{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T06:33:15Z","timestamp":1778567595026,"version":"3.51.4"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T00:00:00Z","timestamp":1610064000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Japanese Society for Radiation Oncology"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>This study aimed to research the post-treatment quality of life (QOL) between radiotherapy (RT)- and operation (OP)-treated early cervical cancer survivors, using separate questionnaires for physicians and patients. We administered an observational questionnaire to patients aged 20\u201370\u00a0years old with Stages IB1\u2013IIB cervical cancer who had undergone RT or OP and without recurrence as outpatients for \u22656\u00a0months after treatment. We divided 100 registered patients equally into two treatment groups (n\u00a0=\u00a050 each). The average age was 53 and 44\u00a0years in the RT and OP groups, respectively. The RT group included 34 and 66% Stage I and II patients, respectively, whereas the OP group included 66 and 34% Stage I and II patients, respectively. The OP group included 58% of patients with postoperative RT. Combination chemotherapy was performed in 84 and 48% of patients in the RT and OP groups, respectively. On the physicians\u2019 questionnaire, we observed significant differences in bone marrow suppression (RT) and leg edema (OP). On the patients\u2019 questionnaire, significantly more patients had dysuria and leg edema in the OP group than in the RT group, and severe (Score 4\u20135) leg edema was significantly higher in the post-operative RT group than in the OP only group. The frequency of sexual intercourse decreased after treatment in both groups. On the patients\u2019 questionnaire, there were no significant differences between the two groups regarding sexual activity. These findings are useful to patients and physicians for shared decision-making in treatment choices. The guidance of everyday life and health information including sexual life after treatment is important.<\/jats:p>","DOI":"10.1093\/jrr\/rraa107","type":"journal-article","created":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T11:10:22Z","timestamp":1602846622000},"page":"269-284","source":"Crossref","is-referenced-by-count":9,"title":["A multi-institutional survey of the quality of life after treatment for uterine cervical cancer: a comparison between radical radiotherapy and surgery in Japan"],"prefix":"10.1093","volume":"62","author":[{"given":"Yuko","family":"Kaneyasu","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, National Hospital Organization Fukuyama Medical Center, Hiroshima, Japan"},{"name":"Department of Radiation Oncology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisaya","family":"Fujiwara","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Chugoku Rosai Hospital, Hiroshima, Japan"},{"name":"Department of Obstetrics and Gynecology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuo","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Radiation and Proton Therapy Center, Shizuoka Cancer Center, Shizuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideyuki","family":"Sakurai","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University of Tsukuba, Ibaraki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoko","family":"Kazumoto","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Fukaya Red Cross Hospital, Saitama, Japan"},{"name":"Department of Radiation Oncology, Saitama Cancer Center, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Ikushima","sequence":"additional","affiliation":[{"name":"Department of Therapeutic Radiology, Tokushima University Graduate School, Tokushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Uno","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology and Radiation Oncology, Chiba University Graduate School of Medicine, Chiba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunao","family":"Tokumaru","sequence":"additional","affiliation":[{"name":"Hyogo Ion Beam Medical Center, Hyogo, Japan"},{"name":"Department of Radiology, Saga University, Saga, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoko","family":"Harima","sequence":"additional","affiliation":[{"name":"Department of Radiology, Kansai Medical University, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromichi","family":"Gomi","sequence":"additional","affiliation":[{"name":"Radiation Oncology Center, St. Marianna University School of Medicine Hospital, Kanagawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takafumi","family":"Toita","sequence":"additional","affiliation":[{"name":"Radiation Therapy Center, Okinawa Chubu Hospital, Okinawa, Japan"},{"name":"Department of Radiology, Graduate School of Medical Science, University of the Ryukyus, Okinawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Midori","family":"Kita","sequence":"additional","affiliation":[{"name":"Department of Radiology, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin-ei","family":"Noda","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Saitama Medical University International Medical Center, Saitama, Japan"},{"name":"Department of Radiation Oncology, Gunma University Graduate School of Medicine, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeo","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Saitama Medical University Saitama Medical Center, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shingo","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Saitama