{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:33:47Z","timestamp":1787772827813,"version":"build-2784847793"},"reference-count":200,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The Citrus genus has considerable ethnopharmacological significance, as it is used globally for its flavouring and nutritional properties. This genus has substantially influenced traditional medicinal practices globally. To provide a detailed summary of recent findings about citrus and citrus-derived phytocompounds and their modes of action in the treatment of metabolic diseases, including fatty liver and type II diabetes (T2DM), by modulating essential cellular and molecular pathways.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This review was conducted using scientific databases to identify recent studies on the pharmacological actions of citrus and citrus-derived phytochemicals, along with their mechanistic insights into oxidative stress, inflammation, insulin signalling, de novo lipogenesis (DNL), and organ-specific effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key findings<\/jats:title>\n                    <jats:p>Citrus phytochemicals include flavonoids, glycosides, and polyphenols. These bioactives regulate complex signalling pathways, including oxidative, apoptotic, insulin receptor, inflammatory, and lipogenic pathways. These phytocompounds have shown the ability to diminish oxidative stress, enhance insulin sensitivity, impede fat formation, and mitigate inflammation in target organs including the liver, adipose tissue, and pancreas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Citrus-derived phytochemicals offer promising therapeutic potential for managing metabolic disorders such as fatty liver and T2DM by targeting multiple pathogenic mechanisms. This will provide a scientific foundation for their incorporation into functional food development and ethnopharmacological applications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jpp\/rgag094","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T11:52:39Z","timestamp":1785930759000},"source":"Crossref","is-referenced-by-count":0,"title":["Intervention effects and underlying mechanisms of bioactive components from\n                    <i>Citrus<\/i>\n                    species on type 2 diabetes and fatty liver diseases: a mechanistic review"],"prefix":"10.1093","volume":"78","author":[{"given":"Arnab","family":"Sarkar","sequence":"first","affiliation":[{"name":"Bioequivalence Study Centre, Department of Pharmaceutical Technology, Jadavpur University , Kolkata, West Bengal 700032 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanmoy","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Bioequivalence Study Centre, Department of Pharmaceutical Technology, Jadavpur University , Kolkata, West Bengal 700032 ,","place":["India"]},{"name":"Molecular Pharmacology Research Laboratory, Department of Pharmaceutical Technology, Jadavpur University , Kolkata, West Bengal 700032 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akash","family":"De","sequence":"additional","affiliation":[{"name":"Bioequivalence Study Centre, Department of Pharmaceutical Technology, Jadavpur University , Kolkata, West Bengal 700032 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhik","family":"Paul","sequence":"additional","affiliation":[{"name":"Department of Health and Family Welfare, Directorate of Health Services, Government of West Bengal , Kolkata, West Bengal 700091 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudranil","family":"Bhowmik","sequence":"additional","affiliation":[{"name":"Bioequivalence Study Centre, Department of Pharmaceutical Technology, Jadavpur University , Kolkata, West Bengal 700032 ,","place":["India"]},{"name":"School of Pharmacy, Sister Nivedita University , DG Block, Action Area I, 1\/2, Newtown, Kolkata, West Bengal 700156 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilanjan","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Molecular Pharmacology Research Laboratory, Department of Pharmaceutical Technology, Jadavpur University , Kolkata, West Bengal 700032 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saikat","family":"Dewanjee","sequence":"additional","affiliation":[{"name":"Advanced Pharmacognosy Research Laboratory, Department of Pharmaceutical Technology, Jadavpur University , Kolkata, West Bengal 700032 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2148-2331","authenticated-orcid":false,"given":"Asis","family":"Bala","sequence":"additional","affiliation":[{"name":"Division of Life Sciences, Institute of Advanced Study in Science and Technology (IASST) , Guwahati, Assam 781035 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2162-5061","authenticated-orcid":false,"given":"Sanmoy","family":"Karmakar","sequence":"additional","affiliation":[{"name":"Bioequivalence Study Centre, Department of Pharmaceutical Technology, Jadavpur University , Kolkata, West Bengal 700032 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"key":"2026082615135019800_ref1","doi-asserted-by":"publisher","first-page":"1382","DOI":"10.1002\/hep.32743","article-title":"Health disparities in chronic liver disease","volume":"77","author":"Kardashian","year":"2023","journal-title":"Hepatology"},{"key":"2026082615135019800_ref2","doi-asserted-by":"publisher","first-page":"101833","DOI":"10.1016\/j.arr.2022.101833","article-title":"Emerging role of aging in the progression of NAFLD to HCC","volume":"84","author":"He","year":"2023","journal-title":"Ageing Res Rev"},{"key":"2026082615135019800_ref3","volume-title":"Diabetes"},{"key":"2026082615135019800_ref4","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.phrs.2017.12.020","article-title":"Medicinal plants and bioactive natural compounds in the treatment of non-alcoholic fatty liver disease: a clinical review","volume":"130","author":"Bagherniya","year":"2018","journal-title":"Pharmacol Res"},{"key":"2026082615135019800_ref5","doi-asserted-by":"publisher","first-page":"113888","DOI":"10.1016\/j.addr.2021.113888","article-title":"Therapeutic targets, novel drugs, and delivery systems for diabetes associated NAFLD and liver fibrosis","volume":"176","author":"Kumar","year":"2021","journal-title":"Adv Drug Deliv Rev"},{"key":"2026082615135019800_ref6","doi-asserted-by":"publisher","first-page":"104213","DOI":"10.1016\/j.jff.2020.104213","article-title":"Limonoids from citrus: chemistry, anti-tumor potential, and other bioactivities","volume":"75","author":"Shi","year":"2020","journal-title":"J Funct Foods"},{"key":"2026082615135019800_ref7","doi-asserted-by":"publisher","first-page":"420","DOI":"10.3389\/fphar.2017.00420","article-title":"Anticancer potential of citrus juices and their extracts: a systematic review of both preclinical and clinical studies","volume":"8","author":"Cirmi","year":"2017","journal-title":"Front Pharmacol"},{"key":"2026082615135019800_ref8","doi-asserted-by":"publisher","first-page":"882","DOI":"10.4239\/wjd.v5.i6.882","article-title":"Diagnosis of hepatic glycogenosis in poorly controlled type 1 diabetes mellitus","volume":"5","author":"Giordano","year":"2014","journal-title":"WJD"},{"key":"2026082615135019800_ref9","doi-asserted-by":"publisher","first-page":"1552171","DOI":"10.3389\/fphar.2025.1552171","article-title":"Bioactive flavonoids metabolites in citrus species: their potential health benefits and medical potentials","volume":"16","author":"Xu","year":"2025","journal-title":"Front Pharmacol"},{"key":"2026082615135019800_ref10","doi-asserted-by":"publisher","first-page":"102884","DOI":"10.1016\/j.dsx.2023.102884","article-title":"A systematic review exploring the mechanisms by which citrus bioflavonoid supplementation benefits blood glucose levels and metabolic complications in type 2 diabetes mellitus","volume":"17","author":"Gupta","year":"2023","journal-title":"Diabetes & Metabolic Syndrome: Clinical Research & Reviews"},{"key":"2026082615135019800_ref11","doi-asserted-by":"publisher","first-page":"239","DOI":"10.3390\/antiox11020239","article-title":"Bioactive compounds of citrus fruits: a review of composition and health benefits of carotenoids, flavonoids, limonoids, and terpenes","volume":"11","author":"Saini","year":"2022","journal-title":"Antioxidants"},{"key":"2026082615135019800_ref12","doi-asserted-by":"publisher","first-page":"968604","DOI":"10.3389\/fnut.2022.968604","article-title":"Review of phytochemical and nutritional characteristics and food applications of citrus L. fruits","volume":"9","author":"Liu","year":"2022","journal-title":"Front Nutr"},{"key":"2026082615135019800_ref13","doi-asserted-by":"publisher","first-page":"2178","DOI":"10.1080\/10408398.2021.1971945","article-title":"Citrus polyphenols and risk of type 2 diabetes: evidence from mechanistic