{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:08:10Z","timestamp":1740136090450,"version":"3.37.3"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T00:00:00Z","timestamp":1606176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["18H04135","25220102"],"award-info":[{"award-number":["18H04135","25220102"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Transgenic expression in medaka of the Xiphophorus oncogene xmrk, under a pigment cell specific mitf promoter, induces hyperpigmentation and pigment cell tumors. In this study, we crossed the Hd-rR and HNI inbred strains because complete genome information is readily available for molecular and genetic analysis. We prepared an Hd-rR (p53+\/\u2212, p53\u2212\/\u2212) and Hd-rR HNI hybrid (p53+\/\u2212) fish-based xmrk model system to study the progression of pigment cells from hyperpigmentation to malignant tumors on different genetic backgrounds. In all strains examined, most of the initial hyperpigmentation occurred in the posterior region. On the Hd-rR background, mitf:xmrk-induced tumorigenesis was less frequent in p53+\/\u2212 fish than in p53\u2212\/\u2212 fish. The incidence of hyperpigmentation was more frequent in Hd-rR\/HNI hybrids than in Hd-rR homozygotes; however, the frequency of malignant tumors was low, which suggested the presence of a tumor suppressor in HNI genetic background fish. The effects on tumorigenesis in xmrk-transgenic immature medaka of a single 1.3\u00a0Gy irradiation was assessed by quantifying tumor progression over 4 consecutive months. The results demonstrate that irradiation has a different level of suppressive effect on the frequency of hyperpigmentation in purebred Hd-rR compared with hybrids.<\/jats:p>","DOI":"10.1093\/jrr\/rraa103","type":"journal-article","created":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T21:19:32Z","timestamp":1605820772000},"page":"12-24","source":"Crossref","is-referenced-by-count":0,"title":["Strain difference in transgene-induced tumorigenesis and suppressive effect of ionizing radiation"],"prefix":"10.1093","volume":"62","author":[{"given":"Bibek","family":"Dutta","sequence":"first","affiliation":[{"name":"Laboratory of Genome Stability, Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, 277-8562, Kashiwa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taichi","family":"Asami","sequence":"additional","affiliation":[{"name":"Laboratory of Genome Stability, Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, 277-8562, Kashiwa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tohru","family":"Imatomi","sequence":"additional","affiliation":[{"name":"Laboratory of Genome Stability, Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, 277-8562, Kashiwa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kento","family":"Igarashi","sequence":"additional","affiliation":[{"name":"Laboratory of Genome Stability, Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, 277-8562, Kashiwa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kento","family":"Nagata","sequence":"additional","affiliation":[{"name":"Laboratory of Genome Stability, Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, 277-8562, Kashiwa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomomi","family":"Watanabe-Asaka","sequence":"additional","affiliation":[{"name":"Laboratory of Genome Stability, Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, 277-8562, Kashiwa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takako","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Laboratory of Genome Stability, Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, 277-8562, Kashiwa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoji","family":"Oda","sequence":"additional","affiliation":[{"name":"Laboratory of Genome Stability, Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, 277-8562, Kashiwa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manfred","family":"Shartl","sequence":"additional","affiliation":[{"name":"University of Wuerzburg, Physiological Chemistry, Biocenter, 97074 Wuerzburg, Germany and the Xiphophorus Genetic Stock Center, Department of Chemistry and Biochemistry, Texas State University, San Marcos, Texas, 78666, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Mitani","sequence":"additional","affiliation":[{"name":"Laboratory of Genome Stability, Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, 277-8562, Kashiwa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,11,24]]},"reference":[{"key":"2021032411575946700_ref1","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/978-3-319-30654-4_23","article-title":"Xiphophorus and medaka cancer models","volume":"916","author":"Schartl","year":"2016","journal-title":"Adv Exp Med Biol"},{"key":"2021032411575946700_ref2","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1093\/genetics\/12.3.253","article-title":"The genetics of a viviparous top-minnow Platypoecilus; the inheritance of two kinds of melanophores","volume":"12","author":"Gordon","year":"1927","journal-title":"Genetics"},{"key":"2021032411575946700_ref3","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1600-0749.1991.tb00309.x","article-title":"Contributions of the Gordon-Kosswig melanoma system to the present concept of neoplasia","volume":"4","author":"Anders","year":"1991","journal-title":"Pigment Cell Res"},{"key":"2021032411575946700_ref4","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1002\/(SICI)1098-2744(199811)23:3<132::AID-MC2>3.0.CO;2-1","article-title":"Molecular biology of human melanoma development and progression","volume":"23","author":"Sauter","year":"1998","journal-title":"Mol