{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:06:41Z","timestamp":1792786001900,"version":"4.5.0"},"reference-count":70,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Sao Paulo Research Foundation","award":["FAPESP\u20142020-14639-7"],"award-info":[{"award-number":["FAPESP\u20142020-14639-7"]}],"id":[{"id":"https:\/\/ror.org\/02ddkpn78","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Brazilian green propolis is notable for its ability to modulate immune cells. In preeclampsia (PE), endothelial dysfunction is caused by the release of damage-associated molecular patterns, oxidative stress, elevated pro-inflammatory cytokines, and adhesion molecules. This study aimed to evaluate the effects of propolis on biomarkers of endothelial dysfunction and oxidative stress using human umbilical vein endothelial cells (HUVECs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>HUVECs were cultured with plasma from early-onset (EOPE; n\u2009=\u200916) or late-onset (LOPE; n\u2009=\u200916) preeclamptic women, as well as from normotensive pregnant women (NT; n\u2009=\u200920). Cells were stimulated with HMGB1 and Hsp70, with or without propolis. This human endothelial cell-based model was used to investigate the disease-associated mechanisms relevant to PE and to evaluate propolis effects. The expression of Flt-1, VEGFR2, endoglin, E-selectin, ICAM-1 and VCAM-1 was assessed by flow cytometry. HMGB1, Hsp70, IL-6, IL-8, sFlt-1, sEng, and VEGF were measured by ELISA, and reactive oxygen species (ROS) by fluorescence assay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key findings<\/jats:title>\n                    <jats:p>Propolis reduced endothelial activation markers, ROS generation, IL-6 and IL-8 in both PE plasma-activated cells and DAMP-stimulated cell cultures. Propolis restored angiogenic balance by increasing VEGF levels while reducing sFlt-1 and sEng levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Propolis attenuated endothelial dysfunction, inflammatory activation, oxidative stress, and angiogenic imbalance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jpp\/rgag110","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T11:39:22Z","timestamp":1788521962000},"source":"Crossref","is-referenced-by-count":0,"title":["Brazilian green propolis attenuates endothelial dysfunction and oxidative stress in a preeclampsia model\n                    <i>in vitro<\/i>"],"prefix":"10.1093","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7629-7689","authenticated-orcid":false,"given":"Vanessa Rocha","family":"Ribeiro-Vasques","sequence":"first","affiliation":[{"name":"Sao Paulo State University (UNESP), Institute of Biosciences , Campus Botucatu, Sao Paulo 18618-691 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Romao-Veiga","sequence":"additional","affiliation":[{"name":"Sao Paulo State University (UNESP), Institute of Biosciences , Campus Botucatu, Sao Paulo 18618-691 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscila Rezeck","family":"Nunes","sequence":"additional","affiliation":[{"name":"Sao Paulo State University (UNESP), Institute of Biosciences , Campus Botucatu, Sao Paulo 18618-691 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Fernando Pereira","family":"Passeti","sequence":"additional","affiliation":[{"name":"Sao Paulo State University (UNESP), Institute of Biosciences , Campus Botucatu, Sao Paulo 18618-691 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela de Oliveira","family":"Franco","sequence":"additional","affiliation":[{"name":"Sao Paulo State University (UNESP), Botucatu Medical School , Campus Botucatu, Sao Paulo 18618-687 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Braga da Silva","sequence":"additional","affiliation":[{"name":"Sao Paulo State University (UNESP), Botucatu Medical School , Campus Botucatu, Sao Paulo 18618-687 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa Ragozo Cardoso","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Sao Paulo State University (UNESP), Institute of Biosciences , Campus Botucatu, Sao Paulo 18618-691 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Carlos","family":"Peracoli","sequence":"additional","affiliation":[{"name":"Sao Paulo State University (UNESP), Botucatu Medical School , Campus Botucatu, Sao Paulo 18618-687 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Terezinha Serrao","family":"Peracoli","sequence":"additional","affiliation":[{"name":"Sao Paulo State University (UNESP), Institute of Biosciences , Campus Botucatu, Sao Paulo 18618-691 ,","place":["Brazil"]},{"name":"Sao Paulo State University (UNESP), Botucatu Medical School , Campus Botucatu, Sao Paulo 18618-687 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Mauricio","family":"Sforcin","sequence":"additional","affiliation":[{"name":"Sao Paulo State University (UNESP), Institute of Biosciences , Campus Botucatu, Sao Paulo 18618-691 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,22]]},"reference":[{"key":"2026092204161158700_ref1","doi-asserted-by":"publisher","first-page":"91","DOI":"10.34172\/bshj.87","article-title":"Propolis\u2019 potential for drug 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