studies","volume":"63","author":"Visvanathan","year":"2023","journal-title":"Crit Rev Food Sci Nutr"},{"key":"2026082615135019800_ref14","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1002\/ptr.7261","article-title":"Citrus flavonoids as potential therapeutic agents: a review","volume":"36","author":"Alam","year":"2022","journal-title":"Phytother Res"},{"key":"2026082615135019800_ref15","doi-asserted-by":"publisher","first-page":"2907","DOI":"10.3390\/nu12102907","article-title":"Citrus flavonoids as promising phytochemicals targeting diabetes and related complications: a systematic review of In vitro and In vivo studies","volume":"12","author":"Gandhi","year":"2020","journal-title":"Nutrients"},{"key":"2026082615135019800_ref16","doi-asserted-by":"publisher","first-page":"421","DOI":"10.4103\/ijem.IJEM_585_17","article-title":"Nonalcoholic fatty liver disease and type 2 diabetes mellitus","volume":"22","author":"Dharmalingam","year":"2018","journal-title":"Indian J Endocr Metab"},{"key":"2026082615135019800_ref17","doi-asserted-by":"publisher","first-page":"382","DOI":"10.4093\/dmj.2020.0010","article-title":"Non-alcoholic fatty liver disease in patients with type 2 diabetes mellitus: a position statement of the fatty liver research Group of the Korean Diabetes Association","volume":"44","author":"Lee","year":"2020","journal-title":"Diabetes Metab J"},{"key":"2026082615135019800_ref18","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/j.jhepr.2019.07.002","article-title":"From NASH to diabetes and from diabetes to NASH: mechanisms and treatment options","volume":"1","author":"Gastaldelli","year":"2019","journal-title":"JHEP Reports"},{"key":"2026082615135019800_ref19","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1016\/j.amepre.2023.11.021","article-title":"Changes in fatty liver disease and incident diabetes mellitus in young Korean adults","volume":"66","author":"Park","year":"2024","journal-title":"Am J Prev Med"},{"key":"2026082615135019800_ref20","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1007\/s12664-010-0069-1","article-title":"Nonalcoholic fatty liver disease in India \u2013 a lot done, yet more required!","volume":"29","author":"Duseja","year":"2010","journal-title":"Indian J Gastroenterol"},{"key":"2026082615135019800_ref21","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.jceh.2022.11.014","article-title":"Indian National Association for study of the liver (INASL) guidance paper on nomenclature, diagnosis and treatment of nonalcoholic fatty liver disease (NAFLD)","volume":"13","author":"Duseja","year":"2023","journal-title":"J Clin Exp Hepatol"},{"key":"2026082615135019800_ref22","doi-asserted-by":"publisher","first-page":"2636","DOI":"10.3390\/ijms23052636","article-title":"Synergistic and detrimental effects of alcohol intake on progression of liver steatosis","volume":"23","author":"Di Ciaula","year":"2022","journal-title":"IJMS"},{"key":"2026082615135019800_ref23","doi-asserted-by":"publisher","first-page":"109119","DOI":"10.1016\/j.diabres.2021.109119","article-title":"IDF diabetes atlas: global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045","volume":"183","author":"Sun","year":"2022","journal-title":"Diabetes Res Clin Pract"},{"key":"2026082615135019800_ref24","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/S0140-6736(23)01301-6","article-title":"Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the global burden of disease study 2021","volume":"402","author":"Ong","year":"2023","journal-title":"Lancet"},{"key":"2026082615135019800_ref25","doi-asserted-by":"publisher","first-page":"6275","DOI":"10.3390\/ijms21176275","article-title":"Pathophysiology of type 2 diabetes mellitus","volume":"21","author":"Galicia-Garcia","year":"2020","journal-title":"IJMS"},{"key":"2026082615135019800_ref26","doi-asserted-by":"publisher","first-page":"382","DOI":"10.5083\/ejcm\/25-01-62","article-title":"Systematic review: risk factors for developing type 2 diabetes mellitus","volume":"15","author":"Samant","year":"2025","journal-title":"European Journal of Cardiovascular Medicine"},{"key":"2026082615135019800_ref27","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.livres.2022.05.002","article-title":"Non-alcoholic fatty liver disease development: a multifactorial pathogenic phenomena","volume":"6","author":"Bashir","year":"2022","journal-title":"Liver Research"},{"key":"2026082615135019800_ref28","volume-title":"StatPearls","author":"Sharma","year":"2025"},{"key":"2026082615135019800_ref29","doi-asserted-by":"publisher","first-page":"884","DOI":"10.5114\/aoms\/150639","article-title":"Non-alcoholic fatty liver disease, metabolic syndrome, and type 2 diabetes mellitus: where do we stand today?","volume":"19","author":"Mitrovic","year":"2022","journal-title":"Arch Med Sci"},{"key":"2026082615135019800_ref30","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1002\/hep.28431","article-title":"Global epidemiology of nonalcoholic fatty liver disease\u2014Meta-analytic assessment of prevalence, incidence, and outcomes","volume":"64","author":"Younossi","year":"2016","journal-title":"Hepatology"},{"key":"2026082615135019800_ref31","doi-asserted-by":"publisher","first-page":"2537","DOI":"10.1016\/j.cell.2021.04.015","article-title":"Mechanisms and disease consequences of nonalcoholic fatty liver disease","volume":"184","author":"Loomba","year":"2021","journal-title":"Cell"},{"key":"2026082615135019800_ref32","doi-asserted-by":"publisher","first-page":"S286","DOI":"10.3350\/cmh.2022.0392","article-title":"Liver transplantation for non-alcoholic fatty liver disease: indications and post-transplant management","volume":"29","author":"Battistella","year":"2023","journal-title":"Clin Mol Hepatol"},{"key":"2026082615135019800_ref33","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.jceh.2022.09.001","article-title":"Epidemiology and disease burden of alcohol associated liver disease","volume":"13","author":"Aslam","year":"2023","journal-title":"J Clin Exp Hepatol"},{"key":"2026082615135019800_ref34","volume-title":"Alcohol"},{"key":"2026082615135019800_ref35","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1097\/HEP.0000000000000899","article-title":"Alcohol-associated liver disease\u2014global epidemiology","volume":"80","author":"\u00c5berg","year":"2024","journal-title":"Hepatology"},{"key":"2026082615135019800_ref36","doi-asserted-by":"publisher","first-page":"44","DOI":"10.2174\/1381612825666191127115601","article-title":"Citrus species: a review of traditional uses, phytochemistry and pharmacology","volume":"26","author":"Zibaee","year":"2020","journal-title":"CPD"},{"key":"2026082615135019800_ref37","doi-asserted-by":"publisher","DOI":"10.54085\/ap.2023.12.2.19","article-title":"Ethnopharmacological relevance of Citrus Limon (L.) Burm. f. as adjuvant therapy","volume":"12","author":"Khan","year":"2023","journal-title":"ap"},{"key":"2026082615135019800_ref38","doi-asserted-by":"publisher","first-page":"104681","DOI":"10.1016\/j.arabjc.2023.104681","article-title":"The young fruit of Citrus aurantium L. or Citrus sinensis Osbeck as a natural health food: a deep insight into the scientific evidence of its health benefits","volume":"16","author":"Luo","year":"2023","journal-title":"Arab J Chem"},{"key":"2026082615135019800_ref39","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.jep.2018.03.031","article-title":"Citri Reticulatae Pericarpium (Chenpi): botany, ethnopharmacology, phytochemistry, and pharmacology of a frequently used traditional Chinese medicine","volume":"220","author":"Yu","year":"2018","journal-title":"J Ethnopharmacol"},{"key":"2026082615135019800_ref40","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.5713\/ajas.2013.13629","article-title":"Investigation on antibacterial and antioxidant activities, phenolic and flavonoid contents of some Thai edible plants as an alternative for antibiotics","volume":"27","author":"Lee","year":"2014","journal-title":"Asian Australas J Anim Sci"},{"key":"2026082615135019800_ref41","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.jep.2005.04.028","article-title":"Traditional pharmacopoeias and medicines among Albanians and Italians in southern Italy: a comparison","volume":"101","author":"Pieroni","year":"2005","journal-title":"J Ethnopharmacol"},{"key":"2026082615135019800_ref42","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/1746-4269-2-45","article-title":"Ethnomedicines used in Trinidad and Tobago for urinary problems and diabetes mellitus","volume":"2","author":"Lans","year":"2006","journal-title":"J Ethnobiology Ethnomedicine"},{"key":"2026082615135019800_ref43","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.1002\/pca.3056","article-title":"Simultaneous quantitative analysis of ten bioactive flavonoids in Citri Reticulatae Pericarpium