000 ,","place":["Vietnam"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Quan","family":"Bui","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology and Food Technology, Industrial University of Ho Chi Minh City , 12 Nguyen Van Bao, Hanh Thong Ward, Ho Chi Minh City 700000 ,","place":["Vietnam"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thi Truc Ly","family":"Le","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology and Food Technology, Industrial University of Ho Chi Minh City , 12 Nguyen Van Bao, Hanh Thong Ward, Ho Chi Minh City 700000 ,","place":["Vietnam"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoa Hong Chau","family":"Truong","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology and Food Technology, Industrial University of Ho Chi Minh City , 12 Nguyen Van Bao, Hanh Thong Ward, Ho Chi Minh City 700000 ,","place":["Vietnam"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,25]]},"reference":[{"key":"2026082513490974100_ref1","doi-asserted-by":"publisher","first-page":"e70406","DOI":"10.1002\/mco2.70406","article-title":"Diabetic wound repair: from mechanism to therapeutic opportunities","volume":"6","author":"Wang","journal-title":"MedComm (2020)"},{"key":"2026082513490974100_ref2","doi-asserted-by":"publisher","first-page":"tkae052","DOI":"10.1093\/burnst\/tkae052","article-title":"Angiogenesis during diabetic wound repair: from mechanism to therapy opportunity","volume":"13","author":"Huang","year":"2025","journal-title":"Burns Trauma"},{"key":"2026082513490974100_ref3","doi-asserted-by":"publisher","first-page":"6007","DOI":"10.2147\/IJN.S386585","article-title":"A comprehensive review of the application of nanoparticles in diabetic wound healing: therapeutic potential and future perspectives","volume":"17","author":"Qin","year":"2022","journal-title":"Int J Nanomedicine"},{"key":"2026082513490974100_ref4","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.35378\/gujs.1625271","article-title":"Therapeutic potential of Citrus hystrix DC. 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