{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T16:21:03Z","timestamp":1792858863132,"version":"4.5.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T00:00:00Z","timestamp":1628467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"JAEA Nuclear Energy S&T and Human Resource Development Project through Concentrating Wisdom","award":["JPJA18B18072098"],"award-info":[{"award-number":["JPJA18B18072098"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Radon inhalation decreases the level of lipid peroxide (LPO); this is attributed to the activation of antioxidative functions. This activation contributes to the beneficial effects of radon therapy, but there are no studies on the risks of radon therapy, such as DNA damage. We evaluated the effect of radon inhalation on DNA damage caused by oxidative stress and explored the underlying mechanisms. Mice were exposed to radon inhalation at concentrations of 2 or 20\u00a0kBq\/m3 (for one, three, or 10\u00a0days). The 8-hydroxy-2\u2032-deoxyguanosine (8-OHdG) levels decreased in the brains of mice that inhaled 20\u00a0kBq\/m3 radon for three\u00a0days and in the kidneys of mice that inhaled 2 or 20\u00a0kBq\/m3 radon for one, three or 10\u00a0days. The 8-OHdG levels in the small intestine decreased by approximately 20\u201340% (2\u00a0kBq\/m3 for three\u00a0days or 20\u00a0kBq\/m3 for one, three or 10\u00a0days), but there were no significant differences in the 8-OHdG levels between mice that inhaled a sham treatment and those that inhaled radon. There was no significant change in the levels of 8-oxoguanine DNA glycosylase, which plays an important role in DNA repair. However, the level of Mn-superoxide dismutase (SOD) increased by 15\u201360% and 15\u201345% in the small intestine and kidney, respectively, following radon inhalation. These results suggest that Mn-SOD probably plays an important role in the inhibition of oxidative DNA damage.<\/jats:p>","DOI":"10.1093\/jrr\/rrab069","type":"journal-article","created":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T11:09:07Z","timestamp":1626952147000},"page":"861-867","source":"Crossref","is-referenced-by-count":12,"title":["Radon inhalation decreases DNA damage induced by oxidative stress in mouse organs via the activation of antioxidative functions"],"prefix":"10.1093","volume":"62","author":[{"given":"Takahiro","family":"Kataoka","sequence":"first","affiliation":[{"name":"Graduate School of Health Sciences, Okayama University, 5-1 Shikata-cho, 2-chome, Kita-ku, Okayama-shi, Okayama 700-8558, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hina","family":"Shuto","sequence":"additional","affiliation":[{"name":"Graduate School of Health Sciences, Okayama University, 5-1 Shikata-cho, 2-chome, Kita-ku, Okayama-shi, Okayama 700-8558, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shota","family":"Naoe","sequence":"additional","affiliation":[{"name":"Graduate School of Health Sciences, Okayama University, 5-1 Shikata-cho, 2-chome, Kita-ku, Okayama-shi, Okayama 700-8558, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junki","family":"Yano","sequence":"additional","affiliation":[{"name":"Graduate School of Health Sciences, Okayama University, 5-1 Shikata-cho, 2-chome, Kita-ku, Okayama-shi, Okayama 700-8558, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norie","family":"Kanzaki","sequence":"additional","affiliation":[{"name":"Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency, 1550 Kamisaibara, Kagamino-cho, Tomata-gun, Okayama 708-0698, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Sakoda","sequence":"additional","affiliation":[{"name":"Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency, 1550 Kamisaibara, Kagamino-cho, Tomata-gun, Okayama 708-0698, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency, 1550 Kamisaibara, Kagamino-cho, Tomata-gun, Okayama 708-0698, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsumi","family":"Hanamoto","sequence":"additional","affiliation":[{"name":"Graduate School of Health Sciences, Okayama University, 5-1 Shikata-cho, 2-chome, Kita-ku, Okayama-shi, Okayama 700-8558, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumihiro","family":"Mitsunobu","sequence":"additional","affiliation":[{"name":"Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama University, 5-1 Shikata-cho, 2-chome, Kita-ku, Okayama-shi, Okayama 700-8558, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Terato","sequence":"additional","affiliation":[{"name":"Advanced Science Research Center Okayama University, 5-1 Shikata-cho 2-chome, Kita-ku, Okayama-shi, Okayama 700-8558, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyonori","family":"Yamaoka","sequence":"additional","affiliation":[{"name":"Graduate School of Health Sciences, Okayama University, 5-1 Shikata-cho, 2-chome, Kita-ku, Okayama-shi, Okayama 700-8558, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,8,9]]},"reference":[{"key":"2021091406113086700_ref1","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1007\/s10067-016-3236-7","article-title":"The impact of serial radon and hyperthermia exposure in a therapeutic adit on pivotal cytokines of bone metabolism in rheumatoid arthritis and 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