Viride (Qing pi) by ultrahigh-performance liquid chromatography and high-resolution mass spectrometry combined with chemometric methods","volume":"32","author":"He","year":"2021","journal-title":"Phytochem Anal"},{"key":"2026082615135019800_ref44","doi-asserted-by":"publisher","first-page":"751671","DOI":"10.1155\/2011\/751671","article-title":"Different influences on tacrolimus pharmacokinetics by coadministrations of Zhi Ke and Zhi Shi in rats","volume":"2011","author":"Lin","year":"2011","journal-title":"Evid Based Complement Alternat Med"},{"key":"2026082615135019800_ref45","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1007\/978-3-030-57408-6_59","volume-title":"Ethnobotany of the Himalayas","author":"RGyawali","year":"2021"},{"key":"2026082615135019800_ref46","article-title":"Varieties in Shankha Vati - An ayurvedic classical formulation for GIT disorders","volume":"1","author":"Kodlady","year":"2012","journal-title":"Annals of Ayurvedic Medicine"},{"key":"2026082615135019800_ref47","doi-asserted-by":"publisher","first-page":"230","DOI":"10.21760\/jaims.8.6.35","article-title":"A review on Gandhak Vati\u00a0: An ayurvedic formulation in patients of Agnimandya and Ajeerna","volume":"8","author":"Mal","year":"2023","journal-title":"Journal of Ayurveda and Integrated Medical Sciences"},{"key":"2026082615135019800_ref48","volume-title":"Materia Medica of Ayurveda","author":"Dash","year":"1980"},{"key":"2026082615135019800_ref49","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1515\/jcim-2020-0124","article-title":"Understanding Humma-e-Wabai (epidemic fever) and Amraz-e-Wabai (epidemic disease) in the light of Unani medicine","volume":"18","author":"Alam","year":"2021","journal-title":"Journal of Complementary and Integrative Medicine"},{"key":"2026082615135019800_ref50","doi-asserted-by":"publisher","first-page":"1653","DOI":"10.1211\/0022357011778052","article-title":"Ethnopharmacology of the Popoluca, Mexico: An evaluation","volume":"53","author":"Leonti","year":"2001","journal-title":"J Pharm Pharmacol"},{"key":"2026082615135019800_ref51","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s40816-020-00166-z","article-title":"Ethnopharmacological review of medicinal plants used to manage diabetes in Morocco","volume":"6","author":"Idm\u2019hand","year":"2020","journal-title":"Clin Phytoscience"},{"key":"2026082615135019800_ref52","first-page":"390","article-title":"An overview of Citrus aurantium used in treatment of various diseases","volume":"5","author":"Suryawanshi","year":"2011","journal-title":"African J Plant Sci"},{"key":"2026082615135019800_ref53","doi-asserted-by":"publisher","first-page":"e29721","DOI":"10.1016\/j.heliyon.2024.e29721","article-title":"Ethnobotany and diversity of citrus spp. (Rutaceae) as a source of \u201cKem-Kem\u201d traditional medicine used among the karo sub-ethnic in North Sumatra, Indonesia","volume":"10","author":"Rahayu","year":"2024","journal-title":"Heliyon"},{"key":"2026082615135019800_ref54","doi-asserted-by":"publisher","first-page":"115502","DOI":"10.1016\/j.biopha.2023.115502","article-title":"Pathophysiology of diabetic hepatopathy and molecular mechanisms underlying the hepatoprotective effects of phytochemicals","volume":"167","author":"Mobasheri","year":"2023","journal-title":"Biomed Pharmacother"},{"key":"2026082615135019800_ref55","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1186\/1471-2431-12-160","article-title":"Prevalence of hepatopathy in type 1 diabetic children","volume":"12","author":"Al-Hussaini","year":"2012","journal-title":"BMC Pediatr"},{"key":"2026082615135019800_ref56","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1055\/a-2277-4805","article-title":"Bioprotective role of phytocompounds against the pathogenesis of non-alcoholic fatty liver disease to non-alcoholic steatohepatitis: unravelling underlying molecular mechanisms","volume":"90","author":"Banerjee","year":"2024","journal-title":"Planta Med"},{"key":"2026082615135019800_ref57","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1007\/978-981-99-7703-1_10","volume-title":"Role of Herbal Medicines","author":"Banerjee","year":"2023"},{"key":"2026082615135019800_ref58","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s43556-026-00408-5","article-title":"Insulin resistance: mechanisms and therapeutic interventions","volume":"7","author":"Yu","year":"2026","journal-title":"Mol Biomed"},{"key":"2026082615135019800_ref59","doi-asserted-by":"publisher","first-page":"2147","DOI":"10.1038\/s12276-023-01101-1","article-title":"A stepwise activation model for the insulin receptor","volume":"55","author":"Yunn","year":"2023","journal-title":"Exp Mol Med"},{"key":"2026082615135019800_ref60","doi-asserted-by":"publisher","first-page":"1613844","DOI":"10.3389\/fphar.2025.1613844","article-title":"MicroRNA: unveiling novel mechanistic and theranostic pathways in diabetic cardiomyopathy","volume":"16","author":"De","year":"2025","journal-title":"Front Pharmacol"},{"key":"2026082615135019800_ref61","doi-asserted-by":"publisher","first-page":"447","DOI":"10.2741\/4218","article-title":"AMPK: a cellular metabolic and redox sensor. A minireview","volume":"19","author":"Shirwany","year":"2014","journal-title":"Front Biosci"},{"key":"2026082615135019800_ref62","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.ebiom.2018.01.008","article-title":"AMPK Re-activation suppresses hepatic steatosis but its downregulation does not promote fatty liver development","volume":"28","author":"Boudaba","year":"2018","journal-title":"EBioMedicine"},{"key":"2026082615135019800_ref63","doi-asserted-by":"publisher","first-page":"1928","DOI":"10.3390\/antiox12111928","article-title":"The roles of NFR2-regulated oxidative stress and mitochondrial quality control in chronic liver diseases","volume":"12","author":"Park","year":"2023","journal-title":"Antioxidants"},{"key":"2026082615135019800_ref64","doi-asserted-by":"publisher","first-page":"100019","DOI":"10.1016\/j.dscb.2021.100019","article-title":"Targeting Nrf2\/HO-1 anti-oxidant signaling pathway in the progression of multiple sclerosis and influences on neurological dysfunctions","volume":"3","author":"Upadhayay","year":"2021","journal-title":"Brain Disorders"},{"key":"2026082615135019800_ref65","doi-asserted-by":"publisher","first-page":"710","DOI":"10.3390\/antiox15060710","article-title":"The pathophysiological interrelationship between metabolic dysfunction-associated Steatotic liver disease and cardiovascular disease","volume":"15","author":"G\u00e1l","year":"2026","journal-title":"Antioxidants"},{"key":"2026082615135019800_ref66","doi-asserted-by":"publisher","first-page":"102849","DOI":"10.1016\/j.jics.2026.102849","article-title":"Decoding mechanisms of phytocompounds obtained from Citrus maxima seeds targeting NAFLD and NASH: a computational approach associating network pharmacology, ADMET profiling, and molecular dynamics simulation","volume":"103","author":"Sarkar","year":"2026","journal-title":"J Indian Chem Soc"},{"key":"2026082615135019800_ref67","doi-asserted-by":"publisher","first-page":"269","DOI":"10.3390\/molecules21030269","article-title":"Solanum nigrum protects against hepatic fibrosis via suppression of Hyperglycemia in high-fat\/ethanol diet-induced rats","volume":"21","author":"Tai","year":"2016","journal-title":"Molecules"},{"key":"2026082615135019800_ref68","doi-asserted-by":"publisher","first-page":"279","DOI":"10.3390\/molecules21030279","article-title":"1-Deoxynojirimycin alleviates liver injury and improves hepatic glucose metabolism in db\/db mice","volume":"21","author":"Liu","year":"2016","journal-title":"Molecules"},{"key":"2026082615135019800_ref69","doi-asserted-by":"publisher","first-page":"e0155598","DOI":"10.1371\/journal.pone.0155598","article-title":"Canine fibroblast growth factor 21 ameliorates Hyperglycemia associated with inhibiting hepatic gluconeogenesis and improving pancreatic Beta-cell survival in diabetic mice and dogs","volume":"11","author":"Xu","year":"2016","journal-title":"PLoS One"},{"key":"2026082615135019800_ref70","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/j.jceh.2018.10.004","article-title":"Molecular and pathological events involved in the pathogenesis of diabetes-associated nonalcoholic fatty liver disease","volume":"9","author":"Bedi","year":"2019","journal-title":"J Clin Exp Hepatol"},{"key":"2026082615135019800_ref71","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1159\/000282083","article-title":"The role of cytokines in non-alcoholic fatty liver disease","volume":"28","author":"Tilg","year":"2010","journal-title":"Dig Dis"},{"key":"2026082615135019800_ref72","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2015\/681612","article-title":"Adipokines as drug targets in diabetes and underlying