{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T04:08:29Z","timestamp":1771646909991,"version":"3.50.1"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T00:00:00Z","timestamp":1607558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Alopecia is one of the common symptoms after high-dose radiation exposure. In our experiments, neonatal mice that received 7\u00a0Gy X-ray exhibited defects in overall hair growth, except for their cheeks. This phenomenon might suggest that some substances were secreted and prevented hair follicle loss in the infant tissues around their cheeks after radiation damage. In this study, we focused on exosome-like vesicles (ELV) secreted from cheek skin tissues and back skin tissues, as control, and examined their radiation protective effects on mouse fibroblast cell lines. We observed that ELV from irradiated cheek skin showed protective effects from radiation. Our results suggest that ELV from radiation-exposed cheek skin tissue is one of the secreted factors that prevent hair follicle loss after high-dose radiation.<\/jats:p>","DOI":"10.1093\/jrr\/rraa106","type":"journal-article","created":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T11:22:47Z","timestamp":1603192967000},"page":"73-78","source":"Crossref","is-referenced-by-count":7,"title":["Extracellular vesicles released from irradiated neonatal mouse cheek tissue increased cell survival after radiation"],"prefix":"10.1093","volume":"62","author":[{"given":"Kentaro","family":"Ariyoshi","sequence":"first","affiliation":[{"name":"Integrated Center for Science and Humanities, Fukushima Medical University, 1 Hikariga-oka, Fukushima City, Fukushima, 960-1295, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yota","family":"Hiroyama","sequence":"additional","affiliation":[{"name":"Department of Radiation Biology, Institute of Radiation Emergency Medicine, Hirosaki University, 66-1 Hon-cho, Hirosaki 036-8564, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoya","family":"Fujiwara","sequence":"additional","affiliation":[{"name":"Department of Radiation Biology, Institute of Radiation Emergency Medicine, Hirosaki University, 66-1 Hon-cho, Hirosaki 036-8564, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomisato","family":"Miura","sequence":"additional","affiliation":[{"name":"Department of Radiation Biology, Institute of Radiation Emergency Medicine, Hirosaki University, 66-1 Hon-cho, Hirosaki 036-8564, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kosuke","family":"Kasai","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Hirosaki University Graduate School of Health Sciences, 66-1 Hon-cho, Hirosaki 036-8564, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akifumi","family":"Nakata","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences, Hokkaido University of Science, 15-4-1, Maeda 7-jo, Teine-ku, Sapporo, Hokkaido 006-8585, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yohei","family":"Fujishima","sequence":"additional","affiliation":[{"name":"Department of Radiation Biology, Tohoku University School of Medicine, Sendai, Miyagi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerie Swee","family":"Ting Goh","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Hirosaki University Graduate School of Health Sciences, 66-1 Hon-cho, Hirosaki 036-8564, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuaki A","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Integrated Center for Science and Humanities, Fukushima Medical University, 1 Hikariga-oka, Fukushima City, Fukushima, 960-1295, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,12,11]]},"reference":[{"issue":"1","key":"2021032414293202000_ref1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/1523-1747.ep12479347","article-title":"Radiobiology of the skin: Review of some effects on epidermis and hair","volume":"77","author":"Malkinson","year":"1981","journal-title":"J Invest Dermatol"},{"issue":"7","key":"2021032414293202000_ref2","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1056\/NEJM199908123410706","article-title":"The biology of hair follicles","volume":"341","author":"Paus","year":"1999","journal-title":"N Engl J Med"},{"issue":"4","key":"2021032414293202000_ref3","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/0360-3016(92)90528-P","article-title":"Topical application of nitroxide protects radiation-induced alopecia in Guinea pigs","volume":"22","author":"Goffman","year":"1992","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"3","key":"2021032414293202000_ref4","first-page":"349","article-title":"Cell death (apoptosis) in hair follicles and consequent changes in the width of hairs after irradiation of growing follicles","volume":"48","author":"Potten","year":"1985","journal-title":"Int J Radiat Biol"},{"issue":"2","key":"2021032414293202000_ref5","first-page":"211","article-title":"Apoptosis in