{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T17:58:39Z","timestamp":1761674319380,"version":"3.37.3"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,10,27]],"date-time":"2021-10-27T00:00:00Z","timestamp":1635292800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006120","name":"Ministry of the Environment","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006120","id-type":"DOI","asserted-by":"publisher"}]},{"name":"JSPS KAKENHI","award":["21K19683"],"award-info":[{"award-number":["21K19683"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Ionizing radiation exposure affects the redox state in vivo. Recently, whole-blood antioxidant capacity (WBAC) has been reported to decrease in a dose-dependent manner after acute total body irradiation (TBI). However, changes in WBAC after localized and chronic irradiations have not been reported. This study analyzed changes to WBAC in mice after either localized irradiation (irradiation of the left hind leg only) or chronic TBI using the i-STrap method. Leg-localized irradiation exerted limited effects on WBAC, while WBAC decreased in a dose rate-dependent manner after TBI. Further, the WBAC reached the minimum value in a shorter period at a smaller dose rate. Our results suggest that changes in WBAC do not directly reflect absorbed dose, but may reflect radiation-induced biological damage at the systemic level. This study will contribute to the understanding of radiation-induced injuries and diseases, and will facilitate the establishment of biomarkers for radiation exposure.<\/jats:p>","DOI":"10.1093\/jrr\/rrab099","type":"journal-article","created":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T02:43:31Z","timestamp":1633574611000},"page":"30-35","source":"Crossref","is-referenced-by-count":3,"title":["Analysis of whole-blood antioxidant capacity after chronic and localized irradiation using the i-STrap method"],"prefix":"10.1093","volume":"63","author":[{"given":"Lue","family":"Sun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yohei","family":"Inaba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Sogo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kumi","family":"Morikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Kunugita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Chida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Moritake","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,10,27]]},"reference":[{"key":"2022012104013331000_ref1","doi-asserted-by":"crossref","first-page":"S107","DOI":"10.1269\/jrr.42.S107","article-title":"Chromosome aberration analysis in persons exposed to low-level radiation from the JCO criticality accident in Tokai-mura","volume":"42","author":"Sasaki","year":"2001","journal-title":"J Radiat Res"},{"key":"2022012104013331000_ref2","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1667\/RR14630.1","article-title":"The causal relationship between DNA damage induction in bovine lymphocytes and the Fukushima nuclear power plant accident","volume":"187","author":"Nakamura","year":"2017","journal-title":"Radiat Res"},{"key":"2022012104013331000_ref3","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/S0891-5849(96)00554-0","article-title":"Blood glutathione as an index of radiation-induced oxidative stress in mice and humans","volume":"22","author":"Navarro","year":"1997","journal-title":"Free Radic Biol Med"},{"key":"2022012104013331000_ref4","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1093\/jrr\/rrw039","article-title":"A novel Nrf2 activator from microbial transformation inhibits radiation-induced dermatitis in mice","volume":"57","author":"Nakagami","year":"2016","journal-title":"J Radiat Res"},{"key":"2022012104013331000_ref5","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/S0360-3016(03)01369-5","article-title":"Overexpression of extracellular superoxide dismutase protects mice from radiation-induced lung injury","volume":"57","author":"Kang","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"2022012104013331000_ref6","doi-asserted-by":"crossref","first-page":"7425","DOI":"10.1038\/s41598-018-25650-y","article-title":"Dose-dependent decrease in anti-oxidant capacity of whole blood after irradiation: a novel potential marker for biodosimetry","volume":"8","author":"Sun","year":"2018","journal-title":"Sci Rep"},{"key":"2022012104013331000_ref7","doi-asserted-by":"crossref","first-page":"6716","DOI":"10.1038\/s41598-021-86187-1","article-title":"Total body irradiation causes a chronic decrease in antioxidant levels","volume":"11","author":"Sun","year":"2021","journal-title":"Sci Rep"},{"key":"2022012104013331000_ref8","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/jat.727","article-title":"A good practice guide to the administration of substances and removal of blood, including routes and volumes","volume":"21","author":"Diehl","year":"2001","journal-title":"J Appl