disturbances","volume":"2015","author":"Andrade-Oliveira","year":"2015","journal-title":"J Diabetes Res"},{"key":"2026082615135019800_ref73","doi-asserted-by":"publisher","first-page":"3066","DOI":"10.1101\/gad.1250704","article-title":"CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum","volume":"18","author":"Marciniak","year":"2004","journal-title":"Genes Dev"},{"key":"2026082615135019800_ref74","doi-asserted-by":"publisher","first-page":"1788","DOI":"10.1007\/s00125-011-2130-8","article-title":"Apoptosis and insulin resistance in liver and peripheral tissues of morbidly obese patients is associated with different stages of non-alcoholic fatty liver disease","volume":"54","author":"Ferreira","year":"2011","journal-title":"Diabetologia"},{"key":"2026082615135019800_ref75","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1002\/hep.20283","article-title":"Free fatty acids promote hepatic lipotoxicity by stimulating TNF-\u03b1 expression via a lysosomal pathway","volume":"40","author":"Feldstein","year":"2004","journal-title":"Hepatology"},{"key":"2026082615135019800_ref76","doi-asserted-by":"publisher","first-page":"101710","DOI":"10.1016\/j.redox.2020.101710","article-title":"Vitamin E treatment in NAFLD patients demonstrates that oxidative stress drives steatosis through upregulation of de-novo lipogenesis","volume":"37","author":"Podszun","year":"2020","journal-title":"Redox Biol"},{"key":"2026082615135019800_ref77","doi-asserted-by":"publisher","first-page":"341","DOI":"10.12691\/jfnr-3-5-9","article-title":"Citrus flavonoids and human cancers","volume":"3","author":"Ke","year":"2015","journal-title":"JFNR"},{"key":"2026082615135019800_ref78","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.cca.2014.06.004","article-title":"Antioxidants and human diseases","volume":"436","author":"Rajendran","year":"2014","journal-title":"Clin Chim Acta"},{"key":"2026082615135019800_ref79","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.livres.2023.11.003","article-title":"In-depth analysis of de novo lipogenesis in non-alcoholic fatty liver disease: mechanism and pharmacological interventions","volume":"7","author":"Zhu","year":"2023","journal-title":"Liver Research"},{"key":"2026082615135019800_ref80","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.aca.2012.11.051","article-title":"Evaluating the antioxidant capacity of natural products: a review on chemical and cellular-based assays","volume":"763","author":"L\u00f3pez-Alarc\u00f3n","year":"2013","journal-title":"Anal Chim Acta"},{"key":"2026082615135019800_ref81","doi-asserted-by":"publisher","first-page":"3898","DOI":"10.1039\/D0FO02736G","article-title":"Hesperetin ameliorates hepatic oxidative stress and inflammation via the PI3K\/AKT-Nrf2-ARE pathway in oleic acid-induced HepG2 cells and a rat model of high-fat diet-induced NAFLD","volume":"12","author":"Li","year":"2021","journal-title":"Food Funct"},{"key":"2026082615135019800_ref82","doi-asserted-by":"publisher","first-page":"15661","DOI":"10.1038\/s41598-022-19459-z","article-title":"FASN inhibition targets multiple drivers of NASH by reducing steatosis, inflammation and fibrosis in preclinical models","volume":"12","author":"O\u2019Farrell","year":"2022","journal-title":"Sci Rep"},{"key":"2026082615135019800_ref83","doi-asserted-by":"publisher","first-page":"2570","DOI":"10.3390\/molecules28062570","article-title":"Nobiletin intake attenuates hepatic lipid profiling and oxidative stress in HFD-induced nonalcoholic-fatty-liver-disease mice","volume":"28","author":"Ke","year":"2023","journal-title":"Molecules"},{"key":"2026082615135019800_ref84","doi-asserted-by":"publisher","first-page":"1049818","DOI":"10.3389\/fphar.2022.1049818","article-title":"Naringin attenuates fructose-induced NAFLD progression in rats through reducing endogenous triglyceride synthesis and activating the Nrf2\/HO-1 pathway","volume":"13","author":"Pengnet","year":"2022","journal-title":"Front Pharmacol"},{"key":"2026082615135019800_ref85","doi-asserted-by":"publisher","first-page":"483","DOI":"10.3389\/fphar.2020.00483","article-title":"Hepatoprotective and anti-oxidative effects of Total flavonoids from Qu Zhi Qiao (fruit of citrus paradisi cv.Changshanhuyou) on nonalcoholic steatohepatitis In vivo and In vitro through Nrf2-ARE Signaling pathway","volume":"11","author":"Shi","year":"2020","journal-title":"Front Pharmacol"},{"key":"2026082615135019800_ref86","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.freeradbiomed.2020.02.025","article-title":"Role of oxidative stress in the pathogenesis of nonalcoholic fatty liver disease","volume":"152","author":"Chen","year":"2020","journal-title":"Free Radic Biol Med"},{"key":"2026082615135019800_ref87","doi-asserted-by":"publisher","first-page":"108426","DOI":"10.1016\/j.jnutbio.2020.108426","article-title":"Citrus reticulata Blanco peel extract ameliorates hepatic steatosis, oxidative stress and inflammation in HF and MCD diet-induced NASH C57BL\/6 J mice","volume":"83","author":"Ke","year":"2020","journal-title":"J Nutr Biochem"},{"key":"2026082615135019800_ref88","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1186\/s12967-023-04790-4","article-title":"Didymin alleviates metabolic dysfunction-associated fatty liver disease (MAFLD) via the stimulation of Sirt1-mediated lipophagy and mitochondrial biogenesis","volume":"21","author":"Yang","year":"2023","journal-title":"J Transl Med"},{"key":"2026082615135019800_ref89","doi-asserted-by":"publisher","first-page":"66","DOI":"10.29219\/fnr.v66.7652","article-title":"Citrus maxima and tea regulate AMPK signaling pathway to retard the progress of nonalcoholic fatty liver disease","volume":"66","author":"Wen","year":"2022","journal-title":"Food Nutr Res"},{"key":"2026082615135019800_ref90","doi-asserted-by":"publisher","first-page":"116559","DOI":"10.1016\/j.jep.2023.116559","article-title":"Exocarpium Citri grandis alleviates the aggravation of NAFLD by mitigating lipid accumulation and iron metabolism disorders","volume":"313","author":"Deng","year":"2023","journal-title":"J Ethnopharmacol"},{"key":"2026082615135019800_ref91","doi-asserted-by":"publisher","first-page":"801730","DOI":"10.3389\/fphar.2021.801730","article-title":"Limonin alleviates non-alcoholic fatty liver disease by reducing lipid accumulation, suppressing inflammation and oxidative stress","volume":"12","author":"Li","year":"2022","journal-title":"Front Pharmacol"},{"key":"2026082615135019800_ref92","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.jff.2018.05.032","article-title":"PMFs-rich citrus extract prevents the development of non-alcoholic fatty liver disease in C57BL\/6J mice induced by a high-fat diet","volume":"47","author":"Ke","year":"2018","journal-title":"J Funct Foods"},{"key":"2026082615135019800_ref93","doi-asserted-by":"publisher","first-page":"3353","DOI":"10.1039\/D1FO03597E","article-title":"Citrus depressa Hayata peel ameliorates nonalcoholic fatty liver and modulates the activity of hepatic drug-metabolizing enzymes and transporters in rats fed a high-fat diet","volume":"13","author":"Li","year":"2022","journal-title":"Food Funct"},{"key":"2026082615135019800_ref94","doi-asserted-by":"publisher","first-page":"967623","DOI":"10.3389\/fphar.2022.967623","article-title":"Chaihu Shugan powder alleviates liver inflammation and hepatic steatosis in NAFLD mice: a network pharmacology study and in vivo experimental validation","volume":"13","author":"Lei","year":"2022","journal-title":"Front Pharmacol"},{"key":"2026082615135019800_ref95","doi-asserted-by":"publisher","first-page":"5221","DOI":"10.3390\/nu14245221","article-title":"Citri Reticulatae Pericarpium (Chenpi) protects against endothelial dysfunction and vascular inflammation in diabetic rats","volume":"14","author":"Wang","year":"2022","journal-title":"Nutrients"},{"key":"2026082615135019800_ref96","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1038\/nri2925","article-title":"Type 2 diabetes as an inflammatory disease","volume":"11","author":"Donath","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"2026082615135019800_ref97","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1186\/s12933-016-0443-0","article-title":"TNF-\u03b1 induces vascular insulin resistance via positive modulation of PTEN and decreased Akt\/eNOS\/NO signaling in high fat diet-fed mice","volume":"15","author":"Da Costa","year":"2016","journal-title":"Cardiovasc Diabetol"},{"key":"2026082615135019800_ref98","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.immuni.2021.12.013","article-title":"Inflammation in obesity, diabetes, and related disorders","volume":"55","author":"Rohm","year":"2022","journal-title":"Immunity"},{"key":"2026082615135019800_ref99","doi-asserted-by":"publisher","first-page":"1796","DOI":"10.1172\/JCI200319246","article-title":"Obesity