Carcinog"},{"key":"2021032411575946700_ref5","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1093\/molbev\/msh017","article-title":"Identification of a second egfr gene in Xiphophorus uncovers an expansion of the epidermal growth factor receptor family in fish","volume":"21","author":"Gomez","year":"2004","journal-title":"Mol Biol Evol"},{"key":"2021032411575946700_ref6","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.tig.2006.09.013","article-title":"From Mendelian to molecular genetics: The Xiphophorus melanoma model","volume":"22","author":"Meierjohann","year":"2006","journal-title":"Trends Genet"},{"key":"2021032411575946700_ref7","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.mod.2004.03.011","article-title":"Medaka as a research organism: Past, present and future","volume":"121","author":"Shima","year":"2004","journal-title":"Mech Dev"},{"key":"2021032411575946700_ref8","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/jid.2009.213","article-title":"A mutated EGFR is sufficient to induce malignant melanoma with genetic background-dependent histopathologies","volume":"130","author":"Schartl","year":"2010","journal-title":"J Invest Dermatol"},{"key":"2021032411575946700_ref9","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.molmed.2006.07.008","article-title":"MITF: Master regulator of melanocyte development and melanoma oncogene","volume":"12","author":"Levy","year":"2006","journal-title":"Trends Mol Med"},{"key":"2021032411575946700_ref10","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1293\/tox.2018-0058","article-title":"Histopathologic features of melanocytic tumors in Xiphophorus melanoma receptor kinase (xmrk)-transgenic medaka (Oryzias latipes)","volume":"32","author":"Sugiyama","year":"2019","journal-title":"J Toxicol Pathol"},{"key":"2021032411575946700_ref11","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/nature05846","article-title":"The medaka draft genome and insights into vertebrate genome evolution","volume":"447","author":"Kasahara","year":"2007","journal-title":"Nature"},{"key":"2021032411575946700_ref12","first-page":"45","article-title":"The lists of the mutants and strains of the medaka, common gambusia, silver crucian carp, goldfish, and golden venus fish maintained in the Laboratory of Freshwater Fish Stocks, Nagoya University","volume":"4","author":"Tomita","year":"1992","journal-title":"The Fish Biology Journal Medaka"},{"key":"2021032411575946700_ref13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0036875","article-title":"Allelic expression changes in Medaka (Oryzias latipes) hybrids between inbred strains derived from genetically distant populations","volume":"7","author":"Murata","year":"2012","journal-title":"PLoS One"},{"key":"2021032411575946700_ref14","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/0141-1136(94)00144-E","article-title":"Transfer, methylation and spontaneous mutation frequency of \u03a6X174am3cs70 sequences in medaka (Oryzias latipes) and mummichog (Fundulus heteroclitus): Implications for gene transfer and environmental mutagenesis in aquatic species","volume":"40","author":"Winn","year":"1995","journal-title":"Mar Environ Res"},{"key":"2021032411575946700_ref15","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/jid.2009.293","article-title":"Xmrk in medaka: A new genetic melanoma model","volume":"130","author":"Patton","year":"2010","journal-title":"J Invest Dermatol"},{"key":"2021032411575946700_ref16","doi-asserted-by":"crossref","DOI":"10.1126\/science.aad2197","article-title":"A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation","volume":"351","author":"Kaufman","year":"2016","journal-title":"Science"},{"key":"2021032411575946700_ref17","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1101\/gad.1437206","article-title":"Malignant melanoma: Genetics and therapeutics in the genomic era","volume":"20","author":"Chin","year":"2006","journal-title":"Genes Dev"},{"key":"2021032411575946700_ref18","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1128\/MCB.21.6.2144-2153.2001","article-title":"Dual inactivation of RB and p53 pathways in RAS-induced melanomas","volume":"21","author":"Bardeesy","year":"2001","journal-title":"Mol Cell Biol"},{"key":"2021032411575946700_ref19","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1089\/zeb.2009.0606","article-title":"Oncogenic NRAS cooperates with p53 loss to generate melanoma in zebrafish","volume":"6","author":"Dovey","year":"2009","journal-title":"Zebrafish"},{"key":"2021032411575946700_ref20","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1242\/dmm.001149","article-title":"Dissecting the roles of Raf- and PI3K-signalling pathways in melanoma formation and progression in a zebrafish model","volume":"2","author":"Michailidou","year":"2009","journal-title":"Dis Model Mech"},{"key":"2021032411575946700_ref21","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1148\/131.3.589","article-title":"Risk of breast cancer following low-dose radiation exposure","volume":"131","author":"Boice","year":"1979","journal-title":"Radiology"},{"key":"2021032411575946700_ref22","doi-asserted-by":"crossref","first-page":"13761","DOI":"10.1073\/pnas.2235592100","article-title":"Cancer risks attributable to low doses of ionizing radiation: Assessing what we really know","volume":"100","author":"Brenner","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2021032411575946700_ref23","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1148\/radiol.2511081686","article-title":"Risks associated with low doses and low dose rates of ionizing radiation: Why linearity may be (almost) the best we can