{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T18:07:30Z","timestamp":1789063650216,"version":"build-2803163510"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Shenzhen Medical Research Fund","award":["C012400118"],"award-info":[{"award-number":["C012400118"]}]},{"name":"Shenzhen Nanshan District Health Technology Planning Project","award":["NS2025008"],"award-info":[{"award-number":["NS2025008"]}]},{"name":"Overseas High-Caliber Personnel Project in Shenzhen","award":["827000771"],"award-info":[{"award-number":["827000771"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273291"],"award-info":[{"award-number":["82273291"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to explore the potential of atorvastatin as an adjuvant on endothelial inflammation, vascular function, and the tumor microenvironment in diabetic pancreatic cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Utilizing a diabetic model of pancreatic cancer, we performed integrated analyses including single-cell RNA sequencing (scRNA-seq), receptor\u2013ligand interaction profiling between endothelial and immune cells, proteomic profiling, and interrogation of the TIMER 2.0 database. Key findings were validated via immunohistochemistry (IHC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key findings<\/jats:title>\n                    <jats:p>An atorvastatin (Lipitor, Lip) dose of 0.05\u00a0g\/kg was identified as optimal for vascular repair in diabetic mice. In diabetic pancreatic cancer models, combination therapy with this dose of atorvastatin and gemcitabine (Gem-Lip) significantly reduced tumor-induced endothelial cells (TECs) and exhausted CD8+ T cells compared with gemcitabine monotherapy. scRNA-seq further revealed an immune-remodeled microenvironment in the Gem-Lip group, characterized by enhanced T-cell cytolytic activity and an increase in CD4+ subsets such as HelperT_Ecm1. Receptor\u2013ligand analysis indicated strengthened interactions between CD8Teff_Fcer1g\/CD8Teff_Nusap1 immune subtypes and other cells. Proteomics validated the upregulation of proteins involved in positive immune regulation. Consistently, TIMER database analysis and IHC indicate increased infiltration of CD4+ and CD8+ T cells in tumors from the combination treatment group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings support the potential of atorvastatin plays a crucial role in suppressing vascular endothelial inflammation and reprogramming immune cell infiltration, thereby potentiating the efficacy of gemcitabine in diabetic pancreatic cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jpp\/rgag102","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T11:34:20Z","timestamp":1787052860000},"source":"Crossref","is-referenced-by-count":0,"title":["Atorvastatin potentiates the efficacy of gemcitabine in diabetic pancreatic cancer via remodeling the tumor immune microenvironment and attenuating vascular endothelial"],"prefix":"10.1093","volume":"78","author":[{"given":"Lu","family":"Li","sequence":"first","affiliation":[{"name":"Department of Transfusion, Shenzhen University General Hospital, Shenzhen University Clinical Medical Academy, Shenzhen University , Shenzhen, Guangdong, 518055 ,","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"He","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Shenzhen University General Hospital, Shenzhen University Clinical Medical Academy, Shenzhen University , Shenzhen, Guangdong, 518055 ,","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peikai","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Shenzhen University General Hospital, Shenzhen University Clinical Medical Academy, Shenzhen University , Shenzhen, Guangdong, 518055 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