is associated with macrophage accumulation in adipose tissue","volume":"112","author":"Weisberg","year":"2003","journal-title":"J Clin Invest"},{"key":"2026082615135019800_ref100","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/cphy.c170040","article-title":"Contribution of adipose tissue inflammation to the development of type 2 diabetes mellitus","volume":"9","author":"Burhans","year":"2018","journal-title":"Compr Physiol"},{"key":"2026082615135019800_ref101","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.bbrc.2020.05.212","article-title":"Citrus flavone tangeretin is a potential insulin sensitizer targeting hepatocytes through suppressing MEK-ERK1\/2 pathway","volume":"529","author":"Guo","year":"2020","journal-title":"Biochem Biophys Res Commun"},{"key":"2026082615135019800_ref102","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1248\/bpb.b20-00849","article-title":"Glucosyl hesperidin has an anti-diabetic effect in high-fat diet-induced obese mice","volume":"44","author":"Yoshida","year":"2021","journal-title":"Biol Pharm Bull"},{"key":"2026082615135019800_ref103","doi-asserted-by":"publisher","first-page":"124865","DOI":"10.1016\/j.ijbiomac.2023.124865","article-title":"Anti-diabetic effect of modified \u2018Guanximiyou\u2019 pummelo peel pectin on type 2 diabetic mice via gut microbiota","volume":"242","author":"Zang","year":"2023","journal-title":"Int J Biol Macromol"},{"key":"2026082615135019800_ref104","doi-asserted-by":"publisher","first-page":"153082","DOI":"10.1016\/j.phymed.2019.153082","article-title":"Hepatoprotective and anti-inflammatory effects of total flavonoids of Qu Zhi Ke (peel of citrus changshan-huyou) on non-alcoholic fatty liver disease in rats via modulation of NF-\u03baB and MAPKs","volume":"64","author":"Jiang","year":"2019","journal-title":"Phytomedicine"},{"key":"2026082615135019800_ref105","doi-asserted-by":"publisher","first-page":"1971","DOI":"10.1039\/D2FO03003A","article-title":"p -synephrine ameliorates alloxan-induced diabetes mellitus through inhibiting oxidative stress and inflammation via suppressing the NF-kappa B and MAPK pathways","volume":"14","author":"Wang","year":"2023","journal-title":"Food Funct"},{"key":"2026082615135019800_ref106","doi-asserted-by":"publisher","first-page":"823","DOI":"10.4314\/tjpr.v17i5.11","article-title":"Ameliorative effect of Citrus aurantifolia and Cinnamomum burmannii extracts on diabetic complications in a hyperglycemic rat model","volume":"17","author":"Mawarti","year":"2018","journal-title":"Trop J Pharm Res"},{"key":"2026082615135019800_ref107","doi-asserted-by":"publisher","first-page":"154944","DOI":"10.1016\/j.phymed.2023.154944","article-title":"Pure total flavonoids from citrus alleviate oxidative stress and inflammation in nonalcoholic fatty liver disease by regulating the miR-137-3p\/NOXA2\/NOX2 pathway","volume":"118","author":"Yan","year":"2023","journal-title":"Phytomedicine"},{"key":"2026082615135019800_ref108","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1042\/CS20110357","article-title":"Toll-like receptors and diabetes: a therapeutic perspective","volume":"122","author":"Dasu","year":"2012","journal-title":"Clin Sci"},{"key":"2026082615135019800_ref109","doi-asserted-by":"publisher","first-page":"34035","DOI":"10.1074\/jbc.M007386200","article-title":"Murine TOLL-like receptor 4 confers lipopolysaccharide responsiveness as determined by activation of NF\u03baB and expression of the inducible cyclooxygenase","volume":"275","author":"Rhee","year":"2000","journal-title":"J Biol Chem"},{"key":"2026082615135019800_ref110","doi-asserted-by":"publisher","first-page":"3160","DOI":"10.1016\/j.ijcard.2013.07.150","article-title":"An overview of the crosstalk between inflammatory processes and metabolic dysregulation during diabetic cardiomyopathy","volume":"168","author":"Palomer","year":"2013","journal-title":"Int J Cardiol"},{"key":"2026082615135019800_ref111","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.cell.2008.10.052","article-title":"SIRT6 links histone H3 lysine 9 deacetylation to NF-\u03baB-dependent gene expression and organismal life span","volume":"136","author":"Kawahara","year":"2009","journal-title":"Cell"},{"key":"2026082615135019800_ref112","doi-asserted-by":"publisher","first-page":"591","DOI":"10.4162\/nrp.2021.15.5.591","article-title":"Hesperetin suppresses LPS\/high glucose-induced inflammatory responses via TLR\/MyD88\/NF-\u03baB signaling pathways in THP-1 cells","volume":"15","author":"Lee","year":"2021","journal-title":"Nutr Res Pract"},{"key":"2026082615135019800_ref113","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.13422","article-title":"Naringenin downregulates inflammation-mediated nitric oxide overproduction and potentiates endogenous antioxidant status during hyperglycemia","volume":"44","author":"Rehman","year":"2020","journal-title":"J Food Biochem"},{"key":"2026082615135019800_ref114","doi-asserted-by":"publisher","first-page":"10186","DOI":"10.1039\/D2FO01682F","article-title":"Nobiletin mitigates NAFLD via lipophagy and inflammation","volume":"13","author":"Yang","year":"2022","journal-title":"Food Funct"},{"key":"2026082615135019800_ref115","doi-asserted-by":"publisher","first-page":"1106875","DOI":"10.3389\/fendo.2022.1106875","article-title":"Qingrequzhuo capsule alleviated methionine and choline deficient diet-induced nonalcoholic steatohepatitis in mice through regulating gut microbiota, enhancing gut tight junction and inhibiting the activation of TLR4\/NF-\u03baB signaling pathway","volume":"13","author":"Lv","year":"2023","journal-title":"Front Endocrinol"},{"key":"2026082615135019800_ref116","doi-asserted-by":"publisher","first-page":"968930","DOI":"10.3389\/fnut.2022.968930","article-title":"Traditional Chinese medicine Tongxie Yaofang treating irritable bowel syndrome with diarrhea and type 2 diabetes mellitus in rats with liver-depression and spleen-deficiency: a preliminary study","volume":"9","author":"Xu","year":"2022","journal-title":"Front Nutr"},{"key":"2026082615135019800_ref117","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1007\/s11418-019-01332-5","article-title":"Naringenin suppresses neutrophil infiltration into adipose tissue in high-fat diet-induced obese mice","volume":"74","author":"Tsuhako","year":"2020","journal-title":"J Nat Med"},{"key":"2026082615135019800_ref118","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1042\/BST20221066","article-title":"Insulin signalling and GLUT4 trafficking in insulin resistance","volume":"51","author":"Van Gerwen","year":"2023","journal-title":"Biochem Soc Trans"},{"key":"2026082615135019800_ref119","doi-asserted-by":"publisher","first-page":"1700362","DOI":"10.1002\/mnfr.201700362","article-title":"Anthocyanins from purple corn ameliorated tumor necrosis factor-\u03b1-induced inflammation and insulin resistance in 3T3-L1 adipocytes via activation of insulin Signaling and enhanced GLUT4 translocation","volume":"61","author":"Luna-Vital","year":"2017","journal-title":"Molecular Nutrition Food Res"},{"key":"2026082615135019800_ref120","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/j.bbrc.2008.07.068","article-title":"Regulation of PPAR\u03b3 function by TNF-\u03b1","volume":"374","author":"Ye","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"2026082615135019800_ref121","doi-asserted-by":"publisher","first-page":"535","DOI":"10.3390\/ph16040535","article-title":"Insulin sensitization by PPAR\u03b3 and GLUT-4 overexpression\/translocation mediates the antidiabetic effect of Plantago australis","volume":"16","author":"Estrada-Soto","year":"2023","journal-title":"Pharmaceuticals"},{"key":"2026082615135019800_ref122","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1007\/s11033-023-09013-z","article-title":"Tangeretin enhances pancreatic beta-TC-6 function by ameliorating tunicamycin-induced cellular perturbations","volume":"51","author":"Anto","year":"2024","journal-title":"Mol Biol Rep"},{"key":"2026082615135019800_ref123","doi-asserted-by":"publisher","first-page":"2120","DOI":"10.1039\/C4FO00154K","article-title":"Modulation of hyperglycemia and TNF\u03b1-mediated inflammation by helichrysum and grapefruit extracts in diabetic db\/db mice","volume":"5","author":"Laura De La Garza","year":"2014","journal-title":"Food Funct"},{"key":"2026082615135019800_ref124","doi-asserted-by":"publisher","first-page":"4411","DOI":"10.3390\/molecules26154411","article-title":"Bioactive compounds from lemon (Citrus Limon) extract overcome TNF-\u03b1-induced insulin resistance in cultured adipocytes","volume":"26","author":"Sorrenti","year":"2021","journal-title":"Molecules"},{"key":"2026082615135019800_ref125","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1080\/21623945.2018.1493901","article-title":"The