growing hair follicles following gamma-irradiation and application for the evaluation of radioprotective agents","volume":"17","author":"Kim","year":"2003","journal-title":"In Vivo (Brooklyn)"},{"issue":"10","key":"2021032414293202000_ref6","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1111\/j.1600-0625.2009.00849.x","article-title":"Evaluation of radiation-induced hair follicle apoptosis in mice and the preventive effects of fibroblast growth factor-1","volume":"18","author":"Nakayama","year":"2009","journal-title":"Exp Dermatol"},{"issue":"22","key":"2021032414293202000_ref7","doi-asserted-by":"crossref","first-page":"6083","DOI":"10.1158\/0008-5472.CAN-17-0667","article-title":"Mobilizing transit-amplifying cell-derived ectopic progenitors prevents hair loss from chemotherapy or radiation therapy","volume":"77","author":"Huang","year":"2017","journal-title":"Cancer Res"},{"issue":"4","key":"2021032414293202000_ref8","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1083\/jcb.201211138","article-title":"Extracellular vesicles: Exosomes, microvesicles, and friends","volume":"200","author":"Raposo","year":"2013","journal-title":"J Cell Biol"},{"issue":"11","key":"2021032414293202000_ref9","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1038\/leu.2016.107","article-title":"Mesenchymal stromal cell-derived extracellular vesicles rescue radiation damage to murine marrow hematopoietic cells","volume":"30","author":"Wen","year":"2016","journal-title":"Leukemia"},{"issue":"7","key":"2021032414293202000_ref10","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1083\/jcb.201601109","article-title":"Extracellular vesicles of stromal origin target and support hematopoietic stem and progenitor cells","volume":"216","author":"Stik","year":"2017","journal-title":"J Cell Biol"},{"issue":"12","key":"2021032414293202000_ref11","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1002\/stem.2716","article-title":"Mesenchymal stromal cell-derived extracellular vesicles provide long-term survival after Total body irradiation without additional hematopoietic stem cell support","volume":"35","author":"Schoefinius","year":"2017","journal-title":"Stem Cells"},{"issue":"1","key":"2021032414293202000_ref12","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-45669-z","article-title":"Radiation-induced bystander effect is mediated by mitochondrial DNA in exosome-like vesicles","volume":"9","author":"Ariyoshi","year":"2019","journal-title":"Sci Rep"},{"key":"2021032414293202000_ref13","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.mrfmmm.2016.06.001","article-title":"Induction of genomic instability and activation of autophagy in artificial human aneuploid cells","volume":"790","author":"Ariyoshi","year":"2016","journal-title":"Mutat Res - Fundam Mol Mech Mutagen"},{"issue":"90","key":"2021032414293202000_ref14","doi-asserted-by":"crossref","first-page":"36083","DOI":"10.18632\/oncotarget.26300","article-title":"Exosomes impact survival to radiation exposure in cell line models of nervous system cancer","volume":"9","author":"Mrowczynski","year":"2018","journal-title":"Oncotarget"},{"issue":"3","key":"2021032414293202000_ref15","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.cell.2014.09.051","article-title":"Exosome transfer from stromal to breast cancer cells regulates therapy resistance pathways","volume":"159","author":"Boelens","year":"2014","journal-title":"Cell"},{"key":"2021032414293202000_ref16","doi-asserted-by":"crossref","first-page":"869","DOI":"10.3389\/fonc.2019.00869","article-title":"Exosomes in cancer Radioresistance","volume":"9","author":"Ni","year":"2019","journal-title":"Front Oncol"},{"issue":"9","key":"2021032414293202000_ref17","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1002\/stem.3043","article-title":"Extracellular vesicles from activated dermal fibroblasts stimulate hair follicle growth through dermal papilla-secreted Norrin","volume":"37","author":"Riche","year":"2019","journal-title":"Stem Cells"}],"container-title":["Journal of Radiation Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jrr\/article-pdf\/62\/1\/73\/36684430\/rraa106.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jrr\/article-pdf\/62\/1\/73\/36684430\/rraa106.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T14:31:52Z","timestamp":1616596312000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jrr\/article\/62\/1\/73\/6030104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,11]]},"references-count":17,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,12,11]]},"published-print":{"date-parts":[[2021,1,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jrr\/rraa106","relation":{},"ISSN":["0449-3060","1349-9157"],"issn-type":[{"value":"0449-3060","type":"print"},{"value":"1349-9157","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,1]]},"published":{"date-parts":[[2020,12,11]]}}}