Medical University International Medical Center, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayako","family":"Ohkawa","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University of Tsukuba, Ibaraki, Japan"},{"name":"Department of Radiation Oncology, National Hospital Organization Mito Medical Center, Ibaraki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Tozawa-Ono","sequence":"additional","affiliation":[{"name":"Department of Gynecology, St. Marianna University School of Medicine, Toyoko Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Ushijima","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Saitama Cancer Center, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoko","family":"Hasumi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Mitsui Memorial Hospital, Tokyo, Japan"},{"name":"Department of Gynecology, Saitama Cancer Center, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuyuki","family":"Hirashima","sequence":"additional","affiliation":[{"name":"Division of Gynecology, Shizuoka Cancer Center, Shizuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuzuru","family":"Niibe","sequence":"additional","affiliation":[{"name":"Department of Public Health, Kurume University School of Medtioicine, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomio","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, National Hospital Organization Fukuyama Medical Center, Hiroshima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Akita","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Infectious Disease Control and Prevention, Graduate school of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junko","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Infectious Disease Control and Prevention, Graduate school of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Ohno","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Gunma University Graduate School of Medicine, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the Working Group of the Gynecological Tumor Committee of the Japanese Radiation Oncology Study Group (JROSG)","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,1,7]]},"reference":[{"key":"2021032416073297800_ref1","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0140-6736(97)02250-2","article-title":"Randomized study of radical surgery versus radiotherapy for stage Ib-IIa cervical 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Do treatment modalities, disease stage, and self-esteem influence outcome","volume":"19","author":"Kobayashi","year":"2009","journal-title":"Int J Gynecol Cancer"},{"key":"2021032416073297800_ref7","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1002\/cncr.22217","article-title":"The European organization for research and treatment of cancer (EORTC) quality-of-life questionnaire cervical cancer module EORTC QLQ-CX24","volume":"107","author":"Greimel","year":"2006","journal-title":"Cancer"},{"key":"2021032416073297800_ref8","article-title":"Sexuality of middle and old age","author":"Araki","year":"2016","journal-title":"Jpn J Sexol"},{"key":"2021032416073297800_ref9","first-page":"187","article-title":"Changes of sexual activity in patients with uterine cervical carcinoma treated with radiation therapy","volume":"15","author":"Sakurai","year":"2003","journal-title":"J Jpn Soc Ther Radiol Oncol"},{"key":"2021032416073297800_ref10","first-page":"682","article-title":"Development of a Japanese QOL questionnaire for patients with uterine cervical cancer","volume":"36","author":"Kaneyasu","year":"2018","journal-title":"Japanese J Gynecol Oncol"},{"key":"2021032416073297800_ref11","volume-title":"Japan Society of Obstetrics and Gynecology, The Japanese Society pf Pathplogy, Japan Radiologinal Society","author":"General Rules for Clinical and Pathological Study of Uterine Cervical Cancer in Japan","year":"1999","edition":"2 nd English ed"},{"key":"2021032416073297800_ref12","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1097\/IGC.0000000000000880","article-title":"Long-term morbidity and quality of life in cervical cancer survivors: A Multicenter comparison between surgery and radiotherapy as primary treatment","volume":"27","author":"Derks","year":"2017","journal-title":"Int J Gynecol Cancer"},{"key":"2021032416073297800_ref13","first-page":"69","volume-title":"Clinical Gynecologic Oncology","author":"Krishnansu","year":"2012","edition":"8th ed."},{"key":"2021032416073297800_ref14","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1007\/s00066-008-1728-3","article-title":"Lymph Edema of the lower extremities after adenectomy and radiotherapy for cervical cancer","author":"Fuller","year":"2008","journal-title":"Strahlenther Onkol"},{"key":"2021032416073297800_ref15","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1136\/ijgc-00009577-200605000-00027","article-title":"An observational longitudinal study to evaluate mictin, defecation, and sexual function after radical hysterectomy with pelvic lymphadenectomy for early-stage cervical cancer","author":"Pieterse","year":"2006","journal-title":"Int J Gynecol Cancer"},{"key":"2021032416073297800_ref16","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.ygyno.2011.09.041","article-title":"Quality of life and emotional distress in early stage and locally advanced cervical cancer patients: A prospective","volume":"124","author":"Ferrandina","year":"2012","journal-title":"longitudinal study. 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