{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:06:56Z","timestamp":1753877216820,"version":"3.41.2"},"reference-count":37,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T00:00:00Z","timestamp":1657065600000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U1967220","82073477"],"award-info":[{"award-number":["U1967220","82073477"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Young Talent Project of China National Nuclear Corporation"},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Radon is a naturally occurring radioactive gas and considered as a serious carcinogen to humans. Continuous radioactive decay of this gas emits high-energy alpha particles. Long-term radon exposure induces oxidative stress and inflammatory response, which results in chronic lung diseases. However, biological effects after radon exposure in other organs have been rarely reported. As the outermost organ of the human body, the skin suffers from environmental damage to agents such as air pollution. Epidemiological studies indicated that areas with high level of radon had a high incidence of skin cancer. However, whether radon exposure induces skin damage has not been reported yet. In this study, we established a radon-exposed mouse model and found that radon exposure affected the structure of skin tissues, which was manifested by inflammatory cell infiltration and skin atrophy. Using proteomic approach, we found 45 preferentially expressed proteins in 60 Working Level Months (WLM) group and 314 preferentially expressed proteins in 120 WLM group from radon-exposed skin tissues. Through microRNA (miRNA) sequencing profiling analysis, 57 dysregulated miRNAs were screened between the control and radon-treated mouse skin. By integrating the dysregulated proteins and miRNAs, radon-induced fatty acid synthase (FASN) was investigated in greater detail. Results showed that FASN was regulated by miR-206-3p and miR-378a-3p and involved in the pathogenesis of radon-induced skin damage. Overexpression of FASN inhibited the proliferation, and induced in WS1 cells. Our present findings illustrate the molecular change during radon-induced skin damage and the potential role of FASN during this process.<\/jats:p>","DOI":"10.1093\/jrr\/rrac037","type":"journal-article","created":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T05:46:38Z","timestamp":1657086398000},"source":"Crossref","is-referenced-by-count":1,"title":["Proteomic and miRNA profiling of radon-induced skin damage in mice: FASN regulated by miRNAs"],"prefix":"10.1093","author":[{"given":"Wei","family":"Mo","sequence":"first","affiliation":[{"name":"School of Radiation Medicine and Protection , State Key Laboratory of Radiation Medicine and Protection, , Suzhou 215123, China"},{"name":"Soochow University , State Key Laboratory of Radiation Medicine and Protection, , Suzhou 215123, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanglei","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Radiation Medicine and Protection , State Key Laboratory of Radiation Medicine and Protection, , Suzhou 215123, China"},{"name":"Soochow University , State Key Laboratory of Radiation Medicine and Protection, , Suzhou 215123, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Hong","sequence":"additional","affiliation":[{"name":"School of Radiation Medicine and Protection , State Key Laboratory of Radiation Medicine and Protection, , Suzhou 215123, China"},{"name":"Soochow University , State Key Laboratory of Radiation Medicine and Protection, , Suzhou 215123, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingyi","family":"Yang","sequence":"additional","affiliation":[{"name":"West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University , Chengdu 610041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhong","family":"Shi","sequence":"additional","affiliation":[{"name":"Second Affiliated Hospital of Chengdu Medical College, China National Nuclear Corporation 416 Hospital , Chengdu 610051, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Jiao","sequence":"additional","affiliation":[{"name":"School of Radiation Medicine and Protection , State Key Laboratory of Radiation Medicine and Protection, , Suzhou 215123, China"},{"name":"Soochow University , State Key Laboratory of Radiation Medicine and Protection, , Suzhou 215123, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jihua","family":"Nie","sequence":"additional","affiliation":[{"name":"School of Radiation Medicine and Protection , State Key Laboratory of Radiation Medicine and Protection, , Suzhou 215123, China"},{"name":"Soochow University , State Key Laboratory of Radiation Medicine and Protection, , Suzhou 215123, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengmei","family":"Cui","sequence":"additional","affiliation":[{"name":"School of Radiation Medicine and Protection , State Key Laboratory of Radiation Medicine and Protection, , Suzhou 215123, China"},{"name":"Soochow University , State Key Laboratory of Radiation Medicine and Protection, , Suzhou 215123, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianping","family":"Cao","sequence":"additional","affiliation":[{"name":"School of Radiation Medicine and Protection , State Key Laboratory of Radiation Medicine and Protection, , Suzhou 215123, China"},{"name":"Soochow University , State Key Laboratory of Radiation Medicine and Protection, , Suzhou 215123, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University , Chengdu 610041, China"},{"name":"Second Affiliated Hospital of Chengdu Medical College, China National Nuclear Corporation 416 Hospital , Chengdu 610051, China"},{"name":"West China Second University Hospital, Sichuan University , Chengdu 610041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,7,5]]},"reference":[{"key":"2022070605463097100_ref1","doi-asserted-by":"crossref","DOI":"10.1289\/EHP825","article-title":"Effects of radon and UV exposure on skin cancer mortality in Switzerland","volume":"125","author":"Vienneau","year":"2017","journal-title":"Environ Health Perspect"},{"key":"2022070605463097100_ref2","doi-asserted-by":"crossref","first-page":"14024","DOI":"10.3390\/ijms140714024","article-title":"The cellular and molecular carcinogenic effects of radon exposure: a review","volume":"14","author":"Robertson","year":"2013","journal-title":"Int J Mol Sci"},{"key":"2022070605463097100_ref3","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1186\/s12885-020-07184-7","article-title":"Low dose environmental radon exposure and breast tumor gene 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