{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:26:11Z","timestamp":1787009171223,"version":"build-2736575974"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,1,17]],"date-time":"2021-01-17T00:00:00Z","timestamp":1610841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007162","name":"Guangdong Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["2014A020212491"],"award-info":[{"award-number":["2014A020212491"]}],"id":[{"id":"10.13039\/501100007162","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The purpose of this study was to use a murine model to determine if melatonin can protect the inner ear from radiation-induced damage. A total of 81 4-week-old Balb\/c mice were randomly divided into five groups: control group; 50\u00a0mg\/kg melatonin group; 5\u00a0mg\/kg melatonin+radiotherapy group; 50\u00a0mg\/kg melatonin+radiotherapy group; radiotherapy group. The radiotherapy groups received 16\u00a0Gy irradiation and melatonin was administered by intraperitoneal injection 30\u00a0min before radiotherapy. On days 3 and 7 after irradiation the function of outer hair cells was determined by auditory brainstem response (ABR) and distortion product otoacoustic emissions (DPOAEs) testing, pathological changes of inner ear cells were observed by light microscopy, and the expression of prestin mRNA was determined. ABR thresholds were increased and wave I latencies were extended after radiotherapy; however, the increases were lower in the groups that received melatonin (P\u00a0&amp;lt;\u00a00.05). DPOAEs showed radiotherapy-induced hearing loss at 8\u201312\u00a0kHz, and hearing loss was greater on day 7 than day 3. However, hearing loss was less in the melatonin groups (P\u00a0&amp;lt;\u00a00.05). Histopathological examination showed irradiation resulted in breaks and distortion of the cochlear basement membrane, disruption of the stria vascularis, and swelling of outer hair cells. Melatonin reduced these changes. Radiotherapy upregulated prestin mRNA expression. Radiotherapy-induced upregulation of prestin was decreased in the melatonin groups (P\u00a0&amp;lt;\u00a00.05), and the decrease was greater in the 50\u00a0mg\/kg melatonin group (P\u00a0&amp;lt;\u00a00.05). Melatonin protects against radiation-induced cochlear damage by reducing damage to outer hair cells.<\/jats:p>","DOI":"10.1093\/jrr\/rraa137","type":"journal-article","created":{"date-parts":[[2020,12,16]],"date-time":"2020-12-16T14:42:29Z","timestamp":1608129749000},"page":"217-225","source":"Crossref","is-referenced-by-count":8,"title":["Melatonin reduces radiation damage in inner ear"],"prefix":"10.1093","volume":"62","author":[{"given":"Ting","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, GuangDong Women and Children Hospital, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuling","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixin","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhao","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molu","family":"Ban","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, the People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,1,18]]},"reference":[{"key":"2021032416081661000_ref1","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0305-7372(03)00066-5","article-title":"Radiotherapy-induced ear toxicity","volume":"29","author":"Jereczek-Fossa","year":"2003","journal-title":"Cancer Treat Rev"},{"key":"2021032416081661000_ref2","doi-asserted-by":"crossref","first-page":"5631","DOI":"10.7314\/APJCP.2013.14.10.5631","article-title":"Radiation-induced cochlea hair cell death: Mechanisms and protection","volume":"14","author":"Tan","year":"2013","journal-title":"Asian Pac J Cancer Prev"},{"key":"2021032416081661000_ref3","doi-asserted-by":"crossref","first-page":"91","DOI":"10.47102\/annals-acadmedsg.V38N1p91","article-title":"12th yahya cohen memorial lecture - the cellular and molecular basis of radiation-induced sensori-neural hearing 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