{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:58:00Z","timestamp":1790747880124,"version":"4.1.0"},"reference-count":67,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100004577","name":"Ministry of Agriculture and Agro-Based Industry, Malaysia","doi-asserted-by":"publisher","award":["HRGS\/NH1015S017"],"award-info":[{"award-number":["HRGS\/NH1015S017"]}],"id":[{"id":"10.13039\/501100004577","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to develop, characterize, and evaluate the efficacy of a soy lecithin-based formulation of AGP (Lipo-AGP) in Balb\/c.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Lipo-AGP was formulated using thin-film hydration. The formulation was characterized, followed by pharmacokinetic evaluation. A 14-day house dust mite (HDM)-induced lung inflammation model in BALB\/c mice was used, comprising sensitization and challenge phases. Bronchoalveolar lavage (BAL) fluid cell analysis, cytokine assays, gene expression, lung histology, serum HDM-specific IgE, and immunoblotting were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key findings<\/jats:title>\n                    <jats:p>The optimized Lipo-AGP formulation demonstrated a vesicle size of 178.9\u2009\u00b1\u200920.78\u00a0nm, a zeta potential of \u221227.73\u2009\u00b1\u20091.02\u00a0mV, and a PDI of 0.28\u2009\u00b1\u20090.001, alongside a high entrapment efficiency of 95.67\u2009\u00b1\u20091.78%. Stability analysis at 4\u00b0C and 25\u00b0C for 6\u00a0months did not show degradation. In vivo pharmacokinetics studies revealed that Lipo-AGP achieved a 1.5-fold improvement in both the rate and extent of AGP absorption compared to free AGP. Lipo-AGP exhibited a dose-dependent decrease in HDM-induced pulmonary cell infiltration, mucus hypersecretion, collagen deposition, and inhibition of nuclear NF-\u03baB p65. These results suggest that Lipo-AGP exerts protective effects against HDM-induced lung inflammation, through inhibition of NF-\u03baB signalling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Liposomal nanocarrier represents a potential strategy to deliver the lipophilic compounds, AGP for improved pharmacokinetics profile and efficacy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jpp\/rgag099","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T11:51:43Z","timestamp":1786535503000},"source":"Crossref","is-referenced-by-count":0,"title":["Development and evaluation of lecithin-based andrographolide liposomal nanoparticles: pharmacokinetics and anti-inflammatory activity in a mouse model of house dust mite-induced allergic lung inflammation"],"prefix":"10.1093","volume":"78","author":[{"given":"Emmanuel Oshiogwe","family":"Okwuofu","sequence":"first","affiliation":[{"name":"Pharmacotherapeutic Unit, Department of Medicine, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia , Serdang, 43400 Selangor ,","place":["Malaysia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey Chee Hui","family":"Yong","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry , Faculty of Pharmacy, MAHSA University, Jenjarom, 42610 Selangor ,","place":["Malaysia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan Chee Woei","family":"Lim","sequence":"additional","affiliation":[{"name":"Pharmacotherapeutic Unit, Department of Medicine, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia , Serdang, 43400 Selangor 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