role of adipocyte-specific IL-6-type cytokine signaling in FFA and leptin release","volume":"7","author":"Wueest","year":"2018","journal-title":"Adipocyte"},{"key":"2026082615135019800_ref126","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1248\/bpb.b14-00700","article-title":"Sinensetin enhances adipogenesis and lipolysis by increasing cyclic adenosine monophosphate levels in 3T3-L1 adipocytes","volume":"38","author":"Kang","year":"2015","journal-title":"Biol Pharm Bull"},{"key":"2026082615135019800_ref127","doi-asserted-by":"publisher","first-page":"e0193704","DOI":"10.1371\/journal.pone.0193704","article-title":"Citrus aurantium L. dry extracts promote C\/ebp\u03b2 expression and improve adipocyte differentiation in 3T3-L1 cells","volume":"13","author":"Raciti","year":"2018","journal-title":"PLoS One"},{"key":"2026082615135019800_ref128","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1016\/j.bbrc.2016.03.015","article-title":"HMGA2 promotes adipogenesis by activating C\/EBP\u03b2-mediated expression of PPAR\u03b3","volume":"472","author":"Xi","year":"2016","journal-title":"Biochem Biophys Res Commun"},{"key":"2026082615135019800_ref129","doi-asserted-by":"publisher","first-page":"336","DOI":"10.3389\/fphar.2017.00336","article-title":"Quercetin, a lead compound against type 2 diabetes ameliorates glucose uptake via AMPK pathway in skeletal muscle cell line","volume":"8","author":"Dhanya","year":"2017","journal-title":"Front Pharmacol"},{"key":"2026082615135019800_ref130","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1016\/j.molcel.2017.05.032","article-title":"AMPK: mechanisms of cellular energy sensing and restoration of metabolic balance","volume":"66","author":"Garcia","year":"2017","journal-title":"Mol Cell"},{"key":"2026082615135019800_ref131","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.jff.2015.02.005","article-title":"Flavanone naringenin: An effective antihyperglycemic and antihyperlipidemic nutraceutical agent on high fat diet fed streptozotocin induced type 2 diabetic rats","volume":"14","author":"Priscilla","year":"2015","journal-title":"J Funct Foods"},{"key":"2026082615135019800_ref132","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2020\/1730492","article-title":"Antidiabetic potency, antioxidant effects, and mode of actions of Citrus reticulata fruit peel hydroethanolic extract, hesperidin, and quercetin in nicotinamide\/streptozotocin-induced Wistar diabetic rats","volume":"2020","author":"Ali","year":"2020","journal-title":"Oxidative Med Cell Longev"},{"key":"2026082615135019800_ref133","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1007\/s43450-023-00477-5","article-title":"Anxiolytic and Hypoglycemic effect of Pectins from Galician lemon citrus fruit on adult zebrafish (Danio rerio): An In vivo and In S\u00edlico approach","volume":"34","author":"Alves","year":"2023","journal-title":"Rev Bras"},{"key":"2026082615135019800_ref134","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1016\/j.ijbiomac.2016.05.015","article-title":"Anti-diabetic effect of citrus pectin in diabetic rats and potential mechanism via PI3K\/Akt signaling pathway","volume":"89","author":"Liu","year":"2016","journal-title":"Int J Biol Macromol"},{"key":"2026082615135019800_ref135","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1111\/1440-1681.12739","article-title":"Antihyperglycaemic action of diosmin, a citrus flavonoid, is induced through endogenous \u03b2-endorphin in type I-like diabetic rats","volume":"44","author":"Hsu","year":"2017","journal-title":"Clin Exp Pharma Physio"},{"key":"2026082615135019800_ref136","doi-asserted-by":"publisher","first-page":"e92","DOI":"10.4142\/jvs.2021.22.e92","article-title":"The effects of naringenin and naringin on the glucose uptake and AMPK phosphorylation in high glucose treated HepG2 cells","volume":"22","author":"Dayarathne","year":"2021","journal-title":"J Vet Sci"},{"key":"2026082615135019800_ref137","doi-asserted-by":"publisher","first-page":"1424","DOI":"10.3390\/molecules21111424","article-title":"Herbal formula HT048 attenuates diet-induced obesity by improving hepatic lipid metabolism and insulin resistance in obese rats","volume":"21","author":"Lee","year":"2016","journal-title":"Molecules"},{"key":"2026082615135019800_ref138","doi-asserted-by":"publisher","first-page":"155575","DOI":"10.1016\/j.phymed.2024.155575","article-title":"Antidiabetic action of the Chinese formula Shouhuitongbian and the underlying mechanism associated with alteration of gut microbiota","volume":"129","author":"Wang","year":"2024","journal-title":"Phytomedicine"},{"key":"2026082615135019800_ref139","doi-asserted-by":"publisher","first-page":"140898","DOI":"10.1016\/j.bbapap.2023.140898","article-title":"Citrus flavanone metabolites significantly modulate global proteomic profile in pancreatic \u03b2-cells under high-glucose-induced metabolic stress","volume":"1871","author":"Fraga","year":"2023","journal-title":"Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics"},{"key":"2026082615135019800_ref140","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1743-7075-12-1","article-title":"The flavonoid, naringenin, decreases adipose tissue mass and attenuates ovariectomy-associated metabolic disturbances in mice","volume":"12","author":"Ke","year":"2015","journal-title":"Nutr Metab (Lond)"},{"key":"2026082615135019800_ref141","doi-asserted-by":"publisher","first-page":"2306","DOI":"10.3390\/pharmaceutics15092306","article-title":"The synergistic influence of polyflavonoids from Citrus aurantifolia on diabetes treatment and their modulation of the PI3K\/AKT\/FOXO1 Signaling pathways: molecular docking analyses and In vivo investigations","volume":"15","author":"Hassan","year":"2023","journal-title":"Pharmaceutics"},{"key":"2026082615135019800_ref142","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.biopha.2017.07.094","article-title":"Navel orange peel hydroethanolic extract, naringin and naringenin have anti-diabetic potentials in type 2 diabetic rats","volume":"94","author":"Ahmed","year":"2017","journal-title":"Biomed Pharmacother"},{"key":"2026082615135019800_ref143","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1007\/s00394-015-0883-4","article-title":"Grapefruit juice improves glucose intolerance in streptozotocin-induced diabetes by suppressing hepatic gluconeogenesis","volume":"55","author":"Hayanga","year":"2016","journal-title":"Eur J Nutr"},{"key":"2026082615135019800_ref144","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.fct.2018.03.050","article-title":"Evidence of insulin-dependent signalling mechanisms produced by Citrus sinensis (L.) Osbeck fruit peel in an insulin resistant diabetic animal model","volume":"116","author":"Sathiyabama","year":"2018","journal-title":"Food Chem Toxicol"},{"key":"2026082615135019800_ref145","doi-asserted-by":"publisher","first-page":"199","DOI":"10.3109\/10409231003667500","article-title":"Genetic control of de novo lipogenesis: role in diet-induced obesity","volume":"45","author":"Strable","year":"2010","journal-title":"Crit Rev Biochem Mol Biol"},{"key":"2026082615135019800_ref146","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/2049-3002-2-17","article-title":"Mitochondrial reactive oxygen species and cancer","volume":"2","author":"Sullivan","year":"2014","journal-title":"Cancer Metab"},{"key":"2026082615135019800_ref147","doi-asserted-by":"publisher","first-page":"101157","DOI":"10.1016\/j.plipres.2022.101157","article-title":"Desaturases and elongases involved in long-chain polyunsaturated fatty acid biosynthesis in aquatic animals: from genes to functions","volume":"86","author":"Monroig","year":"2022","journal-title":"Prog Lipid Res"},{"key":"2026082615135019800_ref148","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.3390\/nu10101383","article-title":"Regulation and metabolic significance of De novo lipogenesis in adipose tissues","volume":"10","author":"Song","year":"2018","journal-title":"Nutrients"},{"key":"2026082615135019800_ref149","doi-asserted-by":"publisher","first-page":"11236","DOI":"10.1021\/acs.jafc.2c02927","article-title":"Tangeretin protects mice from alcohol-induced fatty liver by activating mitophagy through the AMPK\u2013ULK1 pathway","volume":"70","author":"Guo","year":"2022","journal-title":"J Agric Food Chem"},{"key":"2026082615135019800_ref150","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1194\/jlr.RA119000542","article-title":"The citrus flavonoid nobiletin confers protection from metabolic dysregulation in high-fat-fed mice independent of AMPK","volume":"61","author":"Morrow","year":"2020","journal-title":"J Lipid Res"},{"key":"2026082615135019800_ref151","doi-asserted-by":"publisher","first-page":"109353","DOI":"10.1016\/j.jnutbio.2023.109353","article-title":"A