{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:36:09Z","timestamp":1791279369722,"version":"4.1.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2020,9,5]],"date-time":"2020-09-05T00:00:00Z","timestamp":1599264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Tokyo Metropolitan Cancer and Infectious Diseases Center"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,11,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Total body irradiation using intensity-modulated radiation therapy total body irradiation (IMRT-TBI) by helical tomotherapy in allogeneic hematopoietic stem cell transplantation (allo-HSCT) allows for precise evaluation and adjustment of radiation dosage. We conducted a single-center pilot study to evaluate the safety of IMRT-TBI for allo-HSCT recipients. Patients with hematological malignancies in remission who were scheduled for allo-HSCT with TBI-based myeloablative conditioning were eligible. The primary endpoint was the incidence of adverse events (AEs). Secondary endpoints were engraftment rate, overall survival, relapse rate, non-relapse mortality, and the incidence of acute and chronic graft-versus-host disease (aGVHD and cGVHD, respectively). Between July 2018 and November 2018, ten patients were recruited with a median observation duration of 571\u00a0days after allo-HSCT (range, 496\u2013614). D80% for planning target volume (PTV) in all patients was 12.01\u00a0Gy. Average D80% values for lungs, kidneys and lenses (right\/left) were 7.50, 9.03 and 4.41\/4.03\u00a0Gy, respectively. Any early AEs (within 100\u00a0days of allo-HSCT) were reported in all patients. Eight patients experienced oral mucositis and gastrointestinal symptoms. One patient experienced Bearman criteria grade 3 regimen-related toxicity (kidney and liver). All cases achieved neutrophil engraftment. There was no grade III\u2013IV aGVHD or late AE. One patient died of sinusoidal obstruction syndrome 67\u00a0days after allo-HSCT. The remaining nine patients were alive and disease-free at final follow-up. Thus, IMRT-TBI was well tolerated in terms of early AEs in adult patients who underwent allo-HSCT; this warrants further study with longer observation times to monitor late AEs and efficacy.<\/jats:p>","DOI":"10.1093\/jrr\/rraa078","type":"journal-article","created":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T08:03:41Z","timestamp":1597997021000},"page":"969-976","source":"Crossref","is-referenced-by-count":19,"title":["Safety of total body irradiation using intensity-modulated radiation therapy by helical tomotherapy in allogeneic hematopoietic stem cell transplantation: a prospective pilot study"],"prefix":"10.1093","volume":"61","author":[{"given":"Tatsuya","family":"Konishi","sequence":"first","affiliation":[{"name":"Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Division of Radiation 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Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroto","family":"Adachi","sequence":"additional","affiliation":[{"name":"Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryosuke","family":"Konuma","sequence":"additional","affiliation":[{"name":"Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuya","family":"Kishida","sequence":"additional","affiliation":[{"name":"Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihito","family":"Nagata","sequence":"additional","affiliation":[{"name":"Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome 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Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuma","family":"Noguchi","sequence":"additional","affiliation":[{"name":"Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Toya","sequence":"additional","affiliation":[{"name":"Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiko","family":"Igarashi","sequence":"additional","affiliation":[{"name":"Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome 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