{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T12:10:54Z","timestamp":1767183054932},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2020,2,26]],"date-time":"2020-02-26T00:00:00Z","timestamp":1582675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The 141th Northern Japan Regional Meeting of the Japan Radiological Society"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,5,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The purpose of this study was to reveal treatment outcomes and toxicity after pelvic intensity-modulated radiotherapy (IMRT) for postoperative uterine cervical cancer of Japanese patients. Consecutive patients who were treated with pelvic IMRT for postoperative cervical cancer in our institute were retrospectively analyzed. Relapse-free survival (RFS) and overall survival (OS) were calculated using the Kaplan\u2013Meier estimator, and log-rank tests were used to compare differences. From the database, 62 patients were identified. The pathology was squamous cell carcinoma in 44 patients and other pathology in 18 patients. Of the 62 patients, 35 had high-risk prognostic factors and 27 patients had intermediate-risk prognostic factors. The prescribed radiation doses were 50\u00a0Gy in 25 fractions for 58 patients and 50.4\u00a0Gy in 28 fractions for 4 patients. One patient received a vaginal cuff boost. Chemotherapy was administered in 36 patients. During the median follow-up period of 50.9\u00a0months, there was no locoregional failure. Six patients in the high-risk group relapsed, but none of the patients in the intermediate-risk group relapsed (P\u00a0=\u00a00.02). The 3-year OS and RFS rates were 98.2% and 90.9%, respectively. Significant factors related to RFS were squamous cell carcinoma pathology (P\u00a0=\u00a00.02), pathological T stage (P\u00a0=\u00a00.04), surgical margin status (P\u00a0&amp;lt;\u00a00.01) and multiple lymph nodes metastases (P\u00a0&amp;lt;\u00a00.01). Grade 3 or more toxicity occurred in 6 patients. Four patients had obstruction of the intestine, and 2 patients had stenosis of the urinary tract. In clinical practice, the use of pelvic IMRT for postoperative cervical cancer of Japanese patients showed a low rate of toxicity without decreasing the efficacy.<\/jats:p>","DOI":"10.1093\/jrr\/rraa004","type":"journal-article","created":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T20:10:52Z","timestamp":1581451852000},"page":"470-478","source":"Crossref","is-referenced-by-count":6,"title":["Clinical experience of pelvic radiotherapy or chemoradiotherapy for postoperative uterine cervical cancer using intensity-modulated radiation therapy"],"prefix":"10.1093","volume":"61","author":[{"given":"Takaya","family":"Yamamoto","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Tohoku University Graduate School of Medicine, Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rei","family":"Umezawa","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Tohoku University Graduate School of Medicine, Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Tokunaga","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Kubozono","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Miyagi Cancer Center, Natori, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maiko","family":"Kozumi","sequence":"first","affiliation":[{"name":"Division of Radiology, Tohoku Medical and Pharmaceutical University, Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriyoshi","family":"Takahashi","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Tohoku University Graduate School of Medicine, Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruo","family":"Matsushita","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Tohoku University Graduate School of Medicine, Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriyuki","family":"Kadoya","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Tohoku University Graduate School of Medicine, Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kengo","family":"Ito","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Tohoku University Graduate School of Medicine, Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyokazu","family":"Sato","sequence":"first","affiliation":[{"name":"Radiation Technology, Tohoku University Hospital, Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keita","family":"Tsuji","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muneaki","family":"Shimada","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiichi","family":"Jingu","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Tohoku University Graduate School of Medicine, Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,2,26]]},"reference":[{"key":"2020061712032411100_ref1","article-title":"Clinical Practice Guidelines in Oncology","author":"National Comprehensive Cancer 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