{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T23:16:00Z","timestamp":1783984560169,"version":"3.55.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"4","funder":[{"DOI":"10.13039\/501100001691","name":"JSPS","doi-asserted-by":"publisher","award":["JP 18\u00a0K04994"],"award-info":[{"award-number":["JP 18\u00a0K04994"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The forced swim test (FST) is a screening model for antidepressant activity; it causes immobility and induces oxidative stress. We previously reported that radon inhalation has antidepressant-like effects in mice potentially through the activation of antioxidative functions upon radon inhalation. This study aimed to investigate the effect of prior and post low-dose X-irradiation (0.1, 0.5, 1.0 and 2.0\u00a0Gy) on FST-induced immobility and oxidative stress in the mouse brain, and the differences, if any, between the two. Mice received X-irradiation before or after the FST repeatedly for 5 days. In the post-FST-irradiated group, an additional FST was conducted 4\u00a0h after the last irradiation. Consequently, animals receiving prior X-irradiation (0.1\u00a0Gy) had better mobility outcomes than sham-irradiated mice; however, their levels of lipid peroxide (LPO), an oxidative stress marker, remained unchanged. However, animals that received post-FST X-irradiation (0.5\u00a0Gy) had better mobility outcomes and their LPO levels were significantly lower than those of the sham-irradiated mice. The present results indicate that 0.5\u00a0Gy X-irradiation after FST inhibits FST-induced immobility and oxidative stress in mice.<\/jats:p>","DOI":"10.1093\/jrr\/rraa022","type":"journal-article","created":{"date-parts":[[2020,3,23]],"date-time":"2020-03-23T12:07:48Z","timestamp":1584965268000},"page":"517-523","source":"Crossref","is-referenced-by-count":8,"title":["X-Irradiation at 0.5\u00a0Gy after the forced swim test reduces forced swimming-induced immobility in mice"],"prefix":"10.1093","volume":"61","author":[{"given":"Takahiro","family":"Kataoka","sequence":"first","affiliation":[{"name":"Graduate School of Health Sciences, Okayama University, 5-1 Shikata-cho 2-chome, Kita-ku, Okayama-shi, Okayama 700-8558, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hina","family":"Shuto","sequence":"first","affiliation":[{"name":"Graduate School of Health Sciences, Okayama University, 5-1 Shikata-cho 2-chome, Kita-ku, Okayama-shi, Okayama 700-8558, 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Kita-ku, Okayama-shi, Okayama 700-8558, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Yamato","sequence":"first","affiliation":[{"name":"Laboratory of Neurology and Neurosurgery, National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita, Osaka 565-8565, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsumi","family":"Hanamoto","sequence":"first","affiliation":[{"name":"Graduate School of Health Sciences, Okayama University, 5-1 Shikata-cho 2-chome, Kita-ku, Okayama-shi, Okayama 700-8558, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaharu","family":"Nomura","sequence":"first","affiliation":[{"name":"Central Research Institute of Electric Power Industry, 2-11-1 Iwadokita, Komae-shi, Tokyo 201-8511, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyonori","family":"Yamaoka","sequence":"first","affiliation":[{"name":"Graduate School of Health Sciences, 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