Toxicol"},{"key":"2022012104013331000_ref9","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1269\/jrr.44.7","article-title":"Different radiation susceptibility among five strains of mice detected by a skin reaction","volume":"44","author":"Iwakawa","year":"2003","journal-title":"J Radiat Res"},{"key":"2022012104013331000_ref10","article-title":"Analysis of plasma protein concentrations and enzyme activities in cattle within the ex-evacuation zone of the Fukushima Daiichi nuclear plant accident","volume":"11","author":"Urushihara","year":"2016","journal-title":"PLoS One"},{"key":"2022012104013331000_ref11","doi-asserted-by":"crossref","first-page":"4765","DOI":"10.1096\/fj.12-215228","article-title":"Evaluation of systemic markers of inflammation in atomic-bomb survivors with special reference to radiation and age effects","volume":"26","author":"Hayashi","year":"2012","journal-title":"FASEB J"},{"key":"2022012104013331000_ref12","doi-asserted-by":"crossref","first-page":"4252","DOI":"10.1073\/pnas.1603023113","article-title":"Individual variability in human blood metabolites identifies age-related differences","volume":"113","author":"Chaleckis","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2022012104013331000_ref13","article-title":"Identification of potential biomarkers of radiation exposure in blood cells by capillary electrophoresis time-of-flight mass spectrometry","volume":"21","author":"Sun","year":"2020","journal-title":"Int J Mol Sci"},{"key":"2022012104013331000_ref14","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1080\/0284186X.2018.1441542","article-title":"Prophylactically applied Hydrofilm polyurethane film dressings reduce radiation dermatitis in adjuvant radiation therapy of breast cancer patients","volume":"57","author":"Schmeel","year":"2018","journal-title":"Acta Oncol"},{"key":"2022012104013331000_ref15","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1258\/ar.2012.120192","article-title":"The necessity of follow-up for radiation skin injuries in patients after percutaneous coronary interventions: radiation skin injuries will often be overlooked clinically","volume":"53","author":"Kato","year":"2012","journal-title":"Acta Radiol"},{"key":"2022012104013331000_ref16","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1269\/jrr.09112","article-title":"Radiation dose and radiation protection for patients and physicians during interventional procedure","volume":"51","author":"Chida","year":"2010","journal-title":"J Radiat Res"},{"key":"2022012104013331000_ref17","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1093\/rpd\/nch091","article-title":"The variation in biological effectiveness of X-rays and gamma rays with energy","volume":"112","author":"Hill","year":"2004","journal-title":"Radiat Prot Dosimetry"},{"key":"2022012104013331000_ref18","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1667\/RR3190","article-title":"Upper dose thresholds for radiation-induced adaptive response against cancer in high-dose-exposed, cancer-prone, radiation-sensitive Trp53 heterozygous mice","volume":"162","author":"Mitchel","year":"2004","journal-title":"Radiat Res"},{"key":"2022012104013331000_ref19","first-page":"445","article-title":"Differential responses of stress genes to low dose-rate gamma irradiation","volume":"1","author":"Amundson","year":"2003","journal-title":"Mol Cancer Res"},{"key":"2022012104013331000_ref20","doi-asserted-by":"crossref","first-page":"8287","DOI":"10.1038\/s41598-018-26556-5","article-title":"Investigation of dose-rate effects and cell-cycle distribution under protracted exposure to ionizing radiation for various dose-rates","volume":"8","author":"Matsuya","year":"2018","journal-title":"Sci Rep"},{"key":"2022012104013331000_ref21","doi-asserted-by":"crossref","first-page":"S93","DOI":"10.2307\/3578771","article-title":"Dose-rate effect for DNA damage induced by ionizing radiation in human tumor cells","volume":"138","author":"Ruiz de Almod\u00f3var","year":"1994","journal-title":"Radiat Res"}],"container-title":["Journal of Radiation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jrr\/article-pdf\/63\/1\/30\/42245378\/rrab099.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jrr\/article-pdf\/63\/1\/30\/42245378\/rrab099.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,21]],"date-time":"2022-01-21T04:02:20Z","timestamp":1642737740000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jrr\/article\/63\/1\/30\/6411841"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,27]]},"references-count":21,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,10,27]]},"published-print":{"date-parts":[[2022,1,20]]}},"URL":"https:\/\/doi.org\/10.1093\/jrr\/rrab099","relation":{},"ISSN":["0449-3060","1349-9157"],"issn-type":[{"type":"print","value":"0449-3060"},{"type":"electronic","value":"1349-9157"}],"subject":[],"published-other":{"date-parts":[[2022,1]]},"published":{"date-parts":[[2021,10,27]]}}}