{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T16:58:48Z","timestamp":1790441928454,"version":"4.1.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Korea government","award":["RS-2025-24533995"],"award-info":[{"award-number":["RS-2025-24533995"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Thiazide and thiazide-like diuretics remain first-line antihypertensive agents, exerting their primary renal effect through inhibition of the Na+-Cl\u2212 cotransporter (NCC) in the distal convoluted tubule, producing natriuresis and saluresis with relative K+ and Ca2+ sparing. Although numerous medicinal plants possess diuretic properties, most preclinical studies assess only urine volume, preventing mechanistic classification and obscuring whether observed diuresis reflects NCC-mediated tubular activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This focused review applied an electrolyte-based pharmacological framework to critically appraise medicinal plants with putative thiazide-like diuretic activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key findings<\/jats:title>\n                    <jats:p>Of nine studies assessed across seven plant species, Tagetes erecta most closely approximated the thiazide-like fingerprint\u2014natriuresis with relative K+ sparing and a partial Ca2+-sparing effect under HCTZ-referenced conditions, with additive interaction with HCTZ. Remaining candidates showed broader saluretic profiles, HCTZ-comparable natriuresis through mechanistically distinct pathways, or mixed\/loop-like electrolyte patterns, illustrating the pharmacological heterogeneity of herbal diuretics. Isoquercitrin and related flavonol scaffolds were identified as plausible candidates for NCC-targeted investigation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Genuinely thiazide-like electrolyte profiles are uncommon in the herbal diuretic literature, largely due to reliance on urine volume, inconsistent electrolyte profiling, and infrequent HCTZ comparison. Electrolyte-based classification frameworks would improve mechanistic interpretation and facilitate identification of pharmacologically selective candidates. T. erecta represents the priority candidate for future NCC-focused mechanistic investigation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jpp\/rgag107","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T11:20:57Z","timestamp":1788520857000},"source":"Crossref","is-referenced-by-count":0,"title":["Putative thiazide-like diuretic medicinal plants: an electrolyte fingerprint\u2013based review of preclinical evidence"],"prefix":"10.1093","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5958-4944","authenticated-orcid":false,"given":"Junkyu","family":"Park","sequence":"first","affiliation":[{"name":"Department of Science in Korean Medicine, Graduate School, Kyung Hee University , Seoul 02447 ,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5583-473X","authenticated-orcid":false,"given":"Sujin","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Herbal Pharmacology, College of Korean Medicine, Kyung Hee University , Seoul 02447 ,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2540-5905","authenticated-orcid":false,"given":"Youngmin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Science in Korean Medicine, Graduate School, Kyung Hee University , Seoul 02447 ,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6602-6472","authenticated-orcid":false,"given":"Jahyun","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Science in Korean Medicine, Graduate School, Kyung Hee University , Seoul 02447 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