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Seizure behaviors and electroencephalography (EEG) activity were assessed. Cognitive function, hippocampal pathology, ultrastructure and key targets NLRP3, caspase-8 and BDNF were also examined. Additionally, network pharmacology and molecular docking analyses were integrated to complement the experimental findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key findings<\/jats:title>\n                    <jats:p>GEAT reduced the generalized seizures in the MES model. In the PTZ model, GEAT decreased the seizure stages, prolonged the latent period of epileptic seizures, and decreased the death rate. In the chronic PTZ model, GEAT significantly reduced the Racine score during the kindling process, suppressed spontaneous seizures and EEG abnormalities. It also effectively alleviated cognitive memory impairment and anxiety-like behavior. Furthermore, GEAT attenuated hippocampal neuronal loss, microglial and astrocytes activation and mitochondrial damage, and regulated BDNF, Caspase-8, NLRP3, Caspase-1 and IL-1\u03b2 protein expression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>GEAT exerts multi-target effects against epilepsy, associated with synergistic regulation of glial activation, neuroinflammation, and apoptosis involving the NLRP3\/caspase-1\/IL-1\u03b2 pathway, thereby providing a robust theoretical and experimental foundation for its clinical translation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jpp\/rgag096","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T11:42:36Z","timestamp":1786448556000},"source":"Crossref","is-referenced-by-count":1,"title":["<i>Gastrodia elata<\/i>\n                    Blume and\n                    <i>Acorus tatarinowii<\/i>\n                    Schott mixtures alleviate pentylenetetrazol-induced seizures in mice: association with NLRP3 inflammasome signaling changes"],"prefix":"10.1093","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0287-3828","authenticated-orcid":false,"given":"Xirui","family":"He","sequence":"first","affiliation":[{"name":"School of Bioengineering, Zunyi Medical University , Zhuhai, Guangdong 519041 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruoshi","family":"Tian","sequence":"additional","affiliation":[{"name":"School of Bioengineering, Zunyi Medical University , Zhuhai, Guangdong 519041 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xufei","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Resource Biology and Modern Biotechnology in Western China, The College of Life Science, Northwest University , Xi\u2019an, Shaanxi 710069 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqing","family":"Hu","sequence":"additional","affiliation":[{"name":"School of Bioengineering, Zunyi Medical University , Zhuhai, Guangdong 519041 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiulian","family":"Zeng","sequence":"additional","affiliation":[{"name":"School of Bioengineering, Zunyi Medical University , Zhuhai, Guangdong 519041 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Xiao","sequence":"additional","affiliation":[{"name":"School of Bioengineering, Zunyi Medical University , Zhuhai, Guangdong 519041 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Bioengineering, Zunyi Medical University , Zhuhai, Guangdong 519041 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