{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T12:53:35Z","timestamp":1778158415446,"version":"3.51.4"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2020,3,12]],"date-time":"2020-03-12T00:00:00Z","timestamp":1583971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Japanese Society for Radiation Oncology"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,5,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Many patients with positive margins following breast-conserving surgery (BCS) undergo re-excisions that aim to remove residual disease from the breast, which brings a tremendous emotional burden in addition to financial consequences. We sought to determine whether re-excisions could be safely avoided without compromising local control and survival by using whole-breast radiation therapy (WBRT) with a tumor bed boost in patients with early-stage breast cancer with focally positive, tumor-exposed margins after BCS. All patients with ductal carcinoma in situ (DCIS) and\/or invasive breast cancer (IBC) who had pathologically tumor-exposed margins following BCS, without re-excision and treated with WBRT with tumor bed boost between March 2005 and December 2011, were included. The radiotherapy consisted of WBRT at a dose of 50\u00a0Gy in 25 fractions, followed by a tumor bed boost with an additional dose of 16\u00a0Gy in eight fractions. A total of 125 patients fulfilled the eligibility criteria; of the 125 patients, 1 had bilateral breast cancer, resulting in 126 cases. Invasive disease was found in 102 (81%) cases and purely ductal carcinoma in situ (DCIS) disease in 24 (19%) cases. The 10-year ipsilateral breast tumor recurrence (IBTR) -free survival, progression-free survival (PFS), and 10-year overall survival (OS) rates were 95%, 92.5% and 96%, respectively. Patients with early-stage breast cancer who receive BCS and have focally positive, tumor-exposed margins can avoid re-excision by undergoing WBRT followed by a sufficient dose of tumor bed boost, without negatively impacting local control and survival.<\/jats:p>","DOI":"10.1093\/jrr\/rraa005","type":"journal-article","created":{"date-parts":[[2020,3,6]],"date-time":"2020-03-06T12:22:40Z","timestamp":1583497360000},"page":"440-446","source":"Crossref","is-referenced-by-count":14,"title":["Efficacy of radiation boost after breast-conserving surgery for breast cancer with focally positive, tumor-exposed margins"],"prefix":"10.1093","volume":"61","author":[{"given":"Ryoko","family":"Suzuki","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, The Cancer Institute Hospital of JFCR, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Yoshida","sequence":"first","affiliation":[{"name":"Department of Radiology, Toho University Ohashi Medical Center, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiko","family":"Oguchi","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, The Cancer Institute Hospital of JFCR, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuo","family":"Yoshioka","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, The Cancer Institute Hospital of JFCR, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Tokumasu","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, The Cancer Institute Hospital of JFCR, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomo","family":"Osako","sequence":"first","affiliation":[{"name":"Department of Pathology, The Cancer Institute Hospital of JFCR, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Ono","sequence":"first","affiliation":[{"name":"Department of Breast Oncology Center, The Cancer Institute Hospital of JFCR, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Ueno","sequence":"first","affiliation":[{"name":"Department of Breast Oncology Center, The Cancer Institute Hospital of JFCR, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumi","family":"Miyagi","sequence":"first","affiliation":[{"name":"Department of Breast Oncology Center, The Cancer Institute Hospital of JFCR, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,3,12]]},"reference":[{"key":"2020061712032950200_ref1","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1001\/jama.2012.43","article-title":"Variability in reexcision following breast conservation 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