{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:26:10Z","timestamp":1787009170593,"version":"build-2736575974"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2022,2,13]],"date-time":"2022-02-13T00:00:00Z","timestamp":1644710400000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science, and Technology of Japan","doi-asserted-by":"crossref","award":["26\u2009461\u2009879"],"award-info":[{"award-number":["26\u2009461\u2009879"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We herein report a retrospective analysis of the efficacy of a combination therapy of pelvic irradiation that excluded the common iliac lymph nodes region and image-guided brachytherapy (IGBT) for non-bulky (\u22644\u00a0cm) cervical cancer. Thirty-three patients with stage I\u2013II cervical squamous cell carcinoma (\u22644\u00a0cm) and without pelvic\/para-aortic lymphadenopathy who were treated with definitive radiotherapy alone between February 2009 and September 2016 were included. The radiotherapy consisted of CT-based small-pelvis irradiation (whole pelvis minus common iliac lymph node area) of 20\u00a0Gy\/10 fractions followed by pelvic irradiation with a midline block of 30\u00a0Gy\/15 fractions and IGBT of 24\u00a0Gy\/4 fractions (6\u00a0Gy\/fraction for high-risk [HR] clinical target volume [CTV] D90%). In-room computed tomography (CT) imaging with applicator insertion was used for brachytherapy planning, with physical examinations and diagnostic magnetic resonance imaging (MRI) also being referred to for determination of HR CTV. Over a median follow-up of 60.5\u00a0months (range, 7\u201389), two patients developed distant recurrence and one developed local and distant recurrence. Two patients died from cervical cancer, one from hepatocellular carcinoma and one from non-cancerous disease. The 2\/5-year local control (LC), progression-free survival (PFS) and overall survival (OS) rates were 100%\/96.7%, 93.8%\/90.6% and 93.9%\/93.9%, respectively. No pelvic\/para-aortic lymph node recurrence was observed. There were no late complications of grade 3 or higher in the small bowel, large bowel\/rectum, or bladder. Our results suggest that a combination therapy of IGBT plus small-pelvis irradiation excluding common iliac lymph nodes provides reasonable clinical outcomes and can be a treatment option in non-bulky (\u22644\u00a0cm) cervical squamous cell carcinoma.<\/jats:p>","DOI":"10.1093\/jrr\/rrac001","type":"journal-article","created":{"date-parts":[[2022,1,14]],"date-time":"2022-01-14T07:08:12Z","timestamp":1642144092000},"page":"290-295","source":"Crossref","is-referenced-by-count":2,"title":["A retrospective study of small-pelvis radiotherapy plus image-guided brachytherapy in stage I\u2013II non-bulky cervical squamous cell carcinoma"],"prefix":"10.1093","volume":"63","author":[{"given":"Yuya","family":"Yoshimoto","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan"},{"name":"Department of Radiation Oncology, Fukushima Medical University, 1, Hikarigaoka, Fukushima, Fukushima 960-1247, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazutoshi","family":"Murata","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan"},{"name":"QST Hospital, National Institute for Quantum Science and Technology (QST), 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Irie","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Ando","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Adachi","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Aoki","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, National Hospital Organization Takasaki General Medical Center, 36 Takamatsu-cho. Takasaki, Gunma 370-0829, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Hirakawa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin-ei","family":"Noda","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Saitama Medical University International Medical Center, 1397-1 Yamane, Hidaka, Saitama 350-1298, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Nakano","sequence":"additional","affiliation":[{"name":"Quantum Life and Medical Science Directorate, National Institute for Quantum Science and Technology (QST), 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Ohno","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,2,12]]},"reference":[{"key":"2022032516123398000_ref1","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1093\/jrr\/rrw121","article-title":"In-room computed tomography-based brachytherapy for uterine cervical cancer: results of a 5-year retrospective study","volume":"58","author":"Ohno","year":"2017","journal-title":"J Radiat Res"},{"key":"2022032516123398000_ref2","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1093\/jrr\/rru006","article-title":"Dose-volume histogram parameters of high-dose-rate brachytherapy for stage I-II cervical cancer (\u22644cm) arising from a small-sized uterus 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