{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T13:51:42Z","timestamp":1764510702990,"version":"3.37.3"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2020,7,9]],"date-time":"2020-07-09T00:00:00Z","timestamp":1594252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,9,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>This study aimed to determine the maximum tolerance dose (MTD) and to estimate the recommended dose (RD) of concomitant S-1 with carbon-ion radiotherapy (RT) for sinonasal squamous cell carcinoma (SCC). Nine patients with sinonasal SCC received carbon-ion RT with escalating doses of S-1 according to phase I methods. Doses of 40, 60 and 80\u00a0mg\/m2\/day were administered twice daily in dose levels 1, 2 and 3, respectively, from days 1 to 14 and 22 to 35. Carbon-ion RT was administered at a dose of 70.4\u00a0Gy (relative biological effectiveness) in 32 fractions, 5\u00a0days a week. Two patients developed grade 3 acute dermatitis. However, none developed dose-limiting toxicities. Therefore, the MTD of S-1 could not be determined; the RD was estimated to be 80\u00a0mg\/m2\/day with concurrent carbon-ion RT. Partial response and stable disease were noted in 5 and 4 patients, respectively. The 2-year overall survival and local control rates were 56 and 74%, respectively. Overall, 2 patients developed \u2265grade 3 late toxicities; among them, 1 patient developed grade 3 cataract and the other developed grade 4 cataract, optic nerve disorder and hearing impairment. To the best of our knowledge, this phase I study is the first clinical trial to evaluate concomitant S-1 with carbon-ion RT for sinonasal SCC. The MTD of S-1 could not be determined, and the RD was estimated to be 80\u00a0mg\/m2\/day. This study demonstrated a manageable safety profile for this combination. The observed outcomes may facilitate further evaluation of this novel therapy.<\/jats:p>","DOI":"10.1093\/jrr\/rraa037","type":"journal-article","created":{"date-parts":[[2020,5,24]],"date-time":"2020-05-24T11:07:46Z","timestamp":1590318466000},"page":"733-739","source":"Crossref","is-referenced-by-count":3,"title":["Phase I dose-escalation trial of S-1 combined with carbon-ion radiotherapy for sinonasal squamous cell carcinoma"],"prefix":"10.1093","volume":"61","author":[{"given":"Daiki","family":"Takahashi","sequence":"first","affiliation":[{"name":"Department of Radiology, Hyogo Ion Beam Medical Center, 1-2-1 Koto, Shingu-cho, Tatsuno, Hyogo 679-5165, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Demizu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Hyogo Ion Beam Medical Center, 1-2-1 Koto, Shingu-cho, Tatsuno, Hyogo 679-5165, Japan"},{"name":"Department of Radiation Oncology, Hyogo Ion Beam Medical Center Kobe Proton Center, 1-6-8 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Chul","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Radiology, Hyogo Ion Beam Medical Center, 1-2-1 Koto, Shingu-cho, Tatsuno, Hyogo 679-5165, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiro","family":"Matsuo","sequence":"additional","affiliation":[{"name":"Department of Radiology, Hyogo Ion Beam Medical Center, 1-2-1 Koto, Shingu-cho, Tatsuno, Hyogo 679-5165, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nor Shazrina","family":"Sulaiman","sequence":"additional","affiliation":[{"name":"Department of Radiology, Hyogo Ion Beam Medical Center, 1-2-1 Koto, Shingu-cho, Tatsuno, Hyogo 679-5165, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuki","family":"Terashima","sequence":"additional","affiliation":[{"name":"Department of Radiology, Hyogo Ion Beam Medical Center, 1-2-1 Koto, Shingu-cho, Tatsuno, Hyogo 679-5165, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunao","family":"Tokumaru","sequence":"additional","affiliation":[{"name":"Department of Radiology, Hyogo Ion Beam Medical Center, 1-2-1 Koto, Shingu-cho, Tatsuno, Hyogo 679-5165, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaya","family":"Akashi","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, Hyogo, Japan, 650-0017"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoaki","family":"Okimoto","sequence":"additional","affiliation":[{"name":"Department of Radiology, Hyogo Ion Beam Medical Center, 1-2-1 Koto, Shingu-cho, Tatsuno, Hyogo 679-5165, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,7,9]]},"reference":[{"key":"2020091006035888900_ref1","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.canep.2013.09.014","article-title":"International comparisons of the incidence and mortality of sinonasal cancer","volume":"37","author":"Youlden","year":"2013","journal-title":"Cancer Epidemiol"},{"key":"2020091006035888900_ref2","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1002\/hed.21830","article-title":"Incidence and survival in patients with sinonasal cancer: A historical analysis of population-based data","volume":"34","author":"Turner","year":"2012","journal-title":"Head Neck"},{"key":"2020091006035888900_ref3","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1002\/cncr.25721","article-title":"Longitudinal oncology registry of head and neck carcinoma (LORHAN): Analysis of chemoradiation treatment approaches in the United States","volume":"117","author":"Wong","year":"2011","journal-title":"Cancer"},{"key":"2020091006035888900_ref4","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.oraloncology.2018.01.015","article-title":"Combination of post-operative radiotherapy and cetuximab for high-risk cutaneous squamous cell cancer of the head and neck: A propensity score analysis","volume":"78","author":"Palmer","year":"2018","journal-title":"Oral Oncol"},{"key":"2020091006035888900_ref5","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1080\/14786440409463246","article-title":"LXXIV. 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