lipidomic study: nobiletin ameliorates hepatic steatosis through regulation of lipid alternation","volume":"118","author":"Yang","year":"2023","journal-title":"J Nutr Biochem"},{"key":"2026082615135019800_ref152","doi-asserted-by":"publisher","first-page":"153454","DOI":"10.1016\/j.phymed.2020.153454","article-title":"Inhibition of histone acetyltransferase by naringenin and hesperetin suppresses Txnip expression and protects pancreatic \u03b2 cells in diabetic mice","volume":"88","author":"Wang","year":"2021","journal-title":"Phytomedicine"},{"key":"2026082615135019800_ref153","doi-asserted-by":"publisher","first-page":"1601104","DOI":"10.1002\/mnfr.201601104","article-title":"Combination of citrus polymethoxyflavones, green tea polyphenols, and lychee extracts suppresses obesity and hepatic steatosis in high-fat diet induced obese mice","volume":"61","author":"Pan","year":"2017","journal-title":"Molecular Nutrition Food Res"},{"key":"2026082615135019800_ref154","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1039\/D1FO03793E","article-title":"Protective effect of orange essential oil on the formation of non-alcoholic fatty liver disease caused by high-fat diet","volume":"13","author":"Wang","year":"2022","journal-title":"Food Funct"},{"key":"2026082615135019800_ref155","doi-asserted-by":"publisher","first-page":"1819","DOI":"10.1080\/13880209.2022.2106250","article-title":"Integrated strategy of RNA-sequencing and network pharmacology for exploring the protective mechanism of Shen-Shi-Jiang-Zhuo formula in rat with non-alcoholic fatty liver disease","volume":"60","author":"Xu","year":"2022","journal-title":"Pharm Biol"},{"key":"2026082615135019800_ref156","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1007\/s12010-021-03486-z","article-title":"Low molecular pectin inhibited the lipid accumulation by upregulation of METTL7B","volume":"193","author":"Yang","year":"2021","journal-title":"Appl Biochem Biotechnol"},{"key":"2026082615135019800_ref157","doi-asserted-by":"publisher","first-page":"e108408","DOI":"10.1371\/journal.pone.0108408","article-title":"Consumption of clarified grapefruit juice ameliorates high-fat diet induced insulin resistance and weight gain in mice","volume":"9","author":"Chudnovskiy","year":"2014","journal-title":"PLoS One"},{"key":"2026082615135019800_ref158","doi-asserted-by":"publisher","first-page":"585066","DOI":"10.3389\/fmicb.2020.585066","article-title":"Naringin attenuates high fat diet induced non-alcoholic fatty liver disease and gut bacterial dysbiosis in mice","volume":"11","author":"Mu","year":"2020","journal-title":"Front Microbiol"},{"key":"2026082615135019800_ref159","doi-asserted-by":"publisher","first-page":"153412","DOI":"10.1016\/j.phymed.2020.153412","article-title":"Naringenin alleviates nonalcoholic steatohepatitis in middle-aged Apoe\u2212\/\u2212mice: role of SIRT1","volume":"81","author":"Hua","year":"2021","journal-title":"Phytomedicine"},{"key":"2026082615135019800_ref160","doi-asserted-by":"publisher","first-page":"225","DOI":"10.2152\/jmi.65.225","article-title":"Methanol extraction fraction from citrus Sudachi peel exerts lipid reducing effects in cultured cells","volume":"65","author":"Xu","year":"2018","journal-title":"J Med Investig"},{"key":"2026082615135019800_ref161","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.fsi.2021.09.034","article-title":"Polysaccharide extract from pomelo fruitlet ameliorates diet-induced nonalcoholic fatty liver disease in hybrid grouper (Epinephelus lanceolatus\u2642 \u00d7 Epinephelus fuscoguttatus\u2640)","volume":"119","author":"Zou","year":"2021","journal-title":"Fish Shellfish Immunol"},{"key":"2026082615135019800_ref162","doi-asserted-by":"publisher","first-page":"117644","DOI":"10.1016\/j.jep.2023.117644","article-title":"Polymethoxyflavones in citrus extract has a beneficial effect on hypercholesterolemia rats by promoting liver cholesterol metabolism","volume":"322","author":"Du","year":"2024","journal-title":"J Ethnopharmacol"},{"key":"2026082615135019800_ref163","doi-asserted-by":"publisher","first-page":"2565","DOI":"10.1038\/s41598-020-59485-3","article-title":"Bergamot polyphenols improve Dyslipidemia and pathophysiological features in a mouse model of non-alcoholic fatty liver disease","volume":"10","author":"Musolino","year":"2020","journal-title":"Sci Rep"},{"key":"2026082615135019800_ref164","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1039\/C4FO00993B","article-title":"Hypoglycemic and hypolipidemic effects of neohesperidin derived from Citrus aurantium L. in diabetic KK-Ay mice","volume":"6","author":"Jia","year":"2015","journal-title":"Food Funct"},{"key":"2026082615135019800_ref165","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1248\/bpb.b18-00702","article-title":"Preventive effect of Citrus aurantium peel extract on high-fat diet-induced non-alcoholic fatty liver in mice","volume":"42","author":"Han","year":"2019","journal-title":"Biol Pharm Bull"},{"key":"2026082615135019800_ref166","doi-asserted-by":"publisher","first-page":"120428","DOI":"10.1016\/j.lfs.2022.120428","article-title":"Hesperidin attenuates hepatic lipid accumulation in mice fed high-fat diet and oleic acid induced HepG2 via AMPK activation","volume":"296","author":"Chen","year":"2022","journal-title":"Life Sci"},{"key":"2026082615135019800_ref167","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2020\/8812634","article-title":"Diospyros kaki and Citrus unshiu mixture improves disorders of lipid metabolism in nonalcoholic fatty liver disease","volume":"2020","author":"Shin","year":"2020","journal-title":"Can J Gastroenterol Hepatol"},{"key":"2026082615135019800_ref168","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/1743-7075-11-32","article-title":"Sudachitin, a polymethoxylated flavone, improves glucose and lipid metabolism by increasing mitochondrial biogenesis in skeletal muscle","volume":"11","author":"Tsutsumi","year":"2014","journal-title":"Nutr Metab (Lond)"},{"key":"2026082615135019800_ref169","doi-asserted-by":"publisher","first-page":"5168","DOI":"10.1111\/jcmm.15166","article-title":"A network pharmacology-based approach to explore the effects of Chaihu Shugan powder on a non-alcoholic fatty liver rat model through nuclear receptors","volume":"24","author":"Nie","year":"2020","journal-title":"J Cellular Molecular Medi"},{"key":"2026082615135019800_ref170","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.5958\/0974-360X.2019.00207.5","article-title":"A comparative evaluation study of Citrus limetta and metformin against Hyperlipidemia in diabetic and non-diabetic rats","volume":"12","author":"Khan","year":"2019","journal-title":"Rese Jour of Pharm and Technol"},{"key":"2026082615135019800_ref171","doi-asserted-by":"publisher","first-page":"111183","DOI":"10.1016\/j.biopha.2020.111183","article-title":"Pure total flavonoids from citrus attenuate non-alcoholic steatohepatitis via regulating the gut microbiota and bile acid metabolism in mice","volume":"135","author":"He","year":"2021","journal-title":"Biomed Pharmacother"},{"key":"2026082615135019800_ref172","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1080\/09637486.2020.1813262","article-title":"Dietary calamondin supplementation slows the progression of non-alcoholic fatty liver disease in C57BL\/6 mice fed a high-fat diet","volume":"72","author":"Shimizu","year":"2021","journal-title":"Int J Food Sci Nutr"},{"key":"2026082615135019800_ref173","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1007\/s10068-018-0503-1","article-title":"Green Satsuma mandarin orange (Citrus unshiu) extract reduces adiposity and induces uncoupling protein expression in skeletal muscle of obese mice","volume":"28","author":"Kim","year":"2019","journal-title":"Food Sci Biotechnol"},{"key":"2026082615135019800_ref174","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1053\/j.gastro.2018.06.031","article-title":"Bioactive lipid species and metabolic pathways in progression and resolution of nonalcoholic steatohepatitis","volume":"155","author":"Musso","year":"2018","journal-title":"Gastroenterology"},{"key":"2026082615135019800_ref175","doi-asserted-by":"publisher","first-page":"4369","DOI":"10.3390\/ijms20184369","article-title":"Endoplasmic reticulum stress increases DUSP5 expression via PERK-CHOP pathway, leading to hepatocyte death","volume":"20","author":"Jo","year":"2019","journal-title":"IJMS"},{"key":"2026082615135019800_ref176","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1016\/j.tem.2014.08.001","article-title":"Role of metabolic lipases and lipolytic metabolites in the pathogenesis of NAFLD","volume":"25","author":"Fuchs","year":"2014","journal-title":"Trends in Endocrinology & Metabolism"},{"key":"2026082615135019800_ref177","doi-asserted-by":"publisher","first-page":"116322","DOI":"10.1016\/j.biopha.2024.116322","article-title":"Mechanism