do","volume":"251","author":"Little","year":"2009","journal-title":"Radiology"},{"key":"2021032411575946700_ref24","doi-asserted-by":"crossref","first-page":"172","DOI":"10.2203\/dose-response.09-037.Vaiserman","article-title":"Radiation hormesis: Historical perspective and implications for low-dose cancer risk assessment","volume":"8","author":"Vaiserman","year":"2010","journal-title":"Dose Response"},{"key":"2021032411575946700_ref25","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S0531-5131(01)00861-5","article-title":"Suppressive effect of long-term low-dose rate gamma-irradiation on chemical carcinogenesis in mice","volume":"1236","author":"Sakai","year":"2002","journal-title":"Int Congr Ser"},{"key":"2021032411575946700_ref26","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1667\/RR3502.1","article-title":"Mammary tumorigenesis in ApcMin\/+ mice is enhanced by X-irradiation with a characteristic age dependence","volume":"165","author":"Imaoka","year":"2006","journal-title":"Radiat Res"},{"key":"2021032411575946700_ref27","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1269\/jrr.46.83","article-title":"Intestinal tumorigenesis in min mice is enhanced by X-irradiation in an age-dependent manner","volume":"46","author":"Okamoto","year":"2005","journal-title":"J Radiat Res"},{"key":"2021032411575946700_ref28","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0531-5565(02)00152-3","article-title":"Cellular senescence and apoptosis: How cellular responses might influence aging phenotypes","volume":"38","author":"Campisi","year":"2003","journal-title":"Exp Gerontol"},{"key":"2021032411575946700_ref29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1000152","article-title":"The identification of zebrafish mutants showing alterations in senescence-associated biomarkers","volume":"4","author":"Kishi","year":"2008","journal-title":"PLoS Genet"},{"key":"2021032411575946700_ref30","doi-asserted-by":"crossref","first-page":"705","DOI":"10.4236\/abb.2012.326091","article-title":"The relationship between apoptosis and aging","volume":"3","author":"Lu","year":"2012","journal-title":"Adv Biosci Biotechnol"},{"key":"2021032411575946700_ref31","doi-asserted-by":"crossref","first-page":"9363","DOI":"10.1073\/pnas.92.20.9363","article-title":"A biomarker that identifies senescent human cells in culture and in aging skin in vivo","volume":"92","author":"Dimri","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2021032411575946700_ref32","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1667\/0033-7587(2001)156[0232:IOASLP]2.0.CO;2","article-title":"Induction of a senescence-like phenotype in bovine aortic endothelial cells by ionizing radiation","volume":"156","author":"Oh","year":"2001","journal-title":"Radiat Res"},{"key":"2021032411575946700_ref33","doi-asserted-by":"crossref","first-page":"341","DOI":"10.3390\/proteomes2030341","article-title":"Chronic low dose rate ionizing radiation exposure induces premature senescence in human fibroblasts that correlates with up regulation of proteins involved in protection against oxidative stress","volume":"2","author":"Loseva","year":"2014","journal-title":"Proteomes"},{"key":"2021032411575946700_ref34","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/0014-4827(65)90211-9","article-title":"The limited in vitro lifetime of human diploid cell strains","volume":"37","author":"Hayflick","year":"1965","journal-title":"Exp Cell Res"},{"key":"2021032411575946700_ref35","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1269\/jrr.07081","article-title":"Stress-induced premature senescence (SIPS)\u2013influence of SIPS on radiotherapy","volume":"49","author":"Suzuki","year":"2008","journal-title":"J Radiat Res"},{"key":"2021032411575946700_ref36","first-page":"515","article-title":"Tumor suppression by p53: Making cells senescent","volume":"25","author":"Qian","year":"2010","journal-title":"Histol Histopathol"},{"key":"2021032411575946700_ref37","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/978-1-62703-239-1_3","article-title":"Senescence regulation by the p53 protein family","volume":"965","author":"Qian","year":"2013","journal-title":"Methods Mol Biol"},{"key":"2021032411575946700_ref38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms1473","article-title":"p53 and p16(INK4A) independent induction of senescence by chromatin-dependent alteration of S-phase progression","volume":"2","author":"Prieur","year":"2011","journal-title":"Nat Commun"},{"key":"2021032411575946700_ref39","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1007\/s00109-011-0766-y","article-title":"Novel ARF\/p53-independent senescence pathways in cancer repression","volume":"89","author":"Chan","year":"2011","journal-title":"J Mol Med"}],"container-title":["Journal of Radiation Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jrr\/article-pdf\/62\/1\/12\/36683506\/rraa103.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jrr\/article-pdf\/62\/1\/12\/36683506\/rraa103.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T11:59:46Z","timestamp":1616587186000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jrr\/article\/62\/1\/12\/5998897"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,24]]},"references-count":39,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,11,24]]},"published-print":{"date-parts":[[2021,1,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jrr\/rraa103","relation":{},"ISSN":["0449-3060","1349-9157"],"issn-type":[{"type":"print","value":"0449-3060"},{"type":"electronic","value":"1349-9157"}],"subject":[],"published-other":{"date-parts":[[2021,1]]},"published":{"date-parts":[[2020,11,24]]}}}