insights into the pleiotropic effects of nobiletin as a potential therapeutic agent on non-alcoholic fatty liver disease (NAFLD)","volume":"173","author":"Ran","year":"2024","journal-title":"Biomed Pharmacother"},{"key":"2026082615135019800_ref178","doi-asserted-by":"publisher","first-page":"175588","DOI":"10.1016\/j.ejphar.2023.175588","article-title":"Therapeutic advancements in targeting BCL-2 family proteins by epigenetic regulators, natural, and synthetic agents in cancer","volume":"944","author":"Sarkar","year":"2023","journal-title":"Eur J Pharmacol"},{"key":"2026082615135019800_ref179","doi-asserted-by":"publisher","first-page":"673","DOI":"10.3390\/nu12030673","article-title":"Citrus peel extract ameliorates high-fat diet-induced NAFLD via activation of AMPK Signaling","volume":"12","author":"Lee","year":"2020","journal-title":"Nutrients"},{"key":"2026082615135019800_ref180","doi-asserted-by":"publisher","first-page":"4227","DOI":"10.3390\/molecules27134227","article-title":"Naringenin and phytoestrogen 8-prenylnaringenin protect against islet dysfunction and inhibit apoptotic Signaling in insulin-deficient diabetic mice","volume":"27","author":"Park","year":"2022","journal-title":"Molecules"},{"key":"2026082615135019800_ref181","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s13098-023-01244-1","article-title":"Didymin protects pancreatic beta cells by enhancing mitochondrial function in high-fat diet-induced impaired glucose tolerance","volume":"16","author":"Yang","year":"2024","journal-title":"Diabetol Metab Syndr"},{"key":"2026082615135019800_ref182","doi-asserted-by":"publisher","first-page":"5815","DOI":"10.3892\/mmr.2018.9615","article-title":"Nobiletin alleviates palmitic acid-induced NLRP3 inflammasome activation in a sirtuin 1-dependent manner in AML-12 cells","volume":"18","author":"Peng","year":"2018","journal-title":"Mol Med Rep"},{"key":"2026082615135019800_ref183","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/s13098-017-0254-9","article-title":"Interactions between antidiabetic drugs and herbs: An overview of mechanisms of action and clinical implications","volume":"9","author":"Gupta","year":"2017","journal-title":"Diabetol Metab Syndr"},{"key":"2026082615135019800_ref184","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.1093\/nutrit\/nuad116","article-title":"Roles of citrus fruits on energy expenditure, body weight management, and metabolic biomarkers: a comprehensive review","volume":"82","author":"Aslan","year":"2024","journal-title":"Nutr Rev"},{"key":"2026082615135019800_ref185","doi-asserted-by":"publisher","first-page":"6070","DOI":"10.1002\/fsn3.4271","article-title":"Diosmin: a promising phytochemical for functional foods, nutraceuticals and cancer therapy","volume":"12","author":"Rahman","year":"2024","journal-title":"Food Sci Nutr"},{"key":"2026082615135019800_ref186","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1016\/0024-3205(96)00417-1","article-title":"Naringin and naringenin are not the primary CYP3A inhibitors in grapefruit juice","volume":"59","author":"Edwards","year":"1996","journal-title":"Life Sci"},{"key":"2026082615135019800_ref187","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1254\/jphs.11188SC","article-title":"Polymethoxy flavonoids, nobiletin and Tangeretin, prevent lipopolysaccharide-induced inflammatory bone loss in an experimental model for periodontitis","volume":"119","author":"Tominari","year":"2012","journal-title":"J Pharmacol Sci"},{"key":"2026082615135019800_ref188","doi-asserted-by":"publisher","first-page":"119804","DOI":"10.1016\/j.jep.2025.119804","article-title":"Toxicological evaluation of Artocarpus lacucha ethyl acetate extract: in vitro and in vivo assessment","volume":"347","author":"Banerjee","year":"2025","journal-title":"J Ethnopharmacol"},{"key":"2026082615135019800_ref189","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.yrtph.2019.04.001","article-title":"Acute and sub-chronic oral toxicity studies of hesperidin isolated from orange peel extract in Sprague Dawley rats","volume":"105","author":"Li","year":"2019","journal-title":"Regul Toxicol Pharmacol"},{"key":"2026082615135019800_ref190","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1016\/S0367-326X(99)00093-3","article-title":"Antiobesity and cardiovascular toxic effects of Citrus aurantium extracts in the rat: a preliminary report","volume":"70","author":"Calapai","year":"1999","journal-title":"Fitoterapia"},{"key":"2026082615135019800_ref191","doi-asserted-by":"publisher","first-page":"1555","DOI":"10.3390\/biom11111555","article-title":"Phytochemical profile, \u03b1-glucosidase, and \u03b1-amylase inhibition potential and toxicity evaluation of extracts from Citrus aurantium (L) peel, a valuable by-product from Northeastern Morocco","volume":"11","author":"Benayad","year":"2021","journal-title":"Biomolecules"},{"key":"2026082615135019800_ref192","doi-asserted-by":"publisher","first-page":"1934578X1100600941","DOI":"10.1177\/1934578X1100600941","article-title":"Toxic effects of Citrus aurantium and C. Limon essential oils on Spodoptera frugiperda (lepidoptera: Noctuidae)","volume":"6","author":"Villafa\u00f1e","year":"2011","journal-title":"Nat Prod Commun"},{"key":"2026082615135019800_ref193","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.jep.2017.12.029","article-title":"In vitro and in vivo evaluation of systemic and genetic toxicity of Citrus unshiu peel","volume":"215","author":"Park","year":"2018","journal-title":"J Ethnopharmacol"},{"key":"2026082615135019800_ref194","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1023\/B:JOEC.0000017980.66124.d1","article-title":"Toxic effects of lemon peel constituents on Ceratitis capitata","volume":"30","author":"Salvatore","year":"2004","journal-title":"J Chem Ecol"},{"key":"2026082615135019800_ref195","doi-asserted-by":"publisher","DOI":"10.2903\/j.efsa.2021.6709","article-title":"Safety and efficacy of a feed additive consisting of a flavonoid-rich dried extract of citrus \u00d7 aurantium L. fruit (bitter orange extract) for use in all animal species (FEFANA asbl)","volume":"19","author":"EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)","year":"2021","journal-title":"EFS2"},{"key":"2026082615135019800_ref196","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1186\/s12906-020-03079-z","article-title":"In vivo and in vitro safety evaluation of fermented citrus sunki peel extract: acute and 90-day repeated oral toxicity studies with genotoxicity assessment","volume":"20","author":"Park","year":"2020","journal-title":"BMC Complement Med Ther"},{"key":"2026082615135019800_ref197","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1016\/j.toxrep.2019.06.020","article-title":"Chemical profile and in vivo toxicity evaluation of unripe Citrus aurantifolia essential oil","volume":"6","author":"Adokoh","year":"2019","journal-title":"Toxicol Rep"},{"key":"2026082615135019800_ref198","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1080\/01480545.2025.2541653","article-title":"Phenolic profile, in vitro antioxidant and safety evaluation of extract obtained from Citrus maxima Burm. Merr. Seeds","volume":"49","author":"Sarkar","year":"2026","journal-title":"Drug Chem Toxicol"},{"key":"2026082615135019800_ref199","doi-asserted-by":"publisher","first-page":"103095","DOI":"10.1016\/j.redox.2024.103095","article-title":"Factors driving the inter-individual variability in the metabolism and bioavailability of (poly)phenolic metabolites: a systematic review of human studies","volume":"71","author":"Favari","year":"2024","journal-title":"Redox Biol"},{"key":"2026082615135019800_ref200","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1186\/1479-5876-10-50","article-title":"Are hepatic steatosis and carotid intima media thickness associated in obese patients with normal or slightly elevated gamma-glutamyl-transferase?","volume":"10","author":"Tarantino","year":"2012","journal-title":"J Transl Med"}],"container-title":["Journal of Pharmacy and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/78\/8\/rgag094\/70808873\/rgag094.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/78\/8\/rgag094\/70808873\/rgag094.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:14:03Z","timestamp":1787771643000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jpp\/article\/doi\/10.1093\/jpp\/rgag094\/8771356"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":200,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8,3]]}},"URL":"https:\/\/doi.org\/10.1093\/jpp\/rgag094","relation":{},"ISSN":["2042-7158"],"issn-type":[{"value":"2042-7158","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,8]]},"published":{"date-parts":[[2026,8]]},"